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The map label for this gene is guaAA

Identifier: 156938132

GI number: 156938132

Start: 1196710

End: 1197276

Strand: Reverse

Name: guaAA

Synonym: Igni_1345

Alternate gene names: 156938132

Gene position: 1197276-1196710 (Counterclockwise)

Preceding gene: 156938133

Following gene: 156938131

Centisome position: 92.27

GC content: 58.02

Gene sequence:

>567_bases
GTGGTTAAAGTCCTCGTGGTGGCCTTCGGGGGCCAGTACAACCACTTGATAAAGAGGAGTATCGAGAGGATAGGTCACGA
GGCCGCGCTCCGTCCCTACAACCTCCCTCCCCCCGACGAGGGCGAGTTCGACTGCGTGGTCTTTGGAGGCGGTCCCCTAA
CCATGCCTAAGGACTTCGACAAAGTTAAGGGCTTGGAAGCCTACTTGCGTTGGAAGAAGCCGCTGCTGGGCATCTGCTTG
GGCCACCAAGTCTTGGCCCTCTTGAACGGCGGCGAGGTGGGGCCCTCCCCTAAGCCGGAGTACGGCGACGTCACCATATT
CGTAGACGACGAGGACGACATACTGAGGGGGCTGGCCCCCTCCTTTAGGGCTTGGGAGAGCCACAACGAAGAAGTGCTCC
GAGAGCCTCCGAACAGTAAAGTAATAGCCCACAGCGAGAACACCCGGGTGCAAGCCCTCAAATATTACAACGGGCCCTAT
TACGGAGTCCAGTTCCACCCTGAAGTCCAGCACACGGAAAAGGGTTCCTTGGTCTTTCAGAACTTCGTCGAGCTGTGCAA
GAGGTGA

Upstream 100 bases:

>100_bases
AGGGGCTGCAAGCAAGCGAAGGCGAGGCTCGGCCTCAAGTGACGTACTTCACAAAATTTCGTTCATTAATCCACTCCTTT
TTGGCCCTCCGGGGAAGGGA

Downstream 100 bases:

>100_bases
CGTGTATAAATACAGTTTTTTACCCCCGATAGGGCGGGGCGCGAAAGTGTCTCAGACCAAGGGCGTGGAGATCAGTAGGG
CCGAGCTCAAGCGGCTCTTG

Product: glutamine amidotransferase class-I

Products: NA

Alternate protein names: Glutamine amidotransferase

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MVKVLVVAFGGQYNHLIKRSIERIGHEAALRPYNLPPPDEGEFDCVVFGGGPLTMPKDFDKVKGLEAYLRWKKPLLGICL
GHQVLALLNGGEVGPSPKPEYGDVTIFVDDEDDILRGLAPSFRAWESHNEEVLREPPNSKVIAHSENTRVQALKYYNGPY
YGVQFHPEVQHTEKGSLVFQNFVELCKR

Sequences:

>Translated_188_residues
MVKVLVVAFGGQYNHLIKRSIERIGHEAALRPYNLPPPDEGEFDCVVFGGGPLTMPKDFDKVKGLEAYLRWKKPLLGICL
GHQVLALLNGGEVGPSPKPEYGDVTIFVDDEDDILRGLAPSFRAWESHNEEVLREPPNSKVIAHSENTRVQALKYYNGPY
YGVQFHPEVQHTEKGSLVFQNFVELCKR
>Mature_188_residues
MVKVLVVAFGGQYNHLIKRSIERIGHEAALRPYNLPPPDEGEFDCVVFGGGPLTMPKDFDKVKGLEAYLRWKKPLLGICL
GHQVLALLNGGEVGPSPKPEYGDVTIFVDDEDDILRGLAPSFRAWESHNEEVLREPPNSKVIAHSENTRVQALKYYNGPY
YGVQFHPEVQHTEKGSLVFQNFVELCKR

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=186, Percent_Identity=30.1075268817204, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1788854, Length=196, Percent_Identity=26.0204081632653, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1789760, Length=114, Percent_Identity=31.5789473684211, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI133901714, Length=186, Percent_Identity=30.1075268817204, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71992710, Length=186, Percent_Identity=30.1075268817204, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71992717, Length=186, Percent_Identity=30.1075268817204, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323873, Length=186, Percent_Identity=35.4838709677419, Blast_Score=107, Evalue=8e-25,
Organism=Drosophila melanogaster, GI281365319, Length=188, Percent_Identity=27.6595744680851, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAA_IGNH4 (A8AC69)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435928.1
- ProteinModelPortal:   A8AC69
- STRING:   A8AC69
- GeneID:   5563166
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_1345
- eggNOG:   arNOG05587
- HOGENOM:   HBG292341
- OMA:   GQYVHRI
- BioCyc:   IHOS453591:IGNI_1345-MONOMER
- HAMAP:   MF_01510
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096

Pfam domain/function: PF00117 GATase

EC number: =6.3.5.2

Molecular weight: Translated: 21143; Mature: 21143

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 79-79 ACT_SITE 166-166 ACT_SITE 168-168

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVLVVAFGGQYNHLIKRSIERIGHEAALRPYNLPPPDEGEFDCVVFGGGPLTMPKDFD
CEEEEEEEECCCHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHH
KVKGLEAYLRWKKPLLGICLGHQVLALLNGGEVGPSPKPEYGDVTIFVDDEDDILRGLAP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHCCC
SFRAWESHNEEVLREPPNSKVIAHSENTRVQALKYYNGPYYGVQFHPEVQHTEKGSLVFQ
CHHHHHCCCHHHHHCCCCCCEEEECCCCEEEEEEEECCCEECEEECCCCCCCCCCCHHHH
NFVELCKR
HHHHHHCC
>Mature Secondary Structure
MVKVLVVAFGGQYNHLIKRSIERIGHEAALRPYNLPPPDEGEFDCVVFGGGPLTMPKDFD
CEEEEEEEECCCHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHH
KVKGLEAYLRWKKPLLGICLGHQVLALLNGGEVGPSPKPEYGDVTIFVDDEDDILRGLAP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHCCC
SFRAWESHNEEVLREPPNSKVIAHSENTRVQALKYYNGPYYGVQFHPEVQHTEKGSLVFQ
CHHHHHCCCHHHHHCCCCCCEEEECCCCEEEEEEEECCCEECEEECCCCCCCCCCCHHHH
NFVELCKR
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA