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The map label for this gene is hexR [H]

Identifier: 156977568

GI number: 156977568

Start: 1524244

End: 1525107

Strand: Direct

Name: hexR [H]

Synonym: VIBHAR_06356

Alternate gene names: 156977568

Gene position: 1524244-1525107 (Clockwise)

Preceding gene: 156977567

Following gene: 156977569

Centisome position: 69.16

GC content: 48.26

Gene sequence:

>864_bases
TTGAGTTTAGAAGTCGATATTATCTCTCAAATCGCTGAACGTTTCAGTGCGCTGCGCGATGCTGAAAAAAAGGTCGCGAA
GTTGATCATGGACGACATTCAAACTGCCGCCAATGCCAGCATTACTGAACTGGCACAAAGCGCAGAAGTGAGTGAAGCCA
CTATCACCCGTTTTGCCAAAGCTGTTGGCTGCAAAAACGTACGTGATATGAAGATCAAACTGGCACAAACCTTAACGGTT
GGGCAACGATTCATCCTTGAGCCGCCTGACCAAAGTGGCTACCAAGGCATTTATGAATCGATCAAGCAATCCCTTGATGT
AAACCGCAGTTTGATTGTTGAAGAAGATATCGACACTGCTGTGAATTGGCTGCACAGCGCAAGACAAGTGATCTGTATTG
GTATGGGTGGCGGCTCAACCATTGCAGCACAGGAGATGCAGCATCGCTTATTCCGTCTGGGTTACCCTGTTGTGGCATAC
AACGATGGCTTGTTATCGCGCATGATTGCAGCGACGGCAGACGCGAATGATGTGTTGGTGATGATCTCAGCCACTGGCTA
TACCCCTGCCATTATAGAAACCGCGCAATTAGCTAAGCAGTACGGCGTGAAAGTTATTGTGATTACTCCGAAAGACACGC
CTTTGACTGAGCAAGCCGATTTGGTTCTGTCTATTGAGCACCAAGAGACGGACTTCATCTACAAGCCATCCGCTTCTCGC
TACGCGATGTTGGCTTTGGTTGATGTACTTTCGATGGCATTAGCCGTTAATCATAAGCGACGCTCGCGCGATAAACTTCG
CCGACTCAAAGTTGCCCTCGACTCTTATCGTGGCGGTTTGGAAAGACAGCCTCTTGGTGATTAA

Upstream 100 bases:

>100_bases
CCCGTTTCTGATGATGAGCTTAGTGAGGCTTTTCGTTATACTTCATGCCAAACCAGTGGAGACGGCACAATCGTCTCCAT
GCAATAGATAGGAACACAGC

Downstream 100 bases:

>100_bases
ACCAACGTGATTTAGATGCCTTAAGTCTTGGCTATAAAACTCAAACAATGAAGCCCGATGTTCAGCAACGGGCTTTACTT
TATCTAGCCGTTTCTTTACG

Product: glucokinase

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSLEVDIISQIAERFSALRDAEKKVAKLIMDDIQTAANASITELAQSAEVSEATITRFAKAVGCKNVRDMKIKLAQTLTV
GQRFILEPPDQSGYQGIYESIKQSLDVNRSLIVEEDIDTAVNWLHSARQVICIGMGGGSTIAAQEMQHRLFRLGYPVVAY
NDGLLSRMIAATADANDVLVMISATGYTPAIIETAQLAKQYGVKVIVITPKDTPLTEQADLVLSIEHQETDFIYKPSASR
YAMLALVDVLSMALAVNHKRRSRDKLRRLKVALDSYRGGLERQPLGD

Sequences:

>Translated_287_residues
MSLEVDIISQIAERFSALRDAEKKVAKLIMDDIQTAANASITELAQSAEVSEATITRFAKAVGCKNVRDMKIKLAQTLTV
GQRFILEPPDQSGYQGIYESIKQSLDVNRSLIVEEDIDTAVNWLHSARQVICIGMGGGSTIAAQEMQHRLFRLGYPVVAY
NDGLLSRMIAATADANDVLVMISATGYTPAIIETAQLAKQYGVKVIVITPKDTPLTEQADLVLSIEHQETDFIYKPSASR
YAMLALVDVLSMALAVNHKRRSRDKLRRLKVALDSYRGGLERQPLGD
>Mature_286_residues
SLEVDIISQIAERFSALRDAEKKVAKLIMDDIQTAANASITELAQSAEVSEATITRFAKAVGCKNVRDMKIKLAQTLTVG
QRFILEPPDQSGYQGIYESIKQSLDVNRSLIVEEDIDTAVNWLHSARQVICIGMGGGSTIAAQEMQHRLFRLGYPVVAYN
DGLLSRMIAATADANDVLVMISATGYTPAIIETAQLAKQYGVKVIVITPKDTPLTEQADLVLSIEHQETDFIYKPSASRY
AMLALVDVLSMALAVNHKRRSRDKLRRLKVALDSYRGGLERQPLGD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=278, Percent_Identity=33.4532374100719, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI87082369, Length=269, Percent_Identity=21.1895910780669, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082130, Length=224, Percent_Identity=27.2321428571429, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788767, Length=287, Percent_Identity=22.9965156794425, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31583; Mature: 31452

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEVDIISQIAERFSALRDAEKKVAKLIMDDIQTAANASITELAQSAEVSEATITRFAK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHH
AVGCKNVRDMKIKLAQTLTVGQRFILEPPDQSGYQGIYESIKQSLDVNRSLIVEEDIDTA
HHCCCCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECHHHHH
VNWLHSARQVICIGMGGGSTIAAQEMQHRLFRLGYPVVAYNDGLLSRMIAATADANDVLV
HHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCCCEEE
MISATGYTPAIIETAQLAKQYGVKVIVITPKDTPLTEQADLVLSIEHQETDFIYKPSASR
EEEECCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCCEEECCCCCH
YAMLALVDVLSMALAVNHKRRSRDKLRRLKVALDSYRGGLERQPLGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SLEVDIISQIAERFSALRDAEKKVAKLIMDDIQTAANASITELAQSAEVSEATITRFAK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHH
AVGCKNVRDMKIKLAQTLTVGQRFILEPPDQSGYQGIYESIKQSLDVNRSLIVEEDIDTA
HHCCCCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECHHHHH
VNWLHSARQVICIGMGGGSTIAAQEMQHRLFRLGYPVVAYNDGLLSRMIAATADANDVLV
HHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCCCEEE
MISATGYTPAIIETAQLAKQYGVKVIVITPKDTPLTEQADLVLSIEHQETDFIYKPSASR
EEEECCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCCEEECCCCCH
YAMLALVDVLSMALAVNHKRRSRDKLRRLKVALDSYRGGLERQPLGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]