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The map label for this gene is arsB [C]

Identifier: 156937622

GI number: 156937622

Start: 738475

End: 739737

Strand: Direct

Name: arsB [C]

Synonym: Igni_0829

Alternate gene names: 156937622

Gene position: 738475-739737 (Clockwise)

Preceding gene: 156937621

Following gene: 156937623

Centisome position: 56.91

GC content: 56.29

Gene sequence:

>1263_bases
TTGAGGGAGCTGGCGGCCGGAGCGCTCTTCGCGGGAGTGGTAACTGTCATGATCTTCTTGCCCGAGTCCAAGCGCCCTTG
GGCGGCCCTAGCCGGAGCGGCCTTGGCCCTAGCGGCGGGGCTCGTCGAACCCTCCCGCCTCCCGGAGCACTTGAACCTAG
ACGTGCTGGGCTTGATAGCCGGGGCTTGTGTAATTTCCGCTTACTTGACCGAGTCGGGCTTGATGGACGAGTTGGCCCAG
AGGTCCTTGAGGTGGAGCAAGGGCGACTTGAGGAGGCTCACTTGGTCCTTGGCTATGGTCTCCGGAGTGGTTTCGCTCTT
TATAGAGAACGTGACGACGTTAATCATGCTCGCCCCCATGGTGTTCAGCGTAGCGCGCGCGTTGAAGGTAGACGCCGTCC
CGATGCTGCTCGCGGCGGCCTTCGCCTCCAACTTGGGCGGAGCCGCGCTGCTCGTGGGCGACCCCCAGAGCGCGCTGGCC
GCCGGTTACTTCAACTTGGACTTCGGGGACTTCCTCTTCCACGCGGGCAAGCCTTCCATATTCTGGATGGTCTTGACAGC
CTTGATTGCCTCCACCACTGCCTTCACTTATACGTTCGTAAAGGGGAAGTTTAATTTACCGAGCGAATCCAAGGAGAAGA
GGTCGATAAGGGACAAGAAGCTAGCTTACGTCAGCTTAACTGCTTTAGCAATCAAGATATTGCTACTGGCGCTCAGAAAG
CAGTTGGGCATAGGTCTGAGCTTACCGGCATTCATAGGGGCCTCGATAATATTACTATACACTAGAGACGTAAAGTTCGC
TATTAAGTCTATCGAGTGGAAGCTGCTAGCCTTCTTGGCCGGGATGTTCGTACTGGTGGGGGCGCTGCAAGACAGCGGGA
CCATGAGGTTGGTAGCTGAGTCCTTCACCAAGCTCGCCTCTTGCGACTACTACAAGCTGACGGCCTTGATAGTCGCGGCG
TCGGTTGCTGTCTCAGCCGTGGTAGACAACGTTCCCTACTTAATGGCGATGTTCCCCATAATTTCTAAAATATCCTCCCA
CTGCGGCATATACTACTTCAAGCTGCTGTTAGCCCTCTTGATAGGAGCAACCCTCGGTGGGAACATAACTTACTTCGGGA
GCTCGACCAACATAACGGCGGTTCACTTGCTAGAGGAAGAGGGGTACTCGGTGAGGTTTAGGGACTTCCTTAAATACGGC
GCTTACTACACCGCTTGGGCGCTGGGCTCCGCGCTGGCCCTCTACTACGCCTTGTGGAGATGA

Upstream 100 bases:

>100_bases
CTTCGTCTTTAAGGACGCCCAGATAAAGAGGCCCTCTAAGTGCCCGCGCTGTAAGAGCCAGTGGATAGAGCCTCCTAGGT
TCGTGATAAGGTGAGGGGCG

Downstream 100 bases:

>100_bases
CGAGGGATTATCGAAGGGAAGCGGTGACCGGCGGGAGTACGGCGGATCCGTGACACCCTTCCAACCGCTTTAATTACTCG
GGTCGGCGATACTAACGAAG

Product: citrate transporter

Products: ADP; phosphate; arsenite [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MRELAAGALFAGVVTVMIFLPESKRPWAALAGAALALAAGLVEPSRLPEHLNLDVLGLIAGACVISAYLTESGLMDELAQ
RSLRWSKGDLRRLTWSLAMVSGVVSLFIENVTTLIMLAPMVFSVARALKVDAVPMLLAAAFASNLGGAALLVGDPQSALA
AGYFNLDFGDFLFHAGKPSIFWMVLTALIASTTAFTYTFVKGKFNLPSESKEKRSIRDKKLAYVSLTALAIKILLLALRK
QLGIGLSLPAFIGASIILLYTRDVKFAIKSIEWKLLAFLAGMFVLVGALQDSGTMRLVAESFTKLASCDYYKLTALIVAA
SVAVSAVVDNVPYLMAMFPIISKISSHCGIYYFKLLLALLIGATLGGNITYFGSSTNITAVHLLEEEGYSVRFRDFLKYG
AYYTAWALGSALALYYALWR

Sequences:

>Translated_420_residues
MRELAAGALFAGVVTVMIFLPESKRPWAALAGAALALAAGLVEPSRLPEHLNLDVLGLIAGACVISAYLTESGLMDELAQ
RSLRWSKGDLRRLTWSLAMVSGVVSLFIENVTTLIMLAPMVFSVARALKVDAVPMLLAAAFASNLGGAALLVGDPQSALA
AGYFNLDFGDFLFHAGKPSIFWMVLTALIASTTAFTYTFVKGKFNLPSESKEKRSIRDKKLAYVSLTALAIKILLLALRK
QLGIGLSLPAFIGASIILLYTRDVKFAIKSIEWKLLAFLAGMFVLVGALQDSGTMRLVAESFTKLASCDYYKLTALIVAA
SVAVSAVVDNVPYLMAMFPIISKISSHCGIYYFKLLLALLIGATLGGNITYFGSSTNITAVHLLEEEGYSVRFRDFLKYG
AYYTAWALGSALALYYALWR
>Mature_420_residues
MRELAAGALFAGVVTVMIFLPESKRPWAALAGAALALAAGLVEPSRLPEHLNLDVLGLIAGACVISAYLTESGLMDELAQ
RSLRWSKGDLRRLTWSLAMVSGVVSLFIENVTTLIMLAPMVFSVARALKVDAVPMLLAAAFASNLGGAALLVGDPQSALA
AGYFNLDFGDFLFHAGKPSIFWMVLTALIASTTAFTYTFVKGKFNLPSESKEKRSIRDKKLAYVSLTALAIKILLLALRK
QLGIGLSLPAFIGASIILLYTRDVKFAIKSIEWKLLAFLAGMFVLVGALQDSGTMRLVAESFTKLASCDYYKLTALIVAA
SVAVSAVVDNVPYLMAMFPIISKISSHCGIYYFKLLLALLIGATLGGNITYFGSSTNITAVHLLEEEGYSVRFRDFLKYG
AYYTAWALGSALALYYALWR

Specific function: Involved In Arsenical Resistance. Thought To Form The Channel Of An Arsenite Pump (By Similarity). [C]

COG id: COG1055

COG function: function code P; Na+/H+ antiporter NhaD and related arsenite permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CitM (TC 2.A.11) transporter family [H]

Homologues:

Organism=Homo sapiens, GI157266326, Length=205, Percent_Identity=31.219512195122, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI87082277, Length=417, Percent_Identity=23.5011990407674, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221472711, Length=428, Percent_Identity=24.0654205607477, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24581764, Length=428, Percent_Identity=24.0654205607477, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI45550608, Length=407, Percent_Identity=25.5528255528256, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24581759, Length=162, Percent_Identity=30.2469135802469, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19920704, Length=162, Percent_Identity=30.2469135802469, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574683, Length=162, Percent_Identity=30.2469135802469, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574681, Length=162, Percent_Identity=30.2469135802469, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574685, Length=162, Percent_Identity=30.2469135802469, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574678, Length=162, Percent_Identity=30.2469135802469, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000802
- InterPro:   IPR004680 [H]

Pfam domain/function: PF03600 CitMHS [H]

EC number: NA

Molecular weight: Translated: 45311; Mature: 45311

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRELAAGALFAGVVTVMIFLPESKRPWAALAGAALALAAGLVEPSRLPEHLNLDVLGLIA
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHH
GACVISAYLTESGLMDELAQRSLRWSKGDLRRLTWSLAMVSGVVSLFIENVTTLIMLAPM
HHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFSVARALKVDAVPMLLAAAFASNLGGAALLVGDPQSALAAGYFNLDFGDFLFHAGKPSI
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCCHHHHHHHCCCCHH
FWMVLTALIASTTAFTYTFVKGKFNLPSESKEKRSIRDKKLAYVSLTALAIKILLLALRK
HHHHHHHHHHHHHHHEEEEEECEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGIGLSLPAFIGASIILLYTRDVKFAIKSIEWKLLAFLAGMFVLVGALQDSGTMRLVAE
HHCCCCCCHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SFTKLASCDYYKLTALIVAASVAVSAVVDNVPYLMAMFPIISKISSHCGIYYFKLLLALL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGATLGGNITYFGSSTNITAVHLLEEEGYSVRFRDFLKYGAYYTAWALGSALALYYALWR
HHHHCCCCEEEECCCCCEEEEEEEECCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRELAAGALFAGVVTVMIFLPESKRPWAALAGAALALAAGLVEPSRLPEHLNLDVLGLIA
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHH
GACVISAYLTESGLMDELAQRSLRWSKGDLRRLTWSLAMVSGVVSLFIENVTTLIMLAPM
HHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFSVARALKVDAVPMLLAAAFASNLGGAALLVGDPQSALAAGYFNLDFGDFLFHAGKPSI
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCCHHHHHHHCCCCHH
FWMVLTALIASTTAFTYTFVKGKFNLPSESKEKRSIRDKKLAYVSLTALAIKILLLALRK
HHHHHHHHHHHHHHHEEEEEECEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGIGLSLPAFIGASIILLYTRDVKFAIKSIEWKLLAFLAGMFVLVGALQDSGTMRLVAE
HHCCCCCCHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SFTKLASCDYYKLTALIVAASVAVSAVVDNVPYLMAMFPIISKISSHCGIYYFKLLLALL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGATLGGNITYFGSSTNITAVHLLEEEGYSVRFRDFLKYGAYYTAWALGSALALYYALWR
HHHHCCCCEEEECCCCCEEEEEEEECCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; arsenite [Cytoplasm]; H2O [C]

Specific reaction: ATP + arsenite [Cytoplasm] + H2O = ADP + phosphate + arsenite [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]