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The map label for this gene is tyrB [H]

Identifier: 156976934

GI number: 156976934

Start: 921574

End: 922770

Strand: Direct

Name: tyrB [H]

Synonym: VIBHAR_05719

Alternate gene names: 156976934

Gene position: 921574-922770 (Clockwise)

Preceding gene: 156976933

Following gene: 156976935

Centisome position: 41.81

GC content: 44.44

Gene sequence:

>1197_bases
ATGACTTTCATGTTTTCTAATCTACCAACTCCCGTATTAGATCCTATTTTATCTCTTTCCGTCGCATACCGCGGCGATGA
ACGTCCAAACAAGGTTGACCTTGGTATTGGCGTGTACAAAAACAGCGCTGGTGAAACGCCAATCATGAAAGCCATTCAAA
TGGCACAAGAAGTGGTTGTCGAAAACCAAAAGACCAAATCCTACGTTGGGCTTGCAGGCTGTGAAGAATTCAACCAAAGC
ATGATCGATCTGCTTCTGACGGGCACGTCAGCAACAGATCGTGTGGCAGCGATTCAAACGCCTGGTGCAAGTGGTGCGTT
GCGTATGCTGGGTGACCTAATGAAGGTAGCACAACCAGATACGACGGTTTGGATTTCAAACCCAAGCTACGTAAACCACA
AGCCAGTGATGGAAGCGGCTGGGCTTAAGGTGAAGTTCTACCATTACTTCTCACCAGAAACGAAACAAGTTGATACGGCG
AAAATGCTAGAAGACCTATCTAAAGCAGGTCCTTCTGACGTCGTGCTTCTGCATGGCTGTTGCCACAACCCAACGGGTGC
AGATATTGATTTTTCTGCGTGGCAAGCGATTACAGAGCTTTCACAAAAGAACGGTTTTACCCCATTTGTGGATATTGCTT
ACCAAGGTTTTGGTGACGGTCTAGAGGAAGACGCAAAAGGTCTCCGCTTTATTGCTGACAACGTTGAAGAAATGCTGATT
ACAACCTCATGTTCTAAGAACTTTGGTTTGTACCGTGAACGTACTGGTGCTGCAATTGTGATCGGTAAAAACACGAAAGA
CGTGGCAAATGCAAAAGGTAAGCTTCTTACATTAGCTCGTTCAACTTACACTATGCCGCCAGATCACGGTGCTGCATTGG
TGAAAACCATTCTTCAAGATGCCAACCTTACTTCAGTTTGGAAACAAGAATTGAACGAAATGCAGCAACGCTTGCTGAAT
CTTCGTCAAACTTTGTGTAACGAATTGAGAAACAACCATAATACAGATCAATTTGATTTCATTGAGAGTCACAAAGGCAT
GTTTACTGTGCTAGGCTTTAGTGAAAACCAAATGGCGCAACTGCGTGAAGATTATGGCATTTATGGTGTCGGTGATGGTC
GTATCAACATCGCTGGTTTGACCGAAACTCATATTCCTTACGTTGCTGACGCGATCCAAAAAGTATCTCAACGTTAA

Upstream 100 bases:

>100_bases
CAGAATTTTGTACTCTAATTGGCGAAATGTGTGAAAAATCGTTTCGCCATTTATAACGAAAGTGTTACCGTGAGGTTCGA
TACTTGAATTTCAAAGGGTT

Downstream 100 bases:

>100_bases
TTGGGAGAGTTAATGAAGAACTGGAAACTGATTCTGCCGCTAATGATGAGCGGTAGTCTTATTGCTTGTACGTCGACACC
GACGACCACTGAGCCTGTTG

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTFMFSNLPTPVLDPILSLSVAYRGDERPNKVDLGIGVYKNSAGETPIMKAIQMAQEVVVENQKTKSYVGLAGCEEFNQS
MIDLLLTGTSATDRVAAIQTPGASGALRMLGDLMKVAQPDTTVWISNPSYVNHKPVMEAAGLKVKFYHYFSPETKQVDTA
KMLEDLSKAGPSDVVLLHGCCHNPTGADIDFSAWQAITELSQKNGFTPFVDIAYQGFGDGLEEDAKGLRFIADNVEEMLI
TTSCSKNFGLYRERTGAAIVIGKNTKDVANAKGKLLTLARSTYTMPPDHGAALVKTILQDANLTSVWKQELNEMQQRLLN
LRQTLCNELRNNHNTDQFDFIESHKGMFTVLGFSENQMAQLREDYGIYGVGDGRINIAGLTETHIPYVADAIQKVSQR

Sequences:

>Translated_398_residues
MTFMFSNLPTPVLDPILSLSVAYRGDERPNKVDLGIGVYKNSAGETPIMKAIQMAQEVVVENQKTKSYVGLAGCEEFNQS
MIDLLLTGTSATDRVAAIQTPGASGALRMLGDLMKVAQPDTTVWISNPSYVNHKPVMEAAGLKVKFYHYFSPETKQVDTA
KMLEDLSKAGPSDVVLLHGCCHNPTGADIDFSAWQAITELSQKNGFTPFVDIAYQGFGDGLEEDAKGLRFIADNVEEMLI
TTSCSKNFGLYRERTGAAIVIGKNTKDVANAKGKLLTLARSTYTMPPDHGAALVKTILQDANLTSVWKQELNEMQQRLLN
LRQTLCNELRNNHNTDQFDFIESHKGMFTVLGFSENQMAQLREDYGIYGVGDGRINIAGLTETHIPYVADAIQKVSQR
>Mature_397_residues
TFMFSNLPTPVLDPILSLSVAYRGDERPNKVDLGIGVYKNSAGETPIMKAIQMAQEVVVENQKTKSYVGLAGCEEFNQSM
IDLLLTGTSATDRVAAIQTPGASGALRMLGDLMKVAQPDTTVWISNPSYVNHKPVMEAAGLKVKFYHYFSPETKQVDTAK
MLEDLSKAGPSDVVLLHGCCHNPTGADIDFSAWQAITELSQKNGFTPFVDIAYQGFGDGLEEDAKGLRFIADNVEEMLIT
TSCSKNFGLYRERTGAAIVIGKNTKDVANAKGKLLTLARSTYTMPPDHGAALVKTILQDANLTSVWKQELNEMQQRLLNL
RQTLCNELRNNHNTDQFDFIESHKGMFTVLGFSENQMAQLREDYGIYGVGDGRINIAGLTETHIPYVADAIQKVSQR

Specific function: Shows activities toward both dicarboxylic and aromatic substrates [H]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=390, Percent_Identity=31.7948717948718, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI4504067, Length=406, Percent_Identity=32.2660098522167, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI117414139, Length=383, Percent_Identity=25.065274151436, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1787159, Length=395, Percent_Identity=41.7721518987342, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI1790488, Length=396, Percent_Identity=35.6060606060606, Blast_Score=266, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71981858, Length=397, Percent_Identity=31.7380352644836, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI25147133, Length=388, Percent_Identity=30.1546391752577, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17569539, Length=400, Percent_Identity=31, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17569537, Length=391, Percent_Identity=28.1329923273657, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17550384, Length=264, Percent_Identity=29.5454545454545, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25147136, Length=202, Percent_Identity=28.7128712871287, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323055, Length=406, Percent_Identity=30.5418719211823, Blast_Score=205, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6322743, Length=434, Percent_Identity=28.8018433179723, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24580972, Length=400, Percent_Identity=32.5, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24580970, Length=400, Percent_Identity=32.5, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI19920542, Length=391, Percent_Identity=32.7365728900256, Blast_Score=241, Evalue=9e-64,
Organism=Drosophila melanogaster, GI24654046, Length=396, Percent_Identity=32.0707070707071, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI19922362, Length=396, Percent_Identity=32.0707070707071, Blast_Score=228, Evalue=5e-60,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 43758; Mature: 43627

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFMFSNLPTPVLDPILSLSVAYRGDERPNKVDLGIGVYKNSAGETPIMKAIQMAQEVVV
CCEECCCCCHHHHHHHHHHHHEECCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHH
ENQKTKSYVGLAGCEEFNQSMIDLLLTGTSATDRVAAIQTPGASGALRMLGDLMKVAQPD
CCCCHHHHCCCCCHHHHHHHHHHHHEECCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCC
TTVWISNPSYVNHKPVMEAAGLKVKFYHYFSPETKQVDTAKMLEDLSKAGPSDVVLLHGC
CEEEECCCCCCCCCCHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECC
CHNPTGADIDFSAWQAITELSQKNGFTPFVDIAYQGFGDGLEEDAKGLRFIADNVEEMLI
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHE
TTSCSKNFGLYRERTGAAIVIGKNTKDVANAKGKLLTLARSTYTMPPDHGAALVKTILQD
ECCCCCCCCCEEECCCCEEEEECCCHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHC
ANLTSVWKQELNEMQQRLLNLRQTLCNELRNNHNTDQFDFIESHKGMFTVLGFSENQMAQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCCHHHHH
LREDYGIYGVGDGRINIAGLTETHIPYVADAIQKVSQR
HHHCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TFMFSNLPTPVLDPILSLSVAYRGDERPNKVDLGIGVYKNSAGETPIMKAIQMAQEVVV
CEECCCCCHHHHHHHHHHHHEECCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHH
ENQKTKSYVGLAGCEEFNQSMIDLLLTGTSATDRVAAIQTPGASGALRMLGDLMKVAQPD
CCCCHHHHCCCCCHHHHHHHHHHHHEECCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCC
TTVWISNPSYVNHKPVMEAAGLKVKFYHYFSPETKQVDTAKMLEDLSKAGPSDVVLLHGC
CEEEECCCCCCCCCCHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECC
CHNPTGADIDFSAWQAITELSQKNGFTPFVDIAYQGFGDGLEEDAKGLRFIADNVEEMLI
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHE
TTSCSKNFGLYRERTGAAIVIGKNTKDVANAKGKLLTLARSTYTMPPDHGAALVKTILQD
ECCCCCCCCCEEECCCCEEEEECCCHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHC
ANLTSVWKQELNEMQQRLLNLRQTLCNELRNNHNTDQFDFIESHKGMFTVLGFSENQMAQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCCHHHHH
LREDYGIYGVGDGRINIAGLTETHIPYVADAIQKVSQR
HHHCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9058208; 9665848; 9930977 [H]