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The map label for this gene is 156938160

Identifier: 156938160

GI number: 156938160

Start: 1229191

End: 1229982

Strand: Reverse

Name: 156938160

Synonym: Igni_1373

Alternate gene names: NA

Gene position: 1229982-1229191 (Counterclockwise)

Preceding gene: 156938161

Following gene: 156938159

Centisome position: 94.79

GC content: 58.33

Gene sequence:

>792_bases
TTGGAGGACGTCGTAAAAGCCCTCTCTATTTTGAAGAAGTACGTTGATCAGATAGAGAGTAAGGATCCCCAGTTGAAGGC
AATAAAGAAGGTAGTACAAAGGCACGGGCTCGCGTCCTTAGGGGTCGTGGTGGGCAACGCGCTCGTCAGCTACAGGCTCA
AGGGGACTGGGGAGGAGTACTGGACGGAGTTCGGGGAGTTCTTCAGCTCCCACGAACCAACCGTAGAGAACCTCATAAAG
TTCATCAAAAAGAGTAGGTACAACGTCGCGTTGAAGGAGCAGAAGGTGAGGAGGGTAGAGAGGGTCAAGGAGTTCTTGGA
GAGGGTTTCTGCAAACCCCTTGAGGTACAAGGACTTGGACGCGTTAAGGCAAGAGCTCGCGAGGGTCCTAGGAGCTAAGG
GTACGGAGAAGACCGTGGTGTTCGCCTCTAAAATGGCCTACTACGCGTTCAAGGCCGCCGGCGTCGAGGCCGAGGGGGAC
GTGCCCGTACCCGTGGACAGTAGGGTGGCGACGGTGACTTGCGCCTCCGGACTCGTAGAGGGCACGGTCGAAGAGATAAT
GGGAGCAAAGCGGGACGAGGCGGTGAGGACGTGGGCCCGCGCAGCGAGGGAGGCCGGAATGAAGACCTTGAACCTGGACG
CCGTGATATGGCTCCCCGCCCGAGGGCTGAGGAGGGCCTTGTGCAGAGGCGTGGAGGCCGGTAGGGAGCTGTTCGCCTCC
AACTTGAAGGGGCTAGGGGTGGAGGAGGCGGAAGAAGTGAGCGCTCTCCTCATAAAGAAGGCGTGCTGTTAA

Upstream 100 bases:

>100_bases
GAGCGTGCCGTTAGGAAGGGGATCTTGAGGATCCGCGGCCGCGACTTAATAAATTTGATGTTGAACTACTCCAACAGAGC
CAAGAAGTTCGGTGCGTGAG

Downstream 100 bases:

>100_bases
GCATTTTAAACCCCGGTCATACGTACAACACGGATGAAATCTGGTGGGCCCGTAGCTCAGCCAGGCAGAGCGGCGGGCTC
CAGACGAAATCTACGGGTCT

Product: N-glycosylase/DNA lyase

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; AGOG; DNA-(apurinic or apyrimidinic site) lyase; AP lyase; Pa-AGOG [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MEDVVKALSILKKYVDQIESKDPQLKAIKKVVQRHGLASLGVVVGNALVSYRLKGTGEEYWTEFGEFFSSHEPTVENLIK
FIKKSRYNVALKEQKVRRVERVKEFLERVSANPLRYKDLDALRQELARVLGAKGTEKTVVFASKMAYYAFKAAGVEAEGD
VPVPVDSRVATVTCASGLVEGTVEEIMGAKRDEAVRTWARAAREAGMKTLNLDAVIWLPARGLRRALCRGVEAGRELFAS
NLKGLGVEEAEEVSALLIKKACC

Sequences:

>Translated_263_residues
MEDVVKALSILKKYVDQIESKDPQLKAIKKVVQRHGLASLGVVVGNALVSYRLKGTGEEYWTEFGEFFSSHEPTVENLIK
FIKKSRYNVALKEQKVRRVERVKEFLERVSANPLRYKDLDALRQELARVLGAKGTEKTVVFASKMAYYAFKAAGVEAEGD
VPVPVDSRVATVTCASGLVEGTVEEIMGAKRDEAVRTWARAAREAGMKTLNLDAVIWLPARGLRRALCRGVEAGRELFAS
NLKGLGVEEAEEVSALLIKKACC
>Mature_263_residues
MEDVVKALSILKKYVDQIESKDPQLKAIKKVVQRHGLASLGVVVGNALVSYRLKGTGEEYWTEFGEFFSSHEPTVENLIK
FIKKSRYNVALKEQKVRRVERVKEFLERVSANPLRYKDLDALRQELARVLGAKGTEKTVVFASKMAYYAFKAAGVEAEGD
VPVPVDSRVATVTCASGLVEGTVEEIMGAKRDEAVRTWARAAREAGMKTLNLDAVIWLPARGLRRALCRGVEAGRELFAS
NLKGLGVEEAEEVSALLIKKACC

Specific function: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates [H]

COG id: COG4047

COG function: function code S; Uncharacterized protein conserved in archaea

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR023170
- InterPro:   IPR015254
- InterPro:   IPR016544 [H]

Pfam domain/function: PF09171 DUF1886 [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 29089; Mature: 29089

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDVVKALSILKKYVDQIESKDPQLKAIKKVVQRHGLASLGVVVGNALVSYRLKGTGEEY
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHH
WTEFGEFFSSHEPTVENLIKFIKKSRYNVALKEQKVRRVERVKEFLERVSANPLRYKDLD
HHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
ALRQELARVLGAKGTEKTVVFASKMAYYAFKAAGVEAEGDVPVPVDSRVATVTCASGLVE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GTVEEIMGAKRDEAVRTWARAAREAGMKTLNLDAVIWLPARGLRRALCRGVEAGRELFAS
HHHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHH
NLKGLGVEEAEEVSALLIKKACC
HCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEDVVKALSILKKYVDQIESKDPQLKAIKKVVQRHGLASLGVVVGNALVSYRLKGTGEEY
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHH
WTEFGEFFSSHEPTVENLIKFIKKSRYNVALKEQKVRRVERVKEFLERVSANPLRYKDLD
HHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
ALRQELARVLGAKGTEKTVVFASKMAYYAFKAAGVEAEGDVPVPVDSRVATVTCASGLVE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GTVEEIMGAKRDEAVRTWARAAREAGMKTLNLDAVIWLPARGLRRALCRGVEAGRELFAS
HHHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHH
NLKGLGVEEAEEVSALLIKKACC
HCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792869 [H]