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The map label for this gene is trxC [H]

Identifier: 156976914

GI number: 156976914

Start: 900834

End: 901322

Strand: Reverse

Name: trxC [H]

Synonym: VIBHAR_05698

Alternate gene names: 156976914

Gene position: 901322-900834 (Counterclockwise)

Preceding gene: 156976916

Following gene: 156976912

Centisome position: 40.89

GC content: 44.79

Gene sequence:

>489_bases
ATGAGGCTGACTGGTAAGTCATGTTTTCATGAAGTTGTCATAAAGGAAGAAGTCATGTCATCGTTTAAAACTCGTTGTCC
GTCTTGTGGCGGTTTAAATCGTGTCCCTAATGAGCGAGTTGCAGAAGCTGCTAGTTGTGGTAAATGCAAGAACGCTCTAT
TTGATGGTTCACCGGTAGAAGGCACTATCGATAACTTTTCGGTGCTGCTAGAGAGCAACACACCGGTTGTGGTCGATTTT
TGGGCACCGTGGTGTAACCCTTGTGTTGGTTTTGCTCCTGTTTTTGAGGATGTCGCGCAAGAACAGACCGGAAATGCACG
TTTTGTCAAGATTGATACCGAAGCGCAGCAACAGTTGGCAGCGCAATTTGGTATTCGTAGTATCCCGACCATTATGGTTT
TTAAGAACGGCCAACGTGTCGACATGATCAACGGTGCCCTACCAAAAACTCAATTTGATCAGTGGTTAAATCAAGCACTT
AGCAAATAA

Upstream 100 bases:

>100_bases
TTATTGTTGTATTTTAATGAGATTTCTTAGAACCTGTTCGGGTCCAAATACAGACTTGCCGTCTTATATTTCGGCAGGCT
AAAAAATAAGTATACAAATT

Downstream 100 bases:

>100_bases
ACCTCTTCGCCAGCCTTATTCTTAGGCTGGCGTTTTTATTCAGCTTTTCTTCATAGAATTTCGATAAATTTCTTTTGTCG
AAACGACACAAATATATCAT

Product: thioredoxin 2

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MRLTGKSCFHEVVIKEEVMSSFKTRCPSCGGLNRVPNERVAEAASCGKCKNALFDGSPVEGTIDNFSVLLESNTPVVVDF
WAPWCNPCVGFAPVFEDVAQEQTGNARFVKIDTEAQQQLAAQFGIRSIPTIMVFKNGQRVDMINGALPKTQFDQWLNQAL
SK

Sequences:

>Translated_162_residues
MRLTGKSCFHEVVIKEEVMSSFKTRCPSCGGLNRVPNERVAEAASCGKCKNALFDGSPVEGTIDNFSVLLESNTPVVVDF
WAPWCNPCVGFAPVFEDVAQEQTGNARFVKIDTEAQQQLAAQFGIRSIPTIMVFKNGQRVDMINGALPKTQFDQWLNQAL
SK
>Mature_162_residues
MRLTGKSCFHEVVIKEEVMSSFKTRCPSCGGLNRVPNERVAEAASCGKCKNALFDGSPVEGTIDNFSVLLESNTPVVVDF
WAPWCNPCVGFAPVFEDVAQEQTGNARFVKIDTEAQQQLAAQFGIRSIPTIMVFKNGQRVDMINGALPKTQFDQWLNQAL
SK

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=145, Percent_Identity=29.6551724137931, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1788936, Length=139, Percent_Identity=56.8345323741007, Blast_Score=187, Evalue=3e-49,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=36.6336633663366, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI87081747, Length=100, Percent_Identity=36, Blast_Score=74, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=110, Percent_Identity=32.7272727272727, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17507705, Length=89, Percent_Identity=34.8314606741573, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=74, Percent_Identity=43.2432432432432, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25144092, Length=83, Percent_Identity=33.7349397590361, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=71, Percent_Identity=36.6197183098592, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532380, Length=112, Percent_Identity=29.4642857142857, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=42.2535211267606, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=34.4827586206897, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=102, Percent_Identity=30.3921568627451, Blast_Score=63, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17556044, Length=77, Percent_Identity=40.2597402597403, Blast_Score=63, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=82, Percent_Identity=39.0243902439024, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=87, Percent_Identity=36.7816091954023, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573567, Length=111, Percent_Identity=35.1351351351351, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17647799, Length=88, Percent_Identity=35.2272727272727, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 17848; Mature: 17848

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTGKSCFHEVVIKEEVMSSFKTRCPSCGGLNRVPNERVAEAASCGKCKNALFDGSPVE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
GTIDNFSVLLESNTPVVVDFWAPWCNPCVGFAPVFEDVAQEQTGNARFVKIDTEAQQQLA
CCCCCEEEEEECCCCEEEECCCCCCCHHCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHH
AQFGIRSIPTIMVFKNGQRVDMINGALPKTQFDQWLNQALSK
HHHCCCCCCEEEEEECCCEEEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLTGKSCFHEVVIKEEVMSSFKTRCPSCGGLNRVPNERVAEAASCGKCKNALFDGSPVE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
GTIDNFSVLLESNTPVVVDFWAPWCNPCVGFAPVFEDVAQEQTGNARFVKIDTEAQQQLA
CCCCCEEEEEECCCCEEEECCCCCCCHHCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHH
AQFGIRSIPTIMVFKNGQRVDMINGALPKTQFDQWLNQALSK
HHHCCCCCCEEEEEECCCEEEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]