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The map label for this gene is pgcA [H]

Identifier: 156977486

GI number: 156977486

Start: 1455074

End: 1456774

Strand: Direct

Name: pgcA [H]

Synonym: VIBHAR_06273

Alternate gene names: 156977486

Gene position: 1455074-1456774 (Clockwise)

Preceding gene: 156977480

Following gene: 156977487

Centisome position: 66.02

GC content: 48.5

Gene sequence:

>1701_bases
ATGAATATGACAACACAAATTACTCAGTGGCTAGCACGAGACCCAGACCCTAAAACCCGCGAAGAGCTCCAGCACCTAGT
CGATGCAAATAATGAACAAGAACTGACAGATCGATTCGGCTCACGTTTGGCTTTTGGTACTGCTGGTTTGCGTGGCAAAG
TGGGCGCGGGCCCAAACCGAATGAACCGCTTGGTGATTCAAGAAACGGCTACTGGTCTCGGTCACTATCTGATTGAACAG
GTGAAAGATGCTTCGTCTCGTGGTGTGGTTATCGGCTACGATGGTCGCCCTGACTCCAAACAATTCGCACACGATACTGC
TTCAGTACTGACCGCCCTAAGCATCAAGGTTTACCTAACCTACAAGGTAGCGGCAACACCAATTGTTGCCTTCGGTGTTC
GTGAGTTAAATGCGGCTGCGGCTGTCGTCGTGACAGCAAGCCATAACCCACCAGAGTACAATGGCTTTAAAGTCTACTGG
GAAAATGGCGCACAAATCATTCCACCACACGATTCCGGAATTGCTGCAAGAATTGATGAGGCAACAACAAAACCGCTTCC
TCTGATGTCACTGGACGATGCAAAACAAAAAGGTTTGTTAGTTTGGCTTGAAGACGAGTACTACCAAACATACCGCAAAA
CAATGAACGACAATGCCCTGCTAACACCGGACAGCAACACAGATATCTCGATTGTTTACACGGCAATGCACGGTGTCGGT
GCGGACATGGCAGAAACGTTGCTCGCAGATGCTGGCTTTGAAAAAGTGGCAAGTGTTTCGGAACAGCGTGAACCAGACGG
CACGTTCCCTACCGTAAACTTCCCGAACCCTGAAGAAGCAGGCGCGATGGACATGGTGATGGCGCTAGGTAAATCTGTCG
ATGCCGATATTGCCTGCGCAAACGACCCTGACGCAGACCGCTTTGCGGTGGCAGTAAAACGCCCAGATGGCGAATACCAA
ATGCTGACGGGTGACCAAGTGGGTTCATTATTTGGTGATTACTTACTGCAAGGTCAACCAAACGCACTTGTTGGTAATAC
CATTGTGTCTTCTCGCCTATTGAGCAGCATTGCTAAAGCACACGGAGCAGAATACTACCAAACGCTAACGGGCTTTAAAT
GGCTAACCAACGTAGCAATGACGCAAGAGACCGAAGCAAATCCATTCCTATTCGCTTACGAAGAAGCGCTTGGCTACACC
GTAGGTAATAAGGTATGGGATAAAGATGGTTTGTCAGCACTGGTCGCTTTCTCTCAATTGACAGGTAAGCTAAAAGCACA
AGGCAAAACGCTTTGGGATAAGTTAGAAGAGTTATACCGCCAACACGGTTTCTACTTTAACGCACAGCGCAGCATTGCTC
TTGATCCTAAATCACCACCAATCGGTGACAAGCTTCGCGCAAACCCACCGAAAGAGATCGCCGGTAAGCGTATTGAAGTG
ATCGAAGATCTGAAGTCATCACTTCGCTTTGTAACCGATGGCCCAACAGAAGCAATCAACTTACCAGCGAGTGACGTACT
GGTTTACCACCTGGAAGACAAATCACGTGTGATTGTTCGTCCTTCTGGTACTGAGCCTAAGTTGAAGTGTTACTACGAAG
TGATCAGCGACTTCCCTGCAGCGATGGATTACGCGCAAGCTAACCAAGCAGCGGAAGCGAAGATGAATGCATTGATCGAA
GCGCATCAACAAAGTTTGTAA

Upstream 100 bases:

>100_bases
GAAATGTAATTGAGAACCATTTACATTGTAAAAAAGAAAACATTGGGACACTTTCCGTATAAAAGTGTCTAAACAAGTAG
GCTCCCCCTGCTAAGGAAAG

Downstream 100 bases:

>100_bases
TCCAAGCTTGAAGCATAGACTCTGTGACAACAGTAGATAGAAAAAGAGGCGCATCGAGCGCCTCTCTTTTCTATTCAAAA
AGAATCAAACTATCTGTTTT

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MNMTTQITQWLARDPDPKTREELQHLVDANNEQELTDRFGSRLAFGTAGLRGKVGAGPNRMNRLVIQETATGLGHYLIEQ
VKDASSRGVVIGYDGRPDSKQFAHDTASVLTALSIKVYLTYKVAATPIVAFGVRELNAAAAVVVTASHNPPEYNGFKVYW
ENGAQIIPPHDSGIAARIDEATTKPLPLMSLDDAKQKGLLVWLEDEYYQTYRKTMNDNALLTPDSNTDISIVYTAMHGVG
ADMAETLLADAGFEKVASVSEQREPDGTFPTVNFPNPEEAGAMDMVMALGKSVDADIACANDPDADRFAVAVKRPDGEYQ
MLTGDQVGSLFGDYLLQGQPNALVGNTIVSSRLLSSIAKAHGAEYYQTLTGFKWLTNVAMTQETEANPFLFAYEEALGYT
VGNKVWDKDGLSALVAFSQLTGKLKAQGKTLWDKLEELYRQHGFYFNAQRSIALDPKSPPIGDKLRANPPKEIAGKRIEV
IEDLKSSLRFVTDGPTEAINLPASDVLVYHLEDKSRVIVRPSGTEPKLKCYYEVISDFPAAMDYAQANQAAEAKMNALIE
AHQQSL

Sequences:

>Translated_566_residues
MNMTTQITQWLARDPDPKTREELQHLVDANNEQELTDRFGSRLAFGTAGLRGKVGAGPNRMNRLVIQETATGLGHYLIEQ
VKDASSRGVVIGYDGRPDSKQFAHDTASVLTALSIKVYLTYKVAATPIVAFGVRELNAAAAVVVTASHNPPEYNGFKVYW
ENGAQIIPPHDSGIAARIDEATTKPLPLMSLDDAKQKGLLVWLEDEYYQTYRKTMNDNALLTPDSNTDISIVYTAMHGVG
ADMAETLLADAGFEKVASVSEQREPDGTFPTVNFPNPEEAGAMDMVMALGKSVDADIACANDPDADRFAVAVKRPDGEYQ
MLTGDQVGSLFGDYLLQGQPNALVGNTIVSSRLLSSIAKAHGAEYYQTLTGFKWLTNVAMTQETEANPFLFAYEEALGYT
VGNKVWDKDGLSALVAFSQLTGKLKAQGKTLWDKLEELYRQHGFYFNAQRSIALDPKSPPIGDKLRANPPKEIAGKRIEV
IEDLKSSLRFVTDGPTEAINLPASDVLVYHLEDKSRVIVRPSGTEPKLKCYYEVISDFPAAMDYAQANQAAEAKMNALIE
AHQQSL
>Mature_566_residues
MNMTTQITQWLARDPDPKTREELQHLVDANNEQELTDRFGSRLAFGTAGLRGKVGAGPNRMNRLVIQETATGLGHYLIEQ
VKDASSRGVVIGYDGRPDSKQFAHDTASVLTALSIKVYLTYKVAATPIVAFGVRELNAAAAVVVTASHNPPEYNGFKVYW
ENGAQIIPPHDSGIAARIDEATTKPLPLMSLDDAKQKGLLVWLEDEYYQTYRKTMNDNALLTPDSNTDISIVYTAMHGVG
ADMAETLLADAGFEKVASVSEQREPDGTFPTVNFPNPEEAGAMDMVMALGKSVDADIACANDPDADRFAVAVKRPDGEYQ
MLTGDQVGSLFGDYLLQGQPNALVGNTIVSSRLLSSIAKAHGAEYYQTLTGFKWLTNVAMTQETEANPFLFAYEEALGYT
VGNKVWDKDGLSALVAFSQLTGKLKAQGKTLWDKLEELYRQHGFYFNAQRSIALDPKSPPIGDKLRANPPKEIAGKRIEV
IEDLKSSLRFVTDGPTEAINLPASDVLVYHLEDKSRVIVRPSGTEPKLKCYYEVISDFPAAMDYAQANQAAEAKMNALIE
AHQQSL

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=596, Percent_Identity=33.7248322147651, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI31377548, Length=602, Percent_Identity=32.890365448505, Blast_Score=306, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI71993870, Length=556, Percent_Identity=36.1510791366906, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI71993878, Length=319, Percent_Identity=37.9310344827586, Blast_Score=206, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6323934, Length=579, Percent_Identity=36.2694300518135, Blast_Score=306, Evalue=6e-84,
Organism=Drosophila melanogaster, GI20129809, Length=591, Percent_Identity=36.0406091370558, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24651977, Length=480, Percent_Identity=38.5416666666667, Blast_Score=316, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24653722, Length=597, Percent_Identity=30.6532663316583, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 61952; Mature: 61952

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMTTQITQWLARDPDPKTREELQHLVDANNEQELTDRFGSRLAFGTAGLRGKVGAGPNR
CCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHCCEEEECCCCCCCCCCCCHHH
MNRLVIQETATGLGHYLIEQVKDASSRGVVIGYDGRPDSKQFAHDTASVLTALSIKVYLT
HHEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHEEEEEEE
YKVAATPIVAFGVRELNAAAAVVVTASHNPPEYNGFKVYWENGAQIIPPHDSGIAARIDE
EEEHHCCHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEEEECCCEEECCCCCCCEEEECC
ATTKPLPLMSLDDAKQKGLLVWLEDEYYQTYRKTMNDNALLTPDSNTDISIVYTAMHGVG
CCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCEEECCCCCCCEEEEEEEHHCCC
ADMAETLLADAGFEKVASVSEQREPDGTFPTVNFPNPEEAGAMDMVMALGKSVDADIACA
HHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEC
NDPDADRFAVAVKRPDGEYQMLTGDQVGSLFGDYLLQGQPNALVGNTIVSSRLLSSIAKA
CCCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHH
HGAEYYQTLTGFKWLTNVAMTQETEANPFLFAYEEALGYTVGNKVWDKDGLSALVAFSQL
HCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHCHHHCCCCCCCCHHHHHHHHHHH
TGKLKAQGKTLWDKLEELYRQHGFYFNAQRSIALDPKSPPIGDKLRANPPKEIAGKRIEV
HHHHHHCCHHHHHHHHHHHHHCCCEEECCCEEEECCCCCCCCCCCCCCCCHHHHCCHHHH
IEDLKSSLRFVTDGPTEAINLPASDVLVYHLEDKSRVIVRPSGTEPKLKCYYEVISDFPA
HHHHHHHCEEEECCCCCEECCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCHH
AMDYAQANQAAEAKMNALIEAHQQSL
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNMTTQITQWLARDPDPKTREELQHLVDANNEQELTDRFGSRLAFGTAGLRGKVGAGPNR
CCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHCCEEEECCCCCCCCCCCCHHH
MNRLVIQETATGLGHYLIEQVKDASSRGVVIGYDGRPDSKQFAHDTASVLTALSIKVYLT
HHEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHEEEEEEE
YKVAATPIVAFGVRELNAAAAVVVTASHNPPEYNGFKVYWENGAQIIPPHDSGIAARIDE
EEEHHCCHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEEEECCCEEECCCCCCCEEEECC
ATTKPLPLMSLDDAKQKGLLVWLEDEYYQTYRKTMNDNALLTPDSNTDISIVYTAMHGVG
CCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCEEECCCCCCCEEEEEEEHHCCC
ADMAETLLADAGFEKVASVSEQREPDGTFPTVNFPNPEEAGAMDMVMALGKSVDADIACA
HHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEC
NDPDADRFAVAVKRPDGEYQMLTGDQVGSLFGDYLLQGQPNALVGNTIVSSRLLSSIAKA
CCCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHH
HGAEYYQTLTGFKWLTNVAMTQETEANPFLFAYEEALGYTVGNKVWDKDGLSALVAFSQL
HCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHCHHHCCCCCCCCHHHHHHHHHHH
TGKLKAQGKTLWDKLEELYRQHGFYFNAQRSIALDPKSPPIGDKLRANPPKEIAGKRIEV
HHHHHHCCHHHHHHHHHHHHHCCCEEECCCEEEECCCCCCCCCCCCCCCCHHHHCCHHHH
IEDLKSSLRFVTDGPTEAINLPASDVLVYHLEDKSRVIVRPSGTEPKLKCYYEVISDFPA
HHHHHHHCEEEECCCCCEECCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCHH
AMDYAQANQAAEAKMNALIEAHQQSL
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]