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The map label for this gene is glmU [H]

Identifier: 156937666

GI number: 156937666

Start: 773561

End: 774811

Strand: Direct

Name: glmU [H]

Synonym: Igni_0873

Alternate gene names: 156937666

Gene position: 773561-774811 (Clockwise)

Preceding gene: 156937665

Following gene: 156937667

Centisome position: 59.62

GC content: 61.07

Gene sequence:

>1251_bases
GTGACCCCGGATGAACGGAGCCGAGTTGGCCGAGAGCCGTTTTCTGCCCTCCCCTCCTCAGACCCGCGGAGCCCCGCCTT
GAGGACTGCCGCAGTTCTCCTCGCCGCTGGGAAGGGCGAACGCATGTGGCCCCTCACGTCCACGCGCCCCAAGCCCTTGC
TGCCCGTAGCCTTGGGCGAGAGCTTGTTGGAGCGATGGATTAAGGCGCTGAAGGAAATAACGGAAGACATCATCGTAGTC
GTCAATAAAGAACACGTCAAATACTTTGAAAACTTAAGGTCCGAGTACGGAGTCGAGCTGGCAGTACAGATCGCCGCCCC
TGGGACGGGGGCGGCGTTGGCCTCTGTGAAGCCCCCGGAGGCAGACTACGTGGTAGTGGCTTACGCCGACGTGTACTTGC
AGAGGCCGCTCTTAGAGCTGAAGAGGCTCTTGGCCGAGGCCCCCTCGGTACTGGCCGTCCGAGTGGACGACGTGAGCCAG
TACGGCGCGTTGGTCGTCGAGAACGGCGAGGTAAGGGAAGTGATTGAGAAGGAGATGAGCGGCCCCGGTCTCATAAATGG
AGGCGTATACGTCTTCAGTAAGGAAATATTTGAGTTATTGAAGGAGTTAAAGCCTTCCAAGAGGGGCGAATACGAACTGA
CGGACTTGGTCAAAGGGCTTAGGGCGGTGGAGGTCGCGAGCGGATGGAAGGACGTCGGCAGGCCTTGGGACATCTTCGAC
GTGATGAAAATGGAATTCGAGGTGAGGGAGGGCCTCGAGAACCCTTGGGGGCCCGGGAAAGTCTACGGCGAGCTGCCCGA
AGTCAAGGGCGAGGTTTACGTGGAGGGGCCGGTCTACTTCGGCGAGGGCGTCGTTTTGGGCCCCTTCGCCCACGTGAGGC
CCTACGTCGCCTTGCTAGACGGCGTGAAGGTGGGCCCGTTCGTACAAGTTAAGGAGTCTATGATAATGGAGGGTTCGAGG
TTGCCCCACTTGAACTACGTGGGGGACAGCGTGGTGGCCGAGGACGTCAACTTCGGCGCGGGCAGCGTCACGGCCAACTT
GAGGTTCGACGAGAGGGAGGTAGAGGTAACCCTCAAGGGCCAGAGGGTCAGCACGGGGAGGAGGAAACTGGGCGCGATAG
TGGGCGGGGGCGCCAGGATAGGGGTCAACGTGAGCTTGATGCCGGGGACTAGGGTGGGCGCCCGCTCTTGGATTTACCCC
GGCTGCGTAGTGAGGGGCGACGTCCCGGACGGGGCTAGGTACAAGTGCTGA

Upstream 100 bases:

>100_bases
GTTCTTGAGTGAAGTCATGAAGAAGCTATTAAGGGTGGAGGTGTGGGCTAGGGAGGTAGAGAGCAAGAAGAGGAGGCGCA
GATGAGGAGACCGCCAGTGT

Downstream 100 bases:

>100_bases
GGCGGTGTTTAGGAAATGAAGAGGGTACTCGTAGTAACGAGTAAGAGGTTGGAGAGCGCCGTCAAGGCCATGCTCAAGCC
CCCTGAGGGCTACTCCGTGG

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTPDERSRVGREPFSALPSSDPRSPALRTAAVLLAAGKGERMWPLTSTRPKPLLPVALGESLLERWIKALKEITEDIIVV
VNKEHVKYFENLRSEYGVELAVQIAAPGTGAALASVKPPEADYVVVAYADVYLQRPLLELKRLLAEAPSVLAVRVDDVSQ
YGALVVENGEVREVIEKEMSGPGLINGGVYVFSKEIFELLKELKPSKRGEYELTDLVKGLRAVEVASGWKDVGRPWDIFD
VMKMEFEVREGLENPWGPGKVYGELPEVKGEVYVEGPVYFGEGVVLGPFAHVRPYVALLDGVKVGPFVQVKESMIMEGSR
LPHLNYVGDSVVAEDVNFGAGSVTANLRFDEREVEVTLKGQRVSTGRRKLGAIVGGGARIGVNVSLMPGTRVGARSWIYP
GCVVRGDVPDGARYKC

Sequences:

>Translated_416_residues
MTPDERSRVGREPFSALPSSDPRSPALRTAAVLLAAGKGERMWPLTSTRPKPLLPVALGESLLERWIKALKEITEDIIVV
VNKEHVKYFENLRSEYGVELAVQIAAPGTGAALASVKPPEADYVVVAYADVYLQRPLLELKRLLAEAPSVLAVRVDDVSQ
YGALVVENGEVREVIEKEMSGPGLINGGVYVFSKEIFELLKELKPSKRGEYELTDLVKGLRAVEVASGWKDVGRPWDIFD
VMKMEFEVREGLENPWGPGKVYGELPEVKGEVYVEGPVYFGEGVVLGPFAHVRPYVALLDGVKVGPFVQVKESMIMEGSR
LPHLNYVGDSVVAEDVNFGAGSVTANLRFDEREVEVTLKGQRVSTGRRKLGAIVGGGARIGVNVSLMPGTRVGARSWIYP
GCVVRGDVPDGARYKC
>Mature_415_residues
TPDERSRVGREPFSALPSSDPRSPALRTAAVLLAAGKGERMWPLTSTRPKPLLPVALGESLLERWIKALKEITEDIIVVV
NKEHVKYFENLRSEYGVELAVQIAAPGTGAALASVKPPEADYVVVAYADVYLQRPLLELKRLLAEAPSVLAVRVDDVSQY
GALVVENGEVREVIEKEMSGPGLINGGVYVFSKEIFELLKELKPSKRGEYELTDLVKGLRAVEVASGWKDVGRPWDIFDV
MKMEFEVREGLENPWGPGKVYGELPEVKGEVYVEGPVYFGEGVVLGPFAHVRPYVALLDGVKVGPFVQVKESMIMEGSRL
PHLNYVGDSVVAEDVNFGAGSVTANLRFDEREVEVTLKGQRVSTGRRKLGAIVGGGARIGVNVSLMPGTRVGARSWIYPG
CVVRGDVPDGARYKC

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=309, Percent_Identity=24.2718446601942, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI11761619, Length=309, Percent_Identity=24.2718446601942, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790168, Length=462, Percent_Identity=25.1082251082251, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI133931050, Length=327, Percent_Identity=25.0764525993884, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=307, Percent_Identity=25.4071661237785, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355443, Length=319, Percent_Identity=25.705329153605, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644084, Length=319, Percent_Identity=25.705329153605, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 45415; Mature: 45284

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDERSRVGREPFSALPSSDPRSPALRTAAVLLAAGKGERMWPLTSTRPKPLLPVALGE
CCCCHHHHCCCCHHHHCCCCCCCCHHHHHHHHHEECCCCCEECCCCCCCCCCCCHHHHHH
SLLERWIKALKEITEDIIVVVNKEHVKYFENLRSEYGVELAVQIAAPGTGAALASVKPPE
HHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCCC
ADYVVVAYADVYLQRPLLELKRLLAEAPSVLAVRVDDVSQYGALVVENGEVREVIEKEMS
CCEEEEEEHHHHHHCHHHHHHHHHHCCCCEEEEEECCHHHCCEEEEECCHHHHHHHHHCC
GPGLINGGVYVFSKEIFELLKELKPSKRGEYELTDLVKGLRAVEVASGWKDVGRPWDIFD
CCCEECCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCHHH
VMKMEFEVREGLENPWGPGKVYGELPEVKGEVYVEGPVYFGEGVVLGPFAHVRPYVALLD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCEEECCCEEECCHHHHHHHHHHHC
GVKVGPFVQVKESMIMEGSRLPHLNYVGDSVVAEDVNFGAGSVTANLRFDEREVEVTLKG
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEEECCEEEEEEEEC
QRVSTGRRKLGAIVGGGARIGVNVSLMPGTRVGARSWIYPGCVVRGDVPDGARYKC
CCCCCCHHHHHHEECCCEEEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
TPDERSRVGREPFSALPSSDPRSPALRTAAVLLAAGKGERMWPLTSTRPKPLLPVALGE
CCCHHHHCCCCHHHHCCCCCCCCHHHHHHHHHEECCCCCEECCCCCCCCCCCCHHHHHH
SLLERWIKALKEITEDIIVVVNKEHVKYFENLRSEYGVELAVQIAAPGTGAALASVKPPE
HHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCCC
ADYVVVAYADVYLQRPLLELKRLLAEAPSVLAVRVDDVSQYGALVVENGEVREVIEKEMS
CCEEEEEEHHHHHHCHHHHHHHHHHCCCCEEEEEECCHHHCCEEEEECCHHHHHHHHHCC
GPGLINGGVYVFSKEIFELLKELKPSKRGEYELTDLVKGLRAVEVASGWKDVGRPWDIFD
CCCEECCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCHHH
VMKMEFEVREGLENPWGPGKVYGELPEVKGEVYVEGPVYFGEGVVLGPFAHVRPYVALLD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCEEECCCEEECCHHHHHHHHHHHC
GVKVGPFVQVKESMIMEGSRLPHLNYVGDSVVAEDVNFGAGSVTANLRFDEREVEVTLKG
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEEECCEEEEEEEEC
QRVSTGRRKLGAIVGGGARIGVNVSLMPGTRVGARSWIYPGCVVRGDVPDGARYKC
CCCCCCHHHHHHEECCCEEEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]