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The map label for this gene is astC

Identifier: 157158020

GI number: 157158020

Start: 1956384

End: 1957604

Strand: Reverse

Name: astC

Synonym: EcE24377A_1970

Alternate gene names: 157158020

Gene position: 1957604-1956384 (Counterclockwise)

Preceding gene: 157156475

Following gene: 157157503

Centisome position: 39.31

GC content: 54.95

Gene sequence:

>1221_bases
ATGTCTCAGCCAATTACGCGTGAAAACTTTGATGAATGGATGATACCTGTTTACGCTCCGGCACCCTTTATACCGGTACG
TGGCGAAGGTTCGCGCTTGTGGGATCAGCAGGGGAAAGAGTATATCGACTTCGCGGGTGGCATTGCGGTGAACGCGCTGG
GCCATGCGCATCCGGAACTGCGTGAAGCGCTGAACGAACAGGCGAGTAAGTTCTGGCATACCGGCAACGGTTACACCAAC
GAGCCGGTACTGCGACTGGCGAAAAAATTGATCGACGCCACGTTTGCCGATCGCGTCTTCTTTTGTAACTCCGGTGCGGA
AGCCAACGAAGCGGCGCTAAAACTGGCGCGTAAATTCGCTCACGACCGCTACGGCAGCCATAAGAGCGGCATCGTGGCGT
TCAAAAATGCGTTTCATGGTCGCACGCTGTTTACTGTCAGTGCGGGTGGGCAGCCAGCCTATTCACAGGATTTTGCGCCA
CTGCCGGCGGATATTCGTCATGCTGCATATAACGATATTAACTCTGCCAGCGCGCTGATTGACGACTCTACCTGTGCGGT
GATTGTCGAACCCATCCAGGGGGAAGGCGGTGTGGTGCCAGCCAGCAACGCGTTTTTACAAGGTCTGCGTGAATTGTGTA
ACCGCCACAATGCGCTGTTGATTTTTGATGAAGTACAAACCGGCGTCGGGCGCACCGGGGAACTGTATGCCTATATGCAC
TACGGCGTGACGCCTGATCTGTTAACTACCGCCAAAGCGCTGGGCGGCGGTTTTCCGGTCGGTGCGTTGTTGGCAACCGA
AGAGTGCGCCCGCGTGATGACCGTTGGCACTCATGGCACCACCTATGGCGGTAATCCGCTGGCCTCGGCGGTGGCAGGCA
AAGTGCTGGAGCTCATCAACACACCAGAGATGCTTAATGGCGTTAAACAGCGTCACGACTGGTTTGTTGAGCGTCTTAAT
ACTATTAATCACCGCTATGGTTTGTTCAGTGAAGTTCGCGGCTTAGGTTTGCTGATTGGCTGTGTACTGAATGCCGATTA
CGCCGGGCAAGCGAAACAGATCTCTCAGGAAGCGGCGAAAGCAGGCGTGATGGTACTGATTGCGGGTGGCAACGTGGTGC
GTTTTGCGCCTGCGCTCAATGTCAGCGAAGAAGAGGTGACGACCGGACTGGATCGCTTTGCAGCTGCTTGCGAACACTTT
GTTAGCCGAGGTTCATCATGA

Upstream 100 bases:

>100_bases
TTTATCACTGGCTGGCACGAACCCTGCAATCTACATTTACAGCGCAAACATTACTTATTGTTAACATATAAATAACGAAC
TATTTACTGTAGAGGTCGCT

Downstream 100 bases:

>100_bases
TGGTCATCCGTCCCGTTGAGCGATCAGATGTCTCGGCGCTGATGCAGCTTGCCAGCAAAACGGGCGGCGGCCTGACGTCG
CTTCCCGCCAATGAAGCCAC

Product: bifunctional succinylornithine transaminase/acetylornithine transaminase

Products: NA

Alternate protein names: Succinylornithine aminotransferase

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
EPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPADIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMH
YGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLN
TINHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHF
VSRGSS

Sequences:

>Translated_406_residues
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
EPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPADIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMH
YGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLN
TINHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHF
VSRGSS
>Mature_405_residues
SQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTNE
PVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPL
PADIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMHY
GVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLNT
INHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFV
SRGSS

Specific function: Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=379, Percent_Identity=34.8284960422164, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI13994255, Length=452, Percent_Identity=27.8761061946903, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI284507298, Length=293, Percent_Identity=35.4948805460751, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI37574042, Length=422, Percent_Identity=27.7251184834123, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI226442705, Length=422, Percent_Identity=27.0142180094787, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=27.906976744186, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI24119277, Length=413, Percent_Identity=28.3292978208232, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI188536080, Length=431, Percent_Identity=23.2018561484919, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI38679950, Length=431, Percent_Identity=23.2018561484919, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI38679946, Length=431, Percent_Identity=23.2018561484919, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=100, Blast_Score=837, Evalue=0.0,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=60.2015113350126, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI1789016, Length=398, Percent_Identity=33.9195979899498, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI145693181, Length=374, Percent_Identity=34.4919786096257, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1787560, Length=390, Percent_Identity=34.6153846153846, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1786349, Length=312, Percent_Identity=33.0128205128205, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1786991, Length=296, Percent_Identity=32.4324324324324, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI25144271, Length=391, Percent_Identity=35.2941176470588, Blast_Score=237, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=30.3448275862069, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI25144274, Length=287, Percent_Identity=33.7979094076655, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=28.8683602771363, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=308, Percent_Identity=26.9480519480519, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71981843, Length=165, Percent_Identity=33.9393939393939, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=39.8009950248756, Blast_Score=287, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6323470, Length=400, Percent_Identity=33.5, Blast_Score=213, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6324386, Length=325, Percent_Identity=28.9230769230769, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=367, Percent_Identity=26.9754768392371, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21357415, Length=379, Percent_Identity=35.6200527704486, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI161085790, Length=452, Percent_Identity=28.9823008849558, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI28574759, Length=445, Percent_Identity=28.9887640449438, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21356575, Length=362, Percent_Identity=29.2817679558011, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI281366494, Length=429, Percent_Identity=24.4755244755245, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24667139, Length=429, Percent_Identity=24.4755244755245, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24667143, Length=429, Percent_Identity=24.4755244755245, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ASTC_ECO24 (A7ZML6)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001463045.1
- ProteinModelPortal:   A7ZML6
- SMR:   A7ZML6
- STRING:   A7ZML6
- EnsemblBacteria:   EBESCT00000022027
- GeneID:   5588995
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_1970
- eggNOG:   COG4992
- GeneTree:   EBGT00050000010246
- HOGENOM:   HBG725944
- OMA:   HGLLLIM
- ProtClustDB:   PRK12381
- BioCyc:   ECOL331111:ECE24377A_1970-MONOMER
- HAMAP:   MF_01173
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR03246
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.81

Molecular weight: Translated: 43666; Mature: 43535

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHCCCCHHH
REALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPADIRHAAYNDINSASALI
HHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHEE
DDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMH
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHCCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNTINHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHCCCCHHH
REALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPADIRHAAYNDINSASALI
HHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHEE
DDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMH
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHCCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNTINHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA