Click here to switch to the map view.

The map label for this gene is yqeF [H]

Identifier: 157157240

GI number: 157157240

Start: 3181104

End: 3182285

Strand: Reverse

Name: yqeF [H]

Synonym: EcE24377A_3166

Alternate gene names: 157157240

Gene position: 3182285-3181104 (Counterclockwise)

Preceding gene: 157155783

Following gene: 157156429

Centisome position: 63.91

GC content: 53.38

Gene sequence:

>1182_bases
ATGAAAGACGTTGTGATTGTCGGGGCGTTACGGACACCTATCGGCTGCTTTCGCGGTGCGTTAGCGTGTCATTCCGCCGT
GGAACTTGGTAGTCTGGTCGTGAAAGCGTTAATAGAACGTACCGGCGTTCCTGCATATGCGGTGGATGAAGTAATTCTTG
GTCAGGTGTTGACTGCAGGGGCAGGGCAGAATCCGGCAAGGCAATCGGCTATTAAAGGTGGTCTGCCTAATAGCGTTTCT
GCAATCACGATTAATGACGTCTGCGGTTCCGGGCTTAAAGCACTGCATCTGGCTACTCAGGCGATACAGTGTGGCGAGGC
TGATATTGTCATCGCCGGTGGCCAGGAAAACATGAGCCGCGCACCACATGTTCTGACTGATAGCCGCACCGGTGCACAGC
TTGGCAATAGCCAGCTGGTTGACAGTCTTGTGCATGATGGGTTATGGGATGCCTTCAATGATTATCATATTGGTGTCACC
GCCGAAAATCTGGCTCGCGAATATGGCATCAGCCGTCAATTGCAGGATGCTTACGCACTTAGCTCGCAACAAAAAGCGCG
AGCGGCGATTGACGCCGGACGATTTAAAGATGAGATCGTCCCGGTAATGACCCAAAGTAACGGTCAGACGTTGGTTGTTG
ATACCGATGAACAGCCACACACTGACGCCAGTGCAGAAGGTTTAGCCCGTTTAAATCCTTCATTTGATAGTCTCGGTTCT
GTGACAGCGGGTAATGCATCATCCATAAACGATGGCGCAGCTGCGGTAATGATGATGAGCGAAGCCAAAGCACGAGCGTT
GAATTTACCCGTGCTGGCCCGCATCCGCGCATTTGCCAGCGTTGGTGTAGATCCGGCATTGATGGGAATTGCGCCGGTGT
ATGCGACCCGCCGTTGCCTGGAGCGTGTAGGCTGGCAGTTGGCTGATGTTGATCTTATCGAGGCTAATGAAGCGTTTGCT
GCACAGGCGCTTTCGGTTGGCAAGATGCTTGAGTGGGATGAGCGTCGGGTCAATGTCAATGGTGGCGCGATCGCACTCGG
TCACCCGATAGGCGCTTCCGGTTGCCGAATCCTGGTTTCTCTGGTTCATGAAATGGTGAAACGTAATGCCCGCAAAGGAC
TGGCAACGCTTTGTATCGGCGGGGGCCAGGGGGTGGCATTGACCATTGAACGTGACGAATAG

Upstream 100 bases:

>100_bases
GCATATTTCCTTTGTGATAAAAATCACTTTTTTTAAACAATTAAGATAACTGTAATTAACAATCATTTACTATTGCACTG
TTAATTGGTGCGAGGTTGTG

Downstream 100 bases:

>100_bases
CTCTGCATTTCCTCCTTACTGATAAATATCTGCCGTCATTAATCTGTTGAATAATGATGGCTGGCAAGTCGACATACATT
TTCCGGGCTCCCTGATTTTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKDVVIVGALRTPIGCFRGALACHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAGAGQNPARQSAIKGGLPNSVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRQLQDAYALSSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPHTDASAEGLARLNPSFDSLGS
VTAGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCLERVGWQLADVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRNARKGLATLCIGGGQGVALTIERDE

Sequences:

>Translated_393_residues
MKDVVIVGALRTPIGCFRGALACHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAGAGQNPARQSAIKGGLPNSVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRQLQDAYALSSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPHTDASAEGLARLNPSFDSLGS
VTAGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCLERVGWQLADVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRNARKGLATLCIGGGQGVALTIERDE
>Mature_393_residues
MKDVVIVGALRTPIGCFRGALACHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAGAGQNPARQSAIKGGLPNSVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRQLQDAYALSSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPHTDASAEGLARLNPSFDSLGS
VTAGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCLERVGWQLADVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRNARKGLATLCIGGGQGVALTIERDE

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=48.5933503836317, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=43.6224489795918, Blast_Score=328, Evalue=4e-90,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=42.8211586901763, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=38.1313131313131, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=31.3953488372093, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI194353979, Length=396, Percent_Identity=28.5353535353535, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=99.236641221374, Blast_Score=785, Evalue=0.0,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=58.1632653061224, Blast_Score=430, Evalue=1e-122,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=44, Blast_Score=288, Evalue=3e-79,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=40.8977556109726, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=32.6829268292683, Blast_Score=191, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=43.7340153452685, Blast_Score=313, Evalue=9e-86,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=41.5384615384615, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17535921, Length=392, Percent_Identity=40.3061224489796, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=33.6734693877551, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=29.81220657277, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=41.2060301507538, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=37.1212121212121, Blast_Score=225, Evalue=9e-60,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=51.150895140665, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=42.0512820512821, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=41.4322250639386, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=31.0747663551402, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41032; Mature: 41032

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVVIVGALRTPIGCFRGALACHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAG
CCCEEEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
AGQNPARQSAIKGGLPNSVSAITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSR
CCCCHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVTAENLAREYGISRQLQDAYAL
CCCEEECCCCCHHCCHHHHHHHHHHCCHHHCCCCEEEEEEHHHHHHHHCCHHHHHHHHHH
SSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPHTDASAEGLARLNPSFDSLGS
HHHHHHHHHHHHHCCHHHCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHCCCCHHHCCC
VTAGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCL
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERVGWQLADVDLIEANEAFAAQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVS
HHHCCEEECEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHH
LVHEMVKRNARKGLATLCIGGGQGVALTIERDE
HHHHHHHHHHHCCEEEEEEECCCEEEEEEECCC
>Mature Secondary Structure
MKDVVIVGALRTPIGCFRGALACHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAG
CCCEEEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
AGQNPARQSAIKGGLPNSVSAITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSR
CCCCHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVTAENLAREYGISRQLQDAYAL
CCCEEECCCCCHHCCHHHHHHHHHHCCHHHCCCCEEEEEEHHHHHHHHCCHHHHHHHHHH
SSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPHTDASAEGLARLNPSFDSLGS
HHHHHHHHHHHHHCCHHHCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHCCCCHHHCCC
VTAGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCL
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERVGWQLADVDLIEANEAFAAQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVS
HHHCCEEECEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHH
LVHEMVKRNARKGLATLCIGGGQGVALTIERDE
HHHHHHHHHHHCCEEEEEEECCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]