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The map label for this gene is pepA [H]

Identifier: 156937531

GI number: 156937531

Start: 664267

End: 665628

Strand: Direct

Name: pepA [H]

Synonym: Igni_0738

Alternate gene names: 156937531

Gene position: 664267-665628 (Clockwise)

Preceding gene: 156937530

Following gene: 156937532

Centisome position: 51.19

GC content: 53.45

Gene sequence:

>1362_bases
TTGGCGGAGAGGTTGCTGAGGCTTAAACTAACAGACGTTCCTCCGGAAAGGTTAGTAGGCGTAAAGGTTAAAATATTTAA
GAACAAGGATGACTTCGTAGAATTCGCCTCCCCCTTCTATACGGTAGAGGAAGTTAAGCCTAACAGCGTCGTAAAGGTGA
AGAAGGACGGAGAAGGTTACGTGGCCGCCTTCTGTGAGGACGACTTCGAGTGTGCCACATCGCTGGGAAAGGTACTAAAG
CAGCTGAGGACCAGCGTAGTCGACCTAACGAACGTCGAAGACCCTTACCCCTACATAACCGGCATAGCACTGACTGCCTG
GGAGTTTGACAAGTACAAGTCCGAGAAGAGGGAAGTGGAGATAGTTTTCAGTACGCCTAACAAGGAAGTGGCGCAAGAGG
CGTTAAGGCACGCGGAAGCGCAGATGTTCGCCAGAGATCTCGCTTCCGAGCCTCCTAACGTTCTGAACCCCAAAACCTTC
CCGGAGAGAGTAATGGAAAAGGTCAAGGGCTTACCAATAGAGGTAGAAGTCTTAGATGAGAACGACCTCAAGAAGGAAGG
ACTGGAGCTACTCTTGGCGGTCGGCAAGGGTTCCGACGTACCCCCGAGGTTGCTAATAATGAGGTACTACGGAGGCGGGG
AGAAGCTCGCAATGGTAGGAAAGGGAGTCACCTTTGACGCCGGCGGATATAACTTGAAGCCGGCAAATTACATGAAAAAC
ATGCACGCCGACATGAGCGGCGCTGCTGCAGTCGCCGCTGCGACGCTCTACGCAGCAAAACTGAACTTAAACGTCAACTT
AGAGTCATATATTCCGTTAGCAGAGAACCTAATATCCGGGAGGGCCTACAAAATGGAAGATATCATAAGGAGTTACAGTG
GCAAGTACGTCCACATAGGCAACACCGACGCGGAAGGCAGGCTTATCTTGGCCGACGCCCTAGCTTACGCTAAACGCTCG
TCGCCCAAGGTGACTTTTACCTTAGCGACTTTGACGGGCGCCCAGATAATCGCCCTCGGGTACGACATAGCTGCGCTGTA
CGCCACCCACGACGAGGACGCCGAGAAGGTGGAGGAGGCCTCGAAGCGTACGAAGGAGCTGGTGTGGAGAATGCCTCTAT
ACGAGAAGTATAAAGAAGAATTAAAGCATCCAAGTGCGGACTTGAGCAACGTGGGGAAGGGCAGGGGAGCCGGAAGCATA
ATCGGTGCGCTGTTCCTAAAGGAGTTCGCGCCGGAGAGGTGGGTGTACTTAGACATAGCCGGTCCAGCCATGGCCCACGA
GGCCAACGCTTGGTGGTGCTCTCCCTACCCCACCGGTTGGGGCGCCAGGCTGATGTTAGCGACCTTGAAGGAGTACCAGT
AG

Upstream 100 bases:

>100_bases
GACCTCGATGCGACTCAGCGTAACTCTGATTCCTCACCCGAGAGCCTCGGGCTTGCCGAGTTATCATCATCGCCCTTAAC
TCTCCCCTCCCACTGTATGC

Downstream 100 bases:

>100_bases
GGTGAGGCGGCCGTGCCGGTTAGGGTGAGCGAGTACAAGTCGTTTAAGGAGTTGTTAGACGACATGAACAGAGAGTTAGA
ACTGAACTTGGAGGGCCTTA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MAERLLRLKLTDVPPERLVGVKVKIFKNKDDFVEFASPFYTVEEVKPNSVVKVKKDGEGYVAAFCEDDFECATSLGKVLK
QLRTSVVDLTNVEDPYPYITGIALTAWEFDKYKSEKREVEIVFSTPNKEVAQEALRHAEAQMFARDLASEPPNVLNPKTF
PERVMEKVKGLPIEVEVLDENDLKKEGLELLLAVGKGSDVPPRLLIMRYYGGGEKLAMVGKGVTFDAGGYNLKPANYMKN
MHADMSGAAAVAAATLYAAKLNLNVNLESYIPLAENLISGRAYKMEDIIRSYSGKYVHIGNTDAEGRLILADALAYAKRS
SPKVTFTLATLTGAQIIALGYDIAALYATHDEDAEKVEEASKRTKELVWRMPLYEKYKEELKHPSADLSNVGKGRGAGSI
IGALFLKEFAPERWVYLDIAGPAMAHEANAWWCSPYPTGWGARLMLATLKEYQ

Sequences:

>Translated_453_residues
MAERLLRLKLTDVPPERLVGVKVKIFKNKDDFVEFASPFYTVEEVKPNSVVKVKKDGEGYVAAFCEDDFECATSLGKVLK
QLRTSVVDLTNVEDPYPYITGIALTAWEFDKYKSEKREVEIVFSTPNKEVAQEALRHAEAQMFARDLASEPPNVLNPKTF
PERVMEKVKGLPIEVEVLDENDLKKEGLELLLAVGKGSDVPPRLLIMRYYGGGEKLAMVGKGVTFDAGGYNLKPANYMKN
MHADMSGAAAVAAATLYAAKLNLNVNLESYIPLAENLISGRAYKMEDIIRSYSGKYVHIGNTDAEGRLILADALAYAKRS
SPKVTFTLATLTGAQIIALGYDIAALYATHDEDAEKVEEASKRTKELVWRMPLYEKYKEELKHPSADLSNVGKGRGAGSI
IGALFLKEFAPERWVYLDIAGPAMAHEANAWWCSPYPTGWGARLMLATLKEYQ
>Mature_452_residues
AERLLRLKLTDVPPERLVGVKVKIFKNKDDFVEFASPFYTVEEVKPNSVVKVKKDGEGYVAAFCEDDFECATSLGKVLKQ
LRTSVVDLTNVEDPYPYITGIALTAWEFDKYKSEKREVEIVFSTPNKEVAQEALRHAEAQMFARDLASEPPNVLNPKTFP
ERVMEKVKGLPIEVEVLDENDLKKEGLELLLAVGKGSDVPPRLLIMRYYGGGEKLAMVGKGVTFDAGGYNLKPANYMKNM
HADMSGAAAVAAATLYAAKLNLNVNLESYIPLAENLISGRAYKMEDIIRSYSGKYVHIGNTDAEGRLILADALAYAKRSS
PKVTFTLATLTGAQIIALGYDIAALYATHDEDAEKVEEASKRTKELVWRMPLYEKYKEELKHPSADLSNVGKGRGAGSII
GALFLKEFAPERWVYLDIAGPAMAHEANAWWCSPYPTGWGARLMLATLKEYQ

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=355, Percent_Identity=38.3098591549296, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI47155554, Length=316, Percent_Identity=35.4430379746835, Blast_Score=146, Evalue=4e-35,
Organism=Escherichia coli, GI1790710, Length=338, Percent_Identity=36.094674556213, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI87082123, Length=353, Percent_Identity=34.2776203966006, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=380, Percent_Identity=32.3684210526316, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=213, Percent_Identity=33.8028169014084, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24661038, Length=355, Percent_Identity=32.112676056338, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI21355725, Length=355, Percent_Identity=31.5492957746479, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI20129969, Length=334, Percent_Identity=30.8383233532934, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI19922386, Length=392, Percent_Identity=29.3367346938776, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21355645, Length=359, Percent_Identity=29.2479108635098, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24662223, Length=359, Percent_Identity=29.2479108635098, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI161077148, Length=353, Percent_Identity=29.1784702549575, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI20130057, Length=353, Percent_Identity=29.1784702549575, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24662227, Length=334, Percent_Identity=29.0419161676647, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI20129963, Length=430, Percent_Identity=28.6046511627907, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI221379063, Length=315, Percent_Identity=32.3809523809524, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI221379062, Length=315, Percent_Identity=32.3809523809524, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI21357381, Length=315, Percent_Identity=32.3809523809524, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24646701, Length=343, Percent_Identity=27.9883381924198, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646703, Length=343, Percent_Identity=27.9883381924198, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358201, Length=343, Percent_Identity=27.9883381924198, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 50267; Mature: 50136

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERLLRLKLTDVPPERLVGVKVKIFKNKDDFVEFASPFYTVEEVKPNSVVKVKKDGEGY
CCCCEEEEEECCCCHHHHEEEEEEEECCCHHHHHHHCCCEEEEECCCCCEEEEEECCCCE
VAAFCEDDFECATSLGKVLKQLRTSVVDLTNVEDPYPYITGIALTAWEFDKYKSEKREVE
EEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEEEEEEHHHHCCCCCEEE
IVFSTPNKEVAQEALRHAEAQMFARDLASEPPNVLNPKTFPERVMEKVKGLPIEVEVLDE
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECC
NDLKKEGLELLLAVGKGSDVPPRLLIMRYYGGGEKLAMVGKGVTFDAGGYNLKPANYMKN
CCCHHHHHHEEEEECCCCCCCCEEEEEEEECCCCEEEEEECCEEECCCCCCCCHHHHHHH
MHADMSGAAAVAAATLYAAKLNLNVNLESYIPLAENLISGRAYKMEDIIRSYSGKYVHIG
HCCCCCHHHHHHHHHHEEEEEEEEEEHHHCCCHHHHHHCCCCCHHHHHHHHCCCCEEEEC
NTDAEGRLILADALAYAKRSSPKVTFTLATLTGAQIIALGYDIAALYATHDEDAEKVEEA
CCCCCCEEEEEHHHHHHHCCCCEEEEEEEEECCCEEEEECCEEEEEEECCCCHHHHHHHH
SKRTKELVWRMPLYEKYKEELKHPSADLSNVGKGRGAGSIIGALFLKEFAPERWVYLDIA
HHHHHHHHHCCCHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEC
GPAMAHEANAWWCSPYPTGWGARLMLATLKEYQ
CCCHHCCCCCEEECCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AERLLRLKLTDVPPERLVGVKVKIFKNKDDFVEFASPFYTVEEVKPNSVVKVKKDGEGY
CCCEEEEEECCCCHHHHEEEEEEEECCCHHHHHHHCCCEEEEECCCCCEEEEEECCCCE
VAAFCEDDFECATSLGKVLKQLRTSVVDLTNVEDPYPYITGIALTAWEFDKYKSEKREVE
EEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEEEEEEHHHHCCCCCEEE
IVFSTPNKEVAQEALRHAEAQMFARDLASEPPNVLNPKTFPERVMEKVKGLPIEVEVLDE
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECC
NDLKKEGLELLLAVGKGSDVPPRLLIMRYYGGGEKLAMVGKGVTFDAGGYNLKPANYMKN
CCCHHHHHHEEEEECCCCCCCCEEEEEEEECCCCEEEEEECCEEECCCCCCCCHHHHHHH
MHADMSGAAAVAAATLYAAKLNLNVNLESYIPLAENLISGRAYKMEDIIRSYSGKYVHIG
HCCCCCHHHHHHHHHHEEEEEEEEEEHHHCCCHHHHHHCCCCCHHHHHHHHCCCCEEEEC
NTDAEGRLILADALAYAKRSSPKVTFTLATLTGAQIIALGYDIAALYATHDEDAEKVEEA
CCCCCCEEEEEHHHHHHHCCCCEEEEEEEEECCCEEEEECCEEEEEEECCCCHHHHHHHH
SKRTKELVWRMPLYEKYKEELKHPSADLSNVGKGRGAGSIIGALFLKEFAPERWVYLDIA
HHHHHHHHHCCCHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEC
GPAMAHEANAWWCSPYPTGWGARLMLATLKEYQ
CCCHHCCCCCEEECCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]