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The map label for this gene is ptrB [C]

Identifier: 156978109

GI number: 156978109

Start: 2011111

End: 2013078

Strand: Direct

Name: ptrB [C]

Synonym: VIBHAR_06914

Alternate gene names: 156978109

Gene position: 2011111-2013078 (Clockwise)

Preceding gene: 156978108

Following gene: 156978110

Centisome position: 91.25

GC content: 47.51

Gene sequence:

>1968_bases
ATGCTGACCGGTCTGTCACACAAGGAGCGTTATACAATGCGTACTCGCAAGCTCATTCTTGCTACCGCTTTTGGCCTACT
CATCTCGGGTTGCAGCCAAACCTCTACCACCAATACGGCAGAAGTCATTCCGCCAGAGTATCCGGTGGATTACTTCTTCC
GAAATGCTGAAGTCTCTAGCTACCAAATTTCTCCCGCTGGTGATTACATTTCAATGATGAAACCATGGCAAGACCGTAAA
AACGTCTTTGTACATCCTGTTGGCAAGCCAGAGGATGTGAAACGCATTACGTCGATCACCGGACGAGACATTGCGTACTA
CTACTGGGTAGGCGATGACACCATCATTTACTCTCGCGATACAGGTGGTGATGAGAACTTTTACCTCGTCACGGTGAACG
TTAAAACCGGTGAAGAAAAAACCATTACGCCAACGTCTGGTGTTGTGGCTTATGTAATTGACACGTTAGAGAGCCAGCCT
GACGACATTCTTATCACGACCAATGAACGCAACCCACAAGTATTTGATGTTTATCGCCATAACTTGAAAACTGGCGAAAA
CACACTGGTGGCACAAAACCCAGGTAATGTTCGCGATTGGGGTACCGACCACGATGGCAACATTCGATACATTTCAACCT
CTGATGGCGTAAACACCGCCGTACTTTATCGTGATACGGTGGATGAAGAATTCCGCCCATTGAAGAATCTGACTTTTAAA
GAAAGCTTCTCACCGATTTCGTTTACGCCAGATAACAAGAACTTATACGTTGCTTCTCGTATCACACGTGATAAATCGGC
GATCATCGAATACGATGTGAAAGCGAATAAAGAAGTACGCGAAATCTTCTCTCACCCGGAAGTTGACGTGACCAGCGCCA
GTTACTCGAATGCGCTCAATAAGCTAACGGCCATCTCTTATGTCACCGATAAACGTCAGTATCATTTCCTTGATAAAGGT
TATGAAGAGACTTTTGATAGGCTGCAAGAGAAGCTTCCGGGCGTTGAAATTTCTGTCAATAACGCCACGCGCGACGAACG
AAAAATGATTGTCGTCACCTACAGCGATACTGACCGCCCAAATTACTACTATTACGATCGTGATACCGACCAGTTAGAGA
AGTTAGCGGCGAATGCACCGTGGCATAAACCTGAAGACATGGCGAAAATGAAGCCAATCACCTATACCGCTCGTGATGGT
GAGACCATTCATGGTTACTTGACGCTACCAAAAGGTCGTGAAGCCAAAGATTTACCGCTATTAGTGCTGCCACACGGTGG
TCCTTGGGCGCGTGATTACTGGGGCTTCCAACCTGAAGTTCAGCTGTTTGCTAACCGTGGCATTGCAGTGCTGCAAATGA
ACTTCCGTGGTTCAACGGGTTATGGCCGTGAGTTTTGGGAAAAATCGTTCAAGCAGTGGGGTCAGTCAATGCAAGACGAC
ATCACCGATGGCGTAAAGTGGGCGATTGACCAAGGTTATGCTCAAGATGGCGAAGTATGTATCTACGGCGCATCTTACGG
TGGTTACGCGACATTGGCCGGTGTAACGTTCACTCCAGACCTTTACAAATGTGGTATCGACTACGTTGGTGTGTCTAACC
TATTTACCTTCATGGATTCCATTCCACCTTACTGGGCACCATTCCTCGCCATGCTGCATGAGCAAGTGGGCGATCCGAAT
AACCCAGAAGACGCGAAGATGATGAAAGCTTACTCACCAGTGTTCCACGTGGACCAAATCAAAGCACCATTGTTGGTTCT
ACAAGGCGCGAAAGACCCACGAGTGGTGAAGAGTGAATCTGATCAGATCGTCGATGCTCTGCGCGACCGTGGCGTTGAAG
TCGAGTACATCGTTAAAGAGAACGAAGGTCACGGCTTCCGCTCTTTAGAGAATCGTCTCGATGGTTACCAAGCGATGGAC
CGATTCCTGAAAACGCACTTGTTAGAGCAAACTCAACAAGCTCAATAG

Upstream 100 bases:

>100_bases
CTTAAATGATAAGTTAAACCAATATCGGTTGCCCTTTCACTGCTTTGCCGCTGTCCTGTATTTGGCCACGACAATCGACT
CACTCTGACCGACAAGCACG

Downstream 100 bases:

>100_bases
ACTTATACCCAAGTGAATTCAAGATGCAGGATTCAGAGCGTTGTCATTGATTCGAGAGCAAGAAAAACAACGCAGTGTAA
TAGCCAGCTATTTCCAAGTT

Product: prolyl oligopeptidase

Products: NA

Alternate protein names: AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase [H]

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MLTGLSHKERYTMRTRKLILATAFGLLISGCSQTSTTNTAEVIPPEYPVDYFFRNAEVSSYQISPAGDYISMMKPWQDRK
NVFVHPVGKPEDVKRITSITGRDIAYYYWVGDDTIIYSRDTGGDENFYLVTVNVKTGEEKTITPTSGVVAYVIDTLESQP
DDILITTNERNPQVFDVYRHNLKTGENTLVAQNPGNVRDWGTDHDGNIRYISTSDGVNTAVLYRDTVDEEFRPLKNLTFK
ESFSPISFTPDNKNLYVASRITRDKSAIIEYDVKANKEVREIFSHPEVDVTSASYSNALNKLTAISYVTDKRQYHFLDKG
YEETFDRLQEKLPGVEISVNNATRDERKMIVVTYSDTDRPNYYYYDRDTDQLEKLAANAPWHKPEDMAKMKPITYTARDG
ETIHGYLTLPKGREAKDLPLLVLPHGGPWARDYWGFQPEVQLFANRGIAVLQMNFRGSTGYGREFWEKSFKQWGQSMQDD
ITDGVKWAIDQGYAQDGEVCIYGASYGGYATLAGVTFTPDLYKCGIDYVGVSNLFTFMDSIPPYWAPFLAMLHEQVGDPN
NPEDAKMMKAYSPVFHVDQIKAPLLVLQGAKDPRVVKSESDQIVDALRDRGVEVEYIVKENEGHGFRSLENRLDGYQAMD
RFLKTHLLEQTQQAQ

Sequences:

>Translated_655_residues
MLTGLSHKERYTMRTRKLILATAFGLLISGCSQTSTTNTAEVIPPEYPVDYFFRNAEVSSYQISPAGDYISMMKPWQDRK
NVFVHPVGKPEDVKRITSITGRDIAYYYWVGDDTIIYSRDTGGDENFYLVTVNVKTGEEKTITPTSGVVAYVIDTLESQP
DDILITTNERNPQVFDVYRHNLKTGENTLVAQNPGNVRDWGTDHDGNIRYISTSDGVNTAVLYRDTVDEEFRPLKNLTFK
ESFSPISFTPDNKNLYVASRITRDKSAIIEYDVKANKEVREIFSHPEVDVTSASYSNALNKLTAISYVTDKRQYHFLDKG
YEETFDRLQEKLPGVEISVNNATRDERKMIVVTYSDTDRPNYYYYDRDTDQLEKLAANAPWHKPEDMAKMKPITYTARDG
ETIHGYLTLPKGREAKDLPLLVLPHGGPWARDYWGFQPEVQLFANRGIAVLQMNFRGSTGYGREFWEKSFKQWGQSMQDD
ITDGVKWAIDQGYAQDGEVCIYGASYGGYATLAGVTFTPDLYKCGIDYVGVSNLFTFMDSIPPYWAPFLAMLHEQVGDPN
NPEDAKMMKAYSPVFHVDQIKAPLLVLQGAKDPRVVKSESDQIVDALRDRGVEVEYIVKENEGHGFRSLENRLDGYQAMD
RFLKTHLLEQTQQAQ
>Mature_655_residues
MLTGLSHKERYTMRTRKLILATAFGLLISGCSQTSTTNTAEVIPPEYPVDYFFRNAEVSSYQISPAGDYISMMKPWQDRK
NVFVHPVGKPEDVKRITSITGRDIAYYYWVGDDTIIYSRDTGGDENFYLVTVNVKTGEEKTITPTSGVVAYVIDTLESQP
DDILITTNERNPQVFDVYRHNLKTGENTLVAQNPGNVRDWGTDHDGNIRYISTSDGVNTAVLYRDTVDEEFRPLKNLTFK
ESFSPISFTPDNKNLYVASRITRDKSAIIEYDVKANKEVREIFSHPEVDVTSASYSNALNKLTAISYVTDKRQYHFLDKG
YEETFDRLQEKLPGVEISVNNATRDERKMIVVTYSDTDRPNYYYYDRDTDQLEKLAANAPWHKPEDMAKMKPITYTARDG
ETIHGYLTLPKGREAKDLPLLVLPHGGPWARDYWGFQPEVQLFANRGIAVLQMNFRGSTGYGREFWEKSFKQWGQSMQDD
ITDGVKWAIDQGYAQDGEVCIYGASYGGYATLAGVTFTPDLYKCGIDYVGVSNLFTFMDSIPPYWAPFLAMLHEQVGDPN
NPEDAKMMKAYSPVFHVDQIKAPLLVLQGAKDPRVVKSESDQIVDALRDRGVEVEYIVKENEGHGFRSLENRLDGYQAMD
RFLKTHLLEQTQQAQ

Specific function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9C family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=232, Percent_Identity=25.4310344827586, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI16933540, Length=241, Percent_Identity=24.0663900414938, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25144537, Length=660, Percent_Identity=29.2424242424242, Blast_Score=281, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI25144540, Length=437, Percent_Identity=32.4942791762014, Blast_Score=241, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25144543, Length=561, Percent_Identity=28.1639928698752, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17552908, Length=225, Percent_Identity=32.4444444444444, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25149159, Length=260, Percent_Identity=30, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR001375
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9 [H]

EC number: =3.4.19.1 [H]

Molecular weight: Translated: 74551; Mature: 74551

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTGLSHKERYTMRTRKLILATAFGLLISGCSQTSTTNTAEVIPPEYPVDYFFRNAEVSS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHEEECCCCCE
YQISPAGDYISMMKPWQDRKNVFVHPVGKPEDVKRITSITGRDIAYYYWVGDDTIIYSRD
EEECCCCCHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCEEEEEEECCCEEEEECC
TGGDENFYLVTVNVKTGEEKTITPTSGVVAYVIDTLESQPDDILITTNERNPQVFDVYRH
CCCCCCEEEEEEEEECCCCCEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEHHHHH
NLKTGENTLVAQNPGNVRDWGTDHDGNIRYISTSDGVNTAVLYRDTVDEEFRPLKNLTFK
CCCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHCCCCC
ESFSPISFTPDNKNLYVASRITRDKSAIIEYDVKANKEVREIFSHPEVDVTSASYSNALN
CCCCCCEECCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHCCCCCEEECCHHHHHHH
KLTAISYVTDKRQYHFLDKGYEETFDRLQEKLPGVEISVNNATRDERKMIVVTYSDTDRP
HHHHHHEECCCCCEEHHCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCCC
NYYYYDRDTDQLEKLAANAPWHKPEDMAKMKPITYTARDGETIHGYLTLPKGREAKDLPL
CEEEECCCHHHHHHHHCCCCCCCCHHHHHCCCCEEEECCCCEEEEEEECCCCCCCCCCCE
LVLPHGGPWARDYWGFQPEVQLFANRGIAVLQMNFRGSTGYGREFWEKSFKQWGQSMQDD
EEEECCCCCCHHHCCCCCCHHHEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
ITDGVKWAIDQGYAQDGEVCIYGASYGGYATLAGVTFTPDLYKCGIDYVGVSNLFTFMDS
HHCCHHHHHCCCCCCCCCEEEEECCCCCCEEEECEEECCHHHHCCCCCCCHHHHHHHHHC
IPPYWAPFLAMLHEQVGDPNNPEDAKMMKAYSPVFHVDQIKAPLLVLQGAKDPRVVKSES
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEHHHHCCCEEEEECCCCCCEECCCC
DQIVDALRDRGVEVEYIVKENEGHGFRSLENRLDGYQAMDRFLKTHLLEQTQQAQ
HHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTGLSHKERYTMRTRKLILATAFGLLISGCSQTSTTNTAEVIPPEYPVDYFFRNAEVSS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHEEECCCCCE
YQISPAGDYISMMKPWQDRKNVFVHPVGKPEDVKRITSITGRDIAYYYWVGDDTIIYSRD
EEECCCCCHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCEEEEEEECCCEEEEECC
TGGDENFYLVTVNVKTGEEKTITPTSGVVAYVIDTLESQPDDILITTNERNPQVFDVYRH
CCCCCCEEEEEEEEECCCCCEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEHHHHH
NLKTGENTLVAQNPGNVRDWGTDHDGNIRYISTSDGVNTAVLYRDTVDEEFRPLKNLTFK
CCCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHCCCCC
ESFSPISFTPDNKNLYVASRITRDKSAIIEYDVKANKEVREIFSHPEVDVTSASYSNALN
CCCCCCEECCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHCCCCCEEECCHHHHHHH
KLTAISYVTDKRQYHFLDKGYEETFDRLQEKLPGVEISVNNATRDERKMIVVTYSDTDRP
HHHHHHEECCCCCEEHHCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCCC
NYYYYDRDTDQLEKLAANAPWHKPEDMAKMKPITYTARDGETIHGYLTLPKGREAKDLPL
CEEEECCCHHHHHHHHCCCCCCCCHHHHHCCCCEEEECCCCEEEEEEECCCCCCCCCCCE
LVLPHGGPWARDYWGFQPEVQLFANRGIAVLQMNFRGSTGYGREFWEKSFKQWGQSMQDD
EEEECCCCCCHHHCCCCCCHHHEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
ITDGVKWAIDQGYAQDGEVCIYGASYGGYATLAGVTFTPDLYKCGIDYVGVSNLFTFMDS
HHCCHHHHHCCCCCCCCCEEEEECCCCCCEEEECEEECCHHHHCCCCCCCHHHHHHHHHC
IPPYWAPFLAMLHEQVGDPNNPEDAKMMKAYSPVFHVDQIKAPLLVLQGAKDPRVVKSES
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEHHHHCCCEEEEECCCCCCEECCCC
DQIVDALRDRGVEVEYIVKENEGHGFRSLENRLDGYQAMDRFLKTHLLEQTQQAQ
HHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966; 12037315 [H]