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The map label for this gene is eIF5A

Identifier: 156937916

GI number: 156937916

Start: 1006412

End: 1006819

Strand: Reverse

Name: eIF5A

Synonym: Igni_1128

Alternate gene names: 156937916

Gene position: 1006819-1006412 (Counterclockwise)

Preceding gene: 156937917

Following gene: 156937915

Centisome position: 77.59

GC content: 58.33

Gene sequence:

>408_bases
GTGTCCAAGACCTACGCGACCTTGGGAGAGCTCAAGCCGGGCAACTTCATAATGATAGACGGCGAGCCGTGCAAGATAGT
TGAGATGAGCAAGGCCAAGACCGGTAAGCACGGGAGCGCGAAGGCTCACGTGGTCGCCATAAGCTTGATCAGCGGTGCCA
AGAAGACCTTCGTAGCCCCCGTGGACACGAGGGTTGAGGTCCCCATAATTGAGAAGAGGGTGGGCCAAGTGTTGGCCATC
ACCGGCGACAGCGTCCAGCTGATGGACATGGAGACTTACGACACCTTCGAGGTCCCGTTGCCCGAGGAGGAAGAGCTCAA
GTCCCGTCTGGAGCCCGGCGTGGAGGTCGAGTACTGGGTGATGCCGCCCGGAGTTTACAAAATAATGAGGGTCAGGGGAG
GGAAGTAA

Upstream 100 bases:

>100_bases
GGGTAATAATCGAGCTGACGTCCCTCTTAGGCTAGGCGAGCCTCTGCACGCTTCCGACCGTATATTAGCTCCTTACGCCG
ATCGGTGACCGGGTGGGAGC

Downstream 100 bases:

>100_bases
GCGCCTTCTCCTTTTTGCGATATAAGCTCCGGAGCGCCAAAACTTTCCGGAACCCCCCTTGAGGTCCAGGGTTTCGTTCG
AGAGGGAGCTTGCGGGCAAG

Product: translation initiation factor IF-5A

Products: NA

Alternate protein names: Hypusine-containing protein; eIF-5A

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MSKTYATLGELKPGNFIMIDGEPCKIVEMSKAKTGKHGSAKAHVVAISLISGAKKTFVAPVDTRVEVPIIEKRVGQVLAI
TGDSVQLMDMETYDTFEVPLPEEEELKSRLEPGVEVEYWVMPPGVYKIMRVRGGK

Sequences:

>Translated_135_residues
MSKTYATLGELKPGNFIMIDGEPCKIVEMSKAKTGKHGSAKAHVVAISLISGAKKTFVAPVDTRVEVPIIEKRVGQVLAI
TGDSVQLMDMETYDTFEVPLPEEEELKSRLEPGVEVEYWVMPPGVYKIMRVRGGK
>Mature_134_residues
SKTYATLGELKPGNFIMIDGEPCKIVEMSKAKTGKHGSAKAHVVAISLISGAKKTFVAPVDTRVEVPIIEKRVGQVLAIT
GDSVQLMDMETYDTFEVPLPEEEELKSRLEPGVEVEYWVMPPGVYKIMRVRGGK

Specific function: Functions by promoting the formation of the first peptide bond

COG id: COG0231

COG function: function code J; Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-5A family

Homologues:

Organism=Homo sapiens, GI9966867, Length=125, Percent_Identity=36.8, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI153791632, Length=113, Percent_Identity=36.283185840708, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI219555707, Length=114, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI219555712, Length=114, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI219555710, Length=114, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI4503545, Length=114, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17534327, Length=95, Percent_Identity=40, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71990399, Length=93, Percent_Identity=38.7096774193548, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320801, Length=94, Percent_Identity=40.4255319148936, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322507, Length=94, Percent_Identity=39.3617021276596, Blast_Score=74, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19922878, Length=125, Percent_Identity=35.2, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24762531, Length=125, Percent_Identity=35.2, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF5A_IGNH4 (A8ABK3)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435712.1
- ProteinModelPortal:   A8ABK3
- SMR:   A8ABK3
- STRING:   A8ABK3
- GeneID:   5561906
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_1128
- eggNOG:   arNOG10602
- HOGENOM:   HBG497107
- OMA:   IMRIKGE
- ProtClustDB:   PRK03999
- BioCyc:   IHOS453591:IGNI_1128-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00085
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR019769
- InterPro:   IPR001884
- InterPro:   IPR022847
- InterPro:   IPR020189
- InterPro:   IPR013185
- InterPro:   IPR014722
- InterPro:   IPR008991
- Gene3D:   G3DSA:2.40.50.140
- Gene3D:   G3DSA:2.30.30.30
- PANTHER:   PTHR11673
- PIRSF:   PIRSF003025
- TIGRFAMs:   TIGR00037

Pfam domain/function: PF08207 EFP_N; PF01287 eIF-5a; SSF50249 Nucleic_acid_OB; SSF50104 Transl_SH3_like

EC number: NA

Molecular weight: Translated: 14851; Mature: 14719

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00302 IF5A_HYPUSINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTYATLGELKPGNFIMIDGEPCKIVEMSKAKTGKHGSAKAHVVAISLISGAKKTFVAP
CCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCEEEECC
VDTRVEVPIIEKRVGQVLAITGDSVQLMDMETYDTFEVPLPEEEELKSRLEPGVEVEYWV
CCCEEECCHHHHCCCEEEEEECCCEEEEEECCCCEEECCCCCHHHHHHHCCCCCEEEEEE
MPPGVYKIMRVRGGK
ECCCCEEEEEECCCC
>Mature Secondary Structure 
SKTYATLGELKPGNFIMIDGEPCKIVEMSKAKTGKHGSAKAHVVAISLISGAKKTFVAP
CCCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCEEEECC
VDTRVEVPIIEKRVGQVLAITGDSVQLMDMETYDTFEVPLPEEEELKSRLEPGVEVEYWV
CCCEEECCHHHHCCCEEEEEECCCEEEEEECCCCEEECCCCCHHHHHHHCCCCCEEEEEE
MPPGVYKIMRVRGGK
ECCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA