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The map label for this gene is lrp [H]

Identifier: 156978301

GI number: 156978301

Start: 2178437

End: 2178922

Strand: Direct

Name: lrp [H]

Synonym: VIBHAR_07108

Alternate gene names: 156978301

Gene position: 2178437-2178922 (Clockwise)

Preceding gene: 156978299

Following gene: 156978303

Centisome position: 98.84

GC content: 41.56

Gene sequence:

>486_bases
ATGTGGTTAATGAGTTATCAACTAGATAGAATTGATTTACAAATTTTGAGAGTGTTGCATTCTCGAGGGCGAATTCCAGT
GGTGGAATTAGCAAAGCAAGTGAACTTGACCACATCACCATGCTCTGAACGCGTAAAAAGGCTGGAGAAAGAAGGCTACA
TAAATGGCTATCACGCAGAGCTCAATGCAGAGAAGCTTGGCCTAGATGTACAGGTGTTTATTCATATTCGTCTTGATCAA
ACCAGCTTCTCGATTTTCGAGAAATTTGCCAAAGCGGTAGAGCTCATGCCTGAAATTGAAGAGTGTTATTCGTTGTCAGG
TGATTTCGACACCATGATTAAAGTTCGAGTAAAGAACATGAAGGCTTATCAGGAATTTATGTCGAGTAAGCTTGGGACAC
TACCGGGCGTGATCCAAACTCGAAGTGAAGTGGTTATTGAAGAACATAAGACGGGATTTGGTGTGAACCCTGAATTACTC
GGTTAA

Upstream 100 bases:

>100_bases
GGCAATCGTTAAATTCATATGGGTTTCACACGATGTATATTTCACTATTTGCAAACTAAATAGTTACTATTAATCTGGTG
GCTCCTGAGTTGTTACAAGG

Downstream 100 bases:

>100_bases
TACGAGTGGAGATACGTCGATATCAGACACAAAAAAGGAGCCATGAGGCTCCTTTTGTATATCAAGTTTCAATTAGCTTT
TTTATGCGCTTACGGATGTG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MWLMSYQLDRIDLQILRVLHSRGRIPVVELAKQVNLTTSPCSERVKRLEKEGYINGYHAELNAEKLGLDVQVFIHIRLDQ
TSFSIFEKFAKAVELMPEIEECYSLSGDFDTMIKVRVKNMKAYQEFMSSKLGTLPGVIQTRSEVVIEEHKTGFGVNPELL
G

Sequences:

>Translated_161_residues
MWLMSYQLDRIDLQILRVLHSRGRIPVVELAKQVNLTTSPCSERVKRLEKEGYINGYHAELNAEKLGLDVQVFIHIRLDQ
TSFSIFEKFAKAVELMPEIEECYSLSGDFDTMIKVRVKNMKAYQEFMSSKLGTLPGVIQTRSEVVIEEHKTGFGVNPELL
G
>Mature_161_residues
MWLMSYQLDRIDLQILRVLHSRGRIPVVELAKQVNLTTSPCSERVKRLEKEGYINGYHAELNAEKLGLDVQVFIHIRLDQ
TSFSIFEKFAKAVELMPEIEECYSLSGDFDTMIKVRVKNMKAYQEFMSSKLGTLPGVIQTRSEVVIEEHKTGFGVNPELL
G

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=143, Percent_Identity=48.2517482517483, Blast_Score=136, Evalue=6e-34,
Organism=Escherichia coli, GI87081742, Length=143, Percent_Identity=34.965034965035, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1790182, Length=143, Percent_Identity=27.972027972028, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18450; Mature: 18450

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWLMSYQLDRIDLQILRVLHSRGRIPVVELAKQVNLTTSPCSERVKRLEKEGYINGYHAE
CCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEECC
LNAEKLGLDVQVFIHIRLDQTSFSIFEKFAKAVELMPEIEECYSLSGDFDTMIKVRVKNM
CCHHHHCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KAYQEFMSSKLGTLPGVIQTRSEVVIEEHKTGFGVNPELLG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MWLMSYQLDRIDLQILRVLHSRGRIPVVELAKQVNLTTSPCSERVKRLEKEGYINGYHAE
CCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEECC
LNAEKLGLDVQVFIHIRLDQTSFSIFEKFAKAVELMPEIEECYSLSGDFDTMIKVRVKNM
CCHHHHCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KAYQEFMSSKLGTLPGVIQTRSEVVIEEHKTGFGVNPELLG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]