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The map label for this gene is icd [H]

Identifier: 156937853

GI number: 156937853

Start: 946735

End: 947994

Strand: Reverse

Name: icd [H]

Synonym: Igni_1064

Alternate gene names: 156937853

Gene position: 947994-946735 (Counterclockwise)

Preceding gene: 156937854

Following gene: 156937852

Centisome position: 73.06

GC content: 57.7

Gene sequence:

>1260_bases
GTGGAGGAGTACAAGTTCGAGAAGATCAGGCCGCCCGAGGAGGGGAAGTTCATAGAGGTCAAGGACGGAAAGCTCGTGGT
CCCGGACAACCCGATAGTGCCCTACATAGAGGGGGACGGCATAGGGCCGGAAGTGATAGGGGCGGCTAGGAGGATAGTGG
ACGCCGCGGTGGAGGTGGCTTACGGTAGCAAGAGGAGGGTGGTCTGGTGGAAGGTCTACGCCGGGATAGAGGCGGAGCCC
GTTTACGGTACCATGCTCCCCCAAGACACCTTGAACGCAATTAAGGCGGCGAAGGTGGCCCTCAAAGGCCCCATGACCAC
CCCCATAGGCTCCGGGTGGAGGAGCGTCAACGTCGCCTTGAGGCAGCTCCTAGACCTGTACGCGAACATCAGGCCGGTGA
AGTACATCAAGGGGATACCCGCACCTCACAAGTACGCGGACAAGGTGGACATAGTGATATTTAGAGAGAACACCGAGGAC
GTTTACGCCGGGATAGAGTGGAAGTACGACAGCCCGGAGGCCGAGAAGGTGAGGGAGTTCCTCAAGAGGGAGTTCAACAT
AGAGCTCAGGCCGGACACCGGGATAGGGTTGAAGCCCATCTCTCGCTTCGCTACGAGGAGAATAATGAGGAAGGCTCTGG
AGTGGGCGATAAAGTACGGGAGGAAGAGGGTAACTGTGATGCACAAAGGTAACATAATGAAGTACACCGAAGGTTACTTC
AAGATATGGGCCTTCGAGCTGGCCAAGGAGGAGTTCGGAGACAAAGTGGTCTTCGAGGAAGAGCTCCAAGGCGCCGAGGT
CCCCGAAGGGAAGATCTTGGTTAATGACAGGATAGCAGACAACATGTTCAACCAAATAATAACGAGGCCTTGGGACTACG
ACATAATAGTTACTCCCAACCTCAACGGCGACTACTTGAGCGACGCCGCTGCCGCCTTGGTCGGCGGGCTGGGCGTGGCC
CCCGGGGCCAACGTGGGGGACTACGTGGGCATGTTCGAGCCCATCCACGGCTCCGCCCCCAAGTACGCGGGCAAGAACGT
AGCCAACCCCACCGCGGCTACCTTGAGCGCCGCCATGATGTTGGACCACATAGGCTGGTCCGAGGCCGCGGAGCTGGTGA
GGAAAGCTATAGAAGAAACCATAGCCTCCGGCAAGGTGACCCAAGACATAGCTAGGCACTTAGGCATAAAGCCCCTGACC
ACCACGGAGTTCACGGAAGCGGTCATAGAGAACGTCAAGAGGTTGGGTGGAAAGGGTTGA

Upstream 100 bases:

>100_bases
CTCCGTGCCGGCCTTGGCGCTCCTCGCGCTCCTCGTCGCGGCGGCCCTCCGCAAGAGGCCTTAAGGGCCGAGGACCTCCG
ACGGGCTCGAGGGAACACGC

Downstream 100 bases:

>100_bases
AGGAGTTACCCTTGGCGTTCTTGATATACGCCACCCAGACCGTCCCACGCTCCCAGCTGGACGAAGTGATGGCAGAGGTC
ATAGCTAAGGCTATGGAGAG

Product: isocitrate dehydrogenase (NADP)

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MEEYKFEKIRPPEEGKFIEVKDGKLVVPDNPIVPYIEGDGIGPEVIGAARRIVDAAVEVAYGSKRRVVWWKVYAGIEAEP
VYGTMLPQDTLNAIKAAKVALKGPMTTPIGSGWRSVNVALRQLLDLYANIRPVKYIKGIPAPHKYADKVDIVIFRENTED
VYAGIEWKYDSPEAEKVREFLKREFNIELRPDTGIGLKPISRFATRRIMRKALEWAIKYGRKRVTVMHKGNIMKYTEGYF
KIWAFELAKEEFGDKVVFEEELQGAEVPEGKILVNDRIADNMFNQIITRPWDYDIIVTPNLNGDYLSDAAAALVGGLGVA
PGANVGDYVGMFEPIHGSAPKYAGKNVANPTAATLSAAMMLDHIGWSEAAELVRKAIEETIASGKVTQDIARHLGIKPLT
TTEFTEAVIENVKRLGGKG

Sequences:

>Translated_419_residues
MEEYKFEKIRPPEEGKFIEVKDGKLVVPDNPIVPYIEGDGIGPEVIGAARRIVDAAVEVAYGSKRRVVWWKVYAGIEAEP
VYGTMLPQDTLNAIKAAKVALKGPMTTPIGSGWRSVNVALRQLLDLYANIRPVKYIKGIPAPHKYADKVDIVIFRENTED
VYAGIEWKYDSPEAEKVREFLKREFNIELRPDTGIGLKPISRFATRRIMRKALEWAIKYGRKRVTVMHKGNIMKYTEGYF
KIWAFELAKEEFGDKVVFEEELQGAEVPEGKILVNDRIADNMFNQIITRPWDYDIIVTPNLNGDYLSDAAAALVGGLGVA
PGANVGDYVGMFEPIHGSAPKYAGKNVANPTAATLSAAMMLDHIGWSEAAELVRKAIEETIASGKVTQDIARHLGIKPLT
TTEFTEAVIENVKRLGGKG
>Mature_419_residues
MEEYKFEKIRPPEEGKFIEVKDGKLVVPDNPIVPYIEGDGIGPEVIGAARRIVDAAVEVAYGSKRRVVWWKVYAGIEAEP
VYGTMLPQDTLNAIKAAKVALKGPMTTPIGSGWRSVNVALRQLLDLYANIRPVKYIKGIPAPHKYADKVDIVIFRENTED
VYAGIEWKYDSPEAEKVREFLKREFNIELRPDTGIGLKPISRFATRRIMRKALEWAIKYGRKRVTVMHKGNIMKYTEGYF
KIWAFELAKEEFGDKVVFEEELQGAEVPEGKILVNDRIADNMFNQIITRPWDYDIIVTPNLNGDYLSDAAAALVGGLGVA
PGANVGDYVGMFEPIHGSAPKYAGKNVANPTAATLSAAMMLDHIGWSEAAELVRKAIEETIASGKVTQDIARHLGIKPLT
TTEFTEAVIENVKRLGGKG

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=385, Percent_Identity=36.1038961038961, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI4758582, Length=392, Percent_Identity=31.3775510204082, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI28178838, Length=349, Percent_Identity=32.6647564469914, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI28178821, Length=390, Percent_Identity=31.2820512820513, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI28178816, Length=383, Percent_Identity=31.8537859007833, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI28178819, Length=224, Percent_Identity=34.8214285714286, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1787381, Length=413, Percent_Identity=51.5738498789346, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1788101, Length=397, Percent_Identity=31.2342569269521, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081683, Length=396, Percent_Identity=28.7878787878788, Blast_Score=126, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71986051, Length=388, Percent_Identity=36.0824742268041, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI25144293, Length=361, Percent_Identity=32.1329639889197, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17550882, Length=427, Percent_Identity=30.9133489461358, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17505779, Length=389, Percent_Identity=30.3341902313625, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324709, Length=391, Percent_Identity=37.5959079283887, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6322097, Length=361, Percent_Identity=37.6731301939058, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6324291, Length=388, Percent_Identity=33.7628865979381, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319830, Length=408, Percent_Identity=27.2058823529412, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24643268, Length=363, Percent_Identity=35.8126721763085, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24643270, Length=363, Percent_Identity=35.8126721763085, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24661184, Length=387, Percent_Identity=34.3669250645995, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI281362242, Length=385, Percent_Identity=32.2077922077922, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24648872, Length=385, Percent_Identity=32.2077922077922, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI161078635, Length=388, Percent_Identity=30.1546391752577, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI161078637, Length=388, Percent_Identity=30.1546391752577, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI161078633, Length=388, Percent_Identity=30.1546391752577, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24650122, Length=388, Percent_Identity=30.1546391752577, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI161078639, Length=382, Percent_Identity=30.3664921465969, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI20130355, Length=381, Percent_Identity=26.246719160105, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46565; Mature: 46565

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEYKFEKIRPPEEGKFIEVKDGKLVVPDNPIVPYIEGDGIGPEVIGAARRIVDAAVEVA
CCCCCCCCCCCCCCCCEEEEECCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
YGSKRRVVWWKVYAGIEAEPVYGTMLPQDTLNAIKAAKVALKGPMTTPIGSGWRSVNVAL
CCCCCEEEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
RQLLDLYANIRPVKYIKGIPAPHKYADKVDIVIFRENTEDVYAGIEWKYDSPEAEKVREF
HHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEECEEEECCCCHHHHHHHH
LKREFNIELRPDTGIGLKPISRFATRRIMRKALEWAIKYGRKRVTVMHKGNIMKYTEGYF
HHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEECCCHH
KIWAFELAKEEFGDKVVFEEELQGAEVPEGKILVNDRIADNMFNQIITRPWDYDIIVTPN
HHHHHHHHHHHHCCCEEEHHHCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCEEEEECC
LNGDYLSDAAAALVGGLGVAPGANVGDYVGMFEPIHGSAPKYAGKNVANPTAATLSAAMM
CCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LDHIGWSEAAELVRKAIEETIASGKVTQDIARHLGIKPLTTTEFTEAVIENVKRLGGKG
HHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEEYKFEKIRPPEEGKFIEVKDGKLVVPDNPIVPYIEGDGIGPEVIGAARRIVDAAVEVA
CCCCCCCCCCCCCCCCEEEEECCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
YGSKRRVVWWKVYAGIEAEPVYGTMLPQDTLNAIKAAKVALKGPMTTPIGSGWRSVNVAL
CCCCCEEEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
RQLLDLYANIRPVKYIKGIPAPHKYADKVDIVIFRENTEDVYAGIEWKYDSPEAEKVREF
HHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEECEEEECCCCHHHHHHHH
LKREFNIELRPDTGIGLKPISRFATRRIMRKALEWAIKYGRKRVTVMHKGNIMKYTEGYF
HHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEECCCHH
KIWAFELAKEEFGDKVVFEEELQGAEVPEGKILVNDRIADNMFNQIITRPWDYDIIVTPN
HHHHHHHHHHHHCCCEEEHHHCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCEEEEECC
LNGDYLSDAAAALVGGLGVAPGANVGDYVGMFEPIHGSAPKYAGKNVANPTAATLSAAMM
CCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LDHIGWSEAAELVRKAIEETIASGKVTQDIARHLGIKPLTTTEFTEAVIENVKRLGGKG
HHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9325430; 9389475 [H]