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The map label for this gene is qacE [H]

Identifier: 156978105

GI number: 156978105

Start: 2007153

End: 2007602

Strand: Direct

Name: qacE [H]

Synonym: VIBHAR_06909

Alternate gene names: 156978105

Gene position: 2007153-2007602 (Clockwise)

Preceding gene: 156978103

Following gene: 156978106

Centisome position: 91.07

GC content: 46.22

Gene sequence:

>450_bases
GTGCTGCAATTTTTATTATTACAATTACGTAAAGGTCATTTGATTTTTCATGGGATTATCATTTTATTCGATATCAATAT
ACTGACGGCATTCCAAAACAACCGAAGACGAATGATAACAATGAGCTGGTTTTTCTTACTTTTAGGCGTGGGCGCCGAAG
CCCTTTCACACGTTGCACTTAAAGCAACCGATGGCTTTAGCAAACCGCTGCCGGCGACCCTAGTGTTGCTTGGCCATTTG
GCCGCATTTGTCTGTTTAGCGCAGGCGATGAAAGGTGGTATGCCAGTGGGCATTGTTCACGCGCTTTGGGCGGGTTTAGC
AATTGTGTCAGTGACCTTAATCTCGCAACTGGTTTACCGTCAGCACATGGATACGAGCCTTTGGATTGGGATGGCGCTTA
TCGCAGCAGGTGTGATGGTGATAAACTTCTCTCACGGACACGCACACTAA

Upstream 100 bases:

>100_bases
AACCCCACCCAGCAAAGTTTTACGCATCCCGACACTCTCTTTTCCAAAGACGGCGGCAGTGTAACGGTTGTCACAAACAG
TTAATGTAAGGGTATGTAAG

Downstream 100 bases:

>100_bases
ACTATAAGGCCGCGACTTGTCAGATACTCAAAAGCCCTCTCTTGCACTGTTTGATTTTGATGGCACCATAACGGATGAAG
ACATGTTCAGTGCCTTCCTC

Product: hypothetical protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant E [H]

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MLQFLLLQLRKGHLIFHGIIILFDINILTAFQNNRRRMITMSWFFLLLGVGAEALSHVALKATDGFSKPLPATLVLLGHL
AAFVCLAQAMKGGMPVGIVHALWAGLAIVSVTLISQLVYRQHMDTSLWIGMALIAAGVMVINFSHGHAH

Sequences:

>Translated_149_residues
MLQFLLLQLRKGHLIFHGIIILFDINILTAFQNNRRRMITMSWFFLLLGVGAEALSHVALKATDGFSKPLPATLVLLGHL
AAFVCLAQAMKGGMPVGIVHALWAGLAIVSVTLISQLVYRQHMDTSLWIGMALIAAGVMVINFSHGHAH
>Mature_149_residues
MLQFLLLQLRKGHLIFHGIIILFDINILTAFQNNRRRMITMSWFFLLLGVGAEALSHVALKATDGFSKPLPATLVLLGHL
AAFVCLAQAMKGGMPVGIVHALWAGLAIVSVTLISQLVYRQHMDTSLWIGMALIAAGVMVINFSHGHAH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=91, Percent_Identity=36.2637362637363, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 16293; Mature: 16293

Theoretical pI: Translated: 10.83; Mature: 10.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQFLLLQLRKGHLIFHGIIILFDINILTAFQNNRRRMITMSWFFLLLGVGAEALSHVAL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCHHHHHHHHH
KATDGFSKPLPATLVLLGHLAAFVCLAQAMKGGMPVGIVHALWAGLAIVSVTLISQLVYR
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QHMDTSLWIGMALIAAGVMVINFSHGHAH
HHCCHHHHHHHHHHHHHHHEEEECCCCCC
>Mature Secondary Structure
MLQFLLLQLRKGHLIFHGIIILFDINILTAFQNNRRRMITMSWFFLLLGVGAEALSHVAL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCHHHHHHHHH
KATDGFSKPLPATLVLLGHLAAFVCLAQAMKGGMPVGIVHALWAGLAIVSVTLISQLVYR
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QHMDTSLWIGMALIAAGVMVINFSHGHAH
HHCCHHHHHHHHHHHHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8494372 [H]