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The map label for this gene is pyrC [H]

Identifier: 156977625

GI number: 156977625

Start: 1576974

End: 1578308

Strand: Reverse

Name: pyrC [H]

Synonym: VIBHAR_06413

Alternate gene names: 156977625

Gene position: 1578308-1576974 (Counterclockwise)

Preceding gene: 156977626

Following gene: 156977624

Centisome position: 71.61

GC content: 49.36

Gene sequence:

>1335_bases
ATGTCTGTAACACTGATTAAAAACGCCCTTGTCGTCAACGAAGGAACCATTATCGAGACCGATTTACGAATTGTCGGTCA
GCGAATTGACACTATCTCAGCCAACATCGCGGCTAAACCGGAAGATACGGTGATTGATGCGAAAGGGTGCTATTTGATTC
CCGGTATGATTGATGACCAAGTGCACTTTCGTGAGCCGGGGTTGACGCACAAAGGTTCGATAGCGACAGAATCCAGGGCG
GCGGTTGCCGGCGGTATTACAAGCTATATGGAAATGCCGAACGTTAGTCCTGCAACGACCACCATTGAGGCGCTAGAACG
TAAATTCTCTATTGCCGAGCAGAGCTCCCTCGCGAACTACTCTTTCTACCTTGGTGCGACCGAAGACAACCTTGAGCAAA
TCAAACAGCTTGATCCGAAGAAGCATTGCGGCGTGAAAGTGTTTATGGGTGCTTCTACGGGCGATTTGTTGGTCGAAGCG
CCTCAAGCCTTAGATGAAATTTTCCGTGATTCACCAGTGATGATAGTGACGCACTGTGAGAGTGGCCCTTTGATTGCGCA
AAACAAACAGCGACTACTTAAAGAGAAGTCGGAATTTACCATTGAAGATCATCCGTTACTGCGTGATGACGAAGCGTGTT
ATGCGTCTTCCTCTTATGCGGTAGAGCTGGCCAAGAAGCACAACAGTCAGCTGCATGTTCTGCACATCACGACAGCAAAA
GAACTGGCTTTGTTTGAAGCGGGCCCGATTCAAGGTAAGAGCATCACTGCAGAAGCGTGTGTTCACCACCTCTGGTTTAG
CAATGAAGATTATGCAGAGCGTGGTAACCAAATTAAATGCAACCCAGCCGTAAAATACCCAAGCGACCGCGAAGCCATTC
TAAAAGCGTTGAGTACTGGCCAAATTGACATTATCGCCACTGATCACGCACCTCACACATGGGAAGAAAAACAGGTGCCT
TATGAGCAAGCGCCAGCGGGCTTACCTCTGGTGCAGCACGCACTGCTGTCTTTGTTCGATCAAGTTGCTCGCGGGCACAT
GACGATGGAGCAAGTGGTAGAGAAAACGGCCCACAACCCAGCGATTCGTTATGGTGTTCAGGAGCGCGGTTTTATCCGTG
AAGGCTATTTTGCAGATTTGGTTCTTGTTGATACAGCAGCACCAACGCCGGTGACGAACGAGAACAGCTTATACCACTGT
GGTTGGTCGCCATTTGCTGGTCACCAGTTCTCGGCTCAAATTAAGAACACATGGGTCAATGGCGGCCTAGTGTATGCCAA
CCAACAAGTGAATGAGCACGCTGCACACGCCATGCGATTGGTATTTGATCGCTAG

Upstream 100 bases:

>100_bases
ATCCAAGTAAATATAGCTGTTTTTGAATGTCCTCTATCTGCGTATTCATCACCACTCAATGACCACTACTAGCATCATCA
GCAAGGAGTTCTGAACCGCT

Downstream 100 bases:

>100_bases
GATTCACGTTTTTCAAAAACTTAGTTTATTTGAAAGCTCAGTTTATTTTCGAAAGCTTACATTTATCCGCTTTCTTTGGG
CTTTATTTGTAGAGGTATAG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSVTLIKNALVVNEGTIIETDLRIVGQRIDTISANIAAKPEDTVIDAKGCYLIPGMIDDQVHFREPGLTHKGSIATESRA
AVAGGITSYMEMPNVSPATTTIEALERKFSIAEQSSLANYSFYLGATEDNLEQIKQLDPKKHCGVKVFMGASTGDLLVEA
PQALDEIFRDSPVMIVTHCESGPLIAQNKQRLLKEKSEFTIEDHPLLRDDEACYASSSYAVELAKKHNSQLHVLHITTAK
ELALFEAGPIQGKSITAEACVHHLWFSNEDYAERGNQIKCNPAVKYPSDREAILKALSTGQIDIIATDHAPHTWEEKQVP
YEQAPAGLPLVQHALLSLFDQVARGHMTMEQVVEKTAHNPAIRYGVQERGFIREGYFADLVLVDTAAPTPVTNENSLYHC
GWSPFAGHQFSAQIKNTWVNGGLVYANQQVNEHAAHAMRLVFDR

Sequences:

>Translated_444_residues
MSVTLIKNALVVNEGTIIETDLRIVGQRIDTISANIAAKPEDTVIDAKGCYLIPGMIDDQVHFREPGLTHKGSIATESRA
AVAGGITSYMEMPNVSPATTTIEALERKFSIAEQSSLANYSFYLGATEDNLEQIKQLDPKKHCGVKVFMGASTGDLLVEA
PQALDEIFRDSPVMIVTHCESGPLIAQNKQRLLKEKSEFTIEDHPLLRDDEACYASSSYAVELAKKHNSQLHVLHITTAK
ELALFEAGPIQGKSITAEACVHHLWFSNEDYAERGNQIKCNPAVKYPSDREAILKALSTGQIDIIATDHAPHTWEEKQVP
YEQAPAGLPLVQHALLSLFDQVARGHMTMEQVVEKTAHNPAIRYGVQERGFIREGYFADLVLVDTAAPTPVTNENSLYHC
GWSPFAGHQFSAQIKNTWVNGGLVYANQQVNEHAAHAMRLVFDR
>Mature_443_residues
SVTLIKNALVVNEGTIIETDLRIVGQRIDTISANIAAKPEDTVIDAKGCYLIPGMIDDQVHFREPGLTHKGSIATESRAA
VAGGITSYMEMPNVSPATTTIEALERKFSIAEQSSLANYSFYLGATEDNLEQIKQLDPKKHCGVKVFMGASTGDLLVEAP
QALDEIFRDSPVMIVTHCESGPLIAQNKQRLLKEKSEFTIEDHPLLRDDEACYASSSYAVELAKKHNSQLHVLHITTAKE
LALFEAGPIQGKSITAEACVHHLWFSNEDYAERGNQIKCNPAVKYPSDREAILKALSTGQIDIIATDHAPHTWEEKQVPY
EQAPAGLPLVQHALLSLFDQVARGHMTMEQVVEKTAHNPAIRYGVQERGFIREGYFADLVLVDTAAPTPVTNENSLYHCG
WSPFAGHQFSAQIKNTWVNGGLVYANQQVNEHAAHAMRLVFDR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=381, Percent_Identity=25.9842519685039, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4503379, Length=424, Percent_Identity=25.4716981132075, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4503051, Length=448, Percent_Identity=23.2142857142857, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI62422571, Length=448, Percent_Identity=23.2142857142857, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI19923821, Length=410, Percent_Identity=23.6585365853659, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4503377, Length=398, Percent_Identity=23.3668341708543, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI190194363, Length=425, Percent_Identity=23.0588235294118, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4503375, Length=362, Percent_Identity=23.4806629834254, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786722, Length=448, Percent_Identity=27.9017857142857, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87082175, Length=451, Percent_Identity=23.5033259423503, Blast_Score=108, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI193204318, Length=422, Percent_Identity=26.7772511848341, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71989490, Length=450, Percent_Identity=24, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17539558, Length=445, Percent_Identity=23.3707865168539, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322218, Length=399, Percent_Identity=25.5639097744361, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24642586, Length=429, Percent_Identity=27.039627039627, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI18859883, Length=449, Percent_Identity=25.1670378619154, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221377917, Length=434, Percent_Identity=25.8064516129032, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48938; Mature: 48807

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTLIKNALVVNEGTIIETDLRIVGQRIDTISANIAAKPEDTVIDAKGCYLIPGMIDDQ
CEEEEEEEEEEECCCCEEEHHHHHHHHHHHHHCCCEECCCCCCEEECCCCEEECCCCCCC
VHFREPGLTHKGSIATESRAAVAGGITSYMEMPNVSPATTTIEALERKFSIAEQSSLANY
EEECCCCCCCCCCCCCCCCHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
SFYLGATEDNLEQIKQLDPKKHCGVKVFMGASTGDLLVEAPQALDEIFRDSPVMIVTHCE
EEEEECCHHHHHHHHHCCCCHHCCEEEEECCCCCCCEEECHHHHHHHHCCCCEEEEEECC
SGPLIAQNKQRLLKEKSEFTIEDHPLLRDDEACYASSSYAVELAKKHNSQLHVLHITTAK
CCCEEHHHHHHHHHHHCCCEECCCCCCCCCCHHHCCCHHEEEEHHCCCCEEEEEEEECHH
ELALFEAGPIQGKSITAEACVHHLWFSNEDYAERGNQIKCNPAVKYPSDREAILKALSTG
HEEEEECCCCCCCCEEHHHHHHHHHCCCCHHHHCCCEEEECCCCCCCCCHHHHHHHHCCC
QIDIIATDHAPHTWEEKQVPYEQAPAGLPLVQHALLSLFDQVARGHMTMEQVVEKTAHNP
CEEEEEECCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
AIRYGVQERGFIREGYFADLVLVDTAAPTPVTNENSLYHCGWSPFAGHQFSAQIKNTWVN
CEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEECCCCCCCCCEEEHEEEEEEEC
GGLVYANQQVNEHAAHAMRLVFDR
CCEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVTLIKNALVVNEGTIIETDLRIVGQRIDTISANIAAKPEDTVIDAKGCYLIPGMIDDQ
EEEEEEEEEEECCCCEEEHHHHHHHHHHHHHCCCEECCCCCCEEECCCCEEECCCCCCC
VHFREPGLTHKGSIATESRAAVAGGITSYMEMPNVSPATTTIEALERKFSIAEQSSLANY
EEECCCCCCCCCCCCCCCCHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
SFYLGATEDNLEQIKQLDPKKHCGVKVFMGASTGDLLVEAPQALDEIFRDSPVMIVTHCE
EEEEECCHHHHHHHHHCCCCHHCCEEEEECCCCCCCEEECHHHHHHHHCCCCEEEEEECC
SGPLIAQNKQRLLKEKSEFTIEDHPLLRDDEACYASSSYAVELAKKHNSQLHVLHITTAK
CCCEEHHHHHHHHHHHCCCEECCCCCCCCCCHHHCCCHHEEEEHHCCCCEEEEEEEECHH
ELALFEAGPIQGKSITAEACVHHLWFSNEDYAERGNQIKCNPAVKYPSDREAILKALSTG
HEEEEECCCCCCCCEEHHHHHHHHHCCCCHHHHCCCEEEECCCCCCCCCHHHHHHHHCCC
QIDIIATDHAPHTWEEKQVPYEQAPAGLPLVQHALLSLFDQVARGHMTMEQVVEKTAHNP
CEEEEEECCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
AIRYGVQERGFIREGYFADLVLVDTAAPTPVTNENSLYHCGWSPFAGHQFSAQIKNTWVN
CEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEECCCCCCCCCEEEHEEEEEEEC
GGLVYANQQVNEHAAHAMRLVFDR
CCEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11016950 [H]