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The map label for this gene is dld [H]

Identifier: 156976897

GI number: 156976897

Start: 884916

End: 886649

Strand: Direct

Name: dld [H]

Synonym: VIBHAR_05675

Alternate gene names: 156976897

Gene position: 884916-886649 (Clockwise)

Preceding gene: 156976896

Following gene: 156976898

Centisome position: 40.15

GC content: 45.62

Gene sequence:

>1734_bases
ATGCCGCTTTGTTTTGGCATGATTATTAGGGATGCGAATATGAAACAAAAGCCGCTGATCGATGCATTTGTCACTATCGT
CGGGGAAGAAAACGTCCTGACCGATCATATCAAAACCAAATATTACCGCAGCGGGTTTCGCTCTGGAGGCGGCACAGCAT
TGGCGGTTATATTTCCTAATACTGTGTTAGAGCAGTGGAAGGTCATACAACAATGTGTGGATAACAATTGCATCATTATC
ATGCAGGCAGCTAAGACGGGTCTAACGGAAGGTTCTGCGCCAAGTGGAGATGATTACGATCGCGATGTCGTGGTGATCAA
CATTACCAAAATGAAGCAAATCTATCTGCTGGATGGTGGTAAGCAAGCGGTTTGCCTTCCGGGCGCGAGTTTGCATTCAT
TAGAAAAAGAACTGCGAGCGGTAAATCGGGCACCGCACTCGATTATTGGTTCCTCATCTTTAGGTGCAACCGTGGTGGGC
GGAATTGCAAACAACTCTGGTGGCGCTTTGGTGAAACGTGGTCCTGCATACACTGAGTTGGCCTTATTTGCCCAGGTCGA
CAAAGACGGTCAGCTTAAACTTGTGAATCATCTTGGTATCGAAGGGTTAGGCTCGACACCTGAAGAGATTTTGCAAAACA
TTCAAGAGGGAAACAAAGTCATTCATGATGAGCGCATGGCGTCAGACAAGGAGTATGAAGAGCGTATCCGCGATGTGACT
TCTGACATCCCGTCACGTTTTAATGCTGATGAACGTCGTTTGTATGAGGCAAGTGGTTGTGCAGGTAAACTTGGCGTGTT
CGCCGTTCGAGTCGATAGCTATCCAATCCCGGAGAAAGAGCAGGTGTTCTATCTAGGAACTAACGATCCGGATAAACTCA
CTAAGCTAAGAAAAGACTTCCTGACTCAGTTTGAAAATTTACCAGAAATGGGTGAATACCTTCATCGTGATATCTTCAAC
ATGGCGGAAGAGTACGGTAAAGATGTGTTTTTATCTATCGACTTATTGGGTACCAATAGGCTACCCAAGTTGTTCTCGCT
AAAAGCCAAGGTTGAAAACGTCTTAGAGCGTATCCCTTTAGTCAGTAAATACCTGCCAGATACGATCTTGTATTATGCAA
GCAAGCTGTTCCCACAACACCTTCCAAAGCGAATGTTTGAATACCGCGATAAGTACGAGCACCACCTTGTCCTAAAGATG
AGTGATGCTGGCATAGCTGAAGCGAAAAAATACCTTAAAGAGGTTTGGGCCGCAGGACATGACAGTGATTTCTTCGTGTG
TACACCAGAAGAGGGCAAGAAAGCGTACCTGCATCGCTTTGCTGCCGCAGGTGCCGCCATTCGTTACGAAACCATTCACC
GTAAGCAGGTGGAAGACATTGTCGCTCTCGATATTGCGTTACGACGTAACGACAATGAGTGGCTGGAGACTTTACCAGAA
GAAGTAAGCAAGAACTTAGTGAAGTCACTCTATTATGGTCACTTTATGTGTTATGTCTTCCATCAAGACTACGTCTTTAA
GAAGGGTACAGATACCAAGCTGATGAAGAAGCTGATGTTGGAGCATCTGAACAGCCGCGGTGCGAAATATCCAGCAGAGC
ACAACGTAGGGCATTTATACGAAGCGGAAAATTCGTTACAGAAGTTCTACCATCAACTTGATCCAACCAATACCTTTAAC
CCCGGCATAGGTAAAATGGATCGCTACAAGCGCAACTGTAACTGTTGTGCTTAA

Upstream 100 bases:

>100_bases
TGCACGTTTGCTAATCATGATTTTTGTTATTATTTCTCTTTGGAAACGAGAAATGGTTCAGTCGTTTTTGCCATTATAAT
CGACTGATTTTAAATAATTA

Downstream 100 bases:

>100_bases
GCATTAAGTCAATATGATGTGGAGAGTCGCTTAAACAGCGGATCTTTTTAGTAATAAATGGTGGTAGTAGTCGTTTGAGT
TTTAATCGAATCGCTCAACT

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: Respiratory D-lactate dehydrogenase [H]

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MPLCFGMIIRDANMKQKPLIDAFVTIVGEENVLTDHIKTKYYRSGFRSGGGTALAVIFPNTVLEQWKVIQQCVDNNCIII
MQAAKTGLTEGSAPSGDDYDRDVVVINITKMKQIYLLDGGKQAVCLPGASLHSLEKELRAVNRAPHSIIGSSSLGATVVG
GIANNSGGALVKRGPAYTELALFAQVDKDGQLKLVNHLGIEGLGSTPEEILQNIQEGNKVIHDERMASDKEYEERIRDVT
SDIPSRFNADERRLYEASGCAGKLGVFAVRVDSYPIPEKEQVFYLGTNDPDKLTKLRKDFLTQFENLPEMGEYLHRDIFN
MAEEYGKDVFLSIDLLGTNRLPKLFSLKAKVENVLERIPLVSKYLPDTILYYASKLFPQHLPKRMFEYRDKYEHHLVLKM
SDAGIAEAKKYLKEVWAAGHDSDFFVCTPEEGKKAYLHRFAAAGAAIRYETIHRKQVEDIVALDIALRRNDNEWLETLPE
EVSKNLVKSLYYGHFMCYVFHQDYVFKKGTDTKLMKKLMLEHLNSRGAKYPAEHNVGHLYEAENSLQKFYHQLDPTNTFN
PGIGKMDRYKRNCNCCA

Sequences:

>Translated_577_residues
MPLCFGMIIRDANMKQKPLIDAFVTIVGEENVLTDHIKTKYYRSGFRSGGGTALAVIFPNTVLEQWKVIQQCVDNNCIII
MQAAKTGLTEGSAPSGDDYDRDVVVINITKMKQIYLLDGGKQAVCLPGASLHSLEKELRAVNRAPHSIIGSSSLGATVVG
GIANNSGGALVKRGPAYTELALFAQVDKDGQLKLVNHLGIEGLGSTPEEILQNIQEGNKVIHDERMASDKEYEERIRDVT
SDIPSRFNADERRLYEASGCAGKLGVFAVRVDSYPIPEKEQVFYLGTNDPDKLTKLRKDFLTQFENLPEMGEYLHRDIFN
MAEEYGKDVFLSIDLLGTNRLPKLFSLKAKVENVLERIPLVSKYLPDTILYYASKLFPQHLPKRMFEYRDKYEHHLVLKM
SDAGIAEAKKYLKEVWAAGHDSDFFVCTPEEGKKAYLHRFAAAGAAIRYETIHRKQVEDIVALDIALRRNDNEWLETLPE
EVSKNLVKSLYYGHFMCYVFHQDYVFKKGTDTKLMKKLMLEHLNSRGAKYPAEHNVGHLYEAENSLQKFYHQLDPTNTFN
PGIGKMDRYKRNCNCCA
>Mature_576_residues
PLCFGMIIRDANMKQKPLIDAFVTIVGEENVLTDHIKTKYYRSGFRSGGGTALAVIFPNTVLEQWKVIQQCVDNNCIIIM
QAAKTGLTEGSAPSGDDYDRDVVVINITKMKQIYLLDGGKQAVCLPGASLHSLEKELRAVNRAPHSIIGSSSLGATVVGG
IANNSGGALVKRGPAYTELALFAQVDKDGQLKLVNHLGIEGLGSTPEEILQNIQEGNKVIHDERMASDKEYEERIRDVTS
DIPSRFNADERRLYEASGCAGKLGVFAVRVDSYPIPEKEQVFYLGTNDPDKLTKLRKDFLTQFENLPEMGEYLHRDIFNM
AEEYGKDVFLSIDLLGTNRLPKLFSLKAKVENVLERIPLVSKYLPDTILYYASKLFPQHLPKRMFEYRDKYEHHLVLKMS
DAGIAEAKKYLKEVWAAGHDSDFFVCTPEEGKKAYLHRFAAAGAAIRYETIHRKQVEDIVALDIALRRNDNEWLETLPEE
VSKNLVKSLYYGHFMCYVFHQDYVFKKGTDTKLMKKLMLEHLNSRGAKYPAEHNVGHLYEAENSLQKFYHQLDPTNTFNP
GIGKMDRYKRNCNCCA

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=558, Percent_Identity=56.0931899641577, Blast_Score=673, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 65228; Mature: 65096

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLCFGMIIRDANMKQKPLIDAFVTIVGEENVLTDHIKTKYYRSGFRSGGGTALAVIFPN
CCCEEEEHEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCH
TVLEQWKVIQQCVDNNCIIIMQAAKTGLTEGSAPSGDDYDRDVVVINITKMKQIYLLDGG
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECEEEEEEEECC
KQAVCLPGASLHSLEKELRAVNRAPHSIIGSSSLGATVVGGIANNSGGALVKRGPAYTEL
CEEEEECCHHHHHHHHHHHHHHCCCCHHCCCCCCCCEEECCCCCCCCCCEEECCCCHHHH
ALFAQVDKDGQLKLVNHLGIEGLGSTPEEILQNIQEGNKVIHDERMASDKEYEERIRDVT
HHHEEECCCCCEEEHHHCCCCCCCCCHHHHHHHHHHCCCEEHHHHHCCCHHHHHHHHHHH
SDIPSRFNADERRLYEASGCAGKLGVFAVRVDSYPIPEKEQVFYLGTNDPDKLTKLRKDF
HHHHHHCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHH
LTQFENLPEMGEYLHRDIFNMAEEYGKDVFLSIDLLGTNRLPKLFSLKAKVENVLERIPL
HHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCH
VSKYLPDTILYYASKLFPQHLPKRMFEYRDKYEHHLVLKMSDAGIAEAKKYLKEVWAAGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCC
DSDFFVCTPEEGKKAYLHRFAAAGAAIRYETIHRKQVEDIVALDIALRRNDNEWLETLPE
CCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
EVSKNLVKSLYYGHFMCYVFHQDYVFKKGTDTKLMKKLMLEHLNSRGAKYPAEHNVGHLY
HHHHHHHHHHHHHHHEEEEEECCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
EAENSLQKFYHQLDPTNTFNPGIGKMDRYKRNCNCCA
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
PLCFGMIIRDANMKQKPLIDAFVTIVGEENVLTDHIKTKYYRSGFRSGGGTALAVIFPN
CCEEEEHEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCH
TVLEQWKVIQQCVDNNCIIIMQAAKTGLTEGSAPSGDDYDRDVVVINITKMKQIYLLDGG
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECEEEEEEEECC
KQAVCLPGASLHSLEKELRAVNRAPHSIIGSSSLGATVVGGIANNSGGALVKRGPAYTEL
CEEEEECCHHHHHHHHHHHHHHCCCCHHCCCCCCCCEEECCCCCCCCCCEEECCCCHHHH
ALFAQVDKDGQLKLVNHLGIEGLGSTPEEILQNIQEGNKVIHDERMASDKEYEERIRDVT
HHHEEECCCCCEEEHHHCCCCCCCCCHHHHHHHHHHCCCEEHHHHHCCCHHHHHHHHHHH
SDIPSRFNADERRLYEASGCAGKLGVFAVRVDSYPIPEKEQVFYLGTNDPDKLTKLRKDF
HHHHHHCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHH
LTQFENLPEMGEYLHRDIFNMAEEYGKDVFLSIDLLGTNRLPKLFSLKAKVENVLERIPL
HHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCH
VSKYLPDTILYYASKLFPQHLPKRMFEYRDKYEHHLVLKMSDAGIAEAKKYLKEVWAAGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCC
DSDFFVCTPEEGKKAYLHRFAAAGAAIRYETIHRKQVEDIVALDIALRRNDNEWLETLPE
CCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
EVSKNLVKSLYYGHFMCYVFHQDYVFKKGTDTKLMKKLMLEHLNSRGAKYPAEHNVGHLY
HHHHHHHHHHHHHHHEEEEEECCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
EAENSLQKFYHQLDPTNTFNPGIGKMDRYKRNCNCCA
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6386470; 3882663; 9278503; 10944213 [H]