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The map label for this gene is dut [H]

Identifier: 156937378

GI number: 156937378

Start: 526108

End: 526530

Strand: Direct

Name: dut [H]

Synonym: Igni_0585

Alternate gene names: 156937378

Gene position: 526108-526530 (Clockwise)

Preceding gene: 156937377

Following gene: 156937381

Centisome position: 40.55

GC content: 59.81

Gene sequence:

>423_bases
ATGCCGAAGAGGGCTAACCCTTGGGACGCGGGTTTGGACCTCCACGCGCTGGAGGAAGTGGTAGTAGAGCCCGGGGAAGT
GAAGGTCGTCCGCACGGGAATAGCGATAGCTATACCCAGGGGGTTCGTGGGGCTGATCAAGGATCGCTCCTCTCGAGCGC
TGAAGGGTCTACACGCGCTGGCCGGGGTAATAGACCCCGGTTACCGGGGGGAAGTTAAGGTTGTTGTTACGAACTTAGGC
AGTGATAAAATAACCATTAGGAAAGGGGAGAGGTTCGCACAGCTAGTTATAGTCCCGGTAGCTTACTTGGAGCCGGTCGA
GGTCGAGGAGTTGCCCCCAAACGACGGCAGGTCGGGGGGTTTCGGCTCTACGGATGAGGAGTTGGTCCGGGTCGCGAGGG
GTGAGCGGAGAGGGCCCCCCTAG

Upstream 100 bases:

>100_bases
AAGAAGCTGCTTATCCCCCCGCCCTTAGCTCTGTTAGGAATAGCCGGTTGGAGGATGAGGAGGCTTGCTGCCCGTAAAGA
GGTTGGAGAAGGACGCCGTA

Downstream 100 bases:

>100_bases
CCGACCTCGCTCAGCGCCCGAACCTCCTCTGCCTCCTCTGGTAGTCCCGGAGGGCCCTCAGTATGTCTATCCTCCTTATT
TCTGGCCAGTAGATGTTGGC

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MPKRANPWDAGLDLHALEEVVVEPGEVKVVRTGIAIAIPRGFVGLIKDRSSRALKGLHALAGVIDPGYRGEVKVVVTNLG
SDKITIRKGERFAQLVIVPVAYLEPVEVEELPPNDGRSGGFGSTDEELVRVARGERRGPP

Sequences:

>Translated_140_residues
MPKRANPWDAGLDLHALEEVVVEPGEVKVVRTGIAIAIPRGFVGLIKDRSSRALKGLHALAGVIDPGYRGEVKVVVTNLG
SDKITIRKGERFAQLVIVPVAYLEPVEVEELPPNDGRSGGFGSTDEELVRVARGERRGPP
>Mature_139_residues
PKRANPWDAGLDLHALEEVVVEPGEVKVVRTGIAIAIPRGFVGLIKDRSSRALKGLHALAGVIDPGYRGEVKVVVTNLGS
DKITIRKGERFAQLVIVPVAYLEPVEVEELPPNDGRSGGFGSTDEELVRVARGERRGPP

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=124, Percent_Identity=42.741935483871, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI4503423, Length=124, Percent_Identity=42.741935483871, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI70906441, Length=127, Percent_Identity=41.7322834645669, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790071, Length=130, Percent_Identity=38.4615384615385, Blast_Score=74, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71988561, Length=127, Percent_Identity=40.9448818897638, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319729, Length=126, Percent_Identity=35.7142857142857, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583610, Length=124, Percent_Identity=33.0645161290323, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921126, Length=124, Percent_Identity=33.0645161290323, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15067; Mature: 14935

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKRANPWDAGLDLHALEEVVVEPGEVKVVRTGIAIAIPRGFVGLIKDRSSRALKGLHAL
CCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCEEEEECCCCEEEHHCCCHHHHHHHHHH
AGVIDPGYRGEVKVVVTNLGSDKITIRKGERFAQLVIVPVAYLEPVEVEELPPNDGRSGG
HHHCCCCCCCEEEEEEEECCCCEEEEECCCCEEEEEEEEHHHCCCCCCCCCCCCCCCCCC
FGSTDEELVRVARGERRGPP
CCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PKRANPWDAGLDLHALEEVVVEPGEVKVVRTGIAIAIPRGFVGLIKDRSSRALKGLHAL
CCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCEEEEECCCCEEEHHCCCHHHHHHHHHH
AGVIDPGYRGEVKVVVTNLGSDKITIRKGERFAQLVIVPVAYLEPVEVEELPPNDGRSGG
HHHCCCCCCCEEEEEEEECCCCEEEEECCCCEEEEEEEEHHHCCCCCCCCCCCCCCCCCC
FGSTDEELVRVARGERRGPP
CCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA