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The map label for this gene is clcA

Identifier: 156977446

GI number: 156977446

Start: 1413408

End: 1414814

Strand: Direct

Name: clcA

Synonym: VIBHAR_06233

Alternate gene names: 156977446

Gene position: 1413408-1414814 (Clockwise)

Preceding gene: 156977444

Following gene: 156977447

Centisome position: 64.13

GC content: 48.12

Gene sequence:

>1407_bases
ATGATCAAACGCGAGAGAATTGTGAAATCTGTGTTAGCGCACGTACCGAAAGATGCGATTAACCAGTTTGTCTCTCGAGG
GTCAACGCCAACATCATTTTCCGTCCTCTTTATGGCGGCGATTGTTGGTACGCTAGCAGGCCTTGTTGGAACCTACTTTG
AAATTGCCGTTCACTTTGTGTCAGAAACTCGTACCGAGTGGTTAAAAAGCGAAATCGGTAGCGTACTGCCTTTGTGGCTC
GCTGCAATTTTGATCAGTGGCGCATTAGCGTTCATCGGTTACTACCTTGTGAACCGTTTTGCCCCTGAGGCATCAGGCTC
TGGTATTCCAGAAATCGAAGGTGCAATGGATAACATTCGCTCCGTTCGTTGGTGGCGAGTGATCCCAGTAAAATTCTTTG
GCGGTATGGGTGCACTTGGCTCAGGTATGGTACTAGGTCGCGAAGGTCCAACAGTACAGATGGGCGGTGCGGTTGGTCGT
ATGGTTACAGACATCTTCCGAGTAAAAGACGATGATACCCGTCACTCTCTATTGGCATCCGGTGCCGCCGGTGGCTTAGC
GGCAGCATTTAACGCACCGTTGGCAGCCATCATGTTTGTGGTTGAGGAGATGCGCCCTCAGTTTCGTTACTCTTTGATTT
CGATTCGCGCAGTGATCATCTCAGCCATCATGGCGAACATTGTGTTTCGAGCCATCAACGGTCAAGAAGCCGTTATCACC
ATGCCACAATACCAATCTCCTGAATTGCAATCGTTGTGGTTGTTCCTGCTTCTCGGTTCTTTGTTCGGCGTGTTTGGTGT
TGTATTCAACAAACTGATAACCATTGCACAAGACAGCTTTGTTGCATTGCATAAAAACGACCGTAAACGCTACCTAATCA
CAGGTACCATTTTAGGCGGCGTATTTGGTCTGTTGCTGCTTTACGTGCCACAGCTTACCGGTGGTGGTATTGGCTTGATC
CCAGATATTACCAATGGTAATTACTCGATCTCGATTTTAGTCATGCTGTTCGTTGGTCGCGTGATTACCACCCTACTTTG
TTTCGGCTCTGGTGCGCCTGGTGGTATTTTTGCACCAATGCTGGCGCTTGGTACTCTCTTTGGCTACGCATTCGGTGCCA
GTGCAGACATGCTGTTGCCTTCACTGACTATCGAGCCGGGTGTATTCGCAATTGCAGGCATGGGGGCGCTATTTGCAGCA
ACAGTGCGTGCACCGATTACTGGTATCTTGCTAGTTATCGAGATGACGAATAACTACTACCTAATCTTGCCACTCATTAT
TACCAGTTTAGGCGCAGTCATCGTAGCGCAGTTACTTGGCGGACAACCGATTTACAGCCAATTGTTACATCGTACGCTTA
AAAATGACAAACTACGTCAACAAGACCTACCAGAAAACCAAGCATAA

Upstream 100 bases:

>100_bases
AGTGGAAAGCTAAATTGCATCTTTATTGATTAGGTCTAGACTCTCGTGAGCGTATAATTTCTTTCGTCCCTTCCAATTAG
TAGTCTAGGAGAATCTGTTA

Downstream 100 bases:

>100_bases
GTTGATATATCCAAGTAACTTCGAGATGCTTGGCTAAACAGGCTCCAAATTATATTCCACATAAGATGTTAGTTTGGAGC
CAGTAATTCTGCGCTTTTGC

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MIKRERIVKSVLAHVPKDAINQFVSRGSTPTSFSVLFMAAIVGTLAGLVGTYFEIAVHFVSETRTEWLKSEIGSVLPLWL
AAILISGALAFIGYYLVNRFAPEASGSGIPEIEGAMDNIRSVRWWRVIPVKFFGGMGALGSGMVLGREGPTVQMGGAVGR
MVTDIFRVKDDDTRHSLLASGAAGGLAAAFNAPLAAIMFVVEEMRPQFRYSLISIRAVIISAIMANIVFRAINGQEAVIT
MPQYQSPELQSLWLFLLLGSLFGVFGVVFNKLITIAQDSFVALHKNDRKRYLITGTILGGVFGLLLLYVPQLTGGGIGLI
PDITNGNYSISILVMLFVGRVITTLLCFGSGAPGGIFAPMLALGTLFGYAFGASADMLLPSLTIEPGVFAIAGMGALFAA
TVRAPITGILLVIEMTNNYYLILPLIITSLGAVIVAQLLGGQPIYSQLLHRTLKNDKLRQQDLPENQA

Sequences:

>Translated_468_residues
MIKRERIVKSVLAHVPKDAINQFVSRGSTPTSFSVLFMAAIVGTLAGLVGTYFEIAVHFVSETRTEWLKSEIGSVLPLWL
AAILISGALAFIGYYLVNRFAPEASGSGIPEIEGAMDNIRSVRWWRVIPVKFFGGMGALGSGMVLGREGPTVQMGGAVGR
MVTDIFRVKDDDTRHSLLASGAAGGLAAAFNAPLAAIMFVVEEMRPQFRYSLISIRAVIISAIMANIVFRAINGQEAVIT
MPQYQSPELQSLWLFLLLGSLFGVFGVVFNKLITIAQDSFVALHKNDRKRYLITGTILGGVFGLLLLYVPQLTGGGIGLI
PDITNGNYSISILVMLFVGRVITTLLCFGSGAPGGIFAPMLALGTLFGYAFGASADMLLPSLTIEPGVFAIAGMGALFAA
TVRAPITGILLVIEMTNNYYLILPLIITSLGAVIVAQLLGGQPIYSQLLHRTLKNDKLRQQDLPENQA
>Mature_468_residues
MIKRERIVKSVLAHVPKDAINQFVSRGSTPTSFSVLFMAAIVGTLAGLVGTYFEIAVHFVSETRTEWLKSEIGSVLPLWL
AAILISGALAFIGYYLVNRFAPEASGSGIPEIEGAMDNIRSVRWWRVIPVKFFGGMGALGSGMVLGREGPTVQMGGAVGR
MVTDIFRVKDDDTRHSLLASGAAGGLAAAFNAPLAAIMFVVEEMRPQFRYSLISIRAVIISAIMANIVFRAINGQEAVIT
MPQYQSPELQSLWLFLLLGSLFGVFGVVFNKLITIAQDSFVALHKNDRKRYLITGTILGGVFGLLLLYVPQLTGGGIGLI
PDITNGNYSISILVMLFVGRVITTLLCFGSGAPGGIFAPMLALGTLFGYAFGASADMLLPSLTIEPGVFAIAGMGALFAA
TVRAPITGILLVIEMTNNYYLILPLIITSLGAVIVAQLLGGQPIYSQLLHRTLKNDKLRQQDLPENQA

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily

Homologues:

Organism=Homo sapiens, GI153252026, Length=457, Percent_Identity=24.0700218818381, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI55770838, Length=467, Percent_Identity=24.8394004282655, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI55770840, Length=467, Percent_Identity=24.8394004282655, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI4557473, Length=531, Percent_Identity=24.2937853107345, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI189217923, Length=531, Percent_Identity=23.9171374764595, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI189217921, Length=531, Percent_Identity=23.9171374764595, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786350, Length=436, Percent_Identity=56.1926605504587, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI87081943, Length=256, Percent_Identity=29.6875, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17559050, Length=477, Percent_Identity=26.2054507337526, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71980824, Length=495, Percent_Identity=24.040404040404, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71980828, Length=495, Percent_Identity=24.040404040404, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71980820, Length=500, Percent_Identity=23.8, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17532615, Length=419, Percent_Identity=21.7183770883055, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322500, Length=409, Percent_Identity=23.7163814180929, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24665008, Length=412, Percent_Identity=25.9708737864078, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45551566, Length=394, Percent_Identity=24.8730964467005, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLCA_VIBHB (A7N6K9)

Other databases:

- EMBL:   CP000790
- RefSeq:   YP_001448352.1
- ProteinModelPortal:   A7N6K9
- SMR:   A7N6K9
- STRING:   A7N6K9
- GeneID:   5557747
- GenomeReviews:   CP000790_GR
- KEGG:   vha:VIBHAR_06233
- NMPDR:   fig|338187.4.peg.3684
- eggNOG:   COG0038
- HOGENOM:   HBG493510
- OMA:   VKSDANI
- ProtClustDB:   PRK05277
- HAMAP:   MF_01128
- InterPro:   IPR014743
- InterPro:   IPR001807
- Gene3D:   G3DSA:1.10.3080.10
- PANTHER:   PTHR11689
- PRINTS:   PR00762

Pfam domain/function: PF00654 Voltage_CLC; SSF81340 Cl-channel_core

EC number: NA

Molecular weight: Translated: 50175; Mature: 50175

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: BINDING 107-107 BINDING 356-356 BINDING 357-357 BINDING 445-445

Signals:

None

Transmembrane regions:

HASH(0x1a829d64)-; HASH(0x1ae2df24)-; HASH(0x1adcaba4)-; HASH(0x1adef408)-; HASH(0x1adf3328)-; HASH(0x1a9dd224)-; HASH(0x1adf334c)-; HASH(0x1a9f73e4)-; HASH(0x1adcabbc)-; HASH(0x1adcaf70)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRERIVKSVLAHVPKDAINQFVSRGSTPTSFSVLFMAAIVGTLAGLVGTYFEIAVHFV
CCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SETRTEWLKSEIGSVLPLWLAAILISGALAFIGYYLVNRFAPEASGSGIPEIEGAMDNIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
SVRWWRVIPVKFFGGMGALGSGMVLGREGPTVQMGGAVGRMVTDIFRVKDDDTRHSLLAS
CCHHEEEEHHHHHCCCCCCCCCEEECCCCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHC
GAAGGLAAAFNAPLAAIMFVVEEMRPQFRYSLISIRAVIISAIMANIVFRAINGQEAVIT
CCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
MPQYQSPELQSLWLFLLLGSLFGVFGVVFNKLITIAQDSFVALHKNDRKRYLITGTILGG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHHHH
VFGLLLLYVPQLTGGGIGLIPDITNGNYSISILVMLFVGRVITTLLCFGSGAPGGIFAPM
HHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LALGTLFGYAFGASADMLLPSLTIEPGVFAIAGMGALFAATVRAPITGILLVIEMTNNYY
HHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEE
LILPLIITSLGAVIVAQLLGGQPIYSQLLHRTLKNDKLRQQDLPENQA
EEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCCH
>Mature Secondary Structure
MIKRERIVKSVLAHVPKDAINQFVSRGSTPTSFSVLFMAAIVGTLAGLVGTYFEIAVHFV
CCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SETRTEWLKSEIGSVLPLWLAAILISGALAFIGYYLVNRFAPEASGSGIPEIEGAMDNIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
SVRWWRVIPVKFFGGMGALGSGMVLGREGPTVQMGGAVGRMVTDIFRVKDDDTRHSLLAS
CCHHEEEEHHHHHCCCCCCCCCEEECCCCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHC
GAAGGLAAAFNAPLAAIMFVVEEMRPQFRYSLISIRAVIISAIMANIVFRAINGQEAVIT
CCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
MPQYQSPELQSLWLFLLLGSLFGVFGVVFNKLITIAQDSFVALHKNDRKRYLITGTILGG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHHHH
VFGLLLLYVPQLTGGGIGLIPDITNGNYSISILVMLFVGRVITTLLCFGSGAPGGIFAPM
HHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LALGTLFGYAFGASADMLLPSLTIEPGVFAIAGMGALFAATVRAPITGILLVIEMTNNYY
HHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEE
LILPLIITSLGAVIVAQLLGGQPIYSQLLHRTLKNDKLRQQDLPENQA
EEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA