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The map label for this gene is gcvT [H]

Identifier: 156977182

GI number: 156977182

Start: 1157566

End: 1158696

Strand: Reverse

Name: gcvT [H]

Synonym: VIBHAR_05968

Alternate gene names: 156977182

Gene position: 1158696-1157566 (Counterclockwise)

Preceding gene: 156977183

Following gene: 156977181

Centisome position: 52.57

GC content: 48.54

Gene sequence:

>1131_bases
ATGGAGACGAAAATGACTCAAGAACTTCTGAAAACACCACTGCATGCACTTCATGTTGAAGTAGGCGCAAAGATGGTCCC
GTTCGCGGGTTACGACATGCCAGTTCAATACCCACTAGGCGTTAAGAAAGAACACTTACACACACGTGATGCAGCAGGTC
TGTTCGATGTTTCTCACATGGGTCAACTTCGTTTGATTGGTGACGGTGCAGCAGCATTCCTAGAAACTTTGGTTCCAGTG
GACATTGTTGACCTAGGCGCAGGCAAACAGCGTTACGCGTTCTTCACTAACGAGCAGGGCGGCATCATGGACGACTTGAT
GGTGGCAAACCTTGGCGATCATCTGTTTGTTGTAGTAAACGCAGCATGTAAAGAGCAAGACATTGCACACCTTCAAGCGC
ATCTTCCTTCTGGTATTGAGCTAGAAATCATCGATGATCGTGCACTGCTTGCGATTCAAGGCCCTAAAGCGGCAGAGGTA
CTAGCACGCTTTGCTCCTGAAGTTGCAGAGATGCTGTTTATGGATGTTCGCAAAGTTGAACTACTCGGCGTTGAGTGCAT
TATTTCTCGTAGTGGTTACACGGGTGAAGATGGTTACGAAATCTCGGTACCGGCTGAAAAAGCAGAAGAGCTTGCTCGTA
AGCTAACTGGCGAAGAAGAAGTTGAGTGGATCGGCCTTGGCGCACGTGACTCACTGCGTCTAGAGTGTGGTCTGTGTCTA
TACGGTCATGACTTAGATACAACAACAACGCCTGTTGAAGCAAGCCTACTATGGGGTATTCAAAAAGTACGTCGCGCTGA
TGGCGAGCGTGCTGGTGGTTTCCCAGGTGCAGACATTATTCTTAAGCAAATCGAAACAAAAGATGTTGCTCGTAAACGTA
TTGGTTTAGTAGGTCAAACCAAAGCACCAGTGCGTGAAGGCGCGGAGCTATTTGATGCAGAAGGCAACAAGATCGGTGTG
GTAACCAGTGGTACAGCAGGTCCTAACGCAGGTAAGCCAGTATCAATGGGTTATGTACGCGCAGACCTTGCGGCGATCGG
TACAGAGCTGTTCGCAGAAGTACGTGGCAAAATGCTACCAATGACGGTAGAAAAAATGCCGTTCGTACCACAACGCTACT
ACCGCGGATAA

Upstream 100 bases:

>100_bases
AGTCGAGGGATGTCTTGTTCGTGCAAAATTGAATCAAGCGTGTTTATTATTGGAAACATTATTCGATGCGAATGCCGACA
GCATTCTCGGGTCTATCTAA

Downstream 100 bases:

>100_bases
CTTAGCTTATTGATTGAGTGAGCTAATTAAAGCTCGTCATTCAGCGAGACTAGGAATCTACCTCCCACGCGCTATATAAC
TACAGTGCCGCGTTTAGAAA

Product: glycine cleavage system protein T2

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
METKMTQELLKTPLHALHVEVGAKMVPFAGYDMPVQYPLGVKKEHLHTRDAAGLFDVSHMGQLRLIGDGAAAFLETLVPV
DIVDLGAGKQRYAFFTNEQGGIMDDLMVANLGDHLFVVVNAACKEQDIAHLQAHLPSGIELEIIDDRALLAIQGPKAAEV
LARFAPEVAEMLFMDVRKVELLGVECIISRSGYTGEDGYEISVPAEKAEELARKLTGEEEVEWIGLGARDSLRLECGLCL
YGHDLDTTTTPVEASLLWGIQKVRRADGERAGGFPGADIILKQIETKDVARKRIGLVGQTKAPVREGAELFDAEGNKIGV
VTSGTAGPNAGKPVSMGYVRADLAAIGTELFAEVRGKMLPMTVEKMPFVPQRYYRG

Sequences:

>Translated_376_residues
METKMTQELLKTPLHALHVEVGAKMVPFAGYDMPVQYPLGVKKEHLHTRDAAGLFDVSHMGQLRLIGDGAAAFLETLVPV
DIVDLGAGKQRYAFFTNEQGGIMDDLMVANLGDHLFVVVNAACKEQDIAHLQAHLPSGIELEIIDDRALLAIQGPKAAEV
LARFAPEVAEMLFMDVRKVELLGVECIISRSGYTGEDGYEISVPAEKAEELARKLTGEEEVEWIGLGARDSLRLECGLCL
YGHDLDTTTTPVEASLLWGIQKVRRADGERAGGFPGADIILKQIETKDVARKRIGLVGQTKAPVREGAELFDAEGNKIGV
VTSGTAGPNAGKPVSMGYVRADLAAIGTELFAEVRGKMLPMTVEKMPFVPQRYYRG
>Mature_376_residues
METKMTQELLKTPLHALHVEVGAKMVPFAGYDMPVQYPLGVKKEHLHTRDAAGLFDVSHMGQLRLIGDGAAAFLETLVPV
DIVDLGAGKQRYAFFTNEQGGIMDDLMVANLGDHLFVVVNAACKEQDIAHLQAHLPSGIELEIIDDRALLAIQGPKAAEV
LARFAPEVAEMLFMDVRKVELLGVECIISRSGYTGEDGYEISVPAEKAEELARKLTGEEEVEWIGLGARDSLRLECGLCL
YGHDLDTTTTPVEASLLWGIQKVRRADGERAGGFPGADIILKQIETKDVARKRIGLVGQTKAPVREGAELFDAEGNKIGV
VTSGTAGPNAGKPVSMGYVRADLAAIGTELFAEVRGKMLPMTVEKMPFVPQRYYRG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=378, Percent_Identity=47.0899470899471, Blast_Score=307, Evalue=8e-84,
Organism=Homo sapiens, GI257796258, Length=358, Percent_Identity=46.3687150837989, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI257796254, Length=371, Percent_Identity=42.8571428571429, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI257796256, Length=322, Percent_Identity=45.9627329192547, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI24797151, Length=351, Percent_Identity=24.7863247863248, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1789272, Length=374, Percent_Identity=35.5614973262032, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17560118, Length=379, Percent_Identity=40.3693931398417, Blast_Score=269, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI32563613, Length=331, Percent_Identity=23.8670694864048, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320222, Length=390, Percent_Identity=41.5384615384615, Blast_Score=272, Evalue=8e-74,
Organism=Drosophila melanogaster, GI20129441, Length=381, Percent_Identity=42.7821522309711, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40795; Mature: 40795

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKMTQELLKTPLHALHVEVGAKMVPFAGYDMPVQYPLGVKKEHLHTRDAAGLFDVSHM
CCCHHHHHHHHCHHHHHHHHHCCEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCEECCCC
GQLRLIGDGAAAFLETLVPVDIVDLGAGKQRYAFFTNEQGGIMDDLMVANLGDHLFVVVN
CCEEEEECCHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEEE
AACKEQDIAHLQAHLPSGIELEIIDDRALLAIQGPKAAEVLARFAPEVAEMLFMDVRKVE
CHHCHHHHHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLGVECIISRSGYTGEDGYEISVPAEKAEELARKLTGEEEVEWIGLGARDSLRLECGLCL
HCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEEE
YGHDLDTTTTPVEASLLWGIQKVRRADGERAGGFPGADIILKQIETKDVARKRIGLVGQT
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
KAPVREGAELFDAEGNKIGVVTSGTAGPNAGKPVSMGYVRADLAAIGTELFAEVRGKMLP
CCCHHHCHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
MTVEKMPFVPQRYYRG
EEHHHCCCCCHHHCCC
>Mature Secondary Structure
METKMTQELLKTPLHALHVEVGAKMVPFAGYDMPVQYPLGVKKEHLHTRDAAGLFDVSHM
CCCHHHHHHHHCHHHHHHHHHCCEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCEECCCC
GQLRLIGDGAAAFLETLVPVDIVDLGAGKQRYAFFTNEQGGIMDDLMVANLGDHLFVVVN
CCEEEEECCHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEEE
AACKEQDIAHLQAHLPSGIELEIIDDRALLAIQGPKAAEVLARFAPEVAEMLFMDVRKVE
CHHCHHHHHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLGVECIISRSGYTGEDGYEISVPAEKAEELARKLTGEEEVEWIGLGARDSLRLECGLCL
HCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEEE
YGHDLDTTTTPVEASLLWGIQKVRRADGERAGGFPGADIILKQIETKDVARKRIGLVGQT
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
KAPVREGAELFDAEGNKIGVVTSGTAGPNAGKPVSMGYVRADLAAIGTELFAEVRGKMLP
CCCHHHCHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
MTVEKMPFVPQRYYRG
EEHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA