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The map label for this gene is argD [H]

Identifier: 156976104

GI number: 156976104

Start: 143559

End: 144938

Strand: Reverse

Name: argD [H]

Synonym: VIBHAR_04875

Alternate gene names: 156976104

Gene position: 144938-143559 (Counterclockwise)

Preceding gene: 156976105

Following gene: 156976103

Centisome position: 6.58

GC content: 50.87

Gene sequence:

>1380_bases
ATGACTCAGAATATCAAACCGACTCATTTCCGCAGCGAAGGCGATGTCAACACAACGCCGGCGCGCCAAGCTTGGAATGC
ATCGATGGACGATGAACGCACGCAAGCATTGTTGAAGCGTGATTCGGAGGTCTTTCTTCATCAAGCCATGTCGACGCCTT
GCCTAGATACCTTGGAAGCAGCAGAAGGCATCTACATCCAAGATGCTAACGGCAAAAAGTACATGGACTTCCATGGCAAT
AACGTCCATCAGCTAGGCTACGGTCATCCACATGTGATTAAACGTGTGCAAAAGCAAATTGCCAAACTGCCGTTTTCACC
ACGTCGTTTTACCAACGAGACCGCGATTAAATGTGCCGAAAAACTCACCCAAATCTGTGGCGGCGAATTGAACCGCGTGT
TGTTTGCTCCGGGTGGCACATCTGCGGTTGGCATGGCACTTAAACTAGCGCGCCACATCACGGGCAACTACAAGGTGGTG
TCTCTGTGGGATTCCTTCCACGGCGCATCGTTGGATGCCATCTCAGTAGGTGGCGAAGCGTGTTTCCGTCAAGGCATGGG
ACCATTAATGGCAGGTGTTGAACGCATTCCACCAGCAGTGTCTTACCGAGGCGCTTTTCCAGTCGCGGACGGCAGCGACG
TACATTACGCCGATTACCTCGAATACGTGATTGAGAAAGAAGGCGGCGTGGGCGCGTTTATCGCAGAAGCAGTTCGTAAT
ACCGACGTACAAGTGCCGAGCAAAGCCTACTGGAAACGCATTCGAGAAATCTGTGACAAACACAATGTCATGTTGATCAT
CGACGACATCCCGAATGGCATGGGTCGCAGCGGAGAATGGTTTACCTACCAAGCCTACGACATCGAGCCAGATATACTCT
GCATCGGTAAAGGCTTGGGCGGAGGCTTAGTGCCTATCGCAGCCATGGCAACCAAAGACAAATACAACACCGCCGAGCAA
ATCTCAATGGGTCATTACACTCATGAGAAAAGCCCTATCGGTTGTGCTGCCGCGCTGGCAACCATGGAAGCCATTGAGCA
AGAGGGCTTGCTAGATAAAGTCAAAGTCGACAGCCAGTTCATGCGTGAAAAGCTGCTAGAGATGAAAGCCAAATACCCAG
TAATTGGTGATGTGCGTGGCATCGGCATGTTATGGGGCATTGAGTTGGTCACTGACCACGAAAGCAAAGCACGCGCGTAT
GACGAAGCGGAAGCTGTGTTGTACCAATGCCTCAACAATGGCGTGAGCTTCAAGGTATCGCAAGGTAACGTGATTCAACT
CAGCCCACCGCTGATCATCACTCGCGAACAACTGACAGAAGCGTTGGCGATCTTCGAAAAAGCCATCGCCAAAGTGTGTA
AAGACTTTAACTACTTCTAA

Upstream 100 bases:

>100_bases
GTGAAGTTTACCCAGCAGATATCGAGCGCTTAATCGGTGCGATTGAAAAAGCAATGTATTGGCAAGTTGCGTAAAGCAGC
CTTCTGATTGAGAAAGCGTT

Downstream 100 bases:

>100_bases
CCTCAACAAAAACCAATTTATCCTGAGCGCAGTTCCGACGTGTAGGCAAGCGCTCTCGCAAGTAAGAAAGAAAAAGGATT
GAACATGAGCAACTCACCAA

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTQNIKPTHFRSEGDVNTTPARQAWNASMDDERTQALLKRDSEVFLHQAMSTPCLDTLEAAEGIYIQDANGKKYMDFHGN
NVHQLGYGHPHVIKRVQKQIAKLPFSPRRFTNETAIKCAEKLTQICGGELNRVLFAPGGTSAVGMALKLARHITGNYKVV
SLWDSFHGASLDAISVGGEACFRQGMGPLMAGVERIPPAVSYRGAFPVADGSDVHYADYLEYVIEKEGGVGAFIAEAVRN
TDVQVPSKAYWKRIREICDKHNVMLIIDDIPNGMGRSGEWFTYQAYDIEPDILCIGKGLGGGLVPIAAMATKDKYNTAEQ
ISMGHYTHEKSPIGCAAALATMEAIEQEGLLDKVKVDSQFMREKLLEMKAKYPVIGDVRGIGMLWGIELVTDHESKARAY
DEAEAVLYQCLNNGVSFKVSQGNVIQLSPPLIITREQLTEALAIFEKAIAKVCKDFNYF

Sequences:

>Translated_459_residues
MTQNIKPTHFRSEGDVNTTPARQAWNASMDDERTQALLKRDSEVFLHQAMSTPCLDTLEAAEGIYIQDANGKKYMDFHGN
NVHQLGYGHPHVIKRVQKQIAKLPFSPRRFTNETAIKCAEKLTQICGGELNRVLFAPGGTSAVGMALKLARHITGNYKVV
SLWDSFHGASLDAISVGGEACFRQGMGPLMAGVERIPPAVSYRGAFPVADGSDVHYADYLEYVIEKEGGVGAFIAEAVRN
TDVQVPSKAYWKRIREICDKHNVMLIIDDIPNGMGRSGEWFTYQAYDIEPDILCIGKGLGGGLVPIAAMATKDKYNTAEQ
ISMGHYTHEKSPIGCAAALATMEAIEQEGLLDKVKVDSQFMREKLLEMKAKYPVIGDVRGIGMLWGIELVTDHESKARAY
DEAEAVLYQCLNNGVSFKVSQGNVIQLSPPLIITREQLTEALAIFEKAIAKVCKDFNYF
>Mature_458_residues
TQNIKPTHFRSEGDVNTTPARQAWNASMDDERTQALLKRDSEVFLHQAMSTPCLDTLEAAEGIYIQDANGKKYMDFHGNN
VHQLGYGHPHVIKRVQKQIAKLPFSPRRFTNETAIKCAEKLTQICGGELNRVLFAPGGTSAVGMALKLARHITGNYKVVS
LWDSFHGASLDAISVGGEACFRQGMGPLMAGVERIPPAVSYRGAFPVADGSDVHYADYLEYVIEKEGGVGAFIAEAVRNT
DVQVPSKAYWKRIREICDKHNVMLIIDDIPNGMGRSGEWFTYQAYDIEPDILCIGKGLGGGLVPIAAMATKDKYNTAEQI
SMGHYTHEKSPIGCAAALATMEAIEQEGLLDKVKVDSQFMREKLLEMKAKYPVIGDVRGIGMLWGIELVTDHESKARAYD
EAEAVLYQCLNNGVSFKVSQGNVIQLSPPLIITREQLTEALAIFEKAIAKVCKDFNYF

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=410, Percent_Identity=31.4634146341463, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=29.7560975609756, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI226442705, Length=410, Percent_Identity=30.4878048780488, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI226442709, Length=386, Percent_Identity=30.8290155440415, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI24119277, Length=396, Percent_Identity=28.7878787878788, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI284507298, Length=318, Percent_Identity=29.559748427673, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI13994255, Length=422, Percent_Identity=26.0663507109005, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1789759, Length=398, Percent_Identity=31.6582914572864, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI1788044, Length=403, Percent_Identity=29.7766749379653, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI145693181, Length=392, Percent_Identity=28.8265306122449, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789016, Length=409, Percent_Identity=28.1173594132029, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1787560, Length=409, Percent_Identity=26.161369193154, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1786349, Length=350, Percent_Identity=28, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786991, Length=434, Percent_Identity=25.3456221198157, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=434, Percent_Identity=28.3410138248848, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71992977, Length=411, Percent_Identity=26.5206812652068, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI32564660, Length=428, Percent_Identity=27.5700934579439, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25144274, Length=424, Percent_Identity=24.5283018867925, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323470, Length=417, Percent_Identity=29.4964028776978, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324432, Length=400, Percent_Identity=28, Blast_Score=133, Evalue=5e-32,
Organism=Drosophila melanogaster, GI21357415, Length=428, Percent_Identity=27.803738317757, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI21356575, Length=411, Percent_Identity=29.683698296837, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI161085790, Length=415, Percent_Identity=27.4698795180723, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI28574759, Length=423, Percent_Identity=26.9503546099291, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 50630; Mature: 50498

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNIKPTHFRSEGDVNTTPARQAWNASMDDERTQALLKRDSEVFLHQAMSTPCLDTLEA
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHH
AEGIYIQDANGKKYMDFHGNNVHQLGYGHPHVIKRVQKQIAKLPFSPRRFTNETAIKCAE
CCCEEEECCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
KLTQICGGELNRVLFAPGGTSAVGMALKLARHITGNYKVVSLWDSFHGASLDAISVGGEA
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCHHH
CFRQGMGPLMAGVERIPPAVSYRGAFPVADGSDVHYADYLEYVIEKEGGVGAFIAEAVRN
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHC
TDVQVPSKAYWKRIREICDKHNVMLIIDDIPNGMGRSGEWFTYQAYDIEPDILCIGKGLG
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEECCCC
GGLVPIAAMATKDKYNTAEQISMGHYTHEKSPIGCAAALATMEAIEQEGLLDKVKVDSQF
CCHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
MREKLLEMKAKYPVIGDVRGIGMLWGIELVTDHESKARAYDEAEAVLYQCLNNGVSFKVS
HHHHHHHHHCCCCCCCCCCCCHHHEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEC
QGNVIQLSPPLIITREQLTEALAIFEKAIAKVCKDFNYF
CCCEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQNIKPTHFRSEGDVNTTPARQAWNASMDDERTQALLKRDSEVFLHQAMSTPCLDTLEA
CCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHH
AEGIYIQDANGKKYMDFHGNNVHQLGYGHPHVIKRVQKQIAKLPFSPRRFTNETAIKCAE
CCCEEEECCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
KLTQICGGELNRVLFAPGGTSAVGMALKLARHITGNYKVVSLWDSFHGASLDAISVGGEA
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCHHH
CFRQGMGPLMAGVERIPPAVSYRGAFPVADGSDVHYADYLEYVIEKEGGVGAFIAEAVRN
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHC
TDVQVPSKAYWKRIREICDKHNVMLIIDDIPNGMGRSGEWFTYQAYDIEPDILCIGKGLG
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEECCCC
GGLVPIAAMATKDKYNTAEQISMGHYTHEKSPIGCAAALATMEAIEQEGLLDKVKVDSQF
CCHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
MREKLLEMKAKYPVIGDVRGIGMLWGIELVTDHESKARAYDEAEAVLYQCLNNGVSFKVS
HHHHHHHHHCCCCCCCCCCCCHHHEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEC
QGNVIQLSPPLIITREQLTEALAIFEKAIAKVCKDFNYF
CCCEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]