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The map label for this gene is wecC [H]

Identifier: 156937415

GI number: 156937415

Start: 558010

End: 559266

Strand: Direct

Name: wecC [H]

Synonym: Igni_0622

Alternate gene names: 156937415

Gene position: 558010-559266 (Clockwise)

Preceding gene: 156937407

Following gene: 156937416

Centisome position: 43.01

GC content: 56.17

Gene sequence:

>1257_bases
TTGAGGATAGCCGTCGTTGGTCTCGGTTACGTCGGCCTACCCTTGGCGACCGCCCTAGCTTCCAAGGGCTTCGAAGTCGT
GGGGATCGATATAGACGAGAAGAAGGTGGAGAAGGTAAACAAGGGCGTAGCGCCAATAGAGGAGCCCAAGCTCCCAGAGA
TGCTAAAAGAGGTAGTCTCCAAAGGCTTATTGAGGGCGACTACGAACTACGACGTTATAGGTGAGACGGACGCTGCAATA
ATAGCGGTCCCTACCCCCGTGAAGGGAGGGAAGGCCGACCTAAGCTACTTGGAGTCCGCGCTGAGGGAAATAGGCAAGAG
GATGAAGGAGGGTTACTTGGTGGTGATCGAGTCCACCATCCCCCCGGGCACCACCCAAGGGTTAGCGAAGAGGGTGCTAG
AGGAGGCCAGCGGCCTGAAGCACGGCGAGTTCTACTTGGCCCACGCCCCGGAGAGGCTCGCGCCGGGGAAGGCGATGGAA
GAGCTCTTCAAGGTGCCGAAGCTCGTGGGGGGCTTGACGGAGGAAGACGCTAAGAGGGCCGCCTCTATATATTCCAAGCT
TACTGAGGGAGGTGTAATAATTACCAGCGCGATAAACGCGGAGATGAGCAAGCTCGCAGAGAACACCTTCCGGGACCTCA
ACATAGCCTTCGCCAATGCGCTGGCACTTCTCGCCGAGAAGCTCGGGGCAGACGTGTGGGAGGTGATAAAGCTGGCGAAC
ACCCACCCAAGGGTAAACATCCACTTGCCGGGGCCCGGCGTGGGGGGCCCGTGCCTCACGAAAGATCCCTACATGTTGGC
AGAACCCATGGAGGATACGTCTAAAAACTTAATAATCACGGCTAGAAAAATAAATGAGAGGATGCCTCACCACTTCGCGG
AGCTCGTCAAGAACATGGTAAAGCGCGGGGAGAAGGTGGCGCTTCTAGGGCTAGCCTACAAAGGAGGGGTGGACGACATA
AGGGAAAGCCCCACCTTGAAGATCTACGACCTCCTCAAAGACGATTACGAGGTGGCCGTACACGACCCCTACGTTAAGGA
AGCTCCGATACCCTTCACCAACGACTTGTTGAGCGCGGTGAGGGGGGCGAGCTTGATAGCAGTAGTTACCGACCACCCAG
ATTACAAGGAAATAGACTGGGGGGAGGTGGCCAAGGTAGTTAAAGAGAAGAAAGTGTTGGACGGCAGGAACGTGGTACCT
AAGGAAGAAGTGTTGAAATTCGGGTTCGTCTACAAGGCGTTGGGCGTGGGCACTTGA

Upstream 100 bases:

>100_bases
GGAAGTCCCGGGTTCAAATCCCGGCGGGCCCGCCACACGGCGGCCAAGGGCTCCTACAACTTTACCTCCCCCTCCTAACC
CTTACCGGAGGCCGCTGAGC

Downstream 100 bases:

>100_bases
TAGCCGTGGTCGTGGGCACCAGGCCAGAAATAATAAAGATGGCGCCGGTGGTCCTCGAGCTCGAGAGCAGAGGAATAGAC
TACACCTTCGTTCACACCGG

Product: UDP-glucose 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MRIAVVGLGYVGLPLATALASKGFEVVGIDIDEKKVEKVNKGVAPIEEPKLPEMLKEVVSKGLLRATTNYDVIGETDAAI
IAVPTPVKGGKADLSYLESALREIGKRMKEGYLVVIESTIPPGTTQGLAKRVLEEASGLKHGEFYLAHAPERLAPGKAME
ELFKVPKLVGGLTEEDAKRAASIYSKLTEGGVIITSAINAEMSKLAENTFRDLNIAFANALALLAEKLGADVWEVIKLAN
THPRVNIHLPGPGVGGPCLTKDPYMLAEPMEDTSKNLIITARKINERMPHHFAELVKNMVKRGEKVALLGLAYKGGVDDI
RESPTLKIYDLLKDDYEVAVHDPYVKEAPIPFTNDLLSAVRGASLIAVVTDHPDYKEIDWGEVAKVVKEKKVLDGRNVVP
KEEVLKFGFVYKALGVGT

Sequences:

>Translated_418_residues
MRIAVVGLGYVGLPLATALASKGFEVVGIDIDEKKVEKVNKGVAPIEEPKLPEMLKEVVSKGLLRATTNYDVIGETDAAI
IAVPTPVKGGKADLSYLESALREIGKRMKEGYLVVIESTIPPGTTQGLAKRVLEEASGLKHGEFYLAHAPERLAPGKAME
ELFKVPKLVGGLTEEDAKRAASIYSKLTEGGVIITSAINAEMSKLAENTFRDLNIAFANALALLAEKLGADVWEVIKLAN
THPRVNIHLPGPGVGGPCLTKDPYMLAEPMEDTSKNLIITARKINERMPHHFAELVKNMVKRGEKVALLGLAYKGGVDDI
RESPTLKIYDLLKDDYEVAVHDPYVKEAPIPFTNDLLSAVRGASLIAVVTDHPDYKEIDWGEVAKVVKEKKVLDGRNVVP
KEEVLKFGFVYKALGVGT
>Mature_418_residues
MRIAVVGLGYVGLPLATALASKGFEVVGIDIDEKKVEKVNKGVAPIEEPKLPEMLKEVVSKGLLRATTNYDVIGETDAAI
IAVPTPVKGGKADLSYLESALREIGKRMKEGYLVVIESTIPPGTTQGLAKRVLEEASGLKHGEFYLAHAPERLAPGKAME
ELFKVPKLVGGLTEEDAKRAASIYSKLTEGGVIITSAINAEMSKLAENTFRDLNIAFANALALLAEKLGADVWEVIKLAN
THPRVNIHLPGPGVGGPCLTKDPYMLAEPMEDTSKNLIITARKINERMPHHFAELVKNMVKRGEKVALLGLAYKGGVDDI
RESPTLKIYDLLKDDYEVAVHDPYVKEAPIPFTNDLLSAVRGASLIAVVTDHPDYKEIDWGEVAKVVKEKKVLDGRNVVP
KEEVLKFGFVYKALGVGT

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=464, Percent_Identity=29.0948275862069, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI296040438, Length=370, Percent_Identity=28.3783783783784, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI296040443, Length=307, Percent_Identity=28.3387622149837, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI48994968, Length=421, Percent_Identity=39.1923990498812, Blast_Score=287, Evalue=9e-79,
Organism=Escherichia coli, GI1788340, Length=359, Percent_Identity=28.4122562674095, Blast_Score=112, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17560350, Length=462, Percent_Identity=27.0562770562771, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17136908, Length=462, Percent_Identity=26.6233766233766, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45318; Mature: 45318

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAVVGLGYVGLPLATALASKGFEVVGIDIDEKKVEKVNKGVAPIEEPKLPEMLKEVVS
CEEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
KGLLRATTNYDVIGETDAAIIAVPTPVKGGKADLSYLESALREIGKRMKEGYLVVIESTI
CCCEEECCCCCEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCC
PPGTTQGLAKRVLEEASGLKHGEFYLAHAPERLAPGKAMEELFKVPKLVGGLTEEDAKRA
CCCCHHHHHHHHHHHHCCCCCCCEEEEECCHHCCCCHHHHHHHHHHHHHCCCCHHHHHHH
ASIYSKLTEGGVIITSAINAEMSKLAENTFRDLNIAFANALALLAEKLGADVWEVIKLAN
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
THPRVNIHLPGPGVGGPCLTKDPYMLAEPMEDTSKNLIITARKINERMPHHFAELVKNMV
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCHHHHHHHHHHHH
KRGEKVALLGLAYKGGVDDIRESPTLKIYDLLKDDYEVAVHDPYVKEAPIPFTNDLLSAV
HCCCEEEEEEEEECCCHHHHHCCCCEEEHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHH
RGASLIAVVTDHPDYKEIDWGEVAKVVKEKKVLDGRNVVPKEEVLKFGFVYKALGVGT
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRIAVVGLGYVGLPLATALASKGFEVVGIDIDEKKVEKVNKGVAPIEEPKLPEMLKEVVS
CEEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
KGLLRATTNYDVIGETDAAIIAVPTPVKGGKADLSYLESALREIGKRMKEGYLVVIESTI
CCCEEECCCCCEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCC
PPGTTQGLAKRVLEEASGLKHGEFYLAHAPERLAPGKAMEELFKVPKLVGGLTEEDAKRA
CCCCHHHHHHHHHHHHCCCCCCCEEEEECCHHCCCCHHHHHHHHHHHHHCCCCHHHHHHH
ASIYSKLTEGGVIITSAINAEMSKLAENTFRDLNIAFANALALLAEKLGADVWEVIKLAN
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
THPRVNIHLPGPGVGGPCLTKDPYMLAEPMEDTSKNLIITARKINERMPHHFAELVKNMV
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCHHHHHHHHHHHH
KRGEKVALLGLAYKGGVDDIRESPTLKIYDLLKDDYEVAVHDPYVKEAPIPFTNDLLSAV
HCCCEEEEEEEEECCCHHHHHCCCCEEEHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHH
RGASLIAVVTDHPDYKEIDWGEVAKVVKEKKVLDGRNVVPKEEVLKFGFVYKALGVGT
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]