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The map label for this gene is trpE [H]

Identifier: 156937716

GI number: 156937716

Start: 818997

End: 820202

Strand: Reverse

Name: trpE [H]

Synonym: Igni_0925

Alternate gene names: 156937716

Gene position: 820202-818997 (Counterclockwise)

Preceding gene: 156937717

Following gene: 156937713

Centisome position: 63.21

GC content: 60.7

Gene sequence:

>1206_bases
TTGGAAGGTCCTTCCTTAATATTGGAGAGCGCTGCCGGCGGCGAGACCAAGGCGCGTCTGAGCTTGGTCGCGTGGGAGCC
GGAGGTAGACGTAATCGTCAAAGAAGGCGAGGACGTCAGGGAAGCGTTGAGGGAGCTGAGGGGCGGGGACGCGGACACGG
GGACCTTGTACAAGGGGGGCCCGATAGGCTACGTCAGCTACGAAGCCGTGGAGGCGTGGGAGGGGGTCAAGCACAAGGGA
GCTAACGACATGGGGTGGCCTTGGGGCGAGTTCGTCGTGCCAAAGAAGTTCGTCGTCTACGACCACGTGCTTGGCCACGC
CTCCCTCTGCGGGGTCAACAAGGACGAGCTCGGGGTCGGCGAGCCCTCCGAGCTCAAAGTTTTCGACGAGAGGCTCGACG
TTCCTAAGGACGTCTTCGTGAAGTGGGTAGAGGAGGTGAGGAGGTTAGAGGAGGAGGGAGAAGCCATACAAGTGGTCATC
TCAAAGTCCTACACCTACCGTTACGAGGGGGACTTGAGGAGGCTCTACTTCGAGTTGAGGAGAATTAACCCGTCGCCCTA
CATGTTCCACTTGAGAATGAAGAGCGGCGAGGTGTTGGGGAGCTCGCCGGAGCTCTTGTTCCGGGTTGAGCGCGGGAGGG
CGGAGACCTTCCCCATAGCCGGCACCCGCCCTAGGGGGAAGGACGAGTGGGAGGACTTGAGACTTGAGGAGGACTTGAAG
TCAGACCCCAAGGAGAGGGCCGAACACTTGATGTTAGTTGACTTGGCGAGGAACGACTTGGGCAAGGTGTCGAGACCGGG
GACGGTCAGAGTAACTAACATGATGTACGTGGAGAAGTACAGCCACGTGCAACACTTAGTGAGCAAAGTAGAGAGCGAGC
TCGACCCTCTCTTCGGGCCCGAGGACGTCTTGGCCGCTACCTTCCCCGCCGGCACGGTCAGCGGCGCCCCCAAGCCTGCT
GCCATGGAGATCATAGGGAACTTGGAGACGTTGAGAAGAGGTCCCTACGCCGGGGCCGTGGGCTTCGTGAGCGGCGGGGA
GGCGGAGTTCGCAATAACCATAAGGAGCTTCTTCGCGAGGTCCGGGCTGCTGAGGGCCCAAGCCGGGGCGGGGATAGTTT
ACTATTCCGTACCCCTAAAGGAGTGGGAGGAGACCGAGCACAAGCTGGCCGCGCTCAAGAGGGCCTTAGCCCCCTTCTTG
CTGTGA

Upstream 100 bases:

>100_bases
GACCCCGAGAAGGTAATGAAGGTAGCAGAGGTGATCGGCCTCGCGCTGTGAGAGGCTCCCGCTCTCCTCGGTGCCCAAGC
CCGCGGAGCTCTTCTCGTCC

Downstream 100 bases:

>100_bases
GGCCTTCTTCTTCCTCCAAACGTCCGGGTACGTTCCGGGCTTCATTATCACTCTCTTGGTCTTCGCCACCCAACCCTTCT
CCATTTTTAAGGCCTCTTGC

Product: anthranilate synthase, component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MEGPSLILESAAGGETKARLSLVAWEPEVDVIVKEGEDVREALRELRGGDADTGTLYKGGPIGYVSYEAVEAWEGVKHKG
ANDMGWPWGEFVVPKKFVVYDHVLGHASLCGVNKDELGVGEPSELKVFDERLDVPKDVFVKWVEEVRRLEEEGEAIQVVI
SKSYTYRYEGDLRRLYFELRRINPSPYMFHLRMKSGEVLGSSPELLFRVERGRAETFPIAGTRPRGKDEWEDLRLEEDLK
SDPKERAEHLMLVDLARNDLGKVSRPGTVRVTNMMYVEKYSHVQHLVSKVESELDPLFGPEDVLAATFPAGTVSGAPKPA
AMEIIGNLETLRRGPYAGAVGFVSGGEAEFAITIRSFFARSGLLRAQAGAGIVYYSVPLKEWEETEHKLAALKRALAPFL
L

Sequences:

>Translated_401_residues
MEGPSLILESAAGGETKARLSLVAWEPEVDVIVKEGEDVREALRELRGGDADTGTLYKGGPIGYVSYEAVEAWEGVKHKG
ANDMGWPWGEFVVPKKFVVYDHVLGHASLCGVNKDELGVGEPSELKVFDERLDVPKDVFVKWVEEVRRLEEEGEAIQVVI
SKSYTYRYEGDLRRLYFELRRINPSPYMFHLRMKSGEVLGSSPELLFRVERGRAETFPIAGTRPRGKDEWEDLRLEEDLK
SDPKERAEHLMLVDLARNDLGKVSRPGTVRVTNMMYVEKYSHVQHLVSKVESELDPLFGPEDVLAATFPAGTVSGAPKPA
AMEIIGNLETLRRGPYAGAVGFVSGGEAEFAITIRSFFARSGLLRAQAGAGIVYYSVPLKEWEETEHKLAALKRALAPFL
L
>Mature_401_residues
MEGPSLILESAAGGETKARLSLVAWEPEVDVIVKEGEDVREALRELRGGDADTGTLYKGGPIGYVSYEAVEAWEGVKHKG
ANDMGWPWGEFVVPKKFVVYDHVLGHASLCGVNKDELGVGEPSELKVFDERLDVPKDVFVKWVEEVRRLEEEGEAIQVVI
SKSYTYRYEGDLRRLYFELRRINPSPYMFHLRMKSGEVLGSSPELLFRVERGRAETFPIAGTRPRGKDEWEDLRLEEDLK
SDPKERAEHLMLVDLARNDLGKVSRPGTVRVTNMMYVEKYSHVQHLVSKVESELDPLFGPEDVLAATFPAGTVSGAPKPA
AMEIIGNLETLRRGPYAGAVGFVSGGEAEFAITIRSFFARSGLLRAQAGAGIVYYSVPLKEWEETEHKLAALKRALAPFL
L

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=254, Percent_Identity=42.9133858267717, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1788114, Length=351, Percent_Identity=30.7692307692308, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI87082077, Length=264, Percent_Identity=26.8939393939394, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786809, Length=268, Percent_Identity=30.9701492537313, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320935, Length=429, Percent_Identity=32.4009324009324, Blast_Score=199, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6324361, Length=247, Percent_Identity=28.3400809716599, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR010116
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 44666; Mature: 44666

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGPSLILESAAGGETKARLSLVAWEPEVDVIVKEGEDVREALRELRGGDADTGTLYKGG
CCCCCEEEECCCCCCCEEEEEEEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCEECCC
PIGYVSYEAVEAWEGVKHKGANDMGWPWGEFVVPKKFVVYDHVLGHASLCGVNKDELGVG
CEEEEEHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHCCHHHCCCCHHHCCCC
EPSELKVFDERLDVPKDVFVKWVEEVRRLEEEGEAIQVVISKSYTYRYEGDLRRLYFELR
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEECCHHHHHHHHHH
RINPSPYMFHLRMKSGEVLGSSPELLFRVERGRAETFPIAGTRPRGKDEWEDLRLEEDLK
HCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHCCHHHHHC
SDPKERAEHLMLVDLARNDLGKVSRPGTVRVTNMMYVEKYSHVQHLVSKVESELDPLFGP
CCHHHHHHHEEEEEHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EDVLAATFPAGTVSGAPKPAAMEIIGNLETLRRGPYAGAVGFVSGGEAEFAITIRSFFAR
HHHHEEECCCCCCCCCCCHHHHHHHHCHHHHHCCCCCCEEEECCCCCCEEEEEHHHHHHH
SGLLRAQAGAGIVYYSVPLKEWEETEHKLAALKRALAPFLL
CCCEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEGPSLILESAAGGETKARLSLVAWEPEVDVIVKEGEDVREALRELRGGDADTGTLYKGG
CCCCCEEEECCCCCCCEEEEEEEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCEECCC
PIGYVSYEAVEAWEGVKHKGANDMGWPWGEFVVPKKFVVYDHVLGHASLCGVNKDELGVG
CEEEEEHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHCCHHHCCCCHHHCCCC
EPSELKVFDERLDVPKDVFVKWVEEVRRLEEEGEAIQVVISKSYTYRYEGDLRRLYFELR
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEECCHHHHHHHHHH
RINPSPYMFHLRMKSGEVLGSSPELLFRVERGRAETFPIAGTRPRGKDEWEDLRLEEDLK
HCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHCCHHHHHC
SDPKERAEHLMLVDLARNDLGKVSRPGTVRVTNMMYVEKYSHVQHLVSKVESELDPLFGP
CCHHHHHHHEEEEEHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EDVLAATFPAGTVSGAPKPAAMEIIGNLETLRRGPYAGAVGFVSGGEAEFAITIRSFFAR
HHHHEEECCCCCCCCCCCHHHHHHHHCHHHHHCCCCCCEEEECCCCCCEEEEEHHHHHHH
SGLLRAQAGAGIVYYSVPLKEWEETEHKLAALKRALAPFLL
CCCEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8416906; 9016772; 11427726; 10449718 [H]