BacMap

Definition	Ignicoccus hospitalis KIN4/I chromosome, complete genome.
Accession	NC_009776
Length	1,297,538

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The map label for this gene is psmB2

Identifier: 156937771

GI number: 156937771

Start: 871054

End: 871692

Strand: Direct

Name: psmB2

Synonym: Igni_0980

Alternate gene names: 156937771

Gene position: 871054-871692 (Clockwise)

Preceding gene: 156937770

Following gene: 156937772

Centisome position: 67.13

GC content: 57.9

Gene sequence:

>639_bases
TTGAGCGTAGACGAGAAGGTGGCGAGGGCCCTAAAGGGCACTACGACCGTCGGCATAAGGTCCGAAAAGGCGGTCGTCCT
CGCGGCGGACAAGAGGGCCACTGCGGGGAACTTCATAGTCCACAAGAGGGTGGAAAAGATAGTGAAGATCAGCGATTACA
TGGCGATGACCACGGCCGGCCTCGTAGCAGACGCTCAAGTGCTCGCGGACGTGTTGAGGATGGAAGTGAAGAACTACGAG
CTGTTCCATAAAAAGAGAATGAGCGTTAAGGCCGCGGCCACCTTCTTATCGAACGTGCTCCACTCGGCCCGCTTCTACCC
CTACATAGTTCAACTGCTAGTGGGCGGCTTTGACACCGCCCCCAGGCTCTACAGCTTGGACTGGTTCGGGACGGTAGCTG
AAGAGGAGTTCTTAGTCACCGGCTCCGGCTCTCCGATGGCCGTTGGGGTCATCGAGGCTGAGTACAACCCCAATATGGAC
TTAGAGGAGCTGGTGAACTTAGCAGTGCGCGCGGTCTTCGCGGCCACTCGGAGGGACACCGCCTCCGGCGAGGGCATAGA
CGTCGCAGTCATCGATCGGAACGGCATCACAATGCGCCATTACCGCTTAGGTGATGTAATAAGGCTTGTGCGCCCGTAA

Upstream 100 bases:

>100_bases
GAGGCGCTACAGCTGGCAGAACAAGAAGTCTTGGACCCGCGTTAGGCTCAAGTAACTTTTAGTTCTTTCCGTATTCCTTG
CAACCGGAAGGTGTGACGCG

Downstream 100 bases:

>100_bases
GAAATAGGTTTTTCACTCCTCTGAGGAGGAGTTCTGGGCATTAAGCTATGAAGAAGGTGTTGGCGTTCTTACTGACGTTA
GCGGCGGCGGCCTTGGCGCA

Product: proteasome endopeptidase complex

Products: NA

Alternate protein names: 20S proteasome beta subunit 2; Proteasome core protein PsmB 2

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSVDEKVARALKGTTTVGIRSEKAVVLAADKRATAGNFIVHKRVEKIVKISDYMAMTTAGLVADAQVLADVLRMEVKNYE
LFHKKRMSVKAAATFLSNVLHSARFYPYIVQLLVGGFDTAPRLYSLDWFGTVAEEEFLVTGSGSPMAVGVIEAEYNPNMD
LEELVNLAVRAVFAATRRDTASGEGIDVAVIDRNGITMRHYRLGDVIRLVRP

Sequences:

>Translated_212_residues
MSVDEKVARALKGTTTVGIRSEKAVVLAADKRATAGNFIVHKRVEKIVKISDYMAMTTAGLVADAQVLADVLRMEVKNYE
LFHKKRMSVKAAATFLSNVLHSARFYPYIVQLLVGGFDTAPRLYSLDWFGTVAEEEFLVTGSGSPMAVGVIEAEYNPNMD
LEELVNLAVRAVFAATRRDTASGEGIDVAVIDRNGITMRHYRLGDVIRLVRP
>Mature_211_residues
SVDEKVARALKGTTTVGIRSEKAVVLAADKRATAGNFIVHKRVEKIVKISDYMAMTTAGLVADAQVLADVLRMEVKNYEL
FHKKRMSVKAAATFLSNVLHSARFYPYIVQLLVGGFDTAPRLYSLDWFGTVAEEEFLVTGSGSPMAVGVIEAEYNPNMDL
EELVNLAVRAVFAATRRDTASGEGIDVAVIDRNGITMRHYRLGDVIRLVRP

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

Organism=Homo sapiens, GI73747875, Length=184, Percent_Identity=35.3260869565217, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4758970, Length=184, Percent_Identity=35.3260869565217, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI4506201, Length=193, Percent_Identity=33.160621761658, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI22538465, Length=194, Percent_Identity=28.3505154639175, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI4506203, Length=192, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI4506191, Length=193, Percent_Identity=33.160621761658, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI153791216, Length=188, Percent_Identity=31.9148936170213, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4506193, Length=198, Percent_Identity=29.2929292929293, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI23110925, Length=197, Percent_Identity=28.4263959390863, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI23110942, Length=163, Percent_Identity=30.6748466257669, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI222144262, Length=115, Percent_Identity=33.9130434782609, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI4506205, Length=189, Percent_Identity=27.5132275132275, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI195539356, Length=138, Percent_Identity=31.1594202898551, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI68303563, Length=191, Percent_Identity=28.2722513089005, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI4506195, Length=186, Percent_Identity=26.3440860215054, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4506189, Length=191, Percent_Identity=26.7015706806283, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508499, Length=180, Percent_Identity=34.4444444444444, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17541700, Length=192, Percent_Identity=29.1666666666667, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17508495, Length=182, Percent_Identity=32.4175824175824, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17535357, Length=189, Percent_Identity=25.9259259259259, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17554384, Length=194, Percent_Identity=24.2268041237113, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17508493, Length=188, Percent_Identity=25, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508491, Length=164, Percent_Identity=28.0487804878049, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6325360, Length=202, Percent_Identity=29.7029702970297, Blast_Score=108, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6324731, Length=193, Percent_Identity=30.0518134715026, Blast_Score=85, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319430, Length=213, Percent_Identity=25.3521126760563, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320941, Length=198, Percent_Identity=25.7575757575758, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320849, Length=187, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6322459, Length=186, Percent_Identity=24.1935483870968, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321574, Length=183, Percent_Identity=22.9508196721311, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324535, Length=172, Percent_Identity=25.5813953488372, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323974, Length=192, Percent_Identity=26.5625, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20130281, Length=172, Percent_Identity=36.046511627907, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI21355573, Length=184, Percent_Identity=35.8695652173913, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24652553, Length=184, Percent_Identity=35.8695652173913, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24584895, Length=172, Percent_Identity=32.5581395348837, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24639979, Length=190, Percent_Identity=32.6315789473684, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653999, Length=189, Percent_Identity=29.1005291005291, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24664391, Length=192, Percent_Identity=30.7291666666667, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355629, Length=194, Percent_Identity=26.2886597938144, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17737605, Length=202, Percent_Identity=26.7326732673267, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24654391, Length=172, Percent_Identity=29.0697674418605, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24654389, Length=172, Percent_Identity=29.0697674418605, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24581176, Length=189, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922898, Length=139, Percent_Identity=30.9352517985612, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19921232, Length=190, Percent_Identity=28.4210526315789, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573221, Length=182, Percent_Identity=25.8241758241758, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17737405, Length=187, Percent_Identity=29.9465240641711, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB2_IGNH4 (A8AB58)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435567.1
- ProteinModelPortal:   A8AB58
- SMR:   A8AB58
- MEROPS:   T01.002
- GeneID:   5563149
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_0980
- eggNOG:   arNOG10234
- HOGENOM:   HBG499923
- OMA:   LANIMNG
- ProtClustDB:   CLSK964569
- GO:   GO:0005737
- HAMAP:   MF_02113_A
- InterPro:   IPR019983
- InterPro:   IPR000243
- InterPro:   IPR001353
- PRINTS:   PR00141
- TIGRFAMs:   TIGR03634

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 23308; Mature: 23177

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 14-14

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDEKVARALKGTTTVGIRSEKAVVLAADKRATAGNFIVHKRVEKIVKISDYMAMTTAG
CCHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVADAQVLADVLRMEVKNYELFHKKRMSVKAAATFLSNVLHSARFYPYIVQLLVGGFDTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PRLYSLDWFGTVAEEEFLVTGSGSPMAVGVIEAEYNPNMDLEELVNLAVRAVFAATRRDT
CCEEEECCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCC
ASGEGIDVAVIDRNGITMRHYRLGDVIRLVRP
CCCCCEEEEEEECCCCEEEEEHHHHHHHHCCC
>Mature Secondary Structure 
SVDEKVARALKGTTTVGIRSEKAVVLAADKRATAGNFIVHKRVEKIVKISDYMAMTTAG
CHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVADAQVLADVLRMEVKNYELFHKKRMSVKAAATFLSNVLHSARFYPYIVQLLVGGFDTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PRLYSLDWFGTVAEEEFLVTGSGSPMAVGVIEAEYNPNMDLEELVNLAVRAVFAATRRDT
CCEEEECCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCC
ASGEGIDVAVIDRNGITMRHYRLGDVIRLVRP
CCCCCEEEEEEECCCCEEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA