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The map label for this gene is pfeR [H]

Identifier: 156977326

GI number: 156977326

Start: 1273422

End: 1274180

Strand: Direct

Name: pfeR [H]

Synonym: VIBHAR_06112

Alternate gene names: 156977326

Gene position: 1273422-1274180 (Clockwise)

Preceding gene: 156977315

Following gene: 156977327

Centisome position: 57.78

GC content: 45.85

Gene sequence:

>759_bases
ATGTTCAGCCCAGTACTAAGCGATATTCATACAAAGCCATTTAGATCTTCGAGCCAACCCTCTCCCGCTCCATCAATTTT
GTTGGCCGAAGATGACCCAGACCTGAACCTACAACTTACAGAGCTTCTTAAAGCACAGTGCTACAACGTTGTGTCAATGC
TTGAGGGAGACACCGCGTTAAAGGCATTCCAGCAACAAACCTTCGACTTGGTCATTCTGGACGTTAACTTACCCAACCTA
GACGGCTTTGAAGTACTCAATGTGATTCGCTCTCAGTCACAAACCCCGGTTGTCATGCTTACCGCTTACGGTGCAGAAGA
ATATCGAATTCAGGGGCTTAAATGTGGTGCCGACGATTACATCACTAAACCCTGTAACTTCACGGAAGTGAGCTTACGCA
TTGAAGCGATTTTGCGTCGTACTAAACTTATCCAACAGCCCAACTCCCCCACACAATTGAGTGAAAGAGAACTGCTGCTC
GATAAACTAAATCACACAGTCAATATACATCATCGCCCTGAGCTGACCCCAATTCAGCTGACCCCTATTCAATTCATACT
TCTGTGGACCTTGGTCGAGCACCGTGAAGAAGTTTTGAGTAAACCCTTCCTCTATCAAACGGTTTTAGAACGTCAGTTCA
GCCAATACGATCGCGCGCTCGACATGCATCTAAGCCGTGTGCGTAAGCGTCTTATTGCTGAGGGTATGTCGAATGACCGA
ATCCAAACCGTGCATGGTAAAGGATATATTTTTAAATGA

Upstream 100 bases:

>100_bases
ACGATTGAAGTAACGAGCGACCTTCTTATTGACCAGATTGATTGTTACTCGGGAATTATTGATAATAATTTACATTATCA
ATAATTAATCATATTCCATT

Downstream 100 bases:

>100_bases
AGAAGATGCTGTTTTGGCGGTTGTTTGTCGTCTTATCTCTGGGCGTGGTGATCTTTTTCTCCTTGATTCACAGCGCGGCC
ATCCTCTCCAACGAGAAAAT

Product: transcriptional regulatory protein CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MFSPVLSDIHTKPFRSSSQPSPAPSILLAEDDPDLNLQLTELLKAQCYNVVSMLEGDTALKAFQQQTFDLVILDVNLPNL
DGFEVLNVIRSQSQTPVVMLTAYGAEEYRIQGLKCGADDYITKPCNFTEVSLRIEAILRRTKLIQQPNSPTQLSERELLL
DKLNHTVNIHHRPELTPIQLTPIQFILLWTLVEHREEVLSKPFLYQTVLERQFSQYDRALDMHLSRVRKRLIAEGMSNDR
IQTVHGKGYIFK

Sequences:

>Translated_252_residues
MFSPVLSDIHTKPFRSSSQPSPAPSILLAEDDPDLNLQLTELLKAQCYNVVSMLEGDTALKAFQQQTFDLVILDVNLPNL
DGFEVLNVIRSQSQTPVVMLTAYGAEEYRIQGLKCGADDYITKPCNFTEVSLRIEAILRRTKLIQQPNSPTQLSERELLL
DKLNHTVNIHHRPELTPIQLTPIQFILLWTLVEHREEVLSKPFLYQTVLERQFSQYDRALDMHLSRVRKRLIAEGMSNDR
IQTVHGKGYIFK
>Mature_252_residues
MFSPVLSDIHTKPFRSSSQPSPAPSILLAEDDPDLNLQLTELLKAQCYNVVSMLEGDTALKAFQQQTFDLVILDVNLPNL
DGFEVLNVIRSQSQTPVVMLTAYGAEEYRIQGLKCGADDYITKPCNFTEVSLRIEAILRRTKLIQQPNSPTQLSERELLL
DKLNHTVNIHHRPELTPIQLTPIQFILLWTLVEHREEVLSKPFLYQTVLERQFSQYDRALDMHLSRVRKRLIAEGMSNDR
IQTVHGKGYIFK

Specific function: Member of the two-component regulatory system pfeR/pfeS. Activates expression of the ferric enterobactin receptor [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=35.9307359307359, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=36.7965367965368, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786599, Length=237, Percent_Identity=35.0210970464135, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=34.061135371179, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=31.5555555555556, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=30.5309734513274, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1786784, Length=235, Percent_Identity=30.6382978723404, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=31.4410480349345, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.9559471365639, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=29.3617021276596, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=28.0851063829787, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786911, Length=212, Percent_Identity=29.7169811320755, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787375, Length=233, Percent_Identity=27.8969957081545, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=30, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788550, Length=115, Percent_Identity=32.1739130434783, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790437, Length=120, Percent_Identity=35.8333333333333, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788713, Length=112, Percent_Identity=39.2857142857143, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28885; Mature: 28885

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSPVLSDIHTKPFRSSSQPSPAPSILLAEDDPDLNLQLTELLKAQCYNVVSMLEGDTAL
CCCHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHH
KAFQQQTFDLVILDVNLPNLDGFEVLNVIRSQSQTPVVMLTAYGAEEYRIQGLKCGADDY
HHHHHCCEEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEECEEECCCCC
ITKPCNFTEVSLRIEAILRRTKLIQQPNSPTQLSERELLLDKLNHTVNIHHRPELTPIQL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCEEE
TPIQFILLWTLVEHREEVLSKPFLYQTVLERQFSQYDRALDMHLSRVRKRLIAEGMSNDR
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IQTVHGKGYIFK
EEEEECCCEEEC
>Mature Secondary Structure
MFSPVLSDIHTKPFRSSSQPSPAPSILLAEDDPDLNLQLTELLKAQCYNVVSMLEGDTAL
CCCHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHH
KAFQQQTFDLVILDVNLPNLDGFEVLNVIRSQSQTPVVMLTAYGAEEYRIQGLKCGADDY
HHHHHCCEEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEECEEECCCCC
ITKPCNFTEVSLRIEAILRRTKLIQQPNSPTQLSERELLLDKLNHTVNIHHRPELTPIQL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCEEE
TPIQFILLWTLVEHREEVLSKPFLYQTVLERQFSQYDRALDMHLSRVRKRLIAEGMSNDR
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IQTVHGKGYIFK
EEEEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8361354; 10984043 [H]