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The map label for this gene is cry2 [H]

Identifier: 156977867

GI number: 156977867

Start: 1795798

End: 1797279

Strand: Direct

Name: cry2 [H]

Synonym: VIBHAR_06659

Alternate gene names: 156977867

Gene position: 1795798-1797279 (Clockwise)

Preceding gene: 156977865

Following gene: 156977868

Centisome position: 81.48

GC content: 46.96

Gene sequence:

>1482_bases
ATGCACACAATCAATCTAGTATGGCTAAAACGCGACTTACGCCTGACCGACCACCTCCCTTTGCAGCATGCTGTATCTTC
TAAGAATCCAACAGTGCTGCTCTACATTTTTGAGCCCATGCTGCTGGATGACCCACATTACTCCGAACGTCATTGGCGCT
TTGTTTGGCAATCAATTCAAGACATGAACGCACAGCTTGCCCAACATAATCAAAAAGTCTCAGTAATGTTTGGCAATGCT
CGGGATTGTTTGAGTGCGATTCAAAACCAATTCAGCATCGATGCCGTTTTCTCCCATCAAGAAATTGGATTGAATTGTAC
GTTTGAGCGAGACAAACAAGTATCAGCATGGCTTCAAGCACAAGACATTCCATGGCATGAGTTTGAACATGGCGCAGTTG
TGCGAGGCGCAAAAGATCGATTCGGCTGGGACAAACATTGGGATACCGTTATGCGATCTCCGATAGAAGAGGTTGAGCTT
GAAAGCGCTTCTCTTATTACTCTCGATGTCGAAGCGCTAGGTTTCACCTTTACTCCTCCCCCTTCTTGGTTAGAAAAAGT
AAAAGGCGTGCAAACTGGCGGGAGCTCAATCGCTTGGCAAACATTGGAAGACTTTTTTCAACGCCGAGGTCGAGATTATT
ACCGAAGTATTTCTAGCCCGACTGCATCTCGGACAGCCTGTACTCGCCTCTCTCCCTATCTTGCATGGGGTAATATTTCG
CTTCGAGAAGTATATCAGTACCTCTTGCAACATTGGCAAGTGACGGGGTTTCGTCGCAGCCTAATTGCGTTGTCTTCAAG
GCTTCATTGGCATTGTCATTTTATGCAGAAATTTGAATCTGAATGTGAGATGGAATTTCGCTGTGTGAACCAAGCCTATG
ACCCTTTGCTTCGCCAAGCGAGCAACAACGACCCAATCCGACTAGATGCTTGGAAGGCGGGAACCACTGGCATACCTCTC
GTCGATGCCTGTATGCGATGCCTTCATCACACCGGATACATCAACTTTCGCATGCGTGCGATGTTAGTGAGCTTTTTAAC
ACATCATATGAACATGGACTGGCGCGATGGCGTAACTCATCTAGCGCAGCTATTTCTCGACTTTGAGCCAGGTATCCATT
ATCCACAATTTCAAATGCAGGCTGGCGTGACGGGCACCAATACCATCCGTATCTACAATCCGACGAAACAAGCACAAGAA
CACGATACAGATGGTGAATTCATTCATAAATGGATTCCGGAGCTCGCCAAGGTACCCACCCCACTGCTGTTTGAACCTTG
GAAAATGACCGCAATGGAAGTCGTGATGTACCAGTTAGAACCGGATTCAAAATACCTCGCCCCAACAATCGATGTAGAAG
CGAGTGCGAAAGCAGCAAGAGAACGCTTATGGGCTTGGCGAAAACGTGTCGACGTAAAAATGGAAGGCACACGCATTTTA
GCTCAGCACGCCCGTCCTTCTAATAAAAAGAAAGCCAGTTGA

Upstream 100 bases:

>100_bases
CCTTGCTCCGTGCCTCTACGTCAGCTGCAATAAAATCGATCACCGAGTGAGAAATTTGCCTCTCTCATGCGTAGAAATCG
GAAAACCAGTGAGGGCTCCG

Downstream 100 bases:

>100_bases
TCGCCAAGAAAAAGGCGTGCGTACAAACTGGGACTTTATCAGGGAGAGAGCAGTACCCAAACAACAAAAGGAACGCATTA
TGTTGAAACGCATCTTGGTC

Product: deoxyribodipyrimidine photolyase

Products: 2 pyrimidine residues (in DNA) [C]

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MHTINLVWLKRDLRLTDHLPLQHAVSSKNPTVLLYIFEPMLLDDPHYSERHWRFVWQSIQDMNAQLAQHNQKVSVMFGNA
RDCLSAIQNQFSIDAVFSHQEIGLNCTFERDKQVSAWLQAQDIPWHEFEHGAVVRGAKDRFGWDKHWDTVMRSPIEEVEL
ESASLITLDVEALGFTFTPPPSWLEKVKGVQTGGSSIAWQTLEDFFQRRGRDYYRSISSPTASRTACTRLSPYLAWGNIS
LREVYQYLLQHWQVTGFRRSLIALSSRLHWHCHFMQKFESECEMEFRCVNQAYDPLLRQASNNDPIRLDAWKAGTTGIPL
VDACMRCLHHTGYINFRMRAMLVSFLTHHMNMDWRDGVTHLAQLFLDFEPGIHYPQFQMQAGVTGTNTIRIYNPTKQAQE
HDTDGEFIHKWIPELAKVPTPLLFEPWKMTAMEVVMYQLEPDSKYLAPTIDVEASAKAARERLWAWRKRVDVKMEGTRIL
AQHARPSNKKKAS

Sequences:

>Translated_493_residues
MHTINLVWLKRDLRLTDHLPLQHAVSSKNPTVLLYIFEPMLLDDPHYSERHWRFVWQSIQDMNAQLAQHNQKVSVMFGNA
RDCLSAIQNQFSIDAVFSHQEIGLNCTFERDKQVSAWLQAQDIPWHEFEHGAVVRGAKDRFGWDKHWDTVMRSPIEEVEL
ESASLITLDVEALGFTFTPPPSWLEKVKGVQTGGSSIAWQTLEDFFQRRGRDYYRSISSPTASRTACTRLSPYLAWGNIS
LREVYQYLLQHWQVTGFRRSLIALSSRLHWHCHFMQKFESECEMEFRCVNQAYDPLLRQASNNDPIRLDAWKAGTTGIPL
VDACMRCLHHTGYINFRMRAMLVSFLTHHMNMDWRDGVTHLAQLFLDFEPGIHYPQFQMQAGVTGTNTIRIYNPTKQAQE
HDTDGEFIHKWIPELAKVPTPLLFEPWKMTAMEVVMYQLEPDSKYLAPTIDVEASAKAARERLWAWRKRVDVKMEGTRIL
AQHARPSNKKKAS
>Mature_493_residues
MHTINLVWLKRDLRLTDHLPLQHAVSSKNPTVLLYIFEPMLLDDPHYSERHWRFVWQSIQDMNAQLAQHNQKVSVMFGNA
RDCLSAIQNQFSIDAVFSHQEIGLNCTFERDKQVSAWLQAQDIPWHEFEHGAVVRGAKDRFGWDKHWDTVMRSPIEEVEL
ESASLITLDVEALGFTFTPPPSWLEKVKGVQTGGSSIAWQTLEDFFQRRGRDYYRSISSPTASRTACTRLSPYLAWGNIS
LREVYQYLLQHWQVTGFRRSLIALSSRLHWHCHFMQKFESECEMEFRCVNQAYDPLLRQASNNDPIRLDAWKAGTTGIPL
VDACMRCLHHTGYINFRMRAMLVSFLTHHMNMDWRDGVTHLAQLFLDFEPGIHYPQFQMQAGVTGTNTIRIYNPTKQAQE
HDTDGEFIHKWIPELAKVPTPLLFEPWKMTAMEVVMYQLEPDSKYLAPTIDVEASAKAARERLWAWRKRVDVKMEGTRIL
AQHARPSNKKKAS

Specific function: Has no photolyase activity [H]

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=497, Percent_Identity=20.7243460764588, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI188536100, Length=457, Percent_Identity=21.8818380743982, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI188536103, Length=282, Percent_Identity=25.531914893617, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786926, Length=488, Percent_Identity=25.4098360655738, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324962, Length=115, Percent_Identity=35.6521739130435, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137248, Length=468, Percent_Identity=22.6495726495727, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24585455, Length=468, Percent_Identity=22.6495726495727, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24648152, Length=548, Percent_Identity=21.1678832116788, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: 4.1.99.3 [C]

Molecular weight: Translated: 57356; Mature: 57356

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTINLVWLKRDLRLTDHLPLQHAVSSKNPTVLLYIFEPMLLDDPHYSERHWRFVWQSIQ
CCEEEEEEEEECCCCCCCCCHHHHHCCCCCEEEEEEECCEEECCCCCCHHHHHHHHHHHH
DMNAQLAQHNQKVSVMFGNARDCLSAIQNQFSIDAVFSHQEIGLNCTFERDKQVSAWLQA
HHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCHHHHHHHH
QDIPWHEFEHGAVVRGAKDRFGWDKHWDTVMRSPIEEVELESASLITLDVEALGFTFTPP
CCCCCCCCCCCCEEECCHHCCCCCHHHHHHHHCCHHHHCCCCCEEEEEEHHHCCEECCCC
PSWLEKVKGVQTGGSSIAWQTLEDFFQRRGRDYYRSISSPTASRTACTRLSPYLAWGNIS
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHCCCEEEECCCC
LREVYQYLLQHWQVTGFRRSLIALSSRLHWHCHFMQKFESECEMEFRCVNQAYDPLLRQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SNNDPIRLDAWKAGTTGIPLVDACMRCLHHTGYINFRMRAMLVSFLTHHMNMDWRDGVTH
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCCCCHHHHHHH
LAQLFLDFEPGIHYPQFQMQAGVTGTNTIRIYNPTKQAQEHDTDGEFIHKWIPELAKVPT
HHHHHHHCCCCCCCCCEEEECCCCCCCEEEEECCCHHHHCCCCCHHHHHHHHHHHHHCCC
PLLFEPWKMTAMEVVMYQLEPDSKYLAPTIDVEASAKAARERLWAWRKRVDVKMEGTRIL
CCEECCHHHHHHHHHHEEECCCCCEECCEECCCCHHHHHHHHHHHHHHHCCEEECCHHHH
AQHARPSNKKKAS
HHHCCCCCCCCCC
>Mature Secondary Structure
MHTINLVWLKRDLRLTDHLPLQHAVSSKNPTVLLYIFEPMLLDDPHYSERHWRFVWQSIQ
CCEEEEEEEEECCCCCCCCCHHHHHCCCCCEEEEEEECCEEECCCCCCHHHHHHHHHHHH
DMNAQLAQHNQKVSVMFGNARDCLSAIQNQFSIDAVFSHQEIGLNCTFERDKQVSAWLQA
HHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCHHHHHHHH
QDIPWHEFEHGAVVRGAKDRFGWDKHWDTVMRSPIEEVELESASLITLDVEALGFTFTPP
CCCCCCCCCCCCEEECCHHCCCCCHHHHHHHHCCHHHHCCCCCEEEEEEHHHCCEECCCC
PSWLEKVKGVQTGGSSIAWQTLEDFFQRRGRDYYRSISSPTASRTACTRLSPYLAWGNIS
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHCCCEEEECCCC
LREVYQYLLQHWQVTGFRRSLIALSSRLHWHCHFMQKFESECEMEFRCVNQAYDPLLRQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SNNDPIRLDAWKAGTTGIPLVDACMRCLHHTGYINFRMRAMLVSFLTHHMNMDWRDGVTH
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCCCCHHHHHHH
LAQLFLDFEPGIHYPQFQMQAGVTGTNTIRIYNPTKQAQEHDTDGEFIHKWIPELAKVPT
HHHHHHHCCCCCCCCCEEEECCCCCCCEEEEECCCHHHHCCCCCHHHHHHHHHHHHHCCC
PLLFEPWKMTAMEVVMYQLEPDSKYLAPTIDVEASAKAARERLWAWRKRVDVKMEGTRIL
CCEECCHHHHHHHHHHEEECCCCCEECCEECCCCHHHHHHHHHHHHHHHCCEEECCHHHH
AQHARPSNKKKAS
HHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: ATP; FADH2; Flavin; pterin [C]

Metal ions: NA

Kcat value (1/min): 2.4 [C]

Specific activity: NA

Km value (mM): NA

Substrates: cyclobutadipyrimidine (in DNA) [C]

Specific reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) [C]

General reaction: C-C-bond cleavage [C]

Inhibitor: yeast DNA [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]