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The map label for this gene is fkpA [H]

Identifier: 156976616

GI number: 156976616

Start: 615787

End: 616260

Strand: Reverse

Name: fkpA [H]

Synonym: VIBHAR_05390

Alternate gene names: 156976616

Gene position: 616260-615787 (Counterclockwise)

Preceding gene: 156976617

Following gene: 156976614

Centisome position: 27.96

GC content: 46.41

Gene sequence:

>474_bases
GTGTCTAAATTTCTGTTTCCTCTTATTATTTTTGTCCTAGCGGCATTCTTTATCTACCGTACTTGGACGAACCACAAAGT
GGCAGACGAAAACTTTTCGAAGGGTCAAGAATTTCTGCTAGAAAATAGCAAGAAAGAAGGCGTGATTACCACTGAGAGCG
GCCTGCAATACCTTGTACTTGAAAAAGGTACTGGTGACGTTCACCCAGCGGCAAACAGCAAAGTGAAAGTGCACTACCAT
GGCACACTGATCGACGGTACGGTTTTCGATAGCTCTGTAGAGCGCGGCGAGCCAATTACGTTTGGTCTAAACCAAGTAAT
TAAAGGCTGGCAAGAAGGCCTGGAGTACATGGTTGTCGGCGAGAAGATTCGCCTATTCGTACCAAGTACACTTGGCTACG
GTAAAAACGGTTCGGGCCCTATCCCACCAGCAAGCGTGCTGATCTTTGACGTGGAACTATTGGACATCCAATAA

Upstream 100 bases:

>100_bases
GTAAGTACCAAGTGATCACAGGTGGTCATGAAACCGTTGAAGCAATGGCAGACACCATCAACTATCTGCTAAAACAACCA
AAATAAGACAAGGAGCTATT

Downstream 100 bases:

>100_bases
TCCTCAGCAAAAATAAAAGAAAAACGCCGCATCAATTGCGGCGTTTTTTATTGGGTATGGTTTTCTGGCTGAAAGTATTA
CGCTTTCGGATAAAACACTA

Product: peptidyl-prolyl cis-trans isomerase-related protein

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MSKFLFPLIIFVLAAFFIYRTWTNHKVADENFSKGQEFLLENSKKEGVITTESGLQYLVLEKGTGDVHPAANSKVKVHYH
GTLIDGTVFDSSVERGEPITFGLNQVIKGWQEGLEYMVVGEKIRLFVPSTLGYGKNGSGPIPPASVLIFDVELLDIQ

Sequences:

>Translated_157_residues
MSKFLFPLIIFVLAAFFIYRTWTNHKVADENFSKGQEFLLENSKKEGVITTESGLQYLVLEKGTGDVHPAANSKVKVHYH
GTLIDGTVFDSSVERGEPITFGLNQVIKGWQEGLEYMVVGEKIRLFVPSTLGYGKNGSGPIPPASVLIFDVELLDIQ
>Mature_156_residues
SKFLFPLIIFVLAAFFIYRTWTNHKVADENFSKGQEFLLENSKKEGVITTESGLQYLVLEKGTGDVHPAANSKVKVHYHG
TLIDGTVFDSSVERGEPITFGLNQVIKGWQEGLEYMVVGEKIRLFVPSTLGYGKNGSGPIPPASVLIFDVELLDIQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=84, Percent_Identity=52.3809523809524, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI17149844, Length=84, Percent_Identity=52.3809523809524, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI17149842, Length=84, Percent_Identity=52.3809523809524, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=41.1214953271028, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=41.1214953271028, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI8923659, Length=86, Percent_Identity=50, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=39.2523364485981, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI33469985, Length=85, Percent_Identity=45.8823529411765, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI4503729, Length=109, Percent_Identity=38.5321100917431, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI4503727, Length=109, Percent_Identity=41.2844036697248, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI224809329, Length=109, Percent_Identity=41.2844036697248, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI224809327, Length=109, Percent_Identity=41.2844036697248, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI4758384, Length=109, Percent_Identity=41.2844036697248, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI224809331, Length=109, Percent_Identity=41.2844036697248, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI7706131, Length=122, Percent_Identity=36.8852459016393, Blast_Score=73, Evalue=8e-14,
Organism=Homo sapiens, GI192448443, Length=85, Percent_Identity=48.2352941176471, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI87082390, Length=125, Percent_Identity=56, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1789745, Length=133, Percent_Identity=48.8721804511278, Blast_Score=116, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17540882, Length=87, Percent_Identity=55.1724137931034, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17561782, Length=107, Percent_Identity=44.8598130841121, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=41.5094339622642, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=56.8181818181818, Blast_Score=98, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324194, Length=109, Percent_Identity=44.954128440367, Blast_Score=89, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323482, Length=92, Percent_Identity=39.1304347826087, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=44.8598130841121, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281363946, Length=84, Percent_Identity=55.952380952381, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17352457, Length=84, Percent_Identity=55.952380952381, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24583150, Length=109, Percent_Identity=40.3669724770642, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356629, Length=87, Percent_Identity=50.5747126436782, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17422; Mature: 17291

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFLFPLIIFVLAAFFIYRTWTNHKVADENFSKGQEFLLENSKKEGVITTESGLQYLVL
CCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHCCCCCCCEEEECCCCEEEEE
EKGTGDVHPAANSKVKVHYHGTLIDGTVFDSSVERGEPITFGLNQVIKGWQEGLEYMVVG
ECCCCCCCCCCCCEEEEEECCEEEECEEECCCCCCCCCEEECHHHHHHHHHHCCEEEEEC
EKIRLFVPSTLGYGKNGSGPIPPASVLIFDVELLDIQ
CEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEEECC
>Mature Secondary Structure 
SKFLFPLIIFVLAAFFIYRTWTNHKVADENFSKGQEFLLENSKKEGVITTESGLQYLVL
CCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHCCCCCCCEEEECCCCEEEEE
EKGTGDVHPAANSKVKVHYHGTLIDGTVFDSSVERGEPITFGLNQVIKGWQEGLEYMVVG
ECCCCCCCCCCCCEEEEEECCEEEECEEECCCCCCCCCEEECHHHHHHHHHHCCEEEEEC
EKIRLFVPSTLGYGKNGSGPIPPASVLIFDVELLDIQ
CEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]