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The map label for this gene is proC [H]

Identifier: 156937452

GI number: 156937452

Start: 593489

End: 594226

Strand: Reverse

Name: proC [H]

Synonym: Igni_0659

Alternate gene names: 156937452

Gene position: 594226-593489 (Counterclockwise)

Preceding gene: 156937453

Following gene: 156937448

Centisome position: 45.8

GC content: 60.57

Gene sequence:

>738_bases
TTGAAGGTTTGCTTAATCGGCTACGGCAAGCTGGGTTCCTCGATAGCTAAGGGGTTGAGGAACGCCGGCGTTGAGGTGAC
CGTTTCCACGCTACCCCCCACCGACGAGTGGGCGCGCGAGGACGGCTTTTCCGTCGTGCCCATGAGGGCTTGCGCGGAGG
GGGTAGACCTAATAATAGTCGCCGTCCCGCCCTCGGCCGTTCCGGCAGTCATGAAGGAGCTGAGAGGGGTCGAAGTCCCG
ATAACCTCCACGGCCGCCTTGGTGAAGCTGGGAGAGCTAAAGAAGTACGCAGACAAGGTTTACAGAGTCATGCCCTCCGT
GACGGTAGAGGTAAACAGCTCCCCCGTGCTGGTCGCTGAAAGGGGAGGCGGAGCTGACTCGGTAGTGGAGGCCGTATGGG
GGAAGCTGGGCAAGGTCTACTGGGTCAACGAGAGGGTACTGGACGCCGCCCTCCCCGTGGTGGGCTCGGGCCCGGCGGTG
CACGCGGAATACTTCCGCTCGGCCGTGGAGGCCTTGGTGGCCTCCGGGGTGGAGAGGTCGCTGGCCGAGGAGTTGGCTAG
GGAGTCAATAATAGGAACGATAAAGATGTTAGAGAAGTACGACCCCTACAAGTTGCGCTCTAAGGTCGAGACCCCCGGGG
GCATCACCGTCGAGATGCTCTTGAAGCTCGAAGAGGAGGGGGTCTTCGGTAAAATAGCTAAAGTCTTAGGAGAGAAGGGG
AGGGAGCTCAGTCGATGA

Upstream 100 bases:

>100_bases
GCAGTGGTTGCCGGTTCTTTGGCGGAGCTCTTGGGAAAGCTCTTCGAGAAGGCCGCGGGGCCCTAAAAGCTCCCCCTCAA
CCCCTATCCCGGTGAAGTCC

Downstream 100 bases:

>100_bases
GCTCTTCTTCCTCCTCTTCTAACTCTCTAACCCAGAGCTCCCTCCTCAAGAGCTCCCTAATAGCCACCCTTATGGCCTCA
CTCCTAGAAGTGAACCTCCC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MKVCLIGYGKLGSSIAKGLRNAGVEVTVSTLPPTDEWAREDGFSVVPMRACAEGVDLIIVAVPPSAVPAVMKELRGVEVP
ITSTAALVKLGELKKYADKVYRVMPSVTVEVNSSPVLVAERGGGADSVVEAVWGKLGKVYWVNERVLDAALPVVGSGPAV
HAEYFRSAVEALVASGVERSLAEELARESIIGTIKMLEKYDPYKLRSKVETPGGITVEMLLKLEEEGVFGKIAKVLGEKG
RELSR

Sequences:

>Translated_245_residues
MKVCLIGYGKLGSSIAKGLRNAGVEVTVSTLPPTDEWAREDGFSVVPMRACAEGVDLIIVAVPPSAVPAVMKELRGVEVP
ITSTAALVKLGELKKYADKVYRVMPSVTVEVNSSPVLVAERGGGADSVVEAVWGKLGKVYWVNERVLDAALPVVGSGPAV
HAEYFRSAVEALVASGVERSLAEELARESIIGTIKMLEKYDPYKLRSKVETPGGITVEMLLKLEEEGVFGKIAKVLGEKG
RELSR
>Mature_245_residues
MKVCLIGYGKLGSSIAKGLRNAGVEVTVSTLPPTDEWAREDGFSVVPMRACAEGVDLIIVAVPPSAVPAVMKELRGVEVP
ITSTAALVKLGELKKYADKVYRVMPSVTVEVNSSPVLVAERGGGADSVVEAVWGKLGKVYWVNERVLDAALPVVGSGPAV
HAEYFRSAVEALVASGVERSLAEELARESIIGTIKMLEKYDPYKLRSKVETPGGITVEMLLKLEEEGVFGKIAKVLGEKG
RELSR

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=246, Percent_Identity=30.0813008130081, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI24797097, Length=255, Percent_Identity=29.0196078431373, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI24797095, Length=255, Percent_Identity=29.0196078431373, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI21361454, Length=257, Percent_Identity=29.1828793774319, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=26.5917602996255, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17569021, Length=256, Percent_Identity=29.296875, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320861, Length=170, Percent_Identity=30.5882352941176, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21358587, Length=252, Percent_Identity=26.5873015873016, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 26135; Mature: 26135

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVCLIGYGKLGSSIAKGLRNAGVEVTVSTLPPTDEWAREDGFSVVPMRACAEGVDLIIV
CEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCEEEEHHHHHCCCCEEEE
AVPPSAVPAVMKELRGVEVPITSTAALVKLGELKKYADKVYRVMPSVTVEVNSSPVLVAE
EECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEE
RGGGADSVVEAVWGKLGKVYWVNERVLDAALPVVGSGPAVHAEYFRSAVEALVASGVERS
CCCCHHHHHHHHHHHCCCEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAEELARESIIGTIKMLEKYDPYKLRSKVETPGGITVEMLLKLEEEGVFGKIAKVLGEKG
HHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCC
RELSR
CCCCC
>Mature Secondary Structure
MKVCLIGYGKLGSSIAKGLRNAGVEVTVSTLPPTDEWAREDGFSVVPMRACAEGVDLIIV
CEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCEEEEHHHHHCCCCEEEE
AVPPSAVPAVMKELRGVEVPITSTAALVKLGELKKYADKVYRVMPSVTVEVNSSPVLVAE
EECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEE
RGGGADSVVEAVWGKLGKVYWVNERVLDAALPVVGSGPAVHAEYFRSAVEALVASGVERS
CCCCHHHHHHHHHHHCCCEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAEELARESIIGTIKMLEKYDPYKLRSKVETPGGITVEMLLKLEEEGVFGKIAKVLGEKG
HHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCC
RELSR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]