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The map label for this gene is argH [H]

Identifier: 156938217

GI number: 156938217

Start: 1284245

End: 1285603

Strand: Direct

Name: argH [H]

Synonym: Igni_1430

Alternate gene names: 156938217

Gene position: 1284245-1285603 (Clockwise)

Preceding gene: 156938212

Following gene: 156938218

Centisome position: 98.98

GC content: 53.94

Gene sequence:

>1359_bases
TTGGGGTACCGAGGCTACGCCTTGGGCTCACAGCCGCGCTGGCTCGCCGACTTCATTAGCTCTCTCCACTTTGACAAAGA
TATCTGTCCCTACGTTATAGACGTGTTAATAGTGCACATCAACGAGTTGGAGAGGAAAGGTTACGTCTCATCCGAAGACG
CAAAGACCTTAAAGGAGTTGCTGGAGCAGTTCGACTGTTCGGCCGACTTCGACGGCTACGAAGATATACACGAAGCCATA
GAGTACTATTTAATTGAAAGGACCGGCGCCGCCAAGCAGATAAACCTCGGTAAGAGCCGAAACGACCAAGTTGCGACCGC
CATAAGGTTAAGGGTCAGGGAGGAGCTTCTGGAGTCCGCGACCGCGCTGTACCACCTCTTAAAGGCTCTATACGCGAAGG
CCAAACTCCACGAAGAAGTCTTCTTTCCGACGTTCACTCACCTACAGCCCGCCCAGCCGGCCAACTTCGGGCTCTTCTTA
ACCAACTTCGCTGAGGAAATAGTAGACAGTTTCGGACTATTGGAAGTCGCGTTAGAAATTACTGACAAGTGCCCCTTAGG
GGCCGCGGCCGCCGCGGGAAGCACCGTAGACCTAGACCGCCGGAGGAGGTGTGAAGAGCTGTGTTTCAAAGACTTAGCAT
ATAACACGCTTTACGCCACCACTTCGAGGGACTTCGCGCTAGTCTCTTTGGGAGCTCTAGCTAGCCTTTCGATACCCTTG
CTCCGGTTCGTCGAAGACGTGTTCGTTTATGCCACCCCACCTTTCAGCTTGATAAGGGTTCCCTTGGACCACGCCGGAAC
CTCTTCGATAATGCCCCACAAGAAGAACCCGGCGACGCTGGAAGTGGTTAGGGCAGAGCTGTCAAAGCTCCTAGGCCATT
ACGTGTCCGCGTTCAGCATACTAAAGGGACTTACGTCCGGCTACAACCTAGACTTACAACAACTCACGCCGCTCTTGTGG
CAAGCCTTCAAGACCTTTAGGAAATCAGTAATAGTGATAACAGACTTCTTGTGGAAGATGGAAGTCAACGAGGAAAGGGC
GAAGGAATTCTTGAGGTACCCGCTGCTCGCGGCCGACCTCGCCGAGTACCTAGTCAAGAACAAAGGATTGACCTTCAGAG
ACGCTTACGCAACTGTTGCTAGGGCCTTGAAGGAGCACAACGACGACCTAGCGAGGGCCGCGGAGGGGCTCGTGGGGGAC
GAGTGGAAGGTAGTTGAGAAGGGAGCTTTGACCTTTAGGAAGGCTCCCGGGGCGCCCGGCAACTTAGGTCCCGTGTTCGT
CAAGATAGAACGTGCTATGTCGAGGATAGCGCGCCTCGTCGTGGTCAGAGAGGAGCTACGGCAGTGTCCTAACTCTTAA

Upstream 100 bases:

>100_bases
AGTCTTCGGCTGCCTTGATCCAAGGGTCCACTCGCTCTAACACCTCCATTTGGTTGCTAACATTAGGTACCCCAAAAACT
CTGATCGGAGGAGTGAGGGG

Downstream 100 bases:

>100_bases
CTTCGCCTTTTGGCTCTGCTCCCGGTAAGAGTCTTGGCGAAGGAACTCCGACTGAGGGTCGCTGAGGCAAAACAGAGGGA
CGTCGGGAGAAAGATCGCTA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MGYRGYALGSQPRWLADFISSLHFDKDICPYVIDVLIVHINELERKGYVSSEDAKTLKELLEQFDCSADFDGYEDIHEAI
EYYLIERTGAAKQINLGKSRNDQVATAIRLRVREELLESATALYHLLKALYAKAKLHEEVFFPTFTHLQPAQPANFGLFL
TNFAEEIVDSFGLLEVALEITDKCPLGAAAAAGSTVDLDRRRRCEELCFKDLAYNTLYATTSRDFALVSLGALASLSIPL
LRFVEDVFVYATPPFSLIRVPLDHAGTSSIMPHKKNPATLEVVRAELSKLLGHYVSAFSILKGLTSGYNLDLQQLTPLLW
QAFKTFRKSVIVITDFLWKMEVNEERAKEFLRYPLLAADLAEYLVKNKGLTFRDAYATVARALKEHNDDLARAAEGLVGD
EWKVVEKGALTFRKAPGAPGNLGPVFVKIERAMSRIARLVVVREELRQCPNS

Sequences:

>Translated_452_residues
MGYRGYALGSQPRWLADFISSLHFDKDICPYVIDVLIVHINELERKGYVSSEDAKTLKELLEQFDCSADFDGYEDIHEAI
EYYLIERTGAAKQINLGKSRNDQVATAIRLRVREELLESATALYHLLKALYAKAKLHEEVFFPTFTHLQPAQPANFGLFL
TNFAEEIVDSFGLLEVALEITDKCPLGAAAAAGSTVDLDRRRRCEELCFKDLAYNTLYATTSRDFALVSLGALASLSIPL
LRFVEDVFVYATPPFSLIRVPLDHAGTSSIMPHKKNPATLEVVRAELSKLLGHYVSAFSILKGLTSGYNLDLQQLTPLLW
QAFKTFRKSVIVITDFLWKMEVNEERAKEFLRYPLLAADLAEYLVKNKGLTFRDAYATVARALKEHNDDLARAAEGLVGD
EWKVVEKGALTFRKAPGAPGNLGPVFVKIERAMSRIARLVVVREELRQCPNS
>Mature_451_residues
GYRGYALGSQPRWLADFISSLHFDKDICPYVIDVLIVHINELERKGYVSSEDAKTLKELLEQFDCSADFDGYEDIHEAIE
YYLIERTGAAKQINLGKSRNDQVATAIRLRVREELLESATALYHLLKALYAKAKLHEEVFFPTFTHLQPAQPANFGLFLT
NFAEEIVDSFGLLEVALEITDKCPLGAAAAAGSTVDLDRRRRCEELCFKDLAYNTLYATTSRDFALVSLGALASLSIPLL
RFVEDVFVYATPPFSLIRVPLDHAGTSSIMPHKKNPATLEVVRAELSKLLGHYVSAFSILKGLTSGYNLDLQQLTPLLWQ
AFKTFRKSVIVITDFLWKMEVNEERAKEFLRYPLLAADLAEYLVKNKGLTFRDAYATVARALKEHNDDLARAAEGLVGDE
WKVVEKGALTFRKAPGAPGNLGPVFVKIERAMSRIARLVVVREELRQCPNS

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=312, Percent_Identity=35.2564102564103, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI68303542, Length=312, Percent_Identity=35.2564102564103, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI68303549, Length=311, Percent_Identity=31.8327974276527, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI68303547, Length=312, Percent_Identity=32.0512820512821, Blast_Score=148, Evalue=8e-36,
Organism=Escherichia coli, GI1790398, Length=314, Percent_Identity=33.4394904458599, Blast_Score=161, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6321806, Length=389, Percent_Identity=30.5912596401028, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI221473854, Length=379, Percent_Identity=31.6622691292876, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI78706858, Length=379, Percent_Identity=31.6622691292876, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 50732; Mature: 50601

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYRGYALGSQPRWLADFISSLHFDKDICPYVIDVLIVHINELERKGYVSSEDAKTLKEL
CCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LEQFDCSADFDGYEDIHEAIEYYLIERTGAAKQINLGKSRNDQVATAIRLRVREELLESA
HHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHH
TALYHLLKALYAKAKLHEEVFFPTFTHLQPAQPANFGLFLTNFAEEIVDSFGLLEVALEI
HHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TDKCPLGAAAAAGSTVDLDRRRRCEELCFKDLAYNTLYATTSRDFALVSLGALASLSIPL
HCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHH
LRFVEDVFVYATPPFSLIRVPLDHAGTSSIMPHKKNPATLEVVRAELSKLLGHYVSAFSI
HHHHHHHHHCCCCCHHEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LKGLTSGYNLDLQQLTPLLWQAFKTFRKSVIVITDFLWKMEVNEERAKEFLRYPLLAADL
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHH
AEYLVKNKGLTFRDAYATVARALKEHNDDLARAAEGLVGDEWKVVEKGALTFRKAPGAPG
HHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHCCHHEECCCCCCC
NLGPVFVKIERAMSRIARLVVVREELRQCPNS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GYRGYALGSQPRWLADFISSLHFDKDICPYVIDVLIVHINELERKGYVSSEDAKTLKEL
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LEQFDCSADFDGYEDIHEAIEYYLIERTGAAKQINLGKSRNDQVATAIRLRVREELLESA
HHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHH
TALYHLLKALYAKAKLHEEVFFPTFTHLQPAQPANFGLFLTNFAEEIVDSFGLLEVALEI
HHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TDKCPLGAAAAAGSTVDLDRRRRCEELCFKDLAYNTLYATTSRDFALVSLGALASLSIPL
HCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHH
LRFVEDVFVYATPPFSLIRVPLDHAGTSSIMPHKKNPATLEVVRAELSKLLGHYVSAFSI
HHHHHHHHHCCCCCHHEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LKGLTSGYNLDLQQLTPLLWQAFKTFRKSVIVITDFLWKMEVNEERAKEFLRYPLLAADL
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHH
AEYLVKNKGLTFRDAYATVARALKEHNDDLARAAEGLVGDEWKVVEKGALTFRKAPGAPG
HHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHCCHHEECCCCCCC
NLGPVFVKIERAMSRIARLVVVREELRQCPNS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA