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The map label for this gene is thiD [H]

Identifier: 156978034

GI number: 156978034

Start: 1949984

End: 1950871

Strand: Direct

Name: thiD [H]

Synonym: VIBHAR_06838

Alternate gene names: 156978034

Gene position: 1949984-1950871 (Clockwise)

Preceding gene: 156978031

Following gene: 156978035

Centisome position: 88.47

GC content: 48.31

Gene sequence:

>888_bases
ATGGCGCAGCAGTCAAGCCAAGAAAAACAATTAACCCAACCACACGCTACAACTTCAATAGACACACCGATTGTGTTGAC
GATTGCAGGTTCTGATAGTGGCGGCGGCGCAGGCATTCAAGCCGACATCAAATCGATGTCCGCAACTGGCAGTTTTGCTT
GCTCGGTAATCACGGCGATTACTTCACAAAATACCCAAGGCGTTTCTGCGATTTTCCCAATCCCTCTCGACCATGTAGAG
AGCCAACTTGATGCGGTATTTACCGACCTCAACATCGTTGCAGTTAAAGTGGGCATGCTGGCCGATTCCAATATCATCAA
AGTCGTTGCCAACAAAATTAAACAATACCAGCCAAAACACCTCGTGATTGACCCTGTTATGGTGGCTACCAGCGGCGATC
TATTACTGGAACAGTCGGCAATCAGCACTTTAAAAGAAGAATTGATTCCGCTCGCAGACATCATTACCCCTAACCTACCC
GAAGGCGCAGCATTGACGGGTAAGCCAGTGCCTCAATCAGAATCTGAAATGAACGATATGATTGCTGATTTACGCGCGCT
CGGGGCAAAAGCGGTGCTGTTAAAAGGCGGCCACTTAGAAAAAGACGAAAACAGCAACGATCTGCTGATCATGCCAGACA
GCTCTGAACTGATCAGCGCTAAACGCTTTCCAACCAAAAACACCCATGGCACAGGCTGTACGCTGTCTTCTGCTATCGCG
TCTTACCTTGGCCAAGGCAACAACCTGCACAAAGCGGTGCACCTTGGTAAGCAGTACATTAGTCAAGCTATCGCGCACGC
AGACGAATTGGATGTAGGTAAAGGTCACGGCCCTGTGAACCACTTTTTTGCAGGTCCTAATTTTGGGAAAAGTAAAGATG
TGCGCTAA

Upstream 100 bases:

>100_bases
GCTTGAGTTTTATTGTCGCAGCTAGCCTCGATGGATCCGATCACCGATCTTCCCTTGCGATGGCCAAGTCAGTTCCTATA
CGTCTGTAATAGGAGCGACC

Downstream 100 bases:

>100_bases
TGCACTCGGCATTCAGCTTACCGAAGCAAGTCTGCAATACAAAGACAGCCAAACGCCAACATTAGCAGGGTTGAGTATGA
CCATCCCTGCCAATCAATGG

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MAQQSSQEKQLTQPHATTSIDTPIVLTIAGSDSGGGAGIQADIKSMSATGSFACSVITAITSQNTQGVSAIFPIPLDHVE
SQLDAVFTDLNIVAVKVGMLADSNIIKVVANKIKQYQPKHLVIDPVMVATSGDLLLEQSAISTLKEELIPLADIITPNLP
EGAALTGKPVPQSESEMNDMIADLRALGAKAVLLKGGHLEKDENSNDLLIMPDSSELISAKRFPTKNTHGTGCTLSSAIA
SYLGQGNNLHKAVHLGKQYISQAIAHADELDVGKGHGPVNHFFAGPNFGKSKDVR

Sequences:

>Translated_295_residues
MAQQSSQEKQLTQPHATTSIDTPIVLTIAGSDSGGGAGIQADIKSMSATGSFACSVITAITSQNTQGVSAIFPIPLDHVE
SQLDAVFTDLNIVAVKVGMLADSNIIKVVANKIKQYQPKHLVIDPVMVATSGDLLLEQSAISTLKEELIPLADIITPNLP
EGAALTGKPVPQSESEMNDMIADLRALGAKAVLLKGGHLEKDENSNDLLIMPDSSELISAKRFPTKNTHGTGCTLSSAIA
SYLGQGNNLHKAVHLGKQYISQAIAHADELDVGKGHGPVNHFFAGPNFGKSKDVR
>Mature_294_residues
AQQSSQEKQLTQPHATTSIDTPIVLTIAGSDSGGGAGIQADIKSMSATGSFACSVITAITSQNTQGVSAIFPIPLDHVES
QLDAVFTDLNIVAVKVGMLADSNIIKVVANKIKQYQPKHLVIDPVMVATSGDLLLEQSAISTLKEELIPLADIITPNLPE
GAALTGKPVPQSESEMNDMIADLRALGAKAVLLKGGHLEKDENSNDLLIMPDSSELISAKRFPTKNTHGTGCTLSSAIAS
YLGQGNNLHKAVHLGKQYISQAIAHADELDVGKGHGPVNHFFAGPNFGKSKDVR

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=259, Percent_Identity=49.8069498069498, Blast_Score=260, Evalue=9e-71,
Organism=Saccharomyces cerevisiae, GI6325378, Length=289, Percent_Identity=36.6782006920415, Blast_Score=146, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6324997, Length=277, Percent_Identity=37.1841155234657, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324517, Length=288, Percent_Identity=36.1111111111111, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 30990; Mature: 30858

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQSSQEKQLTQPHATTSIDTPIVLTIAGSDSGGGAGIQADIKSMSATGSFACSVITAI
CCCCCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
TSQNTQGVSAIFPIPLDHVESQLDAVFTDLNIVAVKVGMLADSNIIKVVANKIKQYQPKH
HCCCCCCCEEEECCCHHHHHHHHHHHHHCCEEEEEEEEHHCCCHHHHHHHHHHHHCCCCE
LVIDPVMVATSGDLLLEQSAISTLKEELIPLADIITPNLPEGAALTGKPVPQSESEMNDM
EEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
IADLRALGAKAVLLKGGHLEKDENSNDLLIMPDSSELISAKRFPTKNTHGTGCTLSSAIA
HHHHHHCCCEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHH
SYLGQGNNLHKAVHLGKQYISQAIAHADELDVGKGHGPVNHFFAGPNFGKSKDVR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCCCCCCCCCC
>Mature Secondary Structure 
AQQSSQEKQLTQPHATTSIDTPIVLTIAGSDSGGGAGIQADIKSMSATGSFACSVITAI
CCCCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
TSQNTQGVSAIFPIPLDHVESQLDAVFTDLNIVAVKVGMLADSNIIKVVANKIKQYQPKH
HCCCCCCCEEEECCCHHHHHHHHHHHHHCCEEEEEEEEHHCCCHHHHHHHHHHHHCCCCE
LVIDPVMVATSGDLLLEQSAISTLKEELIPLADIITPNLPEGAALTGKPVPQSESEMNDM
EEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
IADLRALGAKAVLLKGGHLEKDENSNDLLIMPDSSELISAKRFPTKNTHGTGCTLSSAIA
HHHHHHCCCEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHH
SYLGQGNNLHKAVHLGKQYISQAIAHADELDVGKGHGPVNHFFAGPNFGKSKDVR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]