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The map label for this gene is ptxR [H]

Identifier: 156976826

GI number: 156976826

Start: 802806

End: 803708

Strand: Direct

Name: ptxR [H]

Synonym: VIBHAR_05602

Alternate gene names: 156976826

Gene position: 802806-803708 (Clockwise)

Preceding gene: 156976824

Following gene: 156976827

Centisome position: 36.42

GC content: 40.86

Gene sequence:

>903_bases
ATGACTTTTTTGATGAACTTAATTACGCTAATTAAATCGTTTATTTGCACCGTAGAGGAAGGCAGTTTTACTGGCGCATC
TAAGAAACTAGGTGTGTCTAAATCTCTAGTGAGTCGCAATGTTAGAGATCTAGAAACTTATCTTGGAACGCGATTAATGA
ACCGCTCAACCAAGGCACTCTCTCTTACGGACGCTGGTCATCAGTATTACCAAGAGGCACATGTTCTGATTCTGCAACTT
GAAGCGCTGAACGACACTATGAAATTTAATAGTAATGACATTTCTGGCACTTTAAATATTCTCGCACCAAATGGTTTGAC
AGAAATCATACTCATGCCGTTTATTTGCAGTTTCAGTGATAAATACCCGGAGCTAAGATTGAATTTGCTGCTCGATGATG
GCCTAGATGATCTCTCCTCTCAAGGGTATGACGTAGCTATTCGTTCTGGTCATTTGGTAAAGCAAGACTCTGATTTGATC
GCAACAAAGATTACAGAAAACATGAGTGTGATTTGTGCAACGCCGCAATACTTAGAAAACACCTCCTCACTTTTGCACCC
CCGAGATCTGCATTCTCATCGAATTATCGAAGACCCAAACTTAAAAAATTATAAGTTGTGGCGATTTAACAAAATGGGAA
AAGAGCTTGATGTGCAAGTATCGCCATCTCTTTGCGTTAACAGTGTACAGGCCGTGAAAACTGCGCTGAAGCAAAACTAT
GGAGTTGCAATGCTTCCAAGAGCCTTTGTAGAAGATGAGCTTTGTAGGGGCGAGTTTATAGAAGTACTAAAAGACTACCA
ATTGCCAACGAGAATGGTCTACGCGCTTTATAGAGGACGCTCTAACACACCGAGAAAGGTCAAAGTCTTTATCGAAGAGC
TAAGAGCGTACTTTGTACTTTGA

Upstream 100 bases:

>100_bases
TTATCCTATTGTTGCTTGTTGAGTTGCTTGAATTTTTGATCAGAAAATGATGCTTGAACAGGTCAGATAAGGTCGATAGT
ATGTCAACAAATAGTAAACA

Downstream 100 bases:

>100_bases
TGTTTGTTCGCTTCTGAGTATCCACATGTTCTATGTTTATCGTTATTGAAACCAGGAGTGAGATTATCGATTAGCTTGTT
TACTTTTTGATTCAACCAAG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTFLMNLITLIKSFICTVEEGSFTGASKKLGVSKSLVSRNVRDLETYLGTRLMNRSTKALSLTDAGHQYYQEAHVLILQL
EALNDTMKFNSNDISGTLNILAPNGLTEIILMPFICSFSDKYPELRLNLLLDDGLDDLSSQGYDVAIRSGHLVKQDSDLI
ATKITENMSVICATPQYLENTSSLLHPRDLHSHRIIEDPNLKNYKLWRFNKMGKELDVQVSPSLCVNSVQAVKTALKQNY
GVAMLPRAFVEDELCRGEFIEVLKDYQLPTRMVYALYRGRSNTPRKVKVFIEELRAYFVL

Sequences:

>Translated_300_residues
MTFLMNLITLIKSFICTVEEGSFTGASKKLGVSKSLVSRNVRDLETYLGTRLMNRSTKALSLTDAGHQYYQEAHVLILQL
EALNDTMKFNSNDISGTLNILAPNGLTEIILMPFICSFSDKYPELRLNLLLDDGLDDLSSQGYDVAIRSGHLVKQDSDLI
ATKITENMSVICATPQYLENTSSLLHPRDLHSHRIIEDPNLKNYKLWRFNKMGKELDVQVSPSLCVNSVQAVKTALKQNY
GVAMLPRAFVEDELCRGEFIEVLKDYQLPTRMVYALYRGRSNTPRKVKVFIEELRAYFVL
>Mature_299_residues
TFLMNLITLIKSFICTVEEGSFTGASKKLGVSKSLVSRNVRDLETYLGTRLMNRSTKALSLTDAGHQYYQEAHVLILQLE
ALNDTMKFNSNDISGTLNILAPNGLTEIILMPFICSFSDKYPELRLNLLLDDGLDDLSSQGYDVAIRSGHLVKQDSDLIA
TKITENMSVICATPQYLENTSSLLHPRDLHSHRIIEDPNLKNYKLWRFNKMGKELDVQVSPSLCVNSVQAVKTALKQNYG
VAMLPRAFVEDELCRGEFIEVLKDYQLPTRMVYALYRGRSNTPRKVKVFIEELRAYFVL

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=295, Percent_Identity=31.5254237288136, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786401, Length=280, Percent_Identity=30.7142857142857, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI145693193, Length=292, Percent_Identity=30.8219178082192, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787128, Length=288, Percent_Identity=28.125, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787589, Length=288, Percent_Identity=27.7777777777778, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87081978, Length=297, Percent_Identity=26.2626262626263, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789440, Length=281, Percent_Identity=26.3345195729537, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1787601, Length=171, Percent_Identity=24.5614035087719, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789173, Length=255, Percent_Identity=23.5294117647059, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788706, Length=306, Percent_Identity=23.8562091503268, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI157672245, Length=119, Percent_Identity=32.7731092436975, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI87082132, Length=291, Percent_Identity=25.7731958762887, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790011, Length=282, Percent_Identity=22.6950354609929, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788748, Length=120, Percent_Identity=30.8333333333333, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33998; Mature: 33867

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLMNLITLIKSFICTVEEGSFTGASKKLGVSKSLVSRNVRDLETYLGTRLMNRSTKAL
CHHHHHHHHHHHHHHEECCCCCCCCCCHHCCCHHHHHHCCHHHHHHHHHHHHHCCCCCEE
SLTDAGHQYYQEAHVLILQLEALNDTMKFNSNDISGTLNILAPNGLTEIILMPFICSFSD
EECHHHHHHHHHHHEEEEEEEHHCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCC
KYPELRLNLLLDDGLDDLSSQGYDVAIRSGHLVKQDSDLIATKITENMSVICATPQYLEN
CCCCEEEEEEECCCCHHHHCCCCEEEEECCEEEECCCCHHEEECCCCCEEEECCHHHHHH
TSSLLHPRDLHSHRIIEDPNLKNYKLWRFNKMGKELDVQVSPSLCVNSVQAVKTALKQNY
HHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECHHHHHHHHHHHHHHHHHCC
GVAMLPRAFVEDELCRGEFIEVLKDYQLPTRMVYALYRGRSNTPRKVKVFIEELRAYFVL
CEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TFLMNLITLIKSFICTVEEGSFTGASKKLGVSKSLVSRNVRDLETYLGTRLMNRSTKAL
HHHHHHHHHHHHHHEECCCCCCCCCCHHCCCHHHHHHCCHHHHHHHHHHHHHCCCCCEE
SLTDAGHQYYQEAHVLILQLEALNDTMKFNSNDISGTLNILAPNGLTEIILMPFICSFSD
EECHHHHHHHHHHHEEEEEEEHHCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCC
KYPELRLNLLLDDGLDDLSSQGYDVAIRSGHLVKQDSDLIATKITENMSVICATPQYLEN
CCCCEEEEEEECCCCHHHHCCCCEEEEECCEEEECCCCHHEEECCCCCEEEECCHHHHHH
TSSLLHPRDLHSHRIIEDPNLKNYKLWRFNKMGKELDVQVSPSLCVNSVQAVKTALKQNY
HHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECHHHHHHHHHHHHHHHHHCC
GVAMLPRAFVEDELCRGEFIEVLKDYQLPTRMVYALYRGRSNTPRKVKVFIEELRAYFVL
CEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]