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The map label for this gene is mccB [H]

Identifier: 156937890

GI number: 156937890

Start: 983790

End: 984953

Strand: Reverse

Name: mccB [H]

Synonym: Igni_1102

Alternate gene names: 156937890

Gene position: 984953-983790 (Counterclockwise)

Preceding gene: 156937893

Following gene: 156937884

Centisome position: 75.91

GC content: 57.73

Gene sequence:

>1164_bases
ATGGTGTTCGTAGAACCGCCGGAGGACTGGGAAGAGGAGACCAGACTAGTTCACGGGGGAGAGTATAGGGACTCCGAGAC
GGGTTCCATAGTCACTCCTATCTTCGTCTCGGCGATATACAAGTACCCGGAGGGGAACCCCTACGGCTACAAGTACGCCA
GGAACTCCAGCCCGACTATAGAGGCCTTGGAAAGGAAGGCAGCAGCCGTAGAAAGGGCCGCGGAGGCCGTTGCCTTCTCC
AGCGGCATGGCTGCCATAAGCTCCGCCGCCATGGCCCTCCTCAAGCCGGGGTCCAAGTTGGTCACCACTAAGGACATTTA
CGGGACGAGCTACGAGTTCTTCACCACGTTCCTTAGGTCGTACGGCATTGAAGTGGACGAGAGAGGGGTGGGGGAGGGGG
TGCTCGAGAGGATAGACAAGAATACCGACGTGGTCTTCGTAGAGACCATAAGTAATCCTTTGCTCATAGTCCCGCCCGTG
GACGAGATAGCTAAGGCTTGCGAGGAGGTCGGGGCCAAGCTTATAGTTGACAACACCTTCGCCACCCCGATAAACTTCTT
GCCCTTGAAGGTTGGGGCCTACGGGGTCGTGCACAGCGCCAGCAAGTACTTGGCCGGCCACAACGACGTCTTGGGAGGTA
TATTCGCCACCAACGATAAGAAGTTCGCACTCAACTTGAAGAACGTGAGGAGGATGCTAGGGGGCATCCCCGACCCCCAG
CAAGCTTACTTCATAATAAGGGGCCTCAAGACCTTGCACGTGAGGGTCGCCTACCAGAACGAGGCCGCCCTGAGGATAGC
GAAGTTCTTGAGGGACCACCCGAAGGTTGAGAGGGTTTACTACCCTTGCTTGGAGGAGCACCCCAGCTACCCGGTGGCGA
AGAGGCTCCTCAAGGGCTGCGGAGGGGTGGTGAGCTTCGAGGTTAGGGGCAACGGGTTCGACGCGATAAAGGTCATGAAG
AAGGTCAAGGTAGTTCAGAGGACCGCCTCCCTCGGAGGGGTGGAGAGCATAATAACTCACCCCGCCACCATGACCCACCA
CACCGTCCCCCCCGAGGTGAGGAAGGAGCTCGGGATAAAGGACAACTTGCTGAGGTTGAGCGTTGGCTTGGAAAACGTGG
AGGACTTGGAGGCCGACTTGGACCAAGCCTTGAGCTCTATCTGA

Upstream 100 bases:

>100_bases
AAGGCCGGCAAGGCTCAGCTCCGGGCTCGCTGGGGCCCAAAGCCTTTTTGTGCGTCCGGCCGGAGGCCCTTGAAGATAGC
CATGCGCGGGGGTGATGGCG

Downstream 100 bases:

>100_bases
GGCACCTCACCTTTACCTTGGCGGCCTTGTAGACCGGCGTCCCGGTCGGCTCCCTGGGCTCCCACGGTATTACGGCGTTT
ACCTTCAGGCCTAGGTGGTT

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MVFVEPPEDWEEETRLVHGGEYRDSETGSIVTPIFVSAIYKYPEGNPYGYKYARNSSPTIEALERKAAAVERAAEAVAFS
SGMAAISSAAMALLKPGSKLVTTKDIYGTSYEFFTTFLRSYGIEVDERGVGEGVLERIDKNTDVVFVETISNPLLIVPPV
DEIAKACEEVGAKLIVDNTFATPINFLPLKVGAYGVVHSASKYLAGHNDVLGGIFATNDKKFALNLKNVRRMLGGIPDPQ
QAYFIIRGLKTLHVRVAYQNEAALRIAKFLRDHPKVERVYYPCLEEHPSYPVAKRLLKGCGGVVSFEVRGNGFDAIKVMK
KVKVVQRTASLGGVESIITHPATMTHHTVPPEVRKELGIKDNLLRLSVGLENVEDLEADLDQALSSI

Sequences:

>Translated_387_residues
MVFVEPPEDWEEETRLVHGGEYRDSETGSIVTPIFVSAIYKYPEGNPYGYKYARNSSPTIEALERKAAAVERAAEAVAFS
SGMAAISSAAMALLKPGSKLVTTKDIYGTSYEFFTTFLRSYGIEVDERGVGEGVLERIDKNTDVVFVETISNPLLIVPPV
DEIAKACEEVGAKLIVDNTFATPINFLPLKVGAYGVVHSASKYLAGHNDVLGGIFATNDKKFALNLKNVRRMLGGIPDPQ
QAYFIIRGLKTLHVRVAYQNEAALRIAKFLRDHPKVERVYYPCLEEHPSYPVAKRLLKGCGGVVSFEVRGNGFDAIKVMK
KVKVVQRTASLGGVESIITHPATMTHHTVPPEVRKELGIKDNLLRLSVGLENVEDLEADLDQALSSI
>Mature_387_residues
MVFVEPPEDWEEETRLVHGGEYRDSETGSIVTPIFVSAIYKYPEGNPYGYKYARNSSPTIEALERKAAAVERAAEAVAFS
SGMAAISSAAMALLKPGSKLVTTKDIYGTSYEFFTTFLRSYGIEVDERGVGEGVLERIDKNTDVVFVETISNPLLIVPPV
DEIAKACEEVGAKLIVDNTFATPINFLPLKVGAYGVVHSASKYLAGHNDVLGGIFATNDKKFALNLKNVRRMLGGIPDPQ
QAYFIIRGLKTLHVRVAYQNEAALRIAKFLRDHPKVERVYYPCLEEHPSYPVAKRLLKGCGGVVSFEVRGNGFDAIKVMK
KVKVVQRTASLGGVESIITHPATMTHHTVPPEVRKELGIKDNLLRLSVGLENVEDLEADLDQALSSI

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=378, Percent_Identity=37.037037037037, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI25453487, Length=375, Percent_Identity=34.1333333333333, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI299473759, Length=378, Percent_Identity=34.3915343915344, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1790375, Length=379, Percent_Identity=35.6200527704486, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1789383, Length=391, Percent_Identity=27.6214833759591, Blast_Score=154, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17560056, Length=378, Percent_Identity=40.7407407407407, Blast_Score=251, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17538055, Length=378, Percent_Identity=37.8306878306878, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71980708, Length=376, Percent_Identity=33.5106382978723, Blast_Score=218, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6319307, Length=381, Percent_Identity=38.5826771653543, Blast_Score=249, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6321254, Length=402, Percent_Identity=29.6019900497512, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6323333, Length=386, Percent_Identity=31.0880829015544, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321170, Length=293, Percent_Identity=30.0341296928328, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6321904, Length=399, Percent_Identity=28.3208020050125, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19922554, Length=378, Percent_Identity=35.978835978836, Blast_Score=225, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 42487; Mature: 42487

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFVEPPEDWEEETRLVHGGEYRDSETGSIVTPIFVSAIYKYPEGNPYGYKYARNSSPTI
CEECCCCCCHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCHH
EALERKAAAVERAAEAVAFSSGMAAISSAAMALLKPGSKLVTTKDIYGTSYEFFTTFLRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHH
YGIEVDERGVGEGVLERIDKNTDVVFVETISNPLLIVPPVDEIAKACEEVGAKLIVDNTF
HCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCEEEECCHHHHHHHHHHCCCEEEECCCC
ATPINFLPLKVGAYGVVHSASKYLAGHNDVLGGIFATNDKKFALNLKNVRRMLGGIPDPQ
CCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEHHHHHHHHCCCCCCH
QAYFIIRGLKTLHVRVAYQNEAALRIAKFLRDHPKVERVYYPCLEEHPSYPVAKRLLKGC
HHHHHEECCEEEEEEEEECCHHHHHHHHHHHCCCCHHHHCCCHHHCCCCCHHHHHHHHHC
GGVVSFEVRGNGFDAIKVMKKVKVVQRTASLGGVESIITHPATMTHHTVPPEVRKELGIK
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHCCCC
DNLLRLSVGLENVEDLEADLDQALSSI
CCEEEEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVFVEPPEDWEEETRLVHGGEYRDSETGSIVTPIFVSAIYKYPEGNPYGYKYARNSSPTI
CEECCCCCCHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCHH
EALERKAAAVERAAEAVAFSSGMAAISSAAMALLKPGSKLVTTKDIYGTSYEFFTTFLRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHH
YGIEVDERGVGEGVLERIDKNTDVVFVETISNPLLIVPPVDEIAKACEEVGAKLIVDNTF
HCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCEEEECCHHHHHHHHHHCCCEEEECCCC
ATPINFLPLKVGAYGVVHSASKYLAGHNDVLGGIFATNDKKFALNLKNVRRMLGGIPDPQ
CCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEHHHHHHHHCCCCCCH
QAYFIIRGLKTLHVRVAYQNEAALRIAKFLRDHPKVERVYYPCLEEHPSYPVAKRLLKGC
HHHHHEECCEEEEEEEEECCHHHHHHHHHHHCCCCHHHHCCCHHHCCCCCHHHHHHHHHC
GGVVSFEVRGNGFDAIKVMKKVKVVQRTASLGGVESIITHPATMTHHTVPPEVRKELGIK
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHCCCC
DNLLRLSVGLENVEDLEADLDQALSSI
CCEEEEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]