Click here to switch to the map view.

The map label for this gene is creC [H]

Identifier: 156977837

GI number: 156977837

Start: 1768222

End: 1769667

Strand: Reverse

Name: creC [H]

Synonym: VIBHAR_06625

Alternate gene names: 156977837

Gene position: 1769667-1768222 (Counterclockwise)

Preceding gene: 156977839

Following gene: 156977836

Centisome position: 80.29

GC content: 47.86

Gene sequence:

>1446_bases
ATGATGAATCGCTGGCCGAAGATCCCGCTTGGACTCAGACTGTTTTTTCTCTACTTCATCTTAGTCGGAATGACGGCTTA
CATGGTGAGCAAAACGGTTGTCCAAGAACTCAAGCCAACCGTGCGTCAAACCACCGAAGAGACGCTGGTGGATATGGCGA
ACTTACTCGCGGTATTGGCTGAAGAAGACGTTGCAAACGGAAAGTTATCTGAGAGTCGCTTTTCCAAACTATTAGCAGCT
TATGGGCAGCGAGAGCCTCAAGCGCGCATTTGGGAAATTGGCAAAAAAGCGATTAACCATCGAATTTACATCACCGATAA
ACAAGGCATTGTGATTGCGGATTCTTGGCAGCAAGACGTAGGCAAAGACTACTCGCAATGGAACGATGTGTATCTCACGT
TGCGTGGTCAATACGGCGCGCGCAGTACCATCGAAGACCCGAAAGATCCACCCTCAACCGTTATGCACGTTGCTGCGCCT
ATTTATCACAAAGGCGAAATCATTGGCAGCGTGACGGTGGCAAAATCCAATCGCTCCGTACAACCCTTCATCGATCTTTC
TAAACGCAATGTGCTGTTTTGGATGGTATGGATGAGTGGTTTAGTGTTATTGGCAGGGGCATTGTTTGCTTGGCGAATTC
ACTCGGCACTGAACAAGCTAGAAGACTACGCAACCAAAATGGGTGAGGGCGAAAAGGTCTCTAAGCCGACATTTCGTATC
TTTTATGAGTACGGCACGCTAAGCGACGCATTAGAAAAAATGCGCAATCAGCTCGATGGTAAACAATATGTGGAAGAGTA
CGTACAGACGCTGACTCATGAGCTGAAAAGCCCGTTATCAGCGATTAAAGGCGCGAGTGAAATATTGCAAATGCCGTTGC
CTGAAGAAAAGGTCACGCGCTTTGCTGGCAACATTGAGCGAGAAAGCGACCGCATGCAGTCATTGATTGATAAGTTGCTC
GAACTGGCTCGTCTTGAAAAGCGCCCCGAGTTAGAACAAGTCGAAGCTATCTCGCTAAAACAAATGGTCAATGAAGTGGT
TGAATCGGCGGATGCGCGCTTGAGTGCTAAATCGGTGATTGCCAACATCCAAATTGATGACCATCTCGCCGTGCTTGGTG
ATGCCTTCTTACTGAAACAAGCCGTTTTTAACCTGATGGACAATGCGCTGGATTTTGTTCATTCAGAGGGACGCATTGAA
TGGAAAGCCGAGGTCACGAAAGAGAAAGTGTGCCTGTCGATTTTCAATTCAGGCCCTCGCATTCCCGACTATGCAATGAC
TCGTTTGACCGAGCGCTTCTACTCCCTCGCTCGGGAAAATGGTGTTAAGAGCACTGGGCTCGGGCTGAATTTTGTTGAGC
AGGTGATCAAGCTGCACAAGGGTAAGTTGCAAGTAGAAAACGTCGTTTCTGGCGTGAAAGTGACTCTGATTTTACCAACT
CCATAG

Upstream 100 bases:

>100_bases
CCCACATCAAAGCGATTCGTCACAAGTTGAAGCCATTTGAGATGTCTGAACGCATCTGTACTAAGCGTGGCTTTGGGTAC
TTTTACTGCATTAAAGGTGA

Downstream 100 bases:

>100_bases
AAACTCCACATTAGCTCCATTCGTTCTCCAAATTGCTGATTTAGATTACTCCCATCAGCAAATGGAGAATGAAACATGAA
AAAGATCCTCAATAACCAAC

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MMNRWPKIPLGLRLFFLYFILVGMTAYMVSKTVVQELKPTVRQTTEETLVDMANLLAVLAEEDVANGKLSESRFSKLLAA
YGQREPQARIWEIGKKAINHRIYITDKQGIVIADSWQQDVGKDYSQWNDVYLTLRGQYGARSTIEDPKDPPSTVMHVAAP
IYHKGEIIGSVTVAKSNRSVQPFIDLSKRNVLFWMVWMSGLVLLAGALFAWRIHSALNKLEDYATKMGEGEKVSKPTFRI
FYEYGTLSDALEKMRNQLDGKQYVEEYVQTLTHELKSPLSAIKGASEILQMPLPEEKVTRFAGNIERESDRMQSLIDKLL
ELARLEKRPELEQVEAISLKQMVNEVVESADARLSAKSVIANIQIDDHLAVLGDAFLLKQAVFNLMDNALDFVHSEGRIE
WKAEVTKEKVCLSIFNSGPRIPDYAMTRLTERFYSLARENGVKSTGLGLNFVEQVIKLHKGKLQVENVVSGVKVTLILPT
P

Sequences:

>Translated_481_residues
MMNRWPKIPLGLRLFFLYFILVGMTAYMVSKTVVQELKPTVRQTTEETLVDMANLLAVLAEEDVANGKLSESRFSKLLAA
YGQREPQARIWEIGKKAINHRIYITDKQGIVIADSWQQDVGKDYSQWNDVYLTLRGQYGARSTIEDPKDPPSTVMHVAAP
IYHKGEIIGSVTVAKSNRSVQPFIDLSKRNVLFWMVWMSGLVLLAGALFAWRIHSALNKLEDYATKMGEGEKVSKPTFRI
FYEYGTLSDALEKMRNQLDGKQYVEEYVQTLTHELKSPLSAIKGASEILQMPLPEEKVTRFAGNIERESDRMQSLIDKLL
ELARLEKRPELEQVEAISLKQMVNEVVESADARLSAKSVIANIQIDDHLAVLGDAFLLKQAVFNLMDNALDFVHSEGRIE
WKAEVTKEKVCLSIFNSGPRIPDYAMTRLTERFYSLARENGVKSTGLGLNFVEQVIKLHKGKLQVENVVSGVKVTLILPT
P
>Mature_481_residues
MMNRWPKIPLGLRLFFLYFILVGMTAYMVSKTVVQELKPTVRQTTEETLVDMANLLAVLAEEDVANGKLSESRFSKLLAA
YGQREPQARIWEIGKKAINHRIYITDKQGIVIADSWQQDVGKDYSQWNDVYLTLRGQYGARSTIEDPKDPPSTVMHVAAP
IYHKGEIIGSVTVAKSNRSVQPFIDLSKRNVLFWMVWMSGLVLLAGALFAWRIHSALNKLEDYATKMGEGEKVSKPTFRI
FYEYGTLSDALEKMRNQLDGKQYVEEYVQTLTHELKSPLSAIKGASEILQMPLPEEKVTRFAGNIERESDRMQSLIDKLL
ELARLEKRPELEQVEAISLKQMVNEVVESADARLSAKSVIANIQIDDHLAVLGDAFLLKQAVFNLMDNALDFVHSEGRIE
WKAEVTKEKVCLSIFNSGPRIPDYAMTRLTERFYSLARENGVKSTGLGLNFVEQVIKLHKGKLQVENVVSGVKVTLILPT
P

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=462, Percent_Identity=42.8571428571429, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=28.0701754385965, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=23.0769230769231, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=24.8945147679325, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=276, Percent_Identity=27.1739130434783, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790346, Length=241, Percent_Identity=26.9709543568465, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790300, Length=264, Percent_Identity=25, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=213, Percent_Identity=24.8826291079812, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=25.4716981132075, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=205, Percent_Identity=23.4146341463415, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789403, Length=207, Percent_Identity=27.536231884058, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=223, Percent_Identity=25.5605381165919, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=25.7777777777778, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54382; Mature: 54382

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNRWPKIPLGLRLFFLYFILVGMTAYMVSKTVVQELKPTVRQTTEETLVDMANLLAVLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEDVANGKLSESRFSKLLAAYGQREPQARIWEIGKKAINHRIYITDKQGIVIADSWQQDV
HHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEECCCCEEEECCCHHHH
GKDYSQWNDVYLTLRGQYGARSTIEDPKDPPSTVMHVAAPIYHKGEIIGSVTVAKSNRSV
CCCHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
QPFIDLSKRNVLFWMVWMSGLVLLAGALFAWRIHSALNKLEDYATKMGEGEKVSKPTFRI
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
FYEYGTLSDALEKMRNQLDGKQYVEEYVQTLTHELKSPLSAIKGASEILQMPLPEEKVTR
EEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHH
FAGNIERESDRMQSLIDKLLELARLEKRPELEQVEAISLKQMVNEVVESADARLSAKSVI
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANIQIDDHLAVLGDAFLLKQAVFNLMDNALDFVHSEGRIEWKAEVTKEKVCLSIFNSGPR
EECEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCC
IPDYAMTRLTERFYSLARENGVKSTGLGLNFVEQVIKLHKGKLQVENVVSGVKVTLILPT
CCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCEEEEEECC
P
C
>Mature Secondary Structure
MMNRWPKIPLGLRLFFLYFILVGMTAYMVSKTVVQELKPTVRQTTEETLVDMANLLAVLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEDVANGKLSESRFSKLLAAYGQREPQARIWEIGKKAINHRIYITDKQGIVIADSWQQDV
HHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEECCCCEEEECCCHHHH
GKDYSQWNDVYLTLRGQYGARSTIEDPKDPPSTVMHVAAPIYHKGEIIGSVTVAKSNRSV
CCCHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
QPFIDLSKRNVLFWMVWMSGLVLLAGALFAWRIHSALNKLEDYATKMGEGEKVSKPTFRI
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
FYEYGTLSDALEKMRNQLDGKQYVEEYVQTLTHELKSPLSAIKGASEILQMPLPEEKVTR
EEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHH
FAGNIERESDRMQSLIDKLLELARLEKRPELEQVEAISLKQMVNEVVESADARLSAKSVI
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANIQIDDHLAVLGDAFLLKQAVFNLMDNALDFVHSEGRIEWKAEVTKEKVCLSIFNSGPR
EECEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCC
IPDYAMTRLTERFYSLARENGVKSTGLGLNFVEQVIKLHKGKLQVENVVSGVKVTLILPT
CCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCEEEEEECC
P
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]