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The map label for this gene is atpA

Identifier: 156938092

GI number: 156938092

Start: 1160301

End: 1162091

Strand: Reverse

Name: atpA

Synonym: Igni_1305

Alternate gene names: 156938092

Gene position: 1162091-1160301 (Counterclockwise)

Preceding gene: 156938093

Following gene: 156938090

Centisome position: 89.56

GC content: 59.63

Gene sequence:

>1791_bases
ATGGCAGTCAAGGGCAAGGTTCTTAGAGTACGTGGTCCGGTCGTCATCGCCGAGGACATGCAAGGGGTTCAAATGTACGA
AGTGGTGGAAGTGGGCAAGGACGGGCTCGTGGGGGAGGTAACCAGAATAACGGGAGACAAGGCGGTCATACAAGTGTACG
AGGACACCACAGGCATAACTCCCGGAGAGCCCGTAGTGGGTACGGGCTCGCCCTTCAGCGTCGAGCTGGGGCCGGGCCTC
CTCAGCCACATCTTCGACGGCATACTTAGGCCTCTGGAGAGCATACACGAGGTCGCTAAGTCCCCGTTCATAAAGAGGGG
CATCAAGGTACCCTCGCTCGACCGCTCCAAGAAGTGGGAGTGGCGCCCCAACCCGGAGCTCAAGCCCGGGGACAAGGTGA
GCGGCGACGATATCTTAGGCACCGTCCCGGAGACGCCCTTGATCGAGCACAAGGTCATGGTGCCCCCCAACGTAGTGCCG
GTGGACAAGGCGGCCACCCTCAAGTGGTTGGCCCCCGCCGGCGAGTACACCATAGAAGATACCATAGCTGTGGTCGAGTA
CGAGGGTAAGGAGATAGAGCTCAAGATGTACCACAGGTGGCCGATAAGGAGGCCTAGGCCGGTCAAGGAGAAGTTCGAGC
CAGTGACCCCCTTGATAACCGGCGTCAGGGTGCTCGATACATTGTTCCCCATGGCCAAGGGCGGGACCGGCGCCATACCC
GGCCCCTTCGGCTCCGGCAAAACGGTCACCTTGAGGACGCTAGCCGCTTGGAGCGACGCCAAGGTGGTCATTTACGTCGG
CTGCGGCGAGAGGGGCAACGAGATGACGGACGTCTTGGTAAACTTCCCCCACTACAAGGACCCGTGGAGCGGCAGGCCGC
TTATGGAGAGGACTATATTGGTTGCCAACACCTCTAACATGCCCGTAGCGGCGAGGGAAGCTTCCATCTACGTGGGCGTC
ACCTTGGCTGAGTACTACCGTGACATGGGCTATGACAGCCTCTTGATAGCCGACTCCACCTCCAGGTGGGCCGAGGCCCT
CAGAGACATCGCCGGCAGAATGGAGGAGATGCCCGCGGAGGAGGGCTTCCCGCCCTACTTGGCCTCCAGGTTGGCGGAGT
ACTACGAGAGGGCCGGCAGGGCGAGGATCCCCGGCAGGCCGGAGAGGGTGGGGAGCGTCACGATAGCCTCGGCCGTCTCC
CCGCCAGGAGGCGACTTCAGCGAGCCCGTCACCAGCCACACCAGGAGGTTCGTGAGGGTCTTCTGGGCGCTGGACGCGAG
CTTGGCTTACGCGAGGCACTACCCGGCCATCAACTGGTTGGTGTCCTACAGCTTGTACGTAGACACCGTAGCTAAGTGGT
GGCACGAGAACATAAGCCCCAAGTGGAAGGAGTACAGAGACGAAATGATGAGCATACTCCTCAAGGAGGACGAACTAAAG
GAGATAGTGAGGCTCGTAGGGCCGGAGAGCCTCAGCGAGCCCGACAAGCTGATAATAGAGACGGCTAGGATCATAAAGGA
GGCCTTCCTCCAGCAGAACGCCTTCGACCCCATAGACGCGTTCTGCTCTCCGAAGAAGCAGTTCCTCATGATGAAGATAA
TCATAGACTTCTACAGGAAGGCTAAAGAGCTGGTGAACGCCGGGGTACCCGTCGCCACAATAAGGGAGGCGGTAAAGGAG
GAGGTCGCAGAGCTCATAAGGAGCAGGTTTACTGTGAGGAACGAGGAGCTGGAGAAGCTAGAGGACTTGTACGCCAGGTT
CATGGAGAAGCTCTCCTCCTTGAGTCCCTAA

Upstream 100 bases:

>100_bases
AATGAAGGTAGTGAGAGTTGAAACTTGAGCCCTCCCCCTTCCCTCCAACGGACAAGTCGTTTTAAGGCGCTGGGAAGAGC
ACCAGAGAGGAGGTAAAGGT

Downstream 100 bases:

>100_bases
TCGCGTTTTTGAGCGCGATGATGACCATCCCGACCACTCCCGAAGGGATGGGGACGCGGTGGCTGTCTGAGCTCACGCCA
GCAGCGCGATCATTATTGCG

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A

Number of amino acids: Translated: 596; Mature: 595

Protein sequence:

>596_residues
MAVKGKVLRVRGPVVIAEDMQGVQMYEVVEVGKDGLVGEVTRITGDKAVIQVYEDTTGITPGEPVVGTGSPFSVELGPGL
LSHIFDGILRPLESIHEVAKSPFIKRGIKVPSLDRSKKWEWRPNPELKPGDKVSGDDILGTVPETPLIEHKVMVPPNVVP
VDKAATLKWLAPAGEYTIEDTIAVVEYEGKEIELKMYHRWPIRRPRPVKEKFEPVTPLITGVRVLDTLFPMAKGGTGAIP
GPFGSGKTVTLRTLAAWSDAKVVIYVGCGERGNEMTDVLVNFPHYKDPWSGRPLMERTILVANTSNMPVAAREASIYVGV
TLAEYYRDMGYDSLLIADSTSRWAEALRDIAGRMEEMPAEEGFPPYLASRLAEYYERAGRARIPGRPERVGSVTIASAVS
PPGGDFSEPVTSHTRRFVRVFWALDASLAYARHYPAINWLVSYSLYVDTVAKWWHENISPKWKEYRDEMMSILLKEDELK
EIVRLVGPESLSEPDKLIIETARIIKEAFLQQNAFDPIDAFCSPKKQFLMMKIIIDFYRKAKELVNAGVPVATIREAVKE
EVAELIRSRFTVRNEELEKLEDLYARFMEKLSSLSP

Sequences:

>Translated_596_residues
MAVKGKVLRVRGPVVIAEDMQGVQMYEVVEVGKDGLVGEVTRITGDKAVIQVYEDTTGITPGEPVVGTGSPFSVELGPGL
LSHIFDGILRPLESIHEVAKSPFIKRGIKVPSLDRSKKWEWRPNPELKPGDKVSGDDILGTVPETPLIEHKVMVPPNVVP
VDKAATLKWLAPAGEYTIEDTIAVVEYEGKEIELKMYHRWPIRRPRPVKEKFEPVTPLITGVRVLDTLFPMAKGGTGAIP
GPFGSGKTVTLRTLAAWSDAKVVIYVGCGERGNEMTDVLVNFPHYKDPWSGRPLMERTILVANTSNMPVAAREASIYVGV
TLAEYYRDMGYDSLLIADSTSRWAEALRDIAGRMEEMPAEEGFPPYLASRLAEYYERAGRARIPGRPERVGSVTIASAVS
PPGGDFSEPVTSHTRRFVRVFWALDASLAYARHYPAINWLVSYSLYVDTVAKWWHENISPKWKEYRDEMMSILLKEDELK
EIVRLVGPESLSEPDKLIIETARIIKEAFLQQNAFDPIDAFCSPKKQFLMMKIIIDFYRKAKELVNAGVPVATIREAVKE
EVAELIRSRFTVRNEELEKLEDLYARFMEKLSSLSP
>Mature_595_residues
AVKGKVLRVRGPVVIAEDMQGVQMYEVVEVGKDGLVGEVTRITGDKAVIQVYEDTTGITPGEPVVGTGSPFSVELGPGLL
SHIFDGILRPLESIHEVAKSPFIKRGIKVPSLDRSKKWEWRPNPELKPGDKVSGDDILGTVPETPLIEHKVMVPPNVVPV
DKAATLKWLAPAGEYTIEDTIAVVEYEGKEIELKMYHRWPIRRPRPVKEKFEPVTPLITGVRVLDTLFPMAKGGTGAIPG
PFGSGKTVTLRTLAAWSDAKVVIYVGCGERGNEMTDVLVNFPHYKDPWSGRPLMERTILVANTSNMPVAAREASIYVGVT
LAEYYRDMGYDSLLIADSTSRWAEALRDIAGRMEEMPAEEGFPPYLASRLAEYYERAGRARIPGRPERVGSVTIASAVSP
PGGDFSEPVTSHTRRFVRVFWALDASLAYARHYPAINWLVSYSLYVDTVAKWWHENISPKWKEYRDEMMSILLKEDELKE
IVRLVGPESLSEPDKLIIETARIIKEAFLQQNAFDPIDAFCSPKKQFLMMKIIIDFYRKAKELVNAGVPVATIREAVKEE
VAELIRSRFTVRNEELEKLEDLYARFMEKLSSLSP

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913424, Length=598, Percent_Identity=48.494983277592, Blast_Score=574, Evalue=1e-163,
Organism=Homo sapiens, GI32189394, Length=333, Percent_Identity=28.2282282282282, Blast_Score=113, Evalue=7e-25,
Organism=Homo sapiens, GI19913428, Length=246, Percent_Identity=25.609756097561, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI19913426, Length=288, Percent_Identity=25.6944444444444, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI50345984, Length=241, Percent_Identity=26.5560165975104, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI4757810, Length=241, Percent_Identity=26.5560165975104, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1790170, Length=421, Percent_Identity=28.7410926365796, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1788251, Length=304, Percent_Identity=28.9473684210526, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790172, Length=241, Percent_Identity=27.8008298755187, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565854, Length=545, Percent_Identity=52.2935779816514, Blast_Score=588, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI25144756, Length=325, Percent_Identity=28.9230769230769, Blast_Score=115, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17510931, Length=228, Percent_Identity=26.7543859649123, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17570191, Length=259, Percent_Identity=25.8687258687259, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71988080, Length=241, Percent_Identity=26.9709543568465, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71988063, Length=241, Percent_Identity=26.9709543568465, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71988074, Length=241, Percent_Identity=26.9709543568465, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320016, Length=313, Percent_Identity=49.8402555910543, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6322581, Length=360, Percent_Identity=30.5555555555556, Blast_Score=113, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6319603, Length=259, Percent_Identity=27.4131274131274, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319370, Length=241, Percent_Identity=24.896265560166, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24583988, Length=574, Percent_Identity=50.3484320557491, Blast_Score=583, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24583986, Length=574, Percent_Identity=50.3484320557491, Blast_Score=583, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24583984, Length=574, Percent_Identity=50.3484320557491, Blast_Score=583, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24583992, Length=597, Percent_Identity=48.4087102177554, Blast_Score=569, Evalue=1e-162,
Organism=Drosophila melanogaster, GI20129479, Length=543, Percent_Identity=50.4604051565378, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI28574560, Length=300, Percent_Identity=30.6666666666667, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24638766, Length=300, Percent_Identity=30.3333333333333, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI281361666, Length=259, Percent_Identity=25.4826254826255, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24646341, Length=259, Percent_Identity=25.4826254826255, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17136796, Length=259, Percent_Identity=25.4826254826255, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): VATA_IGNH4 (A8AC29)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435888.1
- ProteinModelPortal:   A8AC29
- SMR:   A8AC29
- DIP:   DIP-58544N
- STRING:   A8AC29
- GeneID:   5563173
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_1305
- eggNOG:   arNOG04086
- HOGENOM:   HBG288114
- OMA:   KITWNVI
- ProtClustDB:   PRK04192
- BioCyc:   IHOS453591:IGNI_1305-MONOMER
- HAMAP:   MF_00309
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR003593
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878
- SMART:   SM00382

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 66714; Mature: 66583

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00152 ATPASE_ALPHA_BETA; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKGKVLRVRGPVVIAEDMQGVQMYEVVEVGKDGLVGEVTRITGDKAVIQVYEDTTGIT
CCCCCCEEEEECCEEEECCCCCCHHHHHHHHCCCCCCEEHHEECCCCEEEEEEECCCCCC
PGEPVVGTGSPFSVELGPGLLSHIFDGILRPLESIHEVAKSPFIKRGIKVPSLDRSKKWE
CCCCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCC
WRPNPELKPGDKVSGDDILGTVPETPLIEHKVMVPPNVVPVDKAATLKWLAPAGEYTIED
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCCCCEEECC
TIAVVEYEGKEIELKMYHRWPIRRPRPVKEKFEPVTPLITGVRVLDTLFPMAKGGTGAIP
EEEEEEECCCEEEEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
GPFGSGKTVTLRTLAAWSDAKVVIYVGCGERGNEMTDVLVNFPHYKDPWSGRPLMERTIL
CCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCHHHHHEECCCCCCCCCCCCHHHCEEE
VANTSNMPVAAREASIYVGVTLAEYYRDMGYDSLLIADSTSRWAEALRDIAGRMEEMPAE
EEECCCCCEEEECCEEEEEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC
EGFPPYLASRLAEYYERAGRARIPGRPERVGSVTIASAVSPPGGDFSEPVTSHTRRFVRV
CCCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
FWALDASLAYARHYPAINWLVSYSLYVDTVAKWWHENISPKWKEYRDEMMSILLKEDELK
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHH
EIVRLVGPESLSEPDKLIIETARIIKEAFLQQNAFDPIDAFCSPKKQFLMMKIIIDFYRK
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHH
AKELVNAGVPVATIREAVKEEVAELIRSRFTVRNEELEKLEDLYARFMEKLSSLSP
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVKGKVLRVRGPVVIAEDMQGVQMYEVVEVGKDGLVGEVTRITGDKAVIQVYEDTTGIT
CCCCCEEEEECCEEEECCCCCCHHHHHHHHCCCCCCEEHHEECCCCEEEEEEECCCCCC
PGEPVVGTGSPFSVELGPGLLSHIFDGILRPLESIHEVAKSPFIKRGIKVPSLDRSKKWE
CCCCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCC
WRPNPELKPGDKVSGDDILGTVPETPLIEHKVMVPPNVVPVDKAATLKWLAPAGEYTIED
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCCCCEEECC
TIAVVEYEGKEIELKMYHRWPIRRPRPVKEKFEPVTPLITGVRVLDTLFPMAKGGTGAIP
EEEEEEECCCEEEEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
GPFGSGKTVTLRTLAAWSDAKVVIYVGCGERGNEMTDVLVNFPHYKDPWSGRPLMERTIL
CCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCHHHHHEECCCCCCCCCCCCHHHCEEE
VANTSNMPVAAREASIYVGVTLAEYYRDMGYDSLLIADSTSRWAEALRDIAGRMEEMPAE
EEECCCCCEEEECCEEEEEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC
EGFPPYLASRLAEYYERAGRARIPGRPERVGSVTIASAVSPPGGDFSEPVTSHTRRFVRV
CCCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
FWALDASLAYARHYPAINWLVSYSLYVDTVAKWWHENISPKWKEYRDEMMSILLKEDELK
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHH
EIVRLVGPESLSEPDKLIIETARIIKEAFLQQNAFDPIDAFCSPKKQFLMMKIIIDFYRK
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHH
AKELVNAGVPVATIREAVKEEVAELIRSRFTVRNEELEKLEDLYARFMEKLSSLSP
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA