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The map label for this gene is zot [H]

Identifier: 156976985

GI number: 156976985

Start: 961672

End: 962940

Strand: Reverse

Name: zot [H]

Synonym: VIBHAR_05770

Alternate gene names: 156976985

Gene position: 962940-961672 (Counterclockwise)

Preceding gene: 156976986

Following gene: 156976984

Centisome position: 43.69

GC content: 47.91

Gene sequence:

>1269_bases
ATGCAGCCGCTCGACATTATCGAGAAACGACTGGGTGAAAAGTTTCCGGACAGTGCTCGCCTCATTCGTATCAGCTCGCG
TAATCCTGAAGGCTTTGAGCTTTGGAAATACTTCTTCTGTTGGGCGCCAATTGGGGCGTTCATCCTCATTGATGAGTGTC
AGCAAATCTACTCCACCAATGCAGGCTTTAAAATGGCGAACATACACAAGCGCCCTTTTGCTGACTTTCAGCCGCATCTA
CCCGAAGGATTCTCTGAGTTGTTTCAGTCTCGTTGGCTGACTGTTGATACATCCAGTTTGGACAATGGCGAGATAGACGA
TTGCCAACGCACACGTTTCGACGAGCAAGGCCGAATCATCTATCCGGAGAACTTCAACAATGCCTTTATGGAGCACCGGC
ACTACAACTGGGACATTGTCCTGCTCACGCCCGACTTTGCTCAAATCCCTAAAGAGTTAAAAGGTGTGGCTGAGTTGGCC
AAGCAGCACAAAGGGAAAGACGGGATCTTCTTTTCCAACCGTAAACCTCGAATCCTAGAACATGACCCAACAAGAACGGT
CACCAAACCAAGCAAAGACGATGTGGTGTACAACCTCAAAGTCCCGCTTGATGTTCACCTACTCTACGCCTCCACTGTTA
CGGGGCAAATCACTAAAGCGGGACTTGGAAAGAACATCTTTCTTAATCCTAAATTCTTAGCAGCTATGGCACTGATGGTG
CTTTCATTTGGGTATGTCATTTATGCGCTTATTGGTCTTTTTTCTGATCCTGAGACGGCAGCTTCGCAAGGAACGCAGCC
TCATCAAACTACGCAGCAAAGTTCTGTTTCGTCTTCGCAAAGTAAATCGAGCCCTGGGCAAACTTCTGCGGATAATTCTG
TCGTGGGTTCTGGTCGTTCTGACTGTACGGGTACTGATTGCGGGACTCGGCCTTATCATGACATAGGCACCGTTCCGGCT
TGGTTTCCACTGGCCAACTCAGAAAGTATCTATGTGTCAGCCGTTGAACGTTGGCACAAACCCAACTCAATTCGAGTGAG
TGTCCATTTTGAGGTAATAACACCGAGAGGTGTTAGCTACCTCGATGACTCGTTTCTAAAAAAGCTAGGTATTCAAATGG
ATTATCTAGACGACTGCCTTGTCCAGCTGTCTAGCGGTGAATCGAACTTTTACGTGACCTGCTCCCCTTACGAGCAATTC
GCACAAGTACAAGAGCAAGACATAGAACTTAAGCCAGTTGGCGGTATCTTTGGCGGGGACGAAACCTAA

Upstream 100 bases:

>100_bases
ATATGGTCACGGCGGCTCATATAAATCAGCGTGTGCAGTATGGTTCGACTTACTGCCAGCCCTTCGTGAAGGTCGAGTTT
GCATCACCAATATTCATGGT

Downstream 100 bases:

>100_bases
TGAACGAATATGTGACACATGGGCAGTTGGTCGAAATCATCGCGCTGTTCGACCACCTCTCAATGATGAATGCGATCATC
ACTATCATTGTTTACGATCT

Product: hypothetical protein

Products: NA

Alternate protein names: Zonular occludens toxin; Zot [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MQPLDIIEKRLGEKFPDSARLIRISSRNPEGFELWKYFFCWAPIGAFILIDECQQIYSTNAGFKMANIHKRPFADFQPHL
PEGFSELFQSRWLTVDTSSLDNGEIDDCQRTRFDEQGRIIYPENFNNAFMEHRHYNWDIVLLTPDFAQIPKELKGVAELA
KQHKGKDGIFFSNRKPRILEHDPTRTVTKPSKDDVVYNLKVPLDVHLLYASTVTGQITKAGLGKNIFLNPKFLAAMALMV
LSFGYVIYALIGLFSDPETAASQGTQPHQTTQQSSVSSSQSKSSPGQTSADNSVVGSGRSDCTGTDCGTRPYHDIGTVPA
WFPLANSESIYVSAVERWHKPNSIRVSVHFEVITPRGVSYLDDSFLKKLGIQMDYLDDCLVQLSSGESNFYVTCSPYEQF
AQVQEQDIELKPVGGIFGGDET

Sequences:

>Translated_422_residues
MQPLDIIEKRLGEKFPDSARLIRISSRNPEGFELWKYFFCWAPIGAFILIDECQQIYSTNAGFKMANIHKRPFADFQPHL
PEGFSELFQSRWLTVDTSSLDNGEIDDCQRTRFDEQGRIIYPENFNNAFMEHRHYNWDIVLLTPDFAQIPKELKGVAELA
KQHKGKDGIFFSNRKPRILEHDPTRTVTKPSKDDVVYNLKVPLDVHLLYASTVTGQITKAGLGKNIFLNPKFLAAMALMV
LSFGYVIYALIGLFSDPETAASQGTQPHQTTQQSSVSSSQSKSSPGQTSADNSVVGSGRSDCTGTDCGTRPYHDIGTVPA
WFPLANSESIYVSAVERWHKPNSIRVSVHFEVITPRGVSYLDDSFLKKLGIQMDYLDDCLVQLSSGESNFYVTCSPYEQF
AQVQEQDIELKPVGGIFGGDET
>Mature_422_residues
MQPLDIIEKRLGEKFPDSARLIRISSRNPEGFELWKYFFCWAPIGAFILIDECQQIYSTNAGFKMANIHKRPFADFQPHL
PEGFSELFQSRWLTVDTSSLDNGEIDDCQRTRFDEQGRIIYPENFNNAFMEHRHYNWDIVLLTPDFAQIPKELKGVAELA
KQHKGKDGIFFSNRKPRILEHDPTRTVTKPSKDDVVYNLKVPLDVHLLYASTVTGQITKAGLGKNIFLNPKFLAAMALMV
LSFGYVIYALIGLFSDPETAASQGTQPHQTTQQSSVSSSQSKSSPGQTSADNSVVGSGRSDCTGTDCGTRPYHDIGTVPA
WFPLANSESIYVSAVERWHKPNSIRVSVHFEVITPRGVSYLDDSFLKKLGIQMDYLDDCLVQLSSGESNFYVTCSPYEQF
AQVQEQDIELKPVGGIFGGDET

Specific function: Increases the permeability of the small intestine mucosa by affecting the structure of intercellular tight junctions (zonula occludens) [H]

COG id: COG4128

COG function: function code R; Zonula occludens toxin

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008900 [H]

Pfam domain/function: PF05707 Zot [H]

EC number: NA

Molecular weight: Translated: 47393; Mature: 47393

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLDIIEKRLGEKFPDSARLIRISSRNPEGFELWKYFFCWAPIGAFILIDECQQIYSTN
CCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEHHHHHHHHCCC
AGFKMANIHKRPFADFQPHLPEGFSELFQSRWLTVDTSSLDNGEIDDCQRTRFDEQGRII
CCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCHHHHCCCCCCCCEE
YPENFNNAFMEHRHYNWDIVLLTPDFAQIPKELKGVAELAKQHKGKDGIFFSNRKPRILE
CCCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCC
HDPTRTVTKPSKDDVVYNLKVPLDVHLLYASTVTGQITKAGLGKNIFLNPKFLAAMALMV
CCCCCCCCCCCCCCEEEEEECCEEEEEEEEEHHCCCHHHCCCCCEEEECHHHHHHHHHHH
LSFGYVIYALIGLFSDPETAASQGTQPHQTTQQSSVSSSQSKSSPGQTSADNSVVGSGRS
HHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
DCTGTDCGTRPYHDIGTVPAWFPLANSESIYVSAVERWHKPNSIRVSVHFEVITPRGVSY
CCCCCCCCCCCCHHCCCCCCEEECCCCCCEEEEEHHHHCCCCEEEEEEEEEEECCCCCHH
LDDSFLKKLGIQMDYLDDCLVQLSSGESNFYVTCSPYEQFAQVQEQDIELKPVGGIFGGD
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCEEEECCCCCCCC
ET
CC
>Mature Secondary Structure
MQPLDIIEKRLGEKFPDSARLIRISSRNPEGFELWKYFFCWAPIGAFILIDECQQIYSTN
CCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEHHHHHHHHCCC
AGFKMANIHKRPFADFQPHLPEGFSELFQSRWLTVDTSSLDNGEIDDCQRTRFDEQGRII
CCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCHHHHCCCCCCCCEE
YPENFNNAFMEHRHYNWDIVLLTPDFAQIPKELKGVAELAKQHKGKDGIFFSNRKPRILE
CCCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCC
HDPTRTVTKPSKDDVVYNLKVPLDVHLLYASTVTGQITKAGLGKNIFLNPKFLAAMALMV
CCCCCCCCCCCCCCEEEEEECCEEEEEEEEEHHCCCHHHCCCCCEEEECHHHHHHHHHHH
LSFGYVIYALIGLFSDPETAASQGTQPHQTTQQSSVSSSQSKSSPGQTSADNSVVGSGRS
HHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
DCTGTDCGTRPYHDIGTVPAWFPLANSESIYVSAVERWHKPNSIRVSVHFEVITPRGVSY
CCCCCCCCCCCCHHCCCCCCEEECCCCCCEEEEEHHHHCCCCEEEEEEEEEEECCCCCHH
LDDSFLKKLGIQMDYLDDCLVQLSSGESNFYVTCSPYEQFAQVQEQDIELKPVGGIFGGD
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCEEEECCCCCCCC
ET
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1730472; 10952301; 2052603 [H]