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The map label for this gene is cobQ

Identifier: 156976939

GI number: 156976939

Start: 926356

End: 927783

Strand: Direct

Name: cobQ

Synonym: VIBHAR_05724

Alternate gene names: 156976939

Gene position: 926356-927783 (Clockwise)

Preceding gene: 156976935

Following gene: 156976940

Centisome position: 42.03

GC content: 47.69

Gene sequence:

>1428_bases
ATGGTTCAAGGCACCACCTCAGATGCCGGAAAAAGCGTCCTTGTGGCAGGTTTATGCCGTGTCTTAGCCCGAAAAGGGAT
AAAGGTTGCCCCATTCAAGCCACAGAATATGGCCCTCAATAGCGCAGTAACCAAAGATGGCGGAGAAATTGGGCGTGCTC
AAGCCGTTCAGGCACAAGCTTGCAATGTTGAGCCTACGGTTCACATGAATCCTGTTCTGATTAAGCCTAACAGCGATACA
GGTGCTCAGATCATCTTACAAGGCAAAGCATTGTCGAATATGGACGCTGTTGGGTTTCATGATTACAAGAGAGTGGCAAT
GGGAACGGTTCTGGATTCATTTGCAAAACTGACGGATGAATACGAATCCGTCATGATTGAAGGCGCTGGTAGTCCTGCGG
AAATCAACTTAAGAGAAAATGACATCGCCAACATGGGGTTTGCTGAAGAGGCCGACGTCCCCGTTATTATCATCGCGGAT
ATCGACCGAGGAGGCGTATTTGCCCACTTGTATGGCACTTTGGCGTTATTATCCGAATCAGAGCAAGCACGCGTTAAAGG
CTTCGTGATCAACCGCTTCCGTGGTGACATCGGCTTACTTGAATCTGGCCTTGATTGGTTAGAAGAAAAGACAGGTAAAC
CTGTGTTGGGCGTATTGCCGTTCTTGCACGGTTTAAACCTAGAGGCGGAAGACGCCATAACGGCAGAGCAAGAGCTGTCT
TCACAAGTGAAACTCAATGTTGTAGTACCAGTACTAACGCGCATCAGTAATCATACCGATTTTGATGTGTTGCGCCTAAA
CCCAGACATTAACCTTCGCTACGTTGGCAAAGGCGAAAAGATCGACAAAGCCGATCTAGTGATCCTGCCGGGAACCAAAT
CAGTTCGTGATGACTTAGATTATTTGCGCAGCCAAGGCTGGGATAAAGACATTCAACGTCACATTCGTCTGGGCGGCAAA
GTCATTGGCATTTGTGGTGGTTACCAGATGCTTGGCAAATTAATTGACGACCCTAATGGCGTCGAAGGCAGTCCAGGGAA
GAGTGAAGGGCTTGGGTTGCTAGACATTACTACGACGCTAACCGACAGCAAACAACTGACCAACACACACGCGCAGCTTT
GCTTAAACGGTAAAACAGCGAATGTGAAAGGTTACGAAATCCATGTTGGACGAAGTGAAGTGCAGGGTGCTCAACCTTTG
AGGTTAAGTTCTGGCGAGGCAGAGGGTGCGATCAGTGAGTGTGGCCAAATTATGGGAACCTACCTACACGGGTTCTTCGA
TGAGGCCGATGTGTTAAGCCTCGTGTCTGAATGGGTAAACGGCACTCAAATCAAGCAGCAAGATTTTGAACAGCTCAAAG
AAAAGGGCATTAATCGCATTGCAGATGCGATAGCACAACATATGAATCTTGACTTTCTGTTCAAATAA

Upstream 100 bases:

>100_bases
TCGATTCATTTTCTTGAGTCCTATGCTGAGATAACGTTATGATTGTTCACCTTCTTTTTTCTCGTATTAAACGTTCATGA
AATCACCAATCCCATCATTA

Downstream 100 bases:

>100_bases
AACCAGTTTTTAACTGTTTGAAGCATAAATAAAAGTAGGCATTGTGCTCTACATTTTCTTTTTCTGCCTGTCTAGCACTG
GAGTGTTTTTATGAAAGCAT

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MVQGTTSDAGKSVLVAGLCRVLARKGIKVAPFKPQNMALNSAVTKDGGEIGRAQAVQAQACNVEPTVHMNPVLIKPNSDT
GAQIILQGKALSNMDAVGFHDYKRVAMGTVLDSFAKLTDEYESVMIEGAGSPAEINLRENDIANMGFAEEADVPVIIIAD
IDRGGVFAHLYGTLALLSESEQARVKGFVINRFRGDIGLLESGLDWLEEKTGKPVLGVLPFLHGLNLEAEDAITAEQELS
SQVKLNVVVPVLTRISNHTDFDVLRLNPDINLRYVGKGEKIDKADLVILPGTKSVRDDLDYLRSQGWDKDIQRHIRLGGK
VIGICGGYQMLGKLIDDPNGVEGSPGKSEGLGLLDITTTLTDSKQLTNTHAQLCLNGKTANVKGYEIHVGRSEVQGAQPL
RLSSGEAEGAISECGQIMGTYLHGFFDEADVLSLVSEWVNGTQIKQQDFEQLKEKGINRIADAIAQHMNLDFLFK

Sequences:

>Translated_475_residues
MVQGTTSDAGKSVLVAGLCRVLARKGIKVAPFKPQNMALNSAVTKDGGEIGRAQAVQAQACNVEPTVHMNPVLIKPNSDT
GAQIILQGKALSNMDAVGFHDYKRVAMGTVLDSFAKLTDEYESVMIEGAGSPAEINLRENDIANMGFAEEADVPVIIIAD
IDRGGVFAHLYGTLALLSESEQARVKGFVINRFRGDIGLLESGLDWLEEKTGKPVLGVLPFLHGLNLEAEDAITAEQELS
SQVKLNVVVPVLTRISNHTDFDVLRLNPDINLRYVGKGEKIDKADLVILPGTKSVRDDLDYLRSQGWDKDIQRHIRLGGK
VIGICGGYQMLGKLIDDPNGVEGSPGKSEGLGLLDITTTLTDSKQLTNTHAQLCLNGKTANVKGYEIHVGRSEVQGAQPL
RLSSGEAEGAISECGQIMGTYLHGFFDEADVLSLVSEWVNGTQIKQQDFEQLKEKGINRIADAIAQHMNLDFLFK
>Mature_475_residues
MVQGTTSDAGKSVLVAGLCRVLARKGIKVAPFKPQNMALNSAVTKDGGEIGRAQAVQAQACNVEPTVHMNPVLIKPNSDT
GAQIILQGKALSNMDAVGFHDYKRVAMGTVLDSFAKLTDEYESVMIEGAGSPAEINLRENDIANMGFAEEADVPVIIIAD
IDRGGVFAHLYGTLALLSESEQARVKGFVINRFRGDIGLLESGLDWLEEKTGKPVLGVLPFLHGLNLEAEDAITAEQELS
SQVKLNVVVPVLTRISNHTDFDVLRLNPDINLRYVGKGEKIDKADLVILPGTKSVRDDLDYLRSQGWDKDIQRHIRLGGK
VIGICGGYQMLGKLIDDPNGVEGSPGKSEGLGLLDITTTLTDSKQLTNTHAQLCLNGKTANVKGYEIHVGRSEVQGAQPL
RLSSGEAEGAISECGQIMGTYLHGFFDEADVLSLVSEWVNGTQIKQQDFEQLKEKGINRIADAIAQHMNLDFLFK

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_VIBHB (A7N8K5)

Other databases:

- EMBL:   CP000790
- RefSeq:   YP_001447845.1
- ProteinModelPortal:   A7N8K5
- STRING:   A7N8K5
- GeneID:   5557497
- GenomeReviews:   CP000790_GR
- KEGG:   vha:VIBHAR_05724
- NMPDR:   fig|338187.4.peg.3372
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   ICLPRIS
- ProtClustDB:   PRK00784
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 51327; Mature: 51327

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 325-325 ACT_SITE 423-423

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQGTTSDAGKSVLVAGLCRVLARKGIKVAPFKPQNMALNSAVTKDGGEIGRAQAVQAQA
CCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHCCCCCHHCHHHHHHHHC
CNVEPTVHMNPVLIKPNSDTGAQIILQGKALSNMDAVGFHDYKRVAMGTVLDSFAKLTDE
CCCCCCEECCCEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YESVMIEGAGSPAEINLRENDIANMGFAEEADVPVIIIADIDRGGVFAHLYGTLALLSES
HHHEEEECCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
EQARVKGFVINRFRGDIGLLESGLDWLEEKTGKPVLGVLPFLHGLNLEAEDAITAEQELS
CHHHHHEEEEEHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
SQVKLNVVVPVLTRISNHTDFDVLRLNPDINLRYVGKGEKIDKADLVILPGTKSVRDDLD
CCEEEEEHHHHHHHHCCCCCCEEEEECCCCEEEECCCCCCCCCCCEEEECCCCHHHHHHH
YLRSQGWDKDIQRHIRLGGKVIGICGGYQMLGKLIDDPNGVEGSPGKSEGLGLLDITTTL
HHHHCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEC
TDSKQLTNTHAQLCLNGKTANVKGYEIHVGRSEVQGAQPLRLSSGEAEGAISECGQIMGT
CCCHHHHCCCCEEEECCCCCCCCEEEEECCHHHCCCCCCEEECCCCCCCHHHHHHHHHHH
YLHGFFDEADVLSLVSEWVNGTQIKQQDFEQLKEKGINRIADAIAQHMNLDFLFK
HHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
>Mature Secondary Structure
MVQGTTSDAGKSVLVAGLCRVLARKGIKVAPFKPQNMALNSAVTKDGGEIGRAQAVQAQA
CCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHCCCCCHHCHHHHHHHHC
CNVEPTVHMNPVLIKPNSDTGAQIILQGKALSNMDAVGFHDYKRVAMGTVLDSFAKLTDE
CCCCCCEECCCEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YESVMIEGAGSPAEINLRENDIANMGFAEEADVPVIIIADIDRGGVFAHLYGTLALLSES
HHHEEEECCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
EQARVKGFVINRFRGDIGLLESGLDWLEEKTGKPVLGVLPFLHGLNLEAEDAITAEQELS
CHHHHHEEEEEHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
SQVKLNVVVPVLTRISNHTDFDVLRLNPDINLRYVGKGEKIDKADLVILPGTKSVRDDLD
CCEEEEEHHHHHHHHCCCCCCEEEEECCCCEEEECCCCCCCCCCCEEEECCCCHHHHHHH
YLRSQGWDKDIQRHIRLGGKVIGICGGYQMLGKLIDDPNGVEGSPGKSEGLGLLDITTTL
HHHHCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEC
TDSKQLTNTHAQLCLNGKTANVKGYEIHVGRSEVQGAQPLRLSSGEAEGAISECGQIMGT
CCCHHHHCCCCEEEECCCCCCCCEEEEECCHHHCCCCCCEEECCCCCCCHHHHHHHHHHH
YLHGFFDEADVLSLVSEWVNGTQIKQQDFEQLKEKGINRIADAIAQHMNLDFLFK
HHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA