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The map label for this gene is argD [H]

Identifier: 157158142

GI number: 157158142

Start: 3803667

End: 3804887

Strand: Reverse

Name: argD [H]

Synonym: EcE24377A_3829

Alternate gene names: 157158142

Gene position: 3804887-3803667 (Counterclockwise)

Preceding gene: 157156286

Following gene: 157158908

Centisome position: 76.41

GC content: 54.79

Gene sequence:

>1221_bases
ATGGCAATTGAACAAACAGCAATTACACGCGCGACTTTCGATGAAGTGATCCTGCCGATTTATGCTCCGGCAGAGTTTAT
TCCGGTAAAAGGTCAGGGCAGCCGAATCTGGGATCAGCAAGGCAAGGAGTATGTCGATTTCGCGGGTGGCATTGCAGTTA
CGGCGTTGGGCCATTGCCATCCTGCGCTGGTGAACGCGTTAAAAACCCAGGGCGAAACTCTGTGGCATATCAGTAACGTT
TTCACCAATGAACCGGCGCTGCGTCTTGGGCGTAAACTGATTGAGGCAACGTTTGCCGAACGCGTGGTGTTTATGAACTC
CGGCACGGAAGCTAACGAAACCGCCTTTAAACTGGCACGTCATTACGCCTGTGTGCGTCATAGCCCGTTCAAAACCAAAA
TTATTGCCTTCCATAACGCTTTTCATGGTCGCTCGCTGTTTACCGTTTCGGTGGGTGGGCAGCCAAAATATTCCGACGGC
TTTGGGCCGAAACCGGCAGACATCATCCACGTTCCCTTTAACGATCTCCACGCAGTGAAAGCAGTGATGGATGATCACAC
CTGTGCGGTGGTGGTTGAGCCGATCCAGGGCGAGGGCGGCGTGACGGCTGCGACGCCAGAGTTTTTGCAGGGCTTGCGCG
AGCTGTGCGATCAACATCAGGCATTATTGGTGTTTGATGAAGTGCAGTGCGGGATGGGGCGGACCGGCGATTTGTTTGCT
TACATGCACTACGGCGTGACGCCGGATATTCTGACCTCTGCGAAAGCGTTAGGCGGCGGCTTCCCGATTAGCGCCATGCT
GACCACGGCGGAAATTGCTTCTGCGTTTCATCCTGGTTCTCACGGTTCCACCTACGGCGGTAATCCTCTGGCCTGTGCAG
TAGCGGGCGCGGCGTTTGATATCATCAATACCCCTGAAGTGCTGGAAGGCATTCAGGCGAAACGCCAGCGTTTTGTTGAC
CATTTGCAGAAGATCGATCAGCAGTACGATGTGTTTAGCGATATTCGCGGTATGGGGCTGTTGATTGGCGCGGAGCTTAA
GCCACAGTTCAAAGGTCGGGCGCGTGATTTCCTGTATGCGGGCGCAGGGGCTGGCGTAATGGTGCTGAATGCCGGACCGG
ATGTGATGCGTTTTGCACCGTCGCTGGTGGTGGAAGATGCGGATATCGATGAAGGGATGCAACGTTTCGCCCACGCGGTG
GCGAAGGTGGTTGGGGCGTAA

Upstream 100 bases:

>100_bases
TTCCTGCATCGCTGATTTCTGATTGCCATTTAGTGATTTTTTATGCATATTTTGTGATTATAATTTCACATTTATTTATG
CGTAACAGGGTGATTATGAG

Downstream 100 bases:

>100_bases
ATACGAAGCATCAGGCAAAAGATGTCGGATGCGGCGTGAATGCCTTATCCGATGGTTTAGCCTGCATTACGCCTTCGAAT
CCCGCAACTTGCGACTCAGC

Product: bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT; DapATase; Succinyldiaminopimelate transferase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNV
FTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDG
FGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFA
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVD
HLQKIDQQYDVFSDIRGMGLLIGAELKPQFKGRARDFLYAGAGAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAV
AKVVGA

Sequences:

>Translated_406_residues
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNV
FTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDG
FGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFA
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVD
HLQKIDQQYDVFSDIRGMGLLIGAELKPQFKGRARDFLYAGAGAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAV
AKVVGA
>Mature_405_residues
AIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNVF
TNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGF
GPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFAY
MHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVDH
LQKIDQQYDVFSDIRGMGLLIGAELKPQFKGRARDFLYAGAGAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVA
KVVGA

Specific function: Involved in both the arginine and lysine biosynthetic pathways [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=378, Percent_Identity=37.037037037037, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI284507298, Length=294, Percent_Identity=38.7755102040816, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=28.9411764705882, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI37574042, Length=401, Percent_Identity=30.6733167082294, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI226442709, Length=374, Percent_Identity=31.0160427807487, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI226442705, Length=401, Percent_Identity=29.426433915212, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI24119277, Length=349, Percent_Identity=28.080229226361, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI188536080, Length=419, Percent_Identity=23.3890214797136, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI38679950, Length=419, Percent_Identity=23.3890214797136, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI38679946, Length=419, Percent_Identity=23.3890214797136, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1789759, Length=406, Percent_Identity=99.5073891625616, Blast_Score=831, Evalue=0.0,
Organism=Escherichia coli, GI1788044, Length=397, Percent_Identity=59.9496221662469, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1789016, Length=413, Percent_Identity=35.5932203389831, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1787560, Length=404, Percent_Identity=33.1683168316832, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI145693181, Length=330, Percent_Identity=36.6666666666667, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI1786349, Length=317, Percent_Identity=31.8611987381703, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786991, Length=299, Percent_Identity=33.4448160535117, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI25144271, Length=375, Percent_Identity=35.7333333333333, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=28.4064665127021, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=260, Percent_Identity=36.5384615384615, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71992977, Length=420, Percent_Identity=28.3333333333333, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=435, Percent_Identity=25.7471264367816, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71981843, Length=164, Percent_Identity=32.3170731707317, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6324432, Length=399, Percent_Identity=38.3458646616541, Blast_Score=276, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6323470, Length=403, Percent_Identity=32.5062034739454, Blast_Score=215, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6324386, Length=314, Percent_Identity=29.6178343949045, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=435, Percent_Identity=23.9080459770115, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357415, Length=377, Percent_Identity=34.7480106100796, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI28574759, Length=426, Percent_Identity=27.9342723004695, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI161085790, Length=421, Percent_Identity=27.790973871734, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21356575, Length=421, Percent_Identity=30.166270783848, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI281366494, Length=430, Percent_Identity=22.5581395348837, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24667139, Length=430, Percent_Identity=22.5581395348837, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24667143, Length=430, Percent_Identity=22.5581395348837, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11; =2.6.1.17 [H]

Molecular weight: Translated: 43679; Mature: 43548

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCH
CCCCHHHHHHHHHHHHHEEEECCCEEEEECCCCCCCHHHCCCHHHHHCCCHHEEHHHCCC
PALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLAR
HHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHH
HYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVK
HHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHH
AVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFA
HHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCCCEEE
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFD
EEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHC
IINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQFKGRARDFLYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEE
GAGAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVAKVVGA
CCCCCEEEEECCCHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCH
CCCHHHHHHHHHHHHHEEEECCCEEEEECCCCCCCHHHCCCHHHHHCCCHHEEHHHCCC
PALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLAR
HHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHH
HYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVK
HHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHH
AVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFA
HHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCCCEEE
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFD
EEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHC
IINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQFKGRARDFLYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEE
GAGAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVAKVVGA
CCCCCEEEEECCCHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]