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The map label for this gene is paaN [H]

Identifier: 157158054

GI number: 157158054

Start: 1560498

End: 1562543

Strand: Reverse

Name: paaN [H]

Synonym: EcE24377A_1572

Alternate gene names: 157158054

Gene position: 1562543-1560498 (Counterclockwise)

Preceding gene: 157155909

Following gene: 157155545

Centisome position: 31.38

GC content: 54.3

Gene sequence:

>2046_bases
ATGCAGCAGTTAGCCAGTTTCTTATCCGGTACCTGGCAGTCTGGCCGGGGCCGTAGCCGTTTGATTCACCACGCTATTAG
CGGCGAGGCGTTATGGGAAGTGACCAGTGAAGGTCTTGATATGGCGGCTGCCCGCCAGTTTGCCATTGAAAAAGGTGCCC
CCGCCCTCCGCGCGATGACCTTTATCGAACGTGCGGCGATGCTTAAAGCGGTCGCTAAACATCTGCTGAGTGAAAAAGAG
CGTTTCTATGCTCTTTCTGCGCAAACAGGCGCAACGCGGGCAGACAGTTGGGTTGATATTGAAGGTGGCATTGGGACGTT
ATTTACTTACGCCAGCCTCGGTAGCCGGGAGCTGCCTGACGATACGCTGTGGCCGGAAGATGAATTGATCCCCTTATCGA
AAGAAGGTGGATTTGCCGCGCGCCATGTACTGACCTCGAAGTCAGGCGTGGCAGTGCATATTAACGCCTTTAACTTCCCC
TGCTGGGGAATGCTGGAAAAGCTGGCACCAACGTGGCTGGGCGGAATGCCAGCCATCATCAAACCAGCTACCGCGACGGC
CCAACTGACTCAGGCGATGGTGAAATCAATTGTCGATAGTGGTCTTGTTCCCGAAGGCGCAATTAGTCTGATCTGCGGTA
GTGCTGGCGACTTGTTGGATCATCTGGACAGCCAGGATGTGGTGACTTTCACGGGGTCAGCGGCGACCGGACAGATGCTG
CGAGTTCAGCCAAATATCGTCGCCAAATCTATCCCCTTCACTATGGAAGCTGATTCCCTGAACTGCTGCGTACTGGGCGA
AGATGTCACCCCGGATCAACCGGAGTTTGCGCTGTTTATTCGTGAAGTTGTGCGTGAGATGACCACAAAAGCCGGGCAAA
AATGTACGGCAATCCGGCGGATTATTGTGCCGCAGGCATTGGTTAATGCTGTCAGTGATGCTCTGGTTGCGCGATTACAG
AAAGTCGTGGTCGGTGATCCTGCTCAGGAAGGCGTGAAAATGGGCGCACTGGTAAATGCTGAGCAGCGTGCCGATGTGCA
GGAAAAAGTGAACATATTGCTGGCTGCAGGATGCGAGATTCGCCTCGGTGGTCAGGCGGATTTATCTGCTGCGGGTGTCT
TCTTCCCGCCAACCTTATTGTACTGTCCGCAGCCGGATGAAACACCGGCGGTACATGCAACAGAAGCCTTTGGCCCTGTC
GCAACGCTGATGCCAGCACAAAACCAGCGACATGCTCTGCAACTGGCTTGTGCAGGCGGCGGTAGCCTTGCGGGAACGCT
GGTGACGGCTGATCCGCAAATTGCGCGTCAGTTTATTACCGACGCGGCACGTACGCATGGGCGAATTCAGATCCTCAATG
AAGAGTCGGCAAAAGAATCCACCGGGCATGGCTCCCCACTGCCACAACTGGTACATGGTGGGCCTGGTCGCGCAGGAGGC
GGTGAAGAATTAGGCGGTTTACGAGCGGTGAAACATTACATGCAGCGAACCGCTGTTCAGGGTAGTCCGACGATGCTTGC
CGCTATCAGTAAACAGTGGGTGCGCGGTGCGAAAGTCGAAGAAGATCGTATTCATCCGTTCCGCAAATATTTTGAGGAGC
TACAACCAGGCGACAGCCTGTTGACTCCCCGCCGCACAATGACAGAGGCCGATATTGTTAACTTTGCTTGCCTCAGCGGC
GATCATTTCTATGCACATATGGATAAGATTGCTGCTGCCGAATCTATTTTCGCTGAGCGGGTGGTGCATGGGTATTTTGT
GCTTTCTGCGGCTGCGGGTCTGTTTGTCGATGCCGGTGTTGGTCCGGTCATTGCTAACTACGGGCTGGAAAGCTTGCGTT
TTATCGAACCCGTAAAGCCAGGCGATACCATCCAGGTGCGTCTCACCTGTAAGCGCAAGACGCTGAAAAAACAGCGTAGC
GCAGAAGAAAAACCAACAGGTGTGGTGGAATGGGCGGTAGAGGTATTCAATCAGCATCAAACCCCGGTGGCGCTGTATTC
AATTCTGACGCTGGTGGCCAGGCAGCACGGTGATTTTGTCGATTAA

Upstream 100 bases:

>100_bases
ACAGATCACGCAGTTAACATTTCGTTAAAAGATCCCTTGCTTTTTATGATTCGCGATTTAACTATTAGCAACAGAAATGT
GAAACATCTGGAGAGTAGCG

Downstream 100 bases:

>100_bases
TCGGTGAATGAAGGGCAACGGCCAATAGTTGCCCTTTTATTTCACTAAGTTTTGTGACGTTGTCACATTATGCATGATGT
GTACATCTATTTTCAGGGCA

Product: bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase

Products: NA

Alternate protein names: Phenylacetic acid degradation protein paaZ [H]

Number of amino acids: Translated: 681; Mature: 681

Protein sequence:

>681_residues
MQQLASFLSGTWQSGRGRSRLIHHAISGEALWEVTSEGLDMAAARQFAIEKGAPALRAMTFIERAAMLKAVAKHLLSEKE
RFYALSAQTGATRADSWVDIEGGIGTLFTYASLGSRELPDDTLWPEDELIPLSKEGGFAARHVLTSKSGVAVHINAFNFP
CWGMLEKLAPTWLGGMPAIIKPATATAQLTQAMVKSIVDSGLVPEGAISLICGSAGDLLDHLDSQDVVTFTGSAATGQML
RVQPNIVAKSIPFTMEADSLNCCVLGEDVTPDQPEFALFIREVVREMTTKAGQKCTAIRRIIVPQALVNAVSDALVARLQ
KVVVGDPAQEGVKMGALVNAEQRADVQEKVNILLAAGCEIRLGGQADLSAAGVFFPPTLLYCPQPDETPAVHATEAFGPV
ATLMPAQNQRHALQLACAGGGSLAGTLVTADPQIARQFITDAARTHGRIQILNEESAKESTGHGSPLPQLVHGGPGRAGG
GEELGGLRAVKHYMQRTAVQGSPTMLAAISKQWVRGAKVEEDRIHPFRKYFEELQPGDSLLTPRRTMTEADIVNFACLSG
DHFYAHMDKIAAAESIFAERVVHGYFVLSAAAGLFVDAGVGPVIANYGLESLRFIEPVKPGDTIQVRLTCKRKTLKKQRS
AEEKPTGVVEWAVEVFNQHQTPVALYSILTLVARQHGDFVD

Sequences:

>Translated_681_residues
MQQLASFLSGTWQSGRGRSRLIHHAISGEALWEVTSEGLDMAAARQFAIEKGAPALRAMTFIERAAMLKAVAKHLLSEKE
RFYALSAQTGATRADSWVDIEGGIGTLFTYASLGSRELPDDTLWPEDELIPLSKEGGFAARHVLTSKSGVAVHINAFNFP
CWGMLEKLAPTWLGGMPAIIKPATATAQLTQAMVKSIVDSGLVPEGAISLICGSAGDLLDHLDSQDVVTFTGSAATGQML
RVQPNIVAKSIPFTMEADSLNCCVLGEDVTPDQPEFALFIREVVREMTTKAGQKCTAIRRIIVPQALVNAVSDALVARLQ
KVVVGDPAQEGVKMGALVNAEQRADVQEKVNILLAAGCEIRLGGQADLSAAGVFFPPTLLYCPQPDETPAVHATEAFGPV
ATLMPAQNQRHALQLACAGGGSLAGTLVTADPQIARQFITDAARTHGRIQILNEESAKESTGHGSPLPQLVHGGPGRAGG
GEELGGLRAVKHYMQRTAVQGSPTMLAAISKQWVRGAKVEEDRIHPFRKYFEELQPGDSLLTPRRTMTEADIVNFACLSG
DHFYAHMDKIAAAESIFAERVVHGYFVLSAAAGLFVDAGVGPVIANYGLESLRFIEPVKPGDTIQVRLTCKRKTLKKQRS
AEEKPTGVVEWAVEVFNQHQTPVALYSILTLVARQHGDFVD
>Mature_681_residues
MQQLASFLSGTWQSGRGRSRLIHHAISGEALWEVTSEGLDMAAARQFAIEKGAPALRAMTFIERAAMLKAVAKHLLSEKE
RFYALSAQTGATRADSWVDIEGGIGTLFTYASLGSRELPDDTLWPEDELIPLSKEGGFAARHVLTSKSGVAVHINAFNFP
CWGMLEKLAPTWLGGMPAIIKPATATAQLTQAMVKSIVDSGLVPEGAISLICGSAGDLLDHLDSQDVVTFTGSAATGQML
RVQPNIVAKSIPFTMEADSLNCCVLGEDVTPDQPEFALFIREVVREMTTKAGQKCTAIRRIIVPQALVNAVSDALVARLQ
KVVVGDPAQEGVKMGALVNAEQRADVQEKVNILLAAGCEIRLGGQADLSAAGVFFPPTLLYCPQPDETPAVHATEAFGPV
ATLMPAQNQRHALQLACAGGGSLAGTLVTADPQIARQFITDAARTHGRIQILNEESAKESTGHGSPLPQLVHGGPGRAGG
GEELGGLRAVKHYMQRTAVQGSPTMLAAISKQWVRGAKVEEDRIHPFRKYFEELQPGDSLLTPRRTMTEADIVNFACLSG
DHFYAHMDKIAAAESIFAERVVHGYFVLSAAAGLFVDAGVGPVIANYGLESLRFIEPVKPGDTIQVRLTCKRKTLKKQRS
AEEKPTGVVEWAVEVFNQHQTPVALYSILTLVARQHGDFVD

Specific function: Phenylacetic acid aerobic catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361176, Length=505, Percent_Identity=25.1485148514851, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI12007648, Length=416, Percent_Identity=25, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI25777724, Length=497, Percent_Identity=23.7424547283702, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI153266822, Length=490, Percent_Identity=23.0612244897959, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI25777732, Length=502, Percent_Identity=24.9003984063745, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI25777728, Length=400, Percent_Identity=24, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI115387104, Length=448, Percent_Identity=23.2142857142857, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI25777730, Length=503, Percent_Identity=25.2485089463221, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4507229, Length=307, Percent_Identity=27.3615635179153, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI1787653, Length=681, Percent_Identity=99.4126284875183, Blast_Score=1389, Evalue=0.0,
Organism=Escherichia coli, GI1789015, Length=457, Percent_Identity=25.382932166302, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1787684, Length=402, Percent_Identity=25.6218905472637, Blast_Score=100, Evalue=6e-22,
Organism=Escherichia coli, GI87081926, Length=343, Percent_Identity=26.2390670553936, Blast_Score=100, Evalue=6e-22,
Organism=Escherichia coli, GI1786504, Length=511, Percent_Identity=25.0489236790607, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI87082295, Length=275, Percent_Identity=25.4545454545455, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1788042, Length=335, Percent_Identity=27.7611940298507, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787715, Length=361, Percent_Identity=25.7617728531856, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787250, Length=404, Percent_Identity=22.029702970297, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1787558, Length=291, Percent_Identity=24.7422680412371, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25143874, Length=452, Percent_Identity=24.5575221238938, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25143876, Length=452, Percent_Identity=24.5575221238938, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI115534176, Length=363, Percent_Identity=26.7217630853994, Blast_Score=83, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17551164, Length=323, Percent_Identity=22.6006191950464, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562198, Length=411, Percent_Identity=24.330900243309, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71995606, Length=429, Percent_Identity=24.2424242424242, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71995613, Length=371, Percent_Identity=24.5283018867925, Blast_Score=66, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324950, Length=355, Percent_Identity=23.3802816901408, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320917, Length=356, Percent_Identity=24.1573033707865, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325196, Length=275, Percent_Identity=25.0909090909091, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20129399, Length=511, Percent_Identity=25.0489236790607, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281362580, Length=302, Percent_Identity=25.1655629139073, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI62472918, Length=302, Percent_Identity=25.1655629139073, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI62472926, Length=302, Percent_Identity=25.1655629139073, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI62472936, Length=302, Percent_Identity=25.1655629139073, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356737, Length=302, Percent_Identity=25.1655629139073, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR002539
- InterPro:   IPR011966 [H]

Pfam domain/function: PF00171 Aldedh; PF01575 MaoC_dehydratas [H]

EC number: NA

Molecular weight: Translated: 73061; Mature: 73061

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQLASFLSGTWQSGRGRSRLIHHAISGEALWEVTSEGLDMAAARQFAIEKGAPALRAMT
CHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHH
FIERAAMLKAVAKHLLSEKERFYALSAQTGATRADSWVDIEGGIGTLFTYASLGSRELPD
HHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCC
DTLWPEDELIPLSKEGGFAARHVLTSKSGVAVHINAFNFPCWGMLEKLAPTWLGGMPAII
CCCCCCCCEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHC
KPATATAQLTQAMVKSIVDSGLVPEGAISLICGSAGDLLDHLDSQDVVTFTGSAATGQML
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCHHHHHHHCCCCCEEEEECCCCCCCEE
RVQPNIVAKSIPFTMEADSLNCCVLGEDVTPDQPEFALFIREVVREMTTKAGQKCTAIRR
EECCCHHHCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
IIVPQALVNAVSDALVARLQKVVVGDPAQEGVKMGALVNAEQRADVQEKVNILLAAGCEI
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCHHHCCHHHHHCEEEEECCEE
RLGGQADLSAAGVFFPPTLLYCPQPDETPAVHATEAFGPVATLMPAQNQRHALQLACAGG
EECCCCCCCCCCEECCCCEEECCCCCCCCCEECHHHHCCHHHHCCCCCCCCEEEEEECCC
GSLAGTLVTADPQIARQFITDAARTHGRIQILNEESAKESTGHGSPLPQLVHGGPGRAGG
CCEECEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCC
GEELGGLRAVKHYMQRTAVQGSPTMLAAISKQWVRGAKVEEDRIHPFRKYFEELQPGDSL
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHCCCCCCC
LTPRRTMTEADIVNFACLSGDHFYAHMDKIAAAESIFAERVVHGYFVLSAAAGLFVDAGV
CCCCHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
GPVIANYGLESLRFIEPVKPGDTIQVRLTCKRKTLKKQRSAEEKPTGVVEWAVEVFNQHQ
CHHHHHCCHHHHHHHCCCCCCCEEEEEEEECHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
TPVALYSILTLVARQHGDFVD
CHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQQLASFLSGTWQSGRGRSRLIHHAISGEALWEVTSEGLDMAAARQFAIEKGAPALRAMT
CHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHH
FIERAAMLKAVAKHLLSEKERFYALSAQTGATRADSWVDIEGGIGTLFTYASLGSRELPD
HHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCC
DTLWPEDELIPLSKEGGFAARHVLTSKSGVAVHINAFNFPCWGMLEKLAPTWLGGMPAII
CCCCCCCCEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHC
KPATATAQLTQAMVKSIVDSGLVPEGAISLICGSAGDLLDHLDSQDVVTFTGSAATGQML
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCHHHHHHHCCCCCEEEEECCCCCCCEE
RVQPNIVAKSIPFTMEADSLNCCVLGEDVTPDQPEFALFIREVVREMTTKAGQKCTAIRR
EECCCHHHCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
IIVPQALVNAVSDALVARLQKVVVGDPAQEGVKMGALVNAEQRADVQEKVNILLAAGCEI
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCHHHCCHHHHHCEEEEECCEE
RLGGQADLSAAGVFFPPTLLYCPQPDETPAVHATEAFGPVATLMPAQNQRHALQLACAGG
EECCCCCCCCCCEECCCCEEECCCCCCCCCEECHHHHCCHHHHCCCCCCCCEEEEEECCC
GSLAGTLVTADPQIARQFITDAARTHGRIQILNEESAKESTGHGSPLPQLVHGGPGRAGG
CCEECEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCC
GEELGGLRAVKHYMQRTAVQGSPTMLAAISKQWVRGAKVEEDRIHPFRKYFEELQPGDSL
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHCCCCCCC
LTPRRTMTEADIVNFACLSGDHFYAHMDKIAAAESIFAERVVHGYFVLSAAAGLFVDAGV
CCCCHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
GPVIANYGLESLRFIEPVKPGDTIQVRLTCKRKTLKKQRSAEEKPTGVVEWAVEVFNQHQ
CHHHHHCCHHHHHHHCCCCCCCEEEEEEEECHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
TPVALYSILTLVARQHGDFVD
CHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]