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The map label for this gene is mprA [H]

Identifier: 156976795

GI number: 156976795

Start: 771316

End: 772044

Strand: Direct

Name: mprA [H]

Synonym: VIBHAR_05570

Alternate gene names: 156976795

Gene position: 771316-772044 (Clockwise)

Preceding gene: 156976792

Following gene: 156976796

Centisome position: 35.0

GC content: 43.35

Gene sequence:

>729_bases
ATGAATTTGGTTGTATCTTATGACGCGTATCGTGAAGTGTTCGTGAAGAAACGTGAGCTTATGAAAATATTAATTGTCGA
TGATAATCACAATGTTTCAGAAACTATTGCTGATTATCTAGAACTGGAAGGGATGACGATAGATTGCGCTTACCATGGAG
AGGCTGCGCTAAATTTAATTCAAGAAAATCATTATGATGTCATCATTATGGACATCATGATGCCAAAACTCGATGGCATT
AGTGCGGTTGAGAAACTGCGTCAAGAATTCTTATGTGGAACGCCAATTTTATTCTTAACCGCCAAAGATACCTTAGATGA
CAAAGTGGCTGCTTTTAATGCGGGTGGCGATGACTATTTGATGAAGCCTTTTGCGATGCAAGAGCTTAGCTTGAGAGTTC
ACGCGCTGGCTAATCGAGGCCCAAGACAAGACATCGGCACGCTGAAGTTTGCTGATATTAGCTTGGATGCCCGCACTGAT
GAGGTGACTCGGATGGGTAAACACATCAAGCTCAGTCGCATTCAAACCAAAATCCTGAAGCTATTATTGAAACGTGCTCC
TTCAGCGGTTTCTCGTACTGAAGTGATTGACAGCGTGTGGGGTGATGAGCCGCCGGGAAGTGATGCGCTGAGAAGCCACA
TTTATGGTTTAAGAACGGCACTCGACAAGGGTTTTGATGATTCCAGATTAGAGACGATTCATGGACAAGGTTACCGACTC
AAAGCATAA

Upstream 100 bases:

>100_bases
CCACCATCTCCAGAACCACCACAACCAGATAATGCCAAACCCACTGCCGCTACAAGCGCTAATTTTTTCATGATATCGAC
CTATTTTTGAAAGCTTATTT

Downstream 100 bases:

>100_bases
AGAATACCCAAGTATATATCGCAAGATCCGCTGGGGTTTTGGCTTGATGACCTTTGCTATGTTTACGTTGTTTTGGTCGT
TGATCTACGTTGCTGAGAAC

Product: hypothetical protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MNLVVSYDAYREVFVKKRELMKILIVDDNHNVSETIADYLELEGMTIDCAYHGEAALNLIQENHYDVIIMDIMMPKLDGI
SAVEKLRQEFLCGTPILFLTAKDTLDDKVAAFNAGGDDYLMKPFAMQELSLRVHALANRGPRQDIGTLKFADISLDARTD
EVTRMGKHIKLSRIQTKILKLLLKRAPSAVSRTEVIDSVWGDEPPGSDALRSHIYGLRTALDKGFDDSRLETIHGQGYRL
KA

Sequences:

>Translated_242_residues
MNLVVSYDAYREVFVKKRELMKILIVDDNHNVSETIADYLELEGMTIDCAYHGEAALNLIQENHYDVIIMDIMMPKLDGI
SAVEKLRQEFLCGTPILFLTAKDTLDDKVAAFNAGGDDYLMKPFAMQELSLRVHALANRGPRQDIGTLKFADISLDARTD
EVTRMGKHIKLSRIQTKILKLLLKRAPSAVSRTEVIDSVWGDEPPGSDALRSHIYGLRTALDKGFDDSRLETIHGQGYRL
KA
>Mature_242_residues
MNLVVSYDAYREVFVKKRELMKILIVDDNHNVSETIADYLELEGMTIDCAYHGEAALNLIQENHYDVIIMDIMMPKLDGI
SAVEKLRQEFLCGTPILFLTAKDTLDDKVAAFNAGGDDYLMKPFAMQELSLRVHALANRGPRQDIGTLKFADISLDARTD
EVTRMGKHIKLSRIQTKILKLLLKRAPSAVSRTEVIDSVWGDEPPGSDALRSHIYGLRTALDKGFDDSRLETIHGQGYRL
KA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=33.1838565022422, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=32.2869955156951, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=33.4821428571429, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=30.316742081448, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=29.0178571428571, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=29.7777777777778, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=27.6785714285714, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=33.0396475770925, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788550, Length=113, Percent_Identity=39.8230088495575, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=26.2222222222222, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=26.5217391304348, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=26.457399103139, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=27.5109170305677, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=27.0742358078603, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1790299, Length=106, Percent_Identity=30.188679245283, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=33.0188679245283, Blast_Score=61, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=120, Percent_Identity=32.5, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27225; Mature: 27225

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVVSYDAYREVFVKKRELMKILIVDDNHNVSETIADYLELEGMTIDCAYHGEAALNLI
CCEEEEHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHH
QENHYDVIIMDIMMPKLDGISAVEKLRQEFLCGTPILFLTAKDTLDDKVAAFNAGGDDYL
HCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHEEECCCCCCHH
MKPFAMQELSLRVHALANRGPRQDIGTLKFADISLDARTDEVTRMGKHIKLSRIQTKILK
CCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHCHHHHHHHHHHHHH
LLLKRAPSAVSRTEVIDSVWGDEPPGSDALRSHIYGLRTALDKGFDDSRLETIHGQGYRL
HHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEE
KA
CC
>Mature Secondary Structure
MNLVVSYDAYREVFVKKRELMKILIVDDNHNVSETIADYLELEGMTIDCAYHGEAALNLI
CCEEEEHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHH
QENHYDVIIMDIMMPKLDGISAVEKLRQEFLCGTPILFLTAKDTLDDKVAAFNAGGDDYL
HCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHEEECCCCCCHH
MKPFAMQELSLRVHALANRGPRQDIGTLKFADISLDARTDEVTRMGKHIKLSRIQTKILK
CCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHCHHHHHHHHHHHHH
LLLKRAPSAVSRTEVIDSVWGDEPPGSDALRSHIYGLRTALDKGFDDSRLETIHGQGYRL
HHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEE
KA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA