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The map label for this gene is tkt1 [H]

Identifier: 156977470

GI number: 156977470

Start: 1437257

End: 1439263

Strand: Direct

Name: tkt1 [H]

Synonym: VIBHAR_06257

Alternate gene names: 156977470

Gene position: 1437257-1439263 (Clockwise)

Preceding gene: 156977469

Following gene: 156977473

Centisome position: 65.21

GC content: 49.48

Gene sequence:

>2007_bases
ATGGATCGCTCTCTTCTAACACGAAAGTATCTAGCTAATGCAATCCGTGCACTGAGCATGGACGGTGTTCAACAAGCTAA
CTCTGGTCACCCAGGTGCACCTATGGGTATGGCTGACATCGCTGAAGTTCTTTGGCGTTCTCACCTAAACCACAACCCAT
CAAACCCAGAGTGGGCTGACCGCGACCGTTTCGTACTGTCTAACGGCCACGGCTCTATGCTTATCTATTCTCTACTGCAC
CTTGCAGGCTACGAGCTATCTATCGACGATCTTAAAAACTTCCGTCAGCTTCACTCTAAGACTCCTGGTCACCCAGAGTA
CGGCTACGCACCTGGTATCGAAACAACAACGGGTCCTCTAGGTCAAGGCATCACTAACGCTGTTGGTATGGCAATGGCTG
AGAAAGCACTAGCGGCTCAGTTCAACAAAGAAGGCCACGACATCGTTGACCACTTCACTTACGTGTTCATGGGTGACGGC
TGTCTAATGGAAGGTATCTCGCACGAGGCTTGTTCTCTTGCTGGTACACTAGGCCTTGGCAAACTGATCGCATTCTGGGA
TGACAACGGTATCTCTATCGATGGTCACGTTGAAGGTTGGTTCTCTGACGATACACCTAAGCGTTTTGAATCTTACGGCT
GGCACGTAATCCCTGCTGTGGATGGTCACGACTCTGAAGCGATCAACGCAGCAATCGAAGCGGCAAAAGCAGATCCACGC
CCTACACTTATCTGTACTAAAACTATCATCGGTTTTGGTTCTCCAAACAAATCTGGTTCACACGACTGTCACGGTGCGCC
ACTAGGTGCTGAAGAAATTGCAGCGACACGTAAAGAACTAGGTTGGGAGCACGGTCCTTTTGAAATTCCGCAGGAAGTCT
ACGCAGAGTGGTCAGCGAAAGAAGCAGGCGCAGCTAAGGAAGCTGCGTGGGACGAGAAATTTGCAGCTTATGAAGCAGCG
TACCCTGAGCTGGCAGCTGAATTCAAACGCCGCGTAAACGGTGACCTACCAGCTGAGTGGGAAGAGAAAGCAAACCAAAT
CATTGCTGACCTTCAAGCAAACCCAGCAAACATCGCATCACGTAAAGCATCTCAAAACGCACTAGAAGCGTTTGGTCAAA
TGCTTCCAGAATTCATGGGCGGCTCTGCTGACCTAGCGCCTTCTAACCTAACTATGTGGTCTGGTTCTAAGTCTCTAGAA
GCGAACGACTTCTCTGGTAACTACATCCACTACGGTGTACGTGAATTTGGTATGACAGCGATCATGAACGGTATCGCGCT
ACACGGCGGTTTTGTTCCTTACGGCGCAACATTCCTAATGTTCATGGAATACGCACGTAACGCTATGCGTATGGCTGCTC
TGATGAAGATTCAGAACATCCAGGTTTACACGCACGACTCTATCGGTCTTGGCGAAGATGGCCCAACTCACCAACCTGTT
GAGCAAATCGCGTCTCTACGCCTGACTCCAAACATGAGCACGTGGCGTCCATGTGACCAAGTTGAGTCTGCAGTAGCATG
GAAACTGGCGATTGAACGTAAAGATGCACCATCTGCACTTATCTTCTCTCGTCAAAACCTAGCACAGCAAGAGCGTACTG
CTGAGCAAGTTGCAGACATCGCAAAAGGTGGCTACATCCTGAAAGACAGCGATGGTAAACCTGAGCTAATCCTTATCGCG
ACTGGTTCAGAAGTTGAGCTAGCTGTGAAAGCGGCAGAACAACTAACGGCTGAAGGTAAGAAAGTACGCGTGGTTTCAAT
GCCAGCTACTGATACTTTCGACAAGCAAGACGCGGCTTACCGTGAATCTGTACTGCCATCAGACGTAACGGCACGTATCG
CTGTAGAAGCGGGCATTGCTGACTTCTGGTACAAGTACGTTGGCTTCGACGGTCGCATCATCGGTATGACAACATTCGGT
GAGTCTGCACCAGCTGACCACCTGTTCGAAATGTTTGGTTTCACTGTAGAAAACGTAGTGAACACAGCAAAAGAACTGCT
AGCTTAA

Upstream 100 bases:

>100_bases
CCTACTCGCTTTTAGCATCAGCGCTTTATTCAAAAAATTCTATTTGAACTTGTTCCGACGAGTTCCCTCTATTTAAATCA
AATATCGAGAAGTAACTACT

Downstream 100 bases:

>100_bases
TCGCTTAGAATTATCAGTTTTCTCTATTGCGAATTTGAAAACTGAAAAGCCCCGCTCTCTGTAGCGGGGCTTTATTTTAT
CTGTTCATTTTGAACAATGA

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MDRSLLTRKYLANAIRALSMDGVQQANSGHPGAPMGMADIAEVLWRSHLNHNPSNPEWADRDRFVLSNGHGSMLIYSLLH
LAGYELSIDDLKNFRQLHSKTPGHPEYGYAPGIETTTGPLGQGITNAVGMAMAEKALAAQFNKEGHDIVDHFTYVFMGDG
CLMEGISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFSDDTPKRFESYGWHVIPAVDGHDSEAINAAIEAAKADPR
PTLICTKTIIGFGSPNKSGSHDCHGAPLGAEEIAATRKELGWEHGPFEIPQEVYAEWSAKEAGAAKEAAWDEKFAAYEAA
YPELAAEFKRRVNGDLPAEWEEKANQIIADLQANPANIASRKASQNALEAFGQMLPEFMGGSADLAPSNLTMWSGSKSLE
ANDFSGNYIHYGVREFGMTAIMNGIALHGGFVPYGATFLMFMEYARNAMRMAALMKIQNIQVYTHDSIGLGEDGPTHQPV
EQIASLRLTPNMSTWRPCDQVESAVAWKLAIERKDAPSALIFSRQNLAQQERTAEQVADIAKGGYILKDSDGKPELILIA
TGSEVELAVKAAEQLTAEGKKVRVVSMPATDTFDKQDAAYRESVLPSDVTARIAVEAGIADFWYKYVGFDGRIIGMTTFG
ESAPADHLFEMFGFTVENVVNTAKELLA

Sequences:

>Translated_668_residues
MDRSLLTRKYLANAIRALSMDGVQQANSGHPGAPMGMADIAEVLWRSHLNHNPSNPEWADRDRFVLSNGHGSMLIYSLLH
LAGYELSIDDLKNFRQLHSKTPGHPEYGYAPGIETTTGPLGQGITNAVGMAMAEKALAAQFNKEGHDIVDHFTYVFMGDG
CLMEGISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFSDDTPKRFESYGWHVIPAVDGHDSEAINAAIEAAKADPR
PTLICTKTIIGFGSPNKSGSHDCHGAPLGAEEIAATRKELGWEHGPFEIPQEVYAEWSAKEAGAAKEAAWDEKFAAYEAA
YPELAAEFKRRVNGDLPAEWEEKANQIIADLQANPANIASRKASQNALEAFGQMLPEFMGGSADLAPSNLTMWSGSKSLE
ANDFSGNYIHYGVREFGMTAIMNGIALHGGFVPYGATFLMFMEYARNAMRMAALMKIQNIQVYTHDSIGLGEDGPTHQPV
EQIASLRLTPNMSTWRPCDQVESAVAWKLAIERKDAPSALIFSRQNLAQQERTAEQVADIAKGGYILKDSDGKPELILIA
TGSEVELAVKAAEQLTAEGKKVRVVSMPATDTFDKQDAAYRESVLPSDVTARIAVEAGIADFWYKYVGFDGRIIGMTTFG
ESAPADHLFEMFGFTVENVVNTAKELLA
>Mature_668_residues
MDRSLLTRKYLANAIRALSMDGVQQANSGHPGAPMGMADIAEVLWRSHLNHNPSNPEWADRDRFVLSNGHGSMLIYSLLH
LAGYELSIDDLKNFRQLHSKTPGHPEYGYAPGIETTTGPLGQGITNAVGMAMAEKALAAQFNKEGHDIVDHFTYVFMGDG
CLMEGISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFSDDTPKRFESYGWHVIPAVDGHDSEAINAAIEAAKADPR
PTLICTKTIIGFGSPNKSGSHDCHGAPLGAEEIAATRKELGWEHGPFEIPQEVYAEWSAKEAGAAKEAAWDEKFAAYEAA
YPELAAEFKRRVNGDLPAEWEEKANQIIADLQANPANIASRKASQNALEAFGQMLPEFMGGSADLAPSNLTMWSGSKSLE
ANDFSGNYIHYGVREFGMTAIMNGIALHGGFVPYGATFLMFMEYARNAMRMAALMKIQNIQVYTHDSIGLGEDGPTHQPV
EQIASLRLTPNMSTWRPCDQVESAVAWKLAIERKDAPSALIFSRQNLAQQERTAEQVADIAKGGYILKDSDGKPELILIA
TGSEVELAVKAAEQLTAEGKKVRVVSMPATDTFDKQDAAYRESVLPSDVTARIAVEAGIADFWYKYVGFDGRIIGMTTFG
ESAPADHLFEMFGFTVENVVNTAKELLA

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=599, Percent_Identity=27.7128547579299, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI4507521, Length=599, Percent_Identity=27.7128547579299, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI133778974, Length=585, Percent_Identity=26.1538461538462, Blast_Score=143, Evalue=6e-34,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=76.7371601208459, Blast_Score=1083, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=70.8898944193062, Blast_Score=1009, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=675, Percent_Identity=25.3333333333333, Blast_Score=157, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=671, Percent_Identity=49.3293591654247, Blast_Score=612, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6319593, Length=671, Percent_Identity=45.75260804769, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI45551847, Length=679, Percent_Identity=27.3932253313697, Blast_Score=167, Evalue=3e-41,
Organism=Drosophila melanogaster, GI45550715, Length=679, Percent_Identity=27.3932253313697, Blast_Score=167, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24645119, Length=645, Percent_Identity=26.9767441860465, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24666278, Length=669, Percent_Identity=24.9626307922272, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72656; Mature: 72656

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRSLLTRKYLANAIRALSMDGVQQANSGHPGAPMGMADIAEVLWRSHLNHNPSNPEWAD
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
RDRFVLSNGHGSMLIYSLLHLAGYELSIDDLKNFRQLHSKTPGHPEYGYAPGIETTTGPL
CCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GQGITNAVGMAMAEKALAAQFNKEGHDIVDHFTYVFMGDGCLMEGISHEACSLAGTLGLG
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEECCCHHHHCCCHHHHHHHHHHCCC
KLIAFWDDNGISIDGHVEGWFSDDTPKRFESYGWHVIPAVDGHDSEAINAAIEAAKADPR
CEEEEECCCCEEECCCCCCCCCCCCHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCC
PTLICTKTIIGFGSPNKSGSHDCHGAPLGAEEIAATRKELGWEHGPFEIPQEVYAEWSAK
CEEEEEHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCH
EAGAAKEAAWDEKFAAYEAAYPELAAEFKRRVNGDLPAEWEEKANQIIADLQANPANIAS
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
RKASQNALEAFGQMLPEFMGGSADLAPSNLTMWSGSKSLEANDFSGNYIHYGVREFGMTA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECHHHHHHHH
IMNGIALHGGFVPYGATFLMFMEYARNAMRMAALMKIQNIQVYTHDSIGLGEDGPTHQPV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCHHH
EQIASLRLTPNMSTWRPCDQVESAVAWKLAIERKDAPSALIFSRQNLAQQERTAEQVADI
HHHHHEECCCCCCCCCCHHHHHHHHHHHEEEECCCCCCCEEECHHHHHHHHHHHHHHHHH
AKGGYILKDSDGKPELILIATGSEVELAVKAAEQLTAEGKKVRVVSMPATDTFDKQDAAY
HHCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
RESVLPSDVTARIAVEAGIADFWYKYVGFDGRIIGMTTFGESAPADHLFEMFGFTVENVV
HHHCCCCCCCEEEEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH
NTAKELLA
HHHHHHHC
>Mature Secondary Structure
MDRSLLTRKYLANAIRALSMDGVQQANSGHPGAPMGMADIAEVLWRSHLNHNPSNPEWAD
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
RDRFVLSNGHGSMLIYSLLHLAGYELSIDDLKNFRQLHSKTPGHPEYGYAPGIETTTGPL
CCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GQGITNAVGMAMAEKALAAQFNKEGHDIVDHFTYVFMGDGCLMEGISHEACSLAGTLGLG
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEECCCHHHHCCCHHHHHHHHHHCCC
KLIAFWDDNGISIDGHVEGWFSDDTPKRFESYGWHVIPAVDGHDSEAINAAIEAAKADPR
CEEEEECCCCEEECCCCCCCCCCCCHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCC
PTLICTKTIIGFGSPNKSGSHDCHGAPLGAEEIAATRKELGWEHGPFEIPQEVYAEWSAK
CEEEEEHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCH
EAGAAKEAAWDEKFAAYEAAYPELAAEFKRRVNGDLPAEWEEKANQIIADLQANPANIAS
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
RKASQNALEAFGQMLPEFMGGSADLAPSNLTMWSGSKSLEANDFSGNYIHYGVREFGMTA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECHHHHHHHH
IMNGIALHGGFVPYGATFLMFMEYARNAMRMAALMKIQNIQVYTHDSIGLGEDGPTHQPV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCHHH
EQIASLRLTPNMSTWRPCDQVESAVAWKLAIERKDAPSALIFSRQNLAQQERTAEQVADI
HHHHHEECCCCCCCCCCHHHHHHHHHHHEEEECCCCCCCEEECHHHHHHHHHHHHHHHHH
AKGGYILKDSDGKPELILIATGSEVELAVKAAEQLTAEGKKVRVVSMPATDTFDKQDAAY
HHCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
RESVLPSDVTARIAVEAGIADFWYKYVGFDGRIIGMTTFGESAPADHLFEMFGFTVENVV
HHHCCCCCCCEEEEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH
NTAKELLA
HHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA