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The map label for this gene is trm1 [H]

Identifier: 156937972

GI number: 156937972

Start: 1055155

End: 1056315

Strand: Direct

Name: trm1 [H]

Synonym: Igni_1184

Alternate gene names: 156937972

Gene position: 1055155-1056315 (Clockwise)

Preceding gene: 156937970

Following gene: 156937973

Centisome position: 81.32

GC content: 64.0

Gene sequence:

>1161_bases
TTGTCGGGGCCGGACTACCCCATAGAGATAATAGAGGAGGGGAAGGTCAAGCTCGCAGTCCCCAGGATGAGCGACTACTT
GAGGCCCGACGGGGTCTACGAGCCCGCCCACGCGCCGGTGTTCTACAACCCCAAGGCTAAGTTCAACAGGGACGTGGCGG
TCGCCATGGGGGCCGCCCTCAAGGAGAGGCTGGGGAGGCTGGAGGTCTTGGAGCCCTTGGCCGGCTCGGGGGTTAGGAGC
TTGAGGTACGCCGTAGAGGCCGGGGCCGACAAGGTGCTTGCGGTGGACGCCGACCCCAAAGCGGTGGAGCTGATAAAGTA
CAATATAAGGTTAAACAAGCTAGAGGACAAAGTAAAGGTCTTGCTCGCAGAGGCGAACGCGGTCTTGCACTCCCGGGAGC
TCAGGGGAGGCTACTACGACTTGGTGGACGTGGACCCCTTCGGCTCTCCCATGCCCTTCGCCGACGGGGCGATCAGGGCG
GCCCGGAGGAGGGGCTTGGTGGCCTTCACCGCGACAGACACCGCCCCCTTGACCGGGGCGAGGCCCCAGTCGGCCTTGCG
CAAGTACGGCGCCTCCGTTAGGAGGACTCCCTTTTCCAAGGAGGTTGCAATAAGGGTCTTGATAGCTGCTTTGGTGAGGG
TTGCGGCTGTGAGGGAGGTGGCACTCAAGCCCGAGGCGGCGTTCTTCAAGGACTACTACGTGAGGGCCCACCTCACCGTC
GAGAGGGGGGCGAGGAGGGTCGAGGAGGCCTTGTCCCAGCTGGGCTACTTGTTCTACCGCCCGGACTACTCCGTCGAGGT
GGTGAGGGGCTACCCCCTCCCCGAGAGGGTGCCCGAGGGGACCGCCTTGGGCCCCCTTTGGCTGGGCCCCCTGACCGGCC
CCTTGGCCAAGAGGGCCGCGGAGCTGGTCGGGGGCGAGGTCAAGCGCTTCTTGGAACACTTGATAGAGGAGGACTCCGTG
GGCGTGCCGTACTCTTACAAGGTTGAGAGGGTCGCGAGCATATTGAAGGTTAACATGCCCAGCCCGAAGCTGGTCGTGGA
GGAGCTCAGGGCTGCGGGCTACAAGGCCTTATTGGCCCACTACGACCACACCTCCGTTAAGACCGACGCCCCGGCGGAGG
AGGTCTTCAAGGTCGTGAAGAAGCTGAGCCCGCGGCCCTAA

Upstream 100 bases:

>100_bases
AGGCGTGCTCGTACTCGTAGAGCAGCCACTCGCTGAACTCCTCCAAGTTTTCCACTATTATCAAGCCGCTCCCCCGGAGG
GGCCCGCGGGGGAAAGTAAA

Downstream 100 bases:

>100_bases
CCGTTAAGCTCGGGCCCCGGGGCTAGCCCTTAGGTGGTCCGCGGGATGAGCGTAGTGGAGAGCGCTGAGGCCGAGCTCAA
GGAGGCGGCGGCCCAGTTCT

Product: tRNA (guanine-N(2)-)-methyltransferase

Products: NA

Alternate protein names: tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSGPDYPIEIIEEGKVKLAVPRMSDYLRPDGVYEPAHAPVFYNPKAKFNRDVAVAMGAALKERLGRLEVLEPLAGSGVRS
LRYAVEAGADKVLAVDADPKAVELIKYNIRLNKLEDKVKVLLAEANAVLHSRELRGGYYDLVDVDPFGSPMPFADGAIRA
ARRRGLVAFTATDTAPLTGARPQSALRKYGASVRRTPFSKEVAIRVLIAALVRVAAVREVALKPEAAFFKDYYVRAHLTV
ERGARRVEEALSQLGYLFYRPDYSVEVVRGYPLPERVPEGTALGPLWLGPLTGPLAKRAAELVGGEVKRFLEHLIEEDSV
GVPYSYKVERVASILKVNMPSPKLVVEELRAAGYKALLAHYDHTSVKTDAPAEEVFKVVKKLSPRP

Sequences:

>Translated_386_residues
MSGPDYPIEIIEEGKVKLAVPRMSDYLRPDGVYEPAHAPVFYNPKAKFNRDVAVAMGAALKERLGRLEVLEPLAGSGVRS
LRYAVEAGADKVLAVDADPKAVELIKYNIRLNKLEDKVKVLLAEANAVLHSRELRGGYYDLVDVDPFGSPMPFADGAIRA
ARRRGLVAFTATDTAPLTGARPQSALRKYGASVRRTPFSKEVAIRVLIAALVRVAAVREVALKPEAAFFKDYYVRAHLTV
ERGARRVEEALSQLGYLFYRPDYSVEVVRGYPLPERVPEGTALGPLWLGPLTGPLAKRAAELVGGEVKRFLEHLIEEDSV
GVPYSYKVERVASILKVNMPSPKLVVEELRAAGYKALLAHYDHTSVKTDAPAEEVFKVVKKLSPRP
>Mature_385_residues
SGPDYPIEIIEEGKVKLAVPRMSDYLRPDGVYEPAHAPVFYNPKAKFNRDVAVAMGAALKERLGRLEVLEPLAGSGVRSL
RYAVEAGADKVLAVDADPKAVELIKYNIRLNKLEDKVKVLLAEANAVLHSRELRGGYYDLVDVDPFGSPMPFADGAIRAA
RRRGLVAFTATDTAPLTGARPQSALRKYGASVRRTPFSKEVAIRVLIAALVRVAAVREVALKPEAAFFKDYYVRAHLTVE
RGARRVEEALSQLGYLFYRPDYSVEVVRGYPLPERVPEGTALGPLWLGPLTGPLAKRAAELVGGEVKRFLEHLIEEDSVG
VPYSYKVERVASILKVNMPSPKLVVEELRAAGYKALLAHYDHTSVKTDAPAEEVFKVVKKLSPRP

Specific function: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups [H]

COG id: COG1867

COG function: function code J; N2,N2-dimethylguanosine tRNA methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TRM1 family [H]

Homologues:

Organism=Homo sapiens, GI8923219, Length=347, Percent_Identity=28.5302593659942, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI209862871, Length=347, Percent_Identity=28.5302593659942, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI216548445, Length=331, Percent_Identity=29.9093655589124, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI163792194, Length=191, Percent_Identity=30.8900523560209, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17564890, Length=444, Percent_Identity=24.7747747747748, Blast_Score=134, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6320325, Length=472, Percent_Identity=24.5762711864407, Blast_Score=129, Evalue=6e-31,
Organism=Drosophila melanogaster, GI19921190, Length=427, Percent_Identity=25.2927400468384, Blast_Score=131, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022923
- InterPro:   IPR002905 [H]

Pfam domain/function: PF02005 TRM [H]

EC number: =2.1.1.32 [H]

Molecular weight: Translated: 42467; Mature: 42335

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPDYPIEIIEEGKVKLAVPRMSDYLRPDGVYEPAHAPVFYNPKAKFNRDVAVAMGAAL
CCCCCCCHHEEECCCEEEECCCHHHCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHH
KERLGRLEVLEPLAGSGVRSLRYAVEAGADKVLAVDADPKAVELIKYNIRLNKLEDKVKV
HHHHCHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEEEEHHHHHHHHH
LLAEANAVLHSRELRGGYYDLVDVDPFGSPMPFADGAIRAARRRGLVAFTATDTAPLTGA
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCC
RPQSALRKYGASVRRTPFSKEVAIRVLIAALVRVAAVREVALKPEAAFFKDYYVRAHLTV
CHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEEEEH
ERGARRVEEALSQLGYLFYRPDYSVEVVRGYPLPERVPEGTALGPLWLGPLTGPLAKRAA
HHHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHH
ELVGGEVKRFLEHLIEEDSVGVPYSYKVERVASILKVNMPSPKLVVEELRAAGYKALLAH
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHH
YDHTSVKTDAPAEEVFKVVKKLSPRP
CCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SGPDYPIEIIEEGKVKLAVPRMSDYLRPDGVYEPAHAPVFYNPKAKFNRDVAVAMGAAL
CCCCCCHHEEECCCEEEECCCHHHCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHH
KERLGRLEVLEPLAGSGVRSLRYAVEAGADKVLAVDADPKAVELIKYNIRLNKLEDKVKV
HHHHCHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEEEEHHHHHHHHH
LLAEANAVLHSRELRGGYYDLVDVDPFGSPMPFADGAIRAARRRGLVAFTATDTAPLTGA
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCC
RPQSALRKYGASVRRTPFSKEVAIRVLIAALVRVAAVREVALKPEAAFFKDYYVRAHLTV
CHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEEEEH
ERGARRVEEALSQLGYLFYRPDYSVEVVRGYPLPERVPEGTALGPLWLGPLTGPLAKRAA
HHHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHH
ELVGGEVKRFLEHLIEEDSVGVPYSYKVERVASILKVNMPSPKLVVEELRAAGYKALLAH
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHH
YDHTSVKTDAPAEEVFKVVKKLSPRP
CCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA