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The map label for this gene is hmuU [H]

Identifier: 156976467

GI number: 156976467

Start: 491899

End: 492936

Strand: Reverse

Name: hmuU [H]

Synonym: VIBHAR_05240

Alternate gene names: 156976467

Gene position: 492936-491899 (Counterclockwise)

Preceding gene: 156976468

Following gene: 156976466

Centisome position: 22.37

GC content: 48.94

Gene sequence:

>1038_bases
ATGCTGTTAAGACGTCTGCCTTTATCTACTACCCTACTTGCGTTGTCTGGTGTTTTAGCCTTTATCGCAGTAGCGTCCAT
AACCGTTGGTCCAATGAATATAAGCTTCTCAGATAGCCTGAGAAGCTTAACCGGAGCAGGTTCAGACCTTGCTCCTCACA
TCCAACTCGTTATCAACGAAATACGACTCCCGCGCACCATTCTCTGTATGTTTATCGGTGCGATCCTCGCTATCTGTGGT
GTCGTGATGCAGGGATTATTCCGAAACCCTCTTGCCGAGCCCGGCATCATCGGCGTTTCCGCTGGTGCAGCACTTGGTGG
TGCATTTGCCATTGTCGTATTTGCTGACTTTAGCCAAAACTATCCGACACTCATGAACTTGGCGGCGTTACCATTCTTCG
CTTTCTTGGGTGGCGCTCTTACAACCGTATTGGTTTACTGGCTAGGAACAAACAAGTTTGGTACGTCAGTAACCATCATG
CTACTGGCTGGTGTCGCTATCAGTGCACTATCTGGTGCTGCTATTGGTTTTATGAACTTCATCGCTGACGACCAGATGCT
GCGTGACTTAACGCTTTGGTCGATGGGCTCGTTAGCAGGCGCCAACTGGTCAGGGATTGCTTTAGCAGCCGTGACACTAG
TACTGCTGATGTTCTGGTTCCAGAAAAAAGCCATGTCACTCAACGCATTGCTCTTAGGTGAGTCAGAAGCTAAGCATCTT
GGCGTTCCCGTTCAAAAGCTTAAACGACAACTTATCCTTTTATCGGCAGTGGGTGTTGGTATCACGGTAAGTATTAGCGG
TGCCATTGGCTTTATTGGCCTAGTGATACCTCACTTAGGTCGTATGCTTGCTGGTCCTGACCATCGTACACTGCTTCCTA
TCTCAGCACTGATGGGCGCATTGCTTCTTACTGCGGCAGATATGTTTGCTCGCGTAGTGGTGGCTCCTGCAGAGCTTCCT
GTCGGTATCGTCACCGCTCTGATCGGCGCACCGTTCTTTATCTACTTACTGTTCCAACAAAAAGGGAAGATTCTGTAA

Upstream 100 bases:

>100_bases
CGTGACAATCGATGGTCATGCGCTGGTTGGCGGCTTAGGGCTTAAAAGCCTGTCTGAAGCGAAGCGTTTGAATGAACTGC
TTTACCCGTAGAGAGTTTCA

Downstream 100 bases:

>100_bases
TGAACAACATCGTTTTGTCTGGCAGAAATATCTCAATGAGGTACGGAAGCCGAGTGGTATTAGACAACGTCAGTATTGAT
ATTCGTGCAGGAGAAGTGAC

Product: ABC-type Fe3+-siderophore transporter permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MLLRRLPLSTTLLALSGVLAFIAVASITVGPMNISFSDSLRSLTGAGSDLAPHIQLVINEIRLPRTILCMFIGAILAICG
VVMQGLFRNPLAEPGIIGVSAGAALGGAFAIVVFADFSQNYPTLMNLAALPFFAFLGGALTTVLVYWLGTNKFGTSVTIM
LLAGVAISALSGAAIGFMNFIADDQMLRDLTLWSMGSLAGANWSGIALAAVTLVLLMFWFQKKAMSLNALLLGESEAKHL
GVPVQKLKRQLILLSAVGVGITVSISGAIGFIGLVIPHLGRMLAGPDHRTLLPISALMGALLLTAADMFARVVVAPAELP
VGIVTALIGAPFFIYLLFQQKGKIL

Sequences:

>Translated_345_residues
MLLRRLPLSTTLLALSGVLAFIAVASITVGPMNISFSDSLRSLTGAGSDLAPHIQLVINEIRLPRTILCMFIGAILAICG
VVMQGLFRNPLAEPGIIGVSAGAALGGAFAIVVFADFSQNYPTLMNLAALPFFAFLGGALTTVLVYWLGTNKFGTSVTIM
LLAGVAISALSGAAIGFMNFIADDQMLRDLTLWSMGSLAGANWSGIALAAVTLVLLMFWFQKKAMSLNALLLGESEAKHL
GVPVQKLKRQLILLSAVGVGITVSISGAIGFIGLVIPHLGRMLAGPDHRTLLPISALMGALLLTAADMFARVVVAPAELP
VGIVTALIGAPFFIYLLFQQKGKIL
>Mature_345_residues
MLLRRLPLSTTLLALSGVLAFIAVASITVGPMNISFSDSLRSLTGAGSDLAPHIQLVINEIRLPRTILCMFIGAILAICG
VVMQGLFRNPLAEPGIIGVSAGAALGGAFAIVVFADFSQNYPTLMNLAALPFFAFLGGALTTVLVYWLGTNKFGTSVTIM
LLAGVAISALSGAAIGFMNFIADDQMLRDLTLWSMGSLAGANWSGIALAAVTLVLLMFWFQKKAMSLNALLLGESEAKHL
GVPVQKLKRQLILLSAVGVGITVSISGAIGFIGLVIPHLGRMLAGPDHRTLLPISALMGALLLTAADMFARVVVAPAELP
VGIVTALIGAPFFIYLLFQQKGKIL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=293, Percent_Identity=39.9317406143345, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1790740, Length=285, Percent_Identity=38.5964912280702, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1790741, Length=308, Percent_Identity=33.4415584415584, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786805, Length=290, Percent_Identity=37.2413793103448, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1786804, Length=340, Percent_Identity=28.8235294117647, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786347, Length=280, Percent_Identity=31.7857142857143, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36100; Mature: 36100

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRRLPLSTTLLALSGVLAFIAVASITVGPMNISFSDSLRSLTGAGSDLAPHIQLVINE
CCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
IRLPRTILCMFIGAILAICGVVMQGLFRNPLAEPGIIGVSAGAALGGAFAIVVFADFSQN
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHCCCEEEEEEECCCCC
YPTLMNLAALPFFAFLGGALTTVLVYWLGTNKFGTSVTIMLLAGVAISALSGAAIGFMNF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IADDQMLRDLTLWSMGSLAGANWSGIALAAVTLVLLMFWFQKKAMSLNALLLGESEAKHL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHC
GVPVQKLKRQLILLSAVGVGITVSISGAIGFIGLVIPHLGRMLAGPDHRTLLPISALMGA
CCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LLLTAADMFARVVVAPAELPVGIVTALIGAPFFIYLLFQQKGKIL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLLRRLPLSTTLLALSGVLAFIAVASITVGPMNISFSDSLRSLTGAGSDLAPHIQLVINE
CCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
IRLPRTILCMFIGAILAICGVVMQGLFRNPLAEPGIIGVSAGAALGGAFAIVVFADFSQN
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHCCCEEEEEEECCCCC
YPTLMNLAALPFFAFLGGALTTVLVYWLGTNKFGTSVTIMLLAGVAISALSGAAIGFMNF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IADDQMLRDLTLWSMGSLAGANWSGIALAAVTLVLLMFWFQKKAMSLNALLLGESEAKHL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHC
GVPVQKLKRQLILLSAVGVGITVSISGAIGFIGLVIPHLGRMLAGPDHRTLLPISALMGA
CCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LLLTAADMFARVVVAPAELPVGIVTALIGAPFFIYLLFQQKGKIL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]