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The map label for this gene is yhbE

Identifier: 157157359

GI number: 157157359

Start: 3668928

End: 3669893

Strand: Reverse

Name: yhbE

Synonym: EcE24377A_3669

Alternate gene names: 157157359

Gene position: 3669893-3668928 (Counterclockwise)

Preceding gene: 157157764

Following gene: 157155525

Centisome position: 73.7

GC content: 52.69

Gene sequence:

>966_bases
ATGAAGCAGCAGGCAGGCATTGGCATTCTTTTGGCGCTCACCACAGCAATTTGCTGGGGGGCGTTGCCAATCGCAATGAA
GCAGGTGCTGGAGGTGATGGAACCTCCGACAATCGTGTTTTACCGTTTCTTGATGGCGAGTATTGGCCTTGGTGCCATTC
TTGCGGTGAAGAAGAGGTTGCCGCCATTACGCGTGTTTCGTAAGCCACGCTGGTTGATTTTGTTGGCAGTGGCGACCGCC
GGGCTGTTTGGGAACTTCATCCTGTTCAGCTCATCCTTGCAATACCTGAGTCCGACCGCTTCGCAGGTGATTGGGCAACT
CTCGCCAGTTGGCATGATGGTTGCCAGCGTATTTATCCTGAAAGAGAAAATGCGCAGCACTCAGGTTGTAGGGGCATTGA
TGCTCCTGAGCGGCCTGGTGATGTTTTTTAACACCAGTCTGGTCGAGATATTTACAAAGCTCACCGATTACACCTGGGGA
GTTATCTTTGGGGTCGGTGCGGCGACGGTTTGGGTGAGTTATGGCGTGGCGCAAAAGGTTTTATTGCGTCGGCTGGCCTC
ACCGCAGATCCTGTTTTTACTGTACACTTTATGTACAATTGCGCTCTTCCCTCTGGCAAAGCCTGGAGTGATAGCGCAGC
TTAGCCACTGGCAGCTCGCATGTTTAATTTTTTGCGGACTGAATACATTGGTAGGATATGGCGCCCTGGCGGAAGCGATG
GCTCGCTGGCAGGCAGCGCAGGTGAGCGCGATCATCACGCTTACCCCACTGTTTACGCTGTTTTTTTCAGATCTTTTATC
ACTGGCCTGGCCCGATTTCTTCGCCAGACCGATGTTAAACCTTTTAGGTTATCTCGGTGCGTTTGTCGTGGTTGCGGGCG
CGATGTATTCCGCCATTGGTCATCGTATTTGGGGCGGATTACGTAAGCATACAACGGTGGTATCGCAACCCCGCGCAGGC
GAATGA

Upstream 100 bases:

>100_bases
AAGCCCCGCAACACGTTGCGGGGCTTTTTACATTCGATAACCGGTAAAAATGCGCATGGTGCGACGTTAATCCGCAAATG
CGCTTTGCAGGGAATACGGT

Downstream 100 bases:

>100_bases
TTTACGGAGAATAAAATGAAGTTTGTTGATGAAGCATCGATTCTGGTCGTTGCAGGTGATGGCGGTAATGGTTGCGTGAG
CTTCCGCCGCGAAAAGTATA

Product: putative transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MKQQAGIGILLALTTAICWGALPIAMKQVLEVMEPPTIVFYRFLMASIGLGAILAVKKRLPPLRVFRKPRWLILLAVATA
GLFGNFILFSSSLQYLSPTASQVIGQLSPVGMMVASVFILKEKMRSTQVVGALMLLSGLVMFFNTSLVEIFTKLTDYTWG
VIFGVGAATVWVSYGVAQKVLLRRLASPQILFLLYTLCTIALFPLAKPGVIAQLSHWQLACLIFCGLNTLVGYGALAEAM
ARWQAAQVSAIITLTPLFTLFFSDLLSLAWPDFFARPMLNLLGYLGAFVVVAGAMYSAIGHRIWGGLRKHTTVVSQPRAG
E

Sequences:

>Translated_321_residues
MKQQAGIGILLALTTAICWGALPIAMKQVLEVMEPPTIVFYRFLMASIGLGAILAVKKRLPPLRVFRKPRWLILLAVATA
GLFGNFILFSSSLQYLSPTASQVIGQLSPVGMMVASVFILKEKMRSTQVVGALMLLSGLVMFFNTSLVEIFTKLTDYTWG
VIFGVGAATVWVSYGVAQKVLLRRLASPQILFLLYTLCTIALFPLAKPGVIAQLSHWQLACLIFCGLNTLVGYGALAEAM
ARWQAAQVSAIITLTPLFTLFFSDLLSLAWPDFFARPMLNLLGYLGAFVVVAGAMYSAIGHRIWGGLRKHTTVVSQPRAG
E
>Mature_321_residues
MKQQAGIGILLALTTAICWGALPIAMKQVLEVMEPPTIVFYRFLMASIGLGAILAVKKRLPPLRVFRKPRWLILLAVATA
GLFGNFILFSSSLQYLSPTASQVIGQLSPVGMMVASVFILKEKMRSTQVVGALMLLSGLVMFFNTSLVEIFTKLTDYTWG
VIFGVGAATVWVSYGVAQKVLLRRLASPQILFLLYTLCTIALFPLAKPGVIAQLSHWQLACLIFCGLNTLVGYGALAEAM
ARWQAAQVSAIITLTPLFTLFFSDLLSLAWPDFFARPMLNLLGYLGAFVVVAGAMYSAIGHRIWGGLRKHTTVVSQPRAG
E

Specific function: Unknown

COG id: COG0697

COG function: function code GER; Permeases of the drug/metabolite transporter (DMT) superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 DUF6 domains

Homologues:

Organism=Escherichia coli, GI1789575, Length=321, Percent_Identity=100, Blast_Score=637, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YHBE_ECO57 (P0AA74)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B85982
- PIR:   G91136
- RefSeq:   NP_289758.1
- RefSeq:   NP_312090.1
- ProteinModelPortal:   P0AA74
- EnsemblBacteria:   EBESCT00000028347
- EnsemblBacteria:   EBESCT00000057543
- GeneID:   916095
- GeneID:   958626
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4546
- KEGG:   ecs:ECs4063
- GeneTree:   EBGT00050000008949
- HOGENOM:   HBG537680
- OMA:   TPLVTFV
- ProtClustDB:   CLSK880614
- BioCyc:   ECOL83334:ECS4063-MONOMER
- GO:   GO:0006810
- InterPro:   IPR000620

Pfam domain/function: PF00892 DUF6

EC number: NA

Molecular weight: Translated: 34964; Mature: 34964

Theoretical pI: Translated: 10.55; Mature: 10.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x20dcd9dc)-; HASH(0x203f7600)-; HASH(0x20da6650)-; HASH(0x21002fc4)-; HASH(0x21167c7c)-; HASH(0x204cf420)-; HASH(0x21005690)-; HASH(0x21031e4c)-; HASH(0x20e31dd0)-; HASH(0x21226b38)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQQAGIGILLALTTAICWGALPIAMKQVLEVMEPPTIVFYRFLMASIGLGAILAVKKRL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHCC
PPLRVFRKPRWLILLAVATAGLFGNFILFSSSLQYLSPTASQVIGQLSPVGMMVASVFIL
CHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHCCHHHHHHHHHHHH
KEKMRSTQVVGALMLLSGLVMFFNTSLVEIFTKLTDYTWGVIFGVGAATVWVSYGVAQKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLRRLASPQILFLLYTLCTIALFPLAKPGVIAQLSHWQLACLIFCGLNTLVGYGALAEAM
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARWQAAQVSAIITLTPLFTLFFSDLLSLAWPDFFARPMLNLLGYLGAFVVVAGAMYSAIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRIWGGLRKHTTVVSQPRAGE
HHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MKQQAGIGILLALTTAICWGALPIAMKQVLEVMEPPTIVFYRFLMASIGLGAILAVKKRL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHCC
PPLRVFRKPRWLILLAVATAGLFGNFILFSSSLQYLSPTASQVIGQLSPVGMMVASVFIL
CHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHCCHHHHHHHHHHHH
KEKMRSTQVVGALMLLSGLVMFFNTSLVEIFTKLTDYTWGVIFGVGAATVWVSYGVAQKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLRRLASPQILFLLYTLCTIALFPLAKPGVIAQLSHWQLACLIFCGLNTLVGYGALAEAM
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARWQAAQVSAIITLTPLFTLFFSDLLSLAWPDFFARPMLNLLGYLGAFVVVAGAMYSAIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRIWGGLRKHTTVVSQPRAGE
HHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796