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The map label for this gene is eIF2A [H]

Identifier: 156937558

GI number: 156937558

Start: 685182

End: 685979

Strand: Reverse

Name: eIF2A [H]

Synonym: Igni_0765

Alternate gene names: 156937558

Gene position: 685979-685182 (Counterclockwise)

Preceding gene: 156937559

Following gene: 156937557

Centisome position: 52.87

GC content: 51.25

Gene sequence:

>798_bases
ATGCCCAAGAAGAGGTTGCCCAGAGTGGGAGAACTAGTCGTCGCGACAGTCAGAGAGGTGTTCGACTACGGCGCTTACGT
CACCCTGGACGAGTATGACGACTTGGAAGCTTACCTCCCTTGGAGCGAAGTGGCGTCCAGGTGGGTTAGGAACATAAGGC
AAGTCTTGAAGGAAAACCAAAAGATAGTTTGCAAAGTCATAAGGGTAAATAAGAAGAGGGGGACGGTCGACCTCTCGCTA
AAGAAGGTGACGGATTCCGAACGAAAGAGAAAGATGTACATGTATAAGAGGTTTAAGAAAGGAGAAAACTTGTTGAAGTT
GGTAGCCGAAGCTCTCGGCGAGGACTACGACAAGTTATACAACATGTTGGAACCCCACATCCAGAAGCACTTCGGTGACT
TGCTGGGAGTGTTTGAGGAGGCCGCCTTAGGAGGGGAGGAAGTGCTAACCAAGCTGGGCATTCCGGAAGAAGTGGCAAAG
GCTATAACAGAAGTTGCGAAGACTCACATAAAGATAAAGCCGGCGAAAGTAGTAGGCATGGCCATATTGCAGTCCTTCGC
GCCGGACGGAGTCGACCGTATCAGGAGGACCCTCATGAGCGCTTACGACTTCATCAAGGGTGACGAGATAAACGTGAGGG
TGTATACTGTGGGGGCGCCTAGGTACATGGTAGAGGTGACGGCTTTAGATTACAAGACCGCGGGGAAGACGCTCGAGGCC
GTGGGAGAGAAGATCCTTGAAGAGGCGAAAGCAGAGGGGTTAGAAGTGGCTAAGTTCGAACAGGTGGGAAGGAAATGA

Upstream 100 bases:

>100_bases
TAGAGCGGGCGAAGCTCCTCTTGAAGGGCGTTCTCAAGGAAGCTTGTGACGCGTAACTACCATTTAACCCCGTAAACCAC
GAAGGAGACGAGGAGGTAAA

Downstream 100 bases:

>100_bases
AGTTCTTAATGAAGAAGTGTGTGAGGTGTGGCAGGTACACCTTCAAGGACGTCTGCCCGGTGTGTAACGGACAGACGACA
GTACCCCACCCGCCGAGGTT

Product: translation initiation factor 2 subunit alpha (aeIF-2a)

Products: NA

Alternate protein names: aIF2-alpha; eIF-2-alpha [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MPKKRLPRVGELVVATVREVFDYGAYVTLDEYDDLEAYLPWSEVASRWVRNIRQVLKENQKIVCKVIRVNKKRGTVDLSL
KKVTDSERKRKMYMYKRFKKGENLLKLVAEALGEDYDKLYNMLEPHIQKHFGDLLGVFEEAALGGEEVLTKLGIPEEVAK
AITEVAKTHIKIKPAKVVGMAILQSFAPDGVDRIRRTLMSAYDFIKGDEINVRVYTVGAPRYMVEVTALDYKTAGKTLEA
VGEKILEEAKAEGLEVAKFEQVGRK

Sequences:

>Translated_265_residues
MPKKRLPRVGELVVATVREVFDYGAYVTLDEYDDLEAYLPWSEVASRWVRNIRQVLKENQKIVCKVIRVNKKRGTVDLSL
KKVTDSERKRKMYMYKRFKKGENLLKLVAEALGEDYDKLYNMLEPHIQKHFGDLLGVFEEAALGGEEVLTKLGIPEEVAK
AITEVAKTHIKIKPAKVVGMAILQSFAPDGVDRIRRTLMSAYDFIKGDEINVRVYTVGAPRYMVEVTALDYKTAGKTLEA
VGEKILEEAKAEGLEVAKFEQVGRK
>Mature_264_residues
PKKRLPRVGELVVATVREVFDYGAYVTLDEYDDLEAYLPWSEVASRWVRNIRQVLKENQKIVCKVIRVNKKRGTVDLSLK
KVTDSERKRKMYMYKRFKKGENLLKLVAEALGEDYDKLYNMLEPHIQKHFGDLLGVFEEAALGGEEVLTKLGIPEEVAKA
ITEVAKTHIKIKPAKVVGMAILQSFAPDGVDRIRRTLMSAYDFIKGDEINVRVYTVGAPRYMVEVTALDYKTAGKTLEAV
GEKILEEAKAEGLEVAKFEQVGRK

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [H]

COG id: COG1093

COG function: function code J; Translation initiation factor 2, alpha subunit (eIF-2alpha)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI4758256, Length=257, Percent_Identity=22.9571984435798, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17509871, Length=232, Percent_Identity=25, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322466, Length=248, Percent_Identity=27.0161290322581, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI18860087, Length=250, Percent_Identity=23.6, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011488
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR022964 [H]

Pfam domain/function: PF07541 EIF_2_alpha; PF00575 S1 [H]

EC number: NA

Molecular weight: Translated: 30113; Mature: 29981

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKKRLPRVGELVVATVREVFDYGAYVTLDEYDDLEAYLPWSEVASRWVRNIRQVLKENQ
CCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHCCH
KIVCKVIRVNKKRGTVDLSLKKVTDSERKRKMYMYKRFKKGENLLKLVAEALGEDYDKLY
HHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHH
NMLEPHIQKHFGDLLGVFEEAALGGEEVLTKLGIPEEVAKAITEVAKTHIKIKPAKVVGM
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHEECCHHHHHHH
AILQSFAPDGVDRIRRTLMSAYDFIKGDEINVRVYTVGAPRYMVEVTALDYKTAGKTLEA
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEEECCHHHHHHHHHH
VGEKILEEAKAEGLEVAKFEQVGRK
HHHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
PKKRLPRVGELVVATVREVFDYGAYVTLDEYDDLEAYLPWSEVASRWVRNIRQVLKENQ
CCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHCCH
KIVCKVIRVNKKRGTVDLSLKKVTDSERKRKMYMYKRFKKGENLLKLVAEALGEDYDKLY
HHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHH
NMLEPHIQKHFGDLLGVFEEAALGGEEVLTKLGIPEEVAKAITEVAKTHIKIKPAKVVGM
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHEECCHHHHHHH
AILQSFAPDGVDRIRRTLMSAYDFIKGDEINVRVYTVGAPRYMVEVTALDYKTAGKTLEA
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEEECCHHHHHHHHHH
VGEKILEEAKAEGLEVAKFEQVGRK
HHHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA