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The map label for this gene is hisB [H]

Identifier: 156937598

GI number: 156937598

Start: 713108

End: 713677

Strand: Direct

Name: hisB [H]

Synonym: Igni_0805

Alternate gene names: 156937598

Gene position: 713108-713677 (Clockwise)

Preceding gene: 156937593

Following gene: 156937603

Centisome position: 54.96

GC content: 57.72

Gene sequence:

>570_bases
TTGGAGAGGAGGACTAAGGAGACCGTGGTCAAAGTGGAGAAGTGCGAGCGCGCGAGCGCAGACGTGGAGATACCCTTCTT
CCGCCACATGCTCGAGACGTTCTTGAAGCATTCCGGCCTGGCCGCTTGCATAAGCGCTCGCGACCTCCAAGGCTTTGATG
ACCACCACTTGGTGGAGGACGTGGCCATAGTTCTGGGAAGGTTCTTGAAAGAAGAGTTCGCTAAGAAGGTGGAAGAGGGA
ACTCTCAAGAGGTTCACGTGGTCTTTGGTCCCCATGGACGAGGCGCTGGCGCGCTGCGCGCTCGACGTCTCAGGGAGAGG
AGGCTTCTACGGCAGTATGGAGTTCGAGCGGGAGGAGATAGGCGGCCTCGCGCTGGAGAACGTGGAGCACTTCTTCGAGA
CCCTCGCTCGGGAGGCAAGGATCACGTTGCACTTAGACCTCCTTAAGGGCAAGAACGACCATCACAAAGTAGAAGCGTTG
TTCAAGGCGTTCGCCAAGTGTGTGTCCGAAGCGCTGGGGTACGGCGGAGAGCTCAGCACCAAGGGGGTGATAGAGATCAA
TGGTCAGTAA

Upstream 100 bases:

>100_bases
TGGTCAAGCTTCCTGTTCGACGTTTCCAACTTCGCACCAGCCCGCCTTTTACACAAAAACGCTCTATTTTACTGGTTCTC
GCAGTCCCGGGGCTCAAGCC

Downstream 100 bases:

>100_bases
ATTGAACGTTTTAAACTTTTGACTCCATTCTATCTATACAATAGTATATCATGCCCTTCAGCCGTAATAATCGATATATA
TCCTAATATTGTGAATCGAG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MERRTKETVVKVEKCERASADVEIPFFRHMLETFLKHSGLAACISARDLQGFDDHHLVEDVAIVLGRFLKEEFAKKVEEG
TLKRFTWSLVPMDEALARCALDVSGRGGFYGSMEFEREEIGGLALENVEHFFETLAREARITLHLDLLKGKNDHHKVEAL
FKAFAKCVSEALGYGGELSTKGVIEINGQ

Sequences:

>Translated_189_residues
MERRTKETVVKVEKCERASADVEIPFFRHMLETFLKHSGLAACISARDLQGFDDHHLVEDVAIVLGRFLKEEFAKKVEEG
TLKRFTWSLVPMDEALARCALDVSGRGGFYGSMEFEREEIGGLALENVEHFFETLAREARITLHLDLLKGKNDHHKVEAL
FKAFAKCVSEALGYGGELSTKGVIEINGQ
>Mature_189_residues
MERRTKETVVKVEKCERASADVEIPFFRHMLETFLKHSGLAACISARDLQGFDDHHLVEDVAIVLGRFLKEEFAKKVEEG
TLKRFTWSLVPMDEALARCALDVSGRGGFYGSMEFEREEIGGLALENVEHFFETLAREARITLHLDLLKGKNDHHKVEAL
FKAFAKCVSEALGYGGELSTKGVIEINGQ

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=188, Percent_Identity=41.4893617021277, Blast_Score=124, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324776, Length=164, Percent_Identity=40.2439024390244, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21258; Mature: 21258

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRTKETVVKVEKCERASADVEIPFFRHMLETFLKHSGLAACISARDLQGFDDHHLVED
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHH
VAIVLGRFLKEEFAKKVEEGTLKRFTWSLVPMDEALARCALDVSGRGGFYGSMEFEREEI
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
GGLALENVEHFFETLAREARITLHLDLLKGKNDHHKVEALFKAFAKCVSEALGYGGELST
CCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KGVIEINGQ
CCEEEECCC
>Mature Secondary Structure
MERRTKETVVKVEKCERASADVEIPFFRHMLETFLKHSGLAACISARDLQGFDDHHLVED
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHH
VAIVLGRFLKEEFAKKVEEGTLKRFTWSLVPMDEALARCALDVSGRGGFYGSMEFEREEI
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
GGLALENVEHFFETLAREARITLHLDLLKGKNDHHKVEALFKAFAKCVSEALGYGGELST
CCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KGVIEINGQ
CCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA