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The map label for this gene is msrAB [H]

Identifier: 156977798

GI number: 156977798

Start: 1732938

End: 1733420

Strand: Direct

Name: msrAB [H]

Synonym: VIBHAR_06586

Alternate gene names: 156977798

Gene position: 1732938-1733420 (Clockwise)

Preceding gene: 156977797

Following gene: 156977799

Centisome position: 78.63

GC content: 48.86

Gene sequence:

>483_bases
ATGATGGAAGAAATTTACTTCGCAGGCGGCTGCCTTTGGGGCGTTCAAGAATTTATGCGCCACCTTCCCGGCGTAATCAG
CACCGAAGCAGGACGAGCAAATGGCACGACGGATAACACTCAATCCGAATACGATGGCTACGCCGAACGCGTGAAAACCC
AGTTCGATCCTGAACAAGTTTCGGTTGAAACTTTAATGGGGTATCTGTTTGAGATCATCGACCCGCACAGTGTAAACAAG
CAAGGTGAGGACGTAGGTGAGAAGTACCGTACCGGTGTCTATAGCCAAAACGAACAACACCTAGCGATTGCCAAAGCATT
TATCGCAGCAAGACCAGATGCCGAGAAGATCGCCGTAGAAGTGCTACCACTCACAAACTATGTGCCAAGTGACGATGAGC
ACCAAGACCGAATCACACGCTTTCCAAACGACTACTGCCATATCCCGTTAGGTTTGCTGCACAAGTACAAGAATCAGTCT
TAA

Upstream 100 bases:

>100_bases
AAAAGAGAGCAAATCACCACCGAGTTGTTCCTGTTTTATGGTTGGAGTTGTGTTTGAGTGAAAGTGATGCCCATAATGGC
GCAAAGATTTTCAGGACAGA

Downstream 100 bases:

>100_bases
TAGGCTATCCAAATCCAGCGTAACAACCCCTCCTAACCTCCCCTTGACTTCAACTTCGGAGCTTAAATTAGCCAATGTAT
ATCAAGGGGAGGAACTGTCC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MMEEIYFAGGCLWGVQEFMRHLPGVISTEAGRANGTTDNTQSEYDGYAERVKTQFDPEQVSVETLMGYLFEIIDPHSVNK
QGEDVGEKYRTGVYSQNEQHLAIAKAFIAARPDAEKIAVEVLPLTNYVPSDDEHQDRITRFPNDYCHIPLGLLHKYKNQS

Sequences:

>Translated_160_residues
MMEEIYFAGGCLWGVQEFMRHLPGVISTEAGRANGTTDNTQSEYDGYAERVKTQFDPEQVSVETLMGYLFEIIDPHSVNK
QGEDVGEKYRTGVYSQNEQHLAIAKAFIAARPDAEKIAVEVLPLTNYVPSDDEHQDRITRFPNDYCHIPLGLLHKYKNQS
>Mature_160_residues
MMEEIYFAGGCLWGVQEFMRHLPGVISTEAGRANGTTDNTQSEYDGYAERVKTQFDPEQVSVETLMGYLFEIIDPHSVNK
QGEDVGEKYRTGVYSQNEQHLAIAKAFIAARPDAEKIAVEVLPLTNYVPSDDEHQDRITRFPNDYCHIPLGLLHKYKNQS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=30.7692307692308, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=30.7692307692308, Blast_Score=78, Evalue=4e-15,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=33.9869281045752, Blast_Score=82, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=156, Percent_Identity=26.2820512820513, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 18143; Mature: 18143

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEEIYFAGGCLWGVQEFMRHLPGVISTEAGRANGTTDNTQSEYDGYAERVKTQFDPEQV
CCCCEEECCCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
SVETLMGYLFEIIDPHSVNKQGEDVGEKYRTGVYSQNEQHLAIAKAFIAARPDAEKIAVE
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHEEE
VLPLTNYVPSDDEHQDRITRFPNDYCHIPLGLLHKYKNQS
EECCCCCCCCCCCHHHHHHHCCCCCEECCHHHHHHHCCCC
>Mature Secondary Structure
MMEEIYFAGGCLWGVQEFMRHLPGVISTEAGRANGTTDNTQSEYDGYAERVKTQFDPEQV
CCCCEEECCCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
SVETLMGYLFEIIDPHSVNKQGEDVGEKYRTGVYSQNEQHLAIAKAFIAARPDAEKIAVE
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHEEE
VLPLTNYVPSDDEHQDRITRFPNDYCHIPLGLLHKYKNQS
EECCCCCCCCCCCHHHHHHHCCCCCEECCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]