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The map label for this gene is murR

Identifier: 157157722

GI number: 157157722

Start: 2701653

End: 2702510

Strand: Reverse

Name: murR

Synonym: EcE24377A_2713

Alternate gene names: 157157722

Gene position: 2702510-2701653 (Counterclockwise)

Preceding gene: 157157932

Following gene: 157158523

Centisome position: 54.27

GC content: 51.28

Gene sequence:

>858_bases
ATGTTGTACCTGACGAAAATAAGCAATGCGGGGAGTGAATTCACCGAAAACGAGCAAAAAATCGCTGACTTTCTGCAGGC
CAACGTGAGTGAGCTGCAATCCGTTTCTTCACGGCAGATGGCGAAACAGCTCGGCATTAGCCAGTCGAGCATAGTGAAAT
TTGCCCAAAAACTCGGCGCGCAAGGATTTACTGAATTGCGTATGGCGTTAATAGGCGAATACAGTGCCAGCCGGGAGAAA
ACGAATGCCACGGCGCTGCACCTGCACAGTTCGATTACCAGTGATGATTCGCTGGAAGTGATTGCCCGCAAATTGAATCG
CGAAAAAGAGCTGGCGCTGGAGCAAACCTGTGCGTTGTTCGACTACGCGCGGCTGCAAAAAATCATTGAGGTCATCAGTA
AAGCACCGTTTATCCAGATAACGGGCCTGGGCGGATCGGCGCTGGTGGGGCGCGATCTGTCGTTCAAACTGATGAAAATT
GGCTATCGCGTGGCCTGCGAAGCCGACACGCACGTACAAGCCACCGTTTCCCAGGCGTTGAAAAAAGGCGATGTACAAAT
CGCTATCTCTTACAGCGGCAGTAAAAAAGAGATTGTCTTATGCGCAGAAGCGGCACGAAAGCAGGGGGCAACGGTGATTG
CCATTACTTCTCTGGCTGATTCTCCGCTGCGGCGGCTGGCGCATTTCACGCTCGATACCGTTTCCGGTGAAACCGAATGG
CGTAGCTCGTCGATGTCTACCCGCACGGCGCAAAATTCTGTTACCGATTTACTGTTTGTTGGTCTTGTGCAACTCAATGA
TGTGGAGTCATTGAAAATGATTCAGCGCAGCAGTGAGCTAACACAACGCCTGAAATGA

Upstream 100 bases:

>100_bases
TGACAGACTTAAAGGAATCATTGAGTCTACACTCGCAGAGTGTGAAGAGCGTCATAAGAACTTAAGCGGAATTTATGCTG
CCAGCCCAGGAGAGTGGAAG

Downstream 100 bases:

>100_bases
TGCATAAAGCAGCGACTGGATTGAGATTTTCCTGAATTAGTGAGCTGATCCGCAGCAATATTTTGTTTATCCTGTATTTT
CAGAGGGAATGGAGTGTAAC

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: MurPQ operon repressor

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MLYLTKISNAGSEFTENEQKIADFLQANVSELQSVSSRQMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREK
TNATALHLHSSITSDDSLEVIARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKI
GYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEW
RSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIQRSSELTQRLK

Sequences:

>Translated_285_residues
MLYLTKISNAGSEFTENEQKIADFLQANVSELQSVSSRQMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREK
TNATALHLHSSITSDDSLEVIARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKI
GYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEW
RSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIQRSSELTQRLK
>Mature_285_residues
MLYLTKISNAGSEFTENEQKIADFLQANVSELQSVSSRQMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREK
TNATALHLHSSITSDDSLEVIARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKI
GYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEW
RSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIQRSSELTQRLK

Specific function: Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of murQ, is the specific inducer tha

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788767, Length=285, Percent_Identity=99.2982456140351, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI87082130, Length=272, Percent_Identity=35.2941176470588, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI87082369, Length=254, Percent_Identity=27.1653543307087, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788159, Length=264, Percent_Identity=27.6515151515151, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): MURR_ECO24 (A7ZPM7)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001463756.1
- ProteinModelPortal:   A7ZPM7
- STRING:   A7ZPM7
- EnsemblBacteria:   EBESCT00000019346
- GeneID:   5588154
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_2713
- eggNOG:   COG1737
- GeneTree:   EBGT00050000010596
- HOGENOM:   HBG725281
- OMA:   AESEFTG
- ProtClustDB:   PRK15482
- BioCyc:   ECOL331111:ECE24377A_2713-MONOMER
- HAMAP:   MF_02108
- InterPro:   IPR022821
- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10

Pfam domain/function: PF01418 HTH_6; PF01380 SIS

EC number: NA

Molecular weight: Translated: 31196; Mature: 31196

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS51071 HTH_RPIR; PS51464 SIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYLTKISNAGSEFTENEQKIADFLQANVSELQSVSSRQMAKQLGISQSSIVKFAQKLGA
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
QGFTELRMALIGEYSASREKTNATALHLHSSITSDDSLEVIARKLNREKELALEQTCALF
CCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHH
DYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTHVQATVSQAL
HHHHHHHHHHHHHCCCEEEEECCCCCCEECCCCHHHHHHCCEEEEECCCCHHHHHHHHHH
KKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEW
HCCCEEEEEEECCCCCEEEEEEHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHH
RSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIQRSSELTQRLK
HCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLYLTKISNAGSEFTENEQKIADFLQANVSELQSVSSRQMAKQLGISQSSIVKFAQKLGA
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
QGFTELRMALIGEYSASREKTNATALHLHSSITSDDSLEVIARKLNREKELALEQTCALF
CCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHH
DYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTHVQATVSQAL
HHHHHHHHHHHHHCCCEEEEECCCCCCEECCCCHHHHHHCCEEEEECCCCHHHHHHHHHH
KKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEW
HCCCEEEEEEECCCCCEEEEEEHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHH
RSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIQRSSELTQRLK
HCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA