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The map label for this gene is thsB [H]

Identifier: 156937688

GI number: 156937688

Start: 796148

End: 797773

Strand: Direct

Name: thsB [H]

Synonym: Igni_0897

Alternate gene names: 156937688

Gene position: 796148-797773 (Clockwise)

Preceding gene: 156937686

Following gene: 156937689

Centisome position: 61.36

GC content: 60.39

Gene sequence:

>1626_bases
ATGGCGGTCAGGCCTATCGAGAGCATGGGCGTTCCGGTAGTGATACTCAAGGAGGGCTCCACCAGGACCTACGGCAGGGA
GGCTCTGAGGACTAACATGATGGCCGCTAGGGCGGTCGCCGAGGTTCTGAGGACCACCTTCGGCCCCAAGGGAATGGACA
AGATGTTGGTAGACAGCTTGGGCGACGTGACCATAACCAACGACGGCGCCACCATATTGGACAAGATGGACTTGCAGCAC
CCCGCCGCCAAGCTGCTGGTCCAGATAGCTAAGGGCCAGGACGAGGAGGTGGGCGACGGCACCAAGAGGGCGGTGATCTT
CGCTGGCGAGCTCTTGAAGCACGCCGAGGACTTGTTGGAGAAGGACGTACACCCCACCATAATTATCCAAGGTTACAAGA
AGGCCCTAGGGAAGGCGCTGGAGAAGATAGAGGAGATCGCCGAGCCCATCGACCCTGAGGACAAGGAGAAGCTCAAGAGG
ATAGCGCTCACCAGCTTGGCCAGCAAGGGCGTGCAAGAGGCTAGGGAGCTGTTCGCCGAGATCGCCGTGGAGGCGGTAAA
CACCATCAAGGAGAAGAGGGGCGACAAGTGGTACGTCGACTTGGACTACGTCCAAATAGTCAAGAAGCACGGCGGCAGCT
TGAAGGACACCAAGCTGATAAAGGGAGTGGTCCTCGACAAGGAGGTAGTCCACCCCAACATGCCGAAGAGGGTAGAGAAC
GCTAAGATAGCCGTGCTCGACGCCCCGCTGGAGCTGGAGAAGCCCGAACTGGACGCCGAGATAAGGATAACCAGCCCCGA
GCAGCTGAAGGCTCTACTGGAGGAGAAGGAGGAGATACTGAGGAAGAAGGTGGAGAAGCTCAAGGAAGTGGGCGCCAACG
TGGTGATAACTCAGAAGGGCATCGACGAGGTCGCTCAGTACTACCTAGCGAAGGCCGGCATAATGGCCGTCAGGAGGGTG
AAGAGGAGCGACCTGGAGAAGGTGGCCAGGGCCACCGGCGCCAAGATAATCAGCAACGTCGAGGACATAACTCCCAACGA
CTTGGGCGAGGCCAAGCTAGTGGAGGAGAGAAAGGTAGGCGACGACAAGATGGTCTTCATCGAGGGCGCCAAGAACCCGA
GAGCAGTGAGCGTGCTGATCAGGGGAGGCTTCGAGAGGATCGTAGACGAGGCCGAGAGGAGCTTGAGGGACGCCCTCAGC
GCAGTGGCTGACGCGGTGAGGGCCGGCAAGATAGTGGGCGCCGGAGGGGCGCCGGAGGTGGAGCTCGCGCTGGCGCTCAG
GGACTACGCCAGGGAGGTGGGCGGCAAGGAGCAGCTAGCGATAGAGGCCTTCGCCAAGGCCCTAGAGGGCATAGTTATGG
CCCTCGTCGAGAACGCCGGCTACGACCCGGTGGAGAAGCTGATGCAGCTGAGGGCCGCCCACGCCAAGGAGGGCTGCAAG
CACTGCGGCGTAGACGTGTACACCGGCGAGATAACTGACATGTTGAAGAAGGGCGCCTTCGAGGCCGTCGCCATACCGGC
CAACGCGATCAAGAGCGGAACCGAGGCCGCCACTCTGATACTGAGGATCGACGACATAGTGATAGCCGGCAAGAAGGAAG
AGGAGAGCAAGGGCGGCGAGAAGTAA

Upstream 100 bases:

>100_bases
AAATTTGGCGATTTGATGTTCTGAGAGGCTAAGGGGCCAGCATGGTGGCAAAAAACTTATATAGAACCGGTTCCACCACA
CCCCACGGTGGGTGAGCGCG

Downstream 100 bases:

>100_bases
ACCCGATTAGGGTTTTTGGGACTCCCTCCTTCGGGAAGCCCTTGGTCAAGCCCATCCTGATTAACGGTTTCCCGCGCTCC
GGGACCACTTACTTGTTTAG

Product: thermosome

Products: NA

Alternate protein names: Chaperonin subunit beta; Thermosome subunit 2 [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MAVRPIESMGVPVVILKEGSTRTYGREALRTNMMAARAVAEVLRTTFGPKGMDKMLVDSLGDVTITNDGATILDKMDLQH
PAAKLLVQIAKGQDEEVGDGTKRAVIFAGELLKHAEDLLEKDVHPTIIIQGYKKALGKALEKIEEIAEPIDPEDKEKLKR
IALTSLASKGVQEARELFAEIAVEAVNTIKEKRGDKWYVDLDYVQIVKKHGGSLKDTKLIKGVVLDKEVVHPNMPKRVEN
AKIAVLDAPLELEKPELDAEIRITSPEQLKALLEEKEEILRKKVEKLKEVGANVVITQKGIDEVAQYYLAKAGIMAVRRV
KRSDLEKVARATGAKIISNVEDITPNDLGEAKLVEERKVGDDKMVFIEGAKNPRAVSVLIRGGFERIVDEAERSLRDALS
AVADAVRAGKIVGAGGAPEVELALALRDYAREVGGKEQLAIEAFAKALEGIVMALVENAGYDPVEKLMQLRAAHAKEGCK
HCGVDVYTGEITDMLKKGAFEAVAIPANAIKSGTEAATLILRIDDIVIAGKKEEESKGGEK

Sequences:

>Translated_541_residues
MAVRPIESMGVPVVILKEGSTRTYGREALRTNMMAARAVAEVLRTTFGPKGMDKMLVDSLGDVTITNDGATILDKMDLQH
PAAKLLVQIAKGQDEEVGDGTKRAVIFAGELLKHAEDLLEKDVHPTIIIQGYKKALGKALEKIEEIAEPIDPEDKEKLKR
IALTSLASKGVQEARELFAEIAVEAVNTIKEKRGDKWYVDLDYVQIVKKHGGSLKDTKLIKGVVLDKEVVHPNMPKRVEN
AKIAVLDAPLELEKPELDAEIRITSPEQLKALLEEKEEILRKKVEKLKEVGANVVITQKGIDEVAQYYLAKAGIMAVRRV
KRSDLEKVARATGAKIISNVEDITPNDLGEAKLVEERKVGDDKMVFIEGAKNPRAVSVLIRGGFERIVDEAERSLRDALS
AVADAVRAGKIVGAGGAPEVELALALRDYAREVGGKEQLAIEAFAKALEGIVMALVENAGYDPVEKLMQLRAAHAKEGCK
HCGVDVYTGEITDMLKKGAFEAVAIPANAIKSGTEAATLILRIDDIVIAGKKEEESKGGEK
>Mature_540_residues
AVRPIESMGVPVVILKEGSTRTYGREALRTNMMAARAVAEVLRTTFGPKGMDKMLVDSLGDVTITNDGATILDKMDLQHP
AAKLLVQIAKGQDEEVGDGTKRAVIFAGELLKHAEDLLEKDVHPTIIIQGYKKALGKALEKIEEIAEPIDPEDKEKLKRI
ALTSLASKGVQEARELFAEIAVEAVNTIKEKRGDKWYVDLDYVQIVKKHGGSLKDTKLIKGVVLDKEVVHPNMPKRVENA
KIAVLDAPLELEKPELDAEIRITSPEQLKALLEEKEEILRKKVEKLKEVGANVVITQKGIDEVAQYYLAKAGIMAVRRVK
RSDLEKVARATGAKIISNVEDITPNDLGEAKLVEERKVGDDKMVFIEGAKNPRAVSVLIRGGFERIVDEAERSLRDALSA
VADAVRAGKIVGAGGAPEVELALALRDYAREVGGKEQLAIEAFAKALEGIVMALVENAGYDPVEKLMQLRAAHAKEGCKH
CGVDVYTGEITDMLKKGAFEAVAIPANAIKSGTEAATLILRIDDIVIAGKKEEESKGGEK

Specific function: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TCP-1 chaperonin family [H]

Homologues:

Organism=Homo sapiens, GI24307939, Length=541, Percent_Identity=42.3290203327172, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI63162572, Length=532, Percent_Identity=37.781954887218, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI5453607, Length=526, Percent_Identity=38.4030418250951, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI38455427, Length=504, Percent_Identity=38.6904761904762, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI57863257, Length=535, Percent_Identity=38.5046728971963, Blast_Score=357, Evalue=2e-98,
Organism=Homo sapiens, GI58761484, Length=469, Percent_Identity=37.3134328358209, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI261399877, Length=483, Percent_Identity=37.888198757764, Blast_Score=322, Evalue=4e-88,
Organism=Homo sapiens, GI4502643, Length=513, Percent_Identity=37.4269005847953, Blast_Score=313, Evalue=4e-85,
Organism=Homo sapiens, GI58331173, Length=509, Percent_Identity=38.1139489194499, Blast_Score=312, Evalue=5e-85,
Organism=Homo sapiens, GI5453603, Length=530, Percent_Identity=35.8490566037736, Blast_Score=301, Evalue=8e-82,
Organism=Homo sapiens, GI261399875, Length=438, Percent_Identity=35.1598173515982, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI302058290, Length=500, Percent_Identity=35.4, Blast_Score=260, Evalue=3e-69,
Organism=Homo sapiens, GI58331171, Length=513, Percent_Identity=33.9181286549708, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI302058292, Length=509, Percent_Identity=34.5776031434185, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI48762932, Length=522, Percent_Identity=32.3754789272031, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI57863259, Length=390, Percent_Identity=35.3846153846154, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI58331185, Length=317, Percent_Identity=35.6466876971609, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI7657253, Length=507, Percent_Identity=25.4437869822485, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI41399285, Length=582, Percent_Identity=22.3367697594502, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI31542947, Length=582, Percent_Identity=22.3367697594502, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1790586, Length=556, Percent_Identity=22.6618705035971, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25144674, Length=521, Percent_Identity=40.8829174664108, Blast_Score=381, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17532601, Length=533, Percent_Identity=38.2739212007505, Blast_Score=353, Evalue=9e-98,
Organism=Caenorhabditis elegans, GI25148561, Length=534, Percent_Identity=34.2696629213483, Blast_Score=348, Evalue=5e-96,
Organism=Caenorhabditis elegans, GI17532603, Length=511, Percent_Identity=38.9432485322896, Blast_Score=345, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17564182, Length=524, Percent_Identity=36.4503816793893, Blast_Score=338, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI25147750, Length=530, Percent_Identity=36.2264150943396, Blast_Score=315, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI32566944, Length=446, Percent_Identity=36.0986547085202, Blast_Score=295, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI25144678, Length=517, Percent_Identity=34.2359767891683, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI25144680, Length=392, Percent_Identity=35.969387755102, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71981457, Length=320, Percent_Identity=38.4375, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71998178, Length=568, Percent_Identity=27.9929577464789, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17555558, Length=564, Percent_Identity=24.468085106383, Blast_Score=92, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6322446, Length=535, Percent_Identity=39.4392523364486, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6322524, Length=541, Percent_Identity=37.7079482439926, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6322350, Length=533, Percent_Identity=38.0863039399625, Blast_Score=351, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6320418, Length=531, Percent_Identity=37.8531073446328, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6320058, Length=513, Percent_Identity=36.6471734892787, Blast_Score=310, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6322049, Length=526, Percent_Identity=33.8403041825095, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6320393, Length=523, Percent_Identity=33.0783938814532, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6322452, Length=518, Percent_Identity=30.1158301158301, Blast_Score=227, Evalue=4e-60,
Organism=Drosophila melanogaster, GI17647245, Length=527, Percent_Identity=39.4686907020873, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652903, Length=500, Percent_Identity=40, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24645179, Length=533, Percent_Identity=38.4615384615385, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24649027, Length=551, Percent_Identity=37.2050816696915, Blast_Score=357, Evalue=1e-98,
Organism=Drosophila melanogaster, GI24649029, Length=551, Percent_Identity=37.2050816696915, Blast_Score=357, Evalue=1e-98,
Organism=Drosophila melanogaster, GI24647512, Length=527, Percent_Identity=36.6223908918406, Blast_Score=352, Evalue=5e-97,
Organism=Drosophila melanogaster, GI24647510, Length=527, Percent_Identity=36.6223908918406, Blast_Score=352, Evalue=5e-97,
Organism=Drosophila melanogaster, GI24583944, Length=504, Percent_Identity=38.6904761904762, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI28571140, Length=524, Percent_Identity=36.4503816793893, Blast_Score=321, Evalue=1e-87,
Organism=Drosophila melanogaster, GI18858175, Length=524, Percent_Identity=36.4503816793893, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI18859933, Length=513, Percent_Identity=33.9181286549708, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI19921848, Length=523, Percent_Identity=32.3135755258126, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI20130093, Length=214, Percent_Identity=29.9065420560748, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI45552711, Length=214, Percent_Identity=29.9065420560748, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24641193, Length=557, Percent_Identity=22.4416517055655, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24641191, Length=557, Percent_Identity=22.4416517055655, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45550936, Length=549, Percent_Identity=23.1329690346084, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550132, Length=549, Percent_Identity=23.1329690346084, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550935, Length=549, Percent_Identity=23.1329690346084, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017998
- InterPro:   IPR002194
- InterPro:   IPR002423
- InterPro:   IPR012714 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58828; Mature: 58697

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00750 TCP1_1 ; PS00751 TCP1_2 ; PS00995 TCP1_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVRPIESMGVPVVILKEGSTRTYGREALRTNMMAARAVAEVLRTTFGPKGMDKMLVDSL
CCCCCCHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
GDVTITNDGATILDKMDLQHPAAKLLVQIAKGQDEEVGDGTKRAVIFAGELLKHAEDLLE
CCEEEECCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
KDVHPTIIIQGYKKALGKALEKIEEIAEPIDPEDKEKLKRIALTSLASKGVQEARELFAE
CCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVEAVNTIKEKRGDKWYVDLDYVQIVKKHGGSLKDTKLIKGVVLDKEVVHPNMPKRVEN
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHCHHHCCCCCCCHHCC
AKIAVLDAPLELEKPELDAEIRITSPEQLKALLEEKEEILRKKVEKLKEVGANVVITQKG
CEEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
IDEVAQYYLAKAGIMAVRRVKRSDLEKVARATGAKIISNVEDITPNDLGEAKLVEERKVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCC
DDKMVFIEGAKNPRAVSVLIRGGFERIVDEAERSLRDALSAVADAVRAGKIVGAGGAPEV
CCCEEEEECCCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCH
ELALALRDYAREVGGKEQLAIEAFAKALEGIVMALVENAGYDPVEKLMQLRAAHAKEGCK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HCGVDVYTGEITDMLKKGAFEAVAIPANAIKSGTEAATLILRIDDIVIAGKKEEESKGGE
HCCCEEEEHHHHHHHHHCCCCEEECCHHHHCCCCCCEEEEEEEEEEEEECCCCCCCCCCC
K
C
>Mature Secondary Structure 
AVRPIESMGVPVVILKEGSTRTYGREALRTNMMAARAVAEVLRTTFGPKGMDKMLVDSL
CCCCCHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
GDVTITNDGATILDKMDLQHPAAKLLVQIAKGQDEEVGDGTKRAVIFAGELLKHAEDLLE
CCEEEECCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
KDVHPTIIIQGYKKALGKALEKIEEIAEPIDPEDKEKLKRIALTSLASKGVQEARELFAE
CCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVEAVNTIKEKRGDKWYVDLDYVQIVKKHGGSLKDTKLIKGVVLDKEVVHPNMPKRVEN
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHCHHHCCCCCCCHHCC
AKIAVLDAPLELEKPELDAEIRITSPEQLKALLEEKEEILRKKVEKLKEVGANVVITQKG
CEEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
IDEVAQYYLAKAGIMAVRRVKRSDLEKVARATGAKIISNVEDITPNDLGEAKLVEERKVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCC
DDKMVFIEGAKNPRAVSVLIRGGFERIVDEAERSLRDALSAVADAVRAGKIVGAGGAPEV
CCCEEEEECCCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCH
ELALALRDYAREVGGKEQLAIEAFAKALEGIVMALVENAGYDPVEKLMQLRAAHAKEGCK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HCGVDVYTGEITDMLKKGAFEAVAIPANAIKSGTEAATLILRIDDIVIAGKKEEESKGGE
HCCCEEEEHHHHHHHHHCCCCEEECCHHHHCCCCCCEEEEEEEEEEEEECCCCCCCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]