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The map label for this gene is fhs

Identifier: 156977157

GI number: 156977157

Start: 1127408

End: 1129156

Strand: Direct

Name: fhs

Synonym: VIBHAR_05943

Alternate gene names: 156977157

Gene position: 1127408-1129156 (Clockwise)

Preceding gene: 156977156

Following gene: 156977158

Centisome position: 51.15

GC content: 47.68

Gene sequence:

>1749_bases
ATGCAGTCTGATATTGAAATTTGCCGAAACACACCGTTGTCTTCTATCGCTACTGTCGCCGCAAACGCTGGCCTTTTGCC
ACACGAACTCGATACGCACGGAAAACACAAAGCTAAAGTTCATCCCCAATGTCTTGAGCGTCTAACTGACAATCAAGATG
GTAAATTGGTGTTGGTCACTGCAATTACGCCTACCCCACTGGGTGAAGGCAAAACGGTTACCACAATCGGCCTATCTCAA
GGTCTATCCAAGATTAACCAATCTGTGATGGCGTGTATTCGTCAGCCTTCTATGGGGCCTGTCTTTGGTGTCAAAGGTGG
CGCTGCTGGTGGCGGTTACTCTCAAGTGGCGCCAATGGACGAGCTCAACCTTCATTTAACTGGCGATATCCATGCTGTCA
CGGCCGCGCATAACCTAGCGTCAGCAGCACTTGATGCTCGCCTCTATCATGAACAACGTGAAGGTTACGATGCATTTGAA
GCTCGCACGAGTTTAAGAGCGCTGAAAATCGATGTTGAGCGAATCACATGGAAACGTGTGATGGACCACAACGACCGAGC
ACTGCGCATGGTAAAAATAGGCTTGAATGAAGAAGGTAAGAACATCAACGGCTTCGAACGTGAAGAAGGTTTTGATATTT
CTGCCGCGTCCGAGCTCATGGCTATCCTTGCGCTAGCAAATGACCTTAAAGATCTTCGTCAGCGTATTGGTCGCATCGTC
GTTGCTTATGATTTGAATGGTAATCCAGTAACGACTGAAGATTTGCAAGTTGCCGGCGCCATGGCGGTCACATTGAAAGA
GACCATTGCCCCTACTCTAATGCAAACGCTTGAAGGCGTACCCACTCTGATCCACGCAGGTCCATTTGCCAACATCGCTC
ACGGTAACTCTTCCATCATTGCAGACCAGATTGCATTAAAACTTTCTAGTTACGTCGTCACGGAAGCTGGATTTGGCTCA
GACATGGGCTTTGAGAAAGCCTGTAACATTAAAGCATTAGCCGCTGACCGTGCACCAGATTGTGTGGTAATTGTCGCGAC
CCTTCGTGGTTTGAAAGCAAATTCAGGTCACTACGACTTACGACCAGGTATGGCGATTCCAGACTCTATTTTCAATCCAG
ACCAAGCCGCACTTGAAGCCGGATTCGAAAACCTGAAATGGCACATCAATAACGTGCATAAATACGGAATCCCTGCAGTT
GTTGCCATCAACCAGTTCCCACAAGATTCAGGACAAGAATTGGCAGAGCTCAAAGCATTGATTGAGCGCTTTAACCCTGA
GGTAAAAGTGGCAGTAAGCACCGTATTTGCACAAGGTGGCGAAGGCGCTATTGAACTCGCACAGCACGTTGTTGAAACTT
GTGAGCAAGGCGCTCAATTCCGCCCTCTTTACACCAAGAAGCAATCCTTGAAAGAAAAGCTGATGGCAGTATGTGAAGTG
GGCTATGGTGCATCAAACATCGAAATGAGCGAGCTAGCGAAACAACAACTGGCACACTTTGAGAAATTAGGCTTTGATGA
CTTAGCGGTGTGCATTGCGAAAACACCGCTTTCAATCACAACGGATTCAGCCATAAAAGGCGCGCCAAGTGGTTTTGCCG
TACCAATTCGTGAGCTGCGTTTATGTGCCGGCGCGGGCTTTGTTTACGCACTGTCTGGGAACGTAATGACTATGCCAGGT
CTGCCAGACAAACCTACATTTATGAACTTAGATCTTGATGATCAAGGCAATATTATCGGCCTTTCATAA

Upstream 100 bases:

>100_bases
TTACCCGTATTTTTCTCGCGCAAACGTTTGCGCAACACTAAGCAAGCTTTTACTTGCCTGGTGTTGAACGCCACGTGTTA
GCCATTTTTTGGGAGTATCC

Downstream 100 bases:

>100_bases
AAACAAGAAGATTGACGAGAAACGGGAGCCACTAGGCTCCCGTTTTGCTATGATAATGCTCTAATATACTGTTTTTGAAC
CTCTTTACATTGTAAACCGG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 582; Mature: 582

Protein sequence:

>582_residues
MQSDIEICRNTPLSSIATVAANAGLLPHELDTHGKHKAKVHPQCLERLTDNQDGKLVLVTAITPTPLGEGKTVTTIGLSQ
GLSKINQSVMACIRQPSMGPVFGVKGGAAGGGYSQVAPMDELNLHLTGDIHAVTAAHNLASAALDARLYHEQREGYDAFE
ARTSLRALKIDVERITWKRVMDHNDRALRMVKIGLNEEGKNINGFEREEGFDISAASELMAILALANDLKDLRQRIGRIV
VAYDLNGNPVTTEDLQVAGAMAVTLKETIAPTLMQTLEGVPTLIHAGPFANIAHGNSSIIADQIALKLSSYVVTEAGFGS
DMGFEKACNIKALAADRAPDCVVIVATLRGLKANSGHYDLRPGMAIPDSIFNPDQAALEAGFENLKWHINNVHKYGIPAV
VAINQFPQDSGQELAELKALIERFNPEVKVAVSTVFAQGGEGAIELAQHVVETCEQGAQFRPLYTKKQSLKEKLMAVCEV
GYGASNIEMSELAKQQLAHFEKLGFDDLAVCIAKTPLSITTDSAIKGAPSGFAVPIRELRLCAGAGFVYALSGNVMTMPG
LPDKPTFMNLDLDDQGNIIGLS

Sequences:

>Translated_582_residues
MQSDIEICRNTPLSSIATVAANAGLLPHELDTHGKHKAKVHPQCLERLTDNQDGKLVLVTAITPTPLGEGKTVTTIGLSQ
GLSKINQSVMACIRQPSMGPVFGVKGGAAGGGYSQVAPMDELNLHLTGDIHAVTAAHNLASAALDARLYHEQREGYDAFE
ARTSLRALKIDVERITWKRVMDHNDRALRMVKIGLNEEGKNINGFEREEGFDISAASELMAILALANDLKDLRQRIGRIV
VAYDLNGNPVTTEDLQVAGAMAVTLKETIAPTLMQTLEGVPTLIHAGPFANIAHGNSSIIADQIALKLSSYVVTEAGFGS
DMGFEKACNIKALAADRAPDCVVIVATLRGLKANSGHYDLRPGMAIPDSIFNPDQAALEAGFENLKWHINNVHKYGIPAV
VAINQFPQDSGQELAELKALIERFNPEVKVAVSTVFAQGGEGAIELAQHVVETCEQGAQFRPLYTKKQSLKEKLMAVCEV
GYGASNIEMSELAKQQLAHFEKLGFDDLAVCIAKTPLSITTDSAIKGAPSGFAVPIRELRLCAGAGFVYALSGNVMTMPG
LPDKPTFMNLDLDDQGNIIGLS
>Mature_582_residues
MQSDIEICRNTPLSSIATVAANAGLLPHELDTHGKHKAKVHPQCLERLTDNQDGKLVLVTAITPTPLGEGKTVTTIGLSQ
GLSKINQSVMACIRQPSMGPVFGVKGGAAGGGYSQVAPMDELNLHLTGDIHAVTAAHNLASAALDARLYHEQREGYDAFE
ARTSLRALKIDVERITWKRVMDHNDRALRMVKIGLNEEGKNINGFEREEGFDISAASELMAILALANDLKDLRQRIGRIV
VAYDLNGNPVTTEDLQVAGAMAVTLKETIAPTLMQTLEGVPTLIHAGPFANIAHGNSSIIADQIALKLSSYVVTEAGFGS
DMGFEKACNIKALAADRAPDCVVIVATLRGLKANSGHYDLRPGMAIPDSIFNPDQAALEAGFENLKWHINNVHKYGIPAV
VAINQFPQDSGQELAELKALIERFNPEVKVAVSTVFAQGGEGAIELAQHVVETCEQGAQFRPLYTKKQSLKEKLMAVCEV
GYGASNIEMSELAKQQLAHFEKLGFDDLAVCIAKTPLSITTDSAIKGAPSGFAVPIRELRLCAGAGFVYALSGNVMTMPG
LPDKPTFMNLDLDDQGNIIGLS

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=614, Percent_Identity=46.4169381107492, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI36796743, Length=614, Percent_Identity=43.8110749185668, Blast_Score=464, Evalue=1e-130,
Organism=Homo sapiens, GI310124614, Length=82, Percent_Identity=37.8048780487805, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=45.6591639871383, Blast_Score=497, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=45.6591639871383, Blast_Score=497, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6321643, Length=629, Percent_Identity=44.3561208267091, Blast_Score=480, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6319558, Length=634, Percent_Identity=42.5867507886435, Blast_Score=466, Evalue=1e-132,
Organism=Drosophila melanogaster, GI62472483, Length=621, Percent_Identity=43.4782608695652, Blast_Score=470, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45551871, Length=621, Percent_Identity=43.4782608695652, Blast_Score=470, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24645718, Length=621, Percent_Identity=43.4782608695652, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17137370, Length=621, Percent_Identity=43.4782608695652, Blast_Score=469, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_VIBHB (A7N5E9)

Other databases:

- EMBL:   CP000790
- RefSeq:   YP_001448063.1
- STRING:   A7N5E9
- GeneID:   5558605
- GenomeReviews:   CP000790_GR
- KEGG:   vha:VIBHAR_05943
- NMPDR:   fig|338187.4.peg.3504
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   AIKPNIM
- ProtClustDB:   PRK13506
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 62331; Mature: 62331

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSDIEICRNTPLSSIATVAANAGLLPHELDTHGKHKAKVHPQCLERLTDNQDGKLVLVT
CCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEE
AITPTPLGEGKTVTTIGLSQGLSKINQSVMACIRQPSMGPVFGVKGGAAGGGYSQVAPMD
EECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCC
ELNLHLTGDIHAVTAAHNLASAALDARLYHEQREGYDAFEARTSLRALKIDVERITWKRV
CCCEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEEEEHHHHHHHHH
MDHNDRALRMVKIGLNEEGKNINGFEREEGFDISAASELMAILALANDLKDLRQRIGRIV
HCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEE
VAYDLNGNPVTTEDLQVAGAMAVTLKETIAPTLMQTLEGVPTLIHAGPFANIAHGNSSII
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEECCCCCHHH
ADQIALKLSSYVVTEAGFGSDMGFEKACNIKALAADRAPDCVVIVATLRGLKANSGHYDL
HHHHHHHHHHHEEEECCCCCCCCCHHHCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCC
RPGMAIPDSIFNPDQAALEAGFENLKWHINNVHKYGIPAVVAINQFPQDSGQELAELKAL
CCCCCCCHHCCCCCHHHHHHCHHHHHEEECCEECCCCCEEEEEECCCCCCHHHHHHHHHH
IERFNPEVKVAVSTVFAQGGEGAIELAQHVVETCEQGAQFRPLYTKKQSLKEKLMAVCEV
HHHCCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GYGASNIEMSELAKQQLAHFEKLGFDDLAVCIAKTPLSITTDSAIKGAPSGFAVPIRELR
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEECCCHHCCCCCCCCCCHHHHH
LCAGAGFVYALSGNVMTMPGLPDKPTFMNLDLDDQGNIIGLS
HHHCCCEEEEEECCEEECCCCCCCCCEEEEEECCCCCEEECC
>Mature Secondary Structure
MQSDIEICRNTPLSSIATVAANAGLLPHELDTHGKHKAKVHPQCLERLTDNQDGKLVLVT
CCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEE
AITPTPLGEGKTVTTIGLSQGLSKINQSVMACIRQPSMGPVFGVKGGAAGGGYSQVAPMD
EECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCC
ELNLHLTGDIHAVTAAHNLASAALDARLYHEQREGYDAFEARTSLRALKIDVERITWKRV
CCCEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEEEEHHHHHHHHH
MDHNDRALRMVKIGLNEEGKNINGFEREEGFDISAASELMAILALANDLKDLRQRIGRIV
HCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEE
VAYDLNGNPVTTEDLQVAGAMAVTLKETIAPTLMQTLEGVPTLIHAGPFANIAHGNSSII
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEECCCCCHHH
ADQIALKLSSYVVTEAGFGSDMGFEKACNIKALAADRAPDCVVIVATLRGLKANSGHYDL
HHHHHHHHHHHEEEECCCCCCCCCHHHCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCC
RPGMAIPDSIFNPDQAALEAGFENLKWHINNVHKYGIPAVVAINQFPQDSGQELAELKAL
CCCCCCCHHCCCCCHHHHHHCHHHHHEEECCEECCCCCEEEEEECCCCCCHHHHHHHHHH
IERFNPEVKVAVSTVFAQGGEGAIELAQHVVETCEQGAQFRPLYTKKQSLKEKLMAVCEV
HHHCCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GYGASNIEMSELAKQQLAHFEKLGFDDLAVCIAKTPLSITTDSAIKGAPSGFAVPIRELR
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEECCCHHCCCCCCCCCCHHHHH
LCAGAGFVYALSGNVMTMPGLPDKPTFMNLDLDDQGNIIGLS
HHHCCCEEEEEECCEEECCCCCCCCCEEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA